Helping our patients take HIV pre-exposure prophylaxis (PrEP): A systematic review of adherence interventions

HIV Medicine

Volumn 15, Issue 7, 2014, Pages 385-395

  Marcus, J L ^a,b   Buisker, T ^b   Horvath, T ^c   Amico, K R ^d   Fuchs, J D ^e   Buchbinder, S P ^e,f   Grant, R M ^a,f   Liu