The World Health Organization Fracture Risk Assessment Tool (FRAX) underestimates incident and recurrent fractures in consecutive patients with fragility fractures

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 7, 2014, Pages 2400-2408

  Roux, Sophie ^a   Cabana, François ^a   Carrier, Nathalie ^a   Beaulieu, Michèle ^b   April, Pierre Marc ^a   Beaulieu, Marie Claude ^a   Boire, Gilles ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b Merck Canada Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CORTICOSTEROID;

ADULT; ARTICLE; BODY MASS; BONE DENSITY; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FRAGILITY FRACTURE; HUMAN; INCIDENCE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENT DISEASE; RISK ASSESSMENT; SCORING SYSTEM; SENSITIVITY ANALYSIS; WORLD HEALTH ORGANIZATION;

AGED; BODY MASS INDEX; BONE DENSITY; COHORT STUDIES; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; OSTEOPOROTIC FRACTURES; PREDICTIVE VALUE OF TESTS; RECURRENCE; RESEARCH DESIGN; RISK ASSESSMENT; RISK FACTORS; WORLD HEALTH ORGANIZATION;

EID: 84904052403     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-4507     Document Type: Article

References (36)

1. Dennison E, Mohamed MA, Cooper C. Epidemiology of osteoporosis. Rheum Dis Clin North Am. 2006;32:617-629. (Pubitemid 46590097)
2. Bessette L, Ste-Marie LG, Jean S, et al. The care gap in diagnosis and treatment of women with a fragility fracture. Osteoporos Int. 2008;19:79-86. (Pubitemid 350198056)
3. Kanis JA, Johnell O, De Laet C, et al. A meta-analysis of previous fracture and subsequent fracture risk. Bone. 2004;35:375-382. (Pubitemid 38953182)
4. Pasco JA, Seeman E, Henry MJ, Merriman EN, Nicholson GC, Kotowicz MA. The population burden of fractures originates inwomen with osteopenia, not osteoporosis. Osteoporos Int. 2006;17:1404-1409. (Pubitemid 44127328)
5. Leslie WD, Berger C, Langsetmo L, et al. Construction and validation of a simplified fracture risk assessment tool for Canadian women and men: results from the CaMos and Manitoba cohorts. Osteoporos Int. 2011;22:1873-1883.
6. Nguyen ND, Frost SA, Center JR, Eisman JA, Nguyen TV. Development of prognostic nomograms for individualizing 5-year and 10-year fracture risks. Osteoporos Int. 2008;19:1431-1444.
7. Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E. FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008;19:385-397.
8. Leslie WD, Lix LM, Johansson H, Oden A, McCloskey E, Kanis JA. Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration. J Bone Miner Res. 2010;25:2350-2358.
9. Chapurlat R. Contribution and limitations of the FRAX tool. Joint Bone Spine. 2013;80:355-357.
10. McCloskey E, Kanis JA. FRAX updates 2012. Curr Opin Rheumatol. 2012;24:554-560.
11. Sambrook PN, Flahive J, Hooven FH, et al. Predicting fractures in an international cohort using risk factor algorithms without BMD. J Bone Miner Res. 2011;26:2770-2777.
12. Briot K, Cortet B, Thomas T, et al. 2012 update of French guidelines for the pharmacological treatment of postmenopausal osteoporosis. Joint Bone Spine. 2012;79:304-313.
13. Leslie WD, Schousboe JT. A review of osteoporosis diagnosis and treatment options in new and recently updated guidelines on case finding around the world. Curr Osteoporos Rep. 2011;9:129-140.
14. Compston J, Bowring C, Cooper A, et al. Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: National Osteoporosis Guideline Group (NOGG) update 2013. Maturitas. 2013;75:392-396.
15. Johnell O, Kanis JA, Oden A, et al. Fracture risk following an osteoporotic fracture. Osteoporos Int. 2004;15:175-179. (Pubitemid 38391531)
