Tumor suppressor TSLC1 inhibits growth, proliferation, invasiveness and angiogenesis in nude mice xenografted tumor of Eca109 cells

International Journal of Clinical and Experimental Medicine

Volumn 7, Issue 6, 2014, Pages 1507-1515

  Liang, Qi Lian ^a   Chen, Guo Qiang ^a   Liu, Qiu Long ^a   Li, Zhou Yu ^b   Zhang, Xiang Ning ^a   Zhou, Yuan ^a   Ou, Wen Ting ^a   Wang, Bi Rong ^b   Hu, Li Ren ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Esophageal cancer; Nude mice; Tumor suppressor gene; Tumor suppressor in lung cancer 1 (TSLC1); Tumorigenic ity

Indexed keywords

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INFILTRATION; CANCER INHIBITION; CANCER PROGNOSIS; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; ESOPHAGEAL CANCER CELL LINE; ESOPHAGUS CANCER; FEMALE; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LUNG CANCER; MALE; METASTASIS; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR INVASION; TUMOR SUPPRESSOR GENE; TUMOR SUPPRESSOR LUNG CANCER 1 GENE; WESTERN BLOTTING;

EID: 84904044213     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Parkin DM, Bray FI and Devesa SS. Cancer burden in the year 2000. The global picture. Eur J Cancer 2001; 37 Suppl 8: S4-S66.
2. Yi Lo PH, Chung Leung AC, Xiong W, Law S, Duh FM, Lerman MI, Stanbridge EJ and Lung ML. Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas. Cancer Lett 2006; 234: 184-192.
3. Lu B, Di W, Wang H, Ma H, Li J and Zhang Q. Tumor suppressor TSLC1 is implicated in cell proliferation, invasion and apoptosis in laryn-geal squamous cell carcinoma by regulating Akt signaling pathway. Tumour Biol 2012; 33: 2007-2017.
4. Dickinson PJ, Surace EI, Cambell M, Higgins RJ, Leutenegger CM, Bollen AW, LeCouteur RA and Gutmann DH. Expression of the tumor suppressor genes NF2, 4.1B, and TSLC1 in canine meningiomas. Vet Pathol 2009; 46: 884-892.
5. Heller G, Geradts J, Ziegler B, Newsham I, Filipits M, Markis-Ritzinger EM, Kandioler D, Berger W, Stiglbauer W, Depisch D, Pirker R, Zielinski CC and Zochbauer-Muller S. Down-regulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. Breast Cancer Res Treat 2007; 103: 283-291.
6. Lung HL, Cheung AK, Xie D, Cheng Y, Kwong FM, Murakami Y, Guan XY, Sham JS, Chua D, Protopopov AI, Zabarovsky ER, Tsao SW, Stanbridge EJ and Lung ML. TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma. Cancer Res 2006; 66: 9385-9392.
7. Qin L, Zhu W, Xu T, Hao Y, Zhang Z, Tian Y and Yang D. Effect of TSLC1 gene on proliferation, invasion and apoptosis of human hepatocellu-lar carcinoma cell line HepG2. J Huazhong Univ Sci Technolog Med Sci 2007; 27: 535-537.
8. Goto A, Niki T, Chi-Pin L, Matsubara D, Murakami Y, Funata N and Fukayama M. Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic signifcance. Cancer Sci 2005; 96: 480-486.
9. Dewan MZ, Takamatsu N, Hidaka T, Hatakeyama K, Nakahata S, Fujisawa J, Katano H, Yamamoto N and Morishita K. Critical role for TSLC1 expression in the growth and organ infltration of adult T-cell leukemia cells in vivo. J Virol 2008; 82: 11958-11963.
10. Zhang J, Ning J, Geng J, Cui B and Dong X. Down-regulation of tumor suppressor in lung cancer 1 (TSLC1) expression correlates with poor prognosis in patients with colon cancer. J Mol Histol 2012; 43: 715-721.
11. Ito T, Shimada Y, Hashimoto Y, Kaganoi J, Kan T, Watanabe G, Murakami Y and Imamura M. Involvement of TSLC1 in progression of esoph-ageal squamous cell carcinoma. Cancer Res 2003; 63: 6320-6326.
12. Liang QL, Wang BR, Li ZY, Chen GQ and Zhou Y. Effect of TSLC1 gene on growth and apoptosis in human esophageal carcinoma Eca109 cells. Arch Med Sci 2012; 8: 987-992.
13. Liang QL, Wang BR, Li ZY, Chen GQ and Zhou Y. Construction of eukaryotic expression vector of TSLC1 gene. Arch Med Sci 2011; 7: 579-585.
14. Shingai T, Ikeda W, Kakunaga S, Morimoto K, Takekuni K, Itoh S, Satoh K, Takeuchi M, Imai T, Monden M and Takai Y. Implications of nec-tin-like molecule-2/IGSF4/RA175/SgIGSF/ TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem 2003; 278: 35421-35427.
15. Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, Takamoto S and Murakami Y. Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. Int J Cancer 2003; 107: 53-59.
16. Sussan TE, Pletcher MT, Murakami Y and Reeves RH. Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression. Mol Cancer 2005; 4: 28.
17. Surace EI, Lusis E, Murakami Y, Scheithauer BW, Perry A and Gutmann DH. Loss of tumor suppressor in lung cancer-1 (TSLC1) expression in meningioma correlates with increased malignancy grade and reduced patient survival. J Neuropathol Exp Neurol 2004; 63: 1015-1027.
18. Yuan L, Chen AM, Guo FJ, Zhu WT, Wang J and Liao H. Effect of TSLC1 gene on cell aggression, Tumor formation and capability of metastasis in human prostatic carcinoma cell line T3B. J Oncol 2009; 15: 990-994. (in Chinese with abstract in English).
19. Mao X, Seidlitz E, Ghosh K, Murakami Y and Ghosh HP. The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer. Cancer Res 2003; 63: 7979-7985.
20. He G, Lei W, Wang S, Xiao R, Guo K, Xia Y, Zhou X, Zhang K, Liu X and Wang Y. Overexpression of tumor suppressor TSLC1 by a survivin-regu-lated oncolytic adenovirus signifcantly inhibits hepatocellular carcinoma growth. J Cancer Res Clin Oncol 2012; 138: 657-670.
21. Liang QL, Chen GQ, Li ZY and Wang BR. Function and histopathology of a cell adhesion molecule TSLC1 in cancer. Cancer Invest 2011; 29: 107-112.