16. Roux S, Beaulieu M, Beaulieu MC, Cabana F, Boire G. Priming primary care physicians to treat osteoporosis after a fragility fracture: an integrated multidisciplinary approach. J Rheumatol. 2013;40:703-711.
17. Kreiger N, Tenenhouse A, Joseph L, et al. The Canadian multicentre osteoroposis study (CaMos): background, rationale, methods. Can J Aging. 1999;18:376-387.
18. Papaioannou A, Morin S, Cheung AM, et al. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ. 2010;182:1864-1873.
19. Giangregorio LM, Leslie WD, Lix LM, et al. FRAX underestimates fracture risk in patients with diabetes. J Bone Miner Res. 2012;27:301-308.
20. Tremollieres FA, Pouilles JM, Drewniak N, Laparra J, Ribot CA, Dargent-Molina P. Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool. J Bone Miner Res. 2010;25:1002-1009.
21. Sornay-Rendu E, Munoz F, Delmas PD, Chapurlat RD. The FRAX tool in French women: how well does it describe the real incidence of fracture in the OFELY cohort? J Bone Miner Res. 2010;25:2101-2107.
22. Aubry-Rozier B, Stoll D, Krieg MA, Lamy O, Hans D. What was your fracture risk evaluated by FRAX(R) the day before your osteoporotic fracture? Clin Rheumatol. 2013;32:219-223.
23. Fraser LA, Langsetmo L, Berger C, et al. Fracture prediction and calibration of a Canadian FRAX(R) tool: a population-based report from CaMos. Osteoporos Int. 2011;22:829-837.
24. Ahmed LA, Center JR, Bjornerem A, et al. Progressively increasing fracture risk with advancing age after initial incident fragility fracture: The Tromso Study. J Bone Miner Res. 2013;28:2214-2221.
25. Gehlbach S, Saag KG, Adachi JD, et al. Previous fractures at multiple sites increase the risk for subsequent fractures: the Global Longitudinal Study of Osteoporosis in Women. J Bone Miner Res. 2012;27:645-653.
26. Kanis JA, McCloskey EV, Johansson H, Strom O, Borgstrom F, Oden A. Case finding for the management of osteoporosis with FRAX-assessment and intervention thresholds for the UK. Osteoporos Int. 2008;19:1395-1408.
27. Rubin KH, Abrahamsen B, Hermann AP, Bech M, Gram J, Brixen K. Prevalence of risk factors for fractures and use of DXA scanning in Danish women. A regional population-based study. Osteoporos Int. 2011;22:1401-1409.
28. Morris CA, Cabral D, Cheng H, et al. Patterns of bone mineral density testing: current guidelines, testing rates, and interventions. J Gen Intern Med. 2004;19:783-790. (Pubitemid 38951953)
29. Davisson L, Warden M, Manivannan S, et al. Osteoporosis screening: factors associated with bone mineral density testing of older women. J Womens Health (Larchmt). 2009;18:989-994.
30. Rubin KH, Friis-Holmberg T, Hermann AP, Abrahamsen B, Brixen K. Risk assessment tools to identify women with increased risk of osteoporotic fracture: complexity or simplicity? A systematic review. J Bone Miner Res. 2013;28:1701-1717.
31. Leslie WD, Morin S, Johansson H, et al. Fracture risk assessment without bone density measurement in routine clinical practice. Osteoporos Int. 2012;23:75-85.
32. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ. 1996;312:1254-1259. (Pubitemid 26147662)
33. Leslie WD, Lix LM, Johansson H, Oden A, McCloskey E, Kanis JA. A comparative study of using non-hip bone density inputs with FRAX(R). Osteoporos Int. 2012;23:853-860.
34. Xu W, Perera S, Medich D, et al. Height loss, vertebral fractures, and the misclassification of osteoporosis. Bone. 2011;48:307-311.
35. Silverman SL, Calderon AD. The utility and limitations of FRAX: a US perspective. Curr Osteoporos Rep. 2010;8:192-197.
36. Akesson K, Marsh D, Mitchell PJ, et al. Capture the fracture: a best practice framework and global campaign to break the fragility fracture cycle. Osteoporos Int. 2013;24:2135-2152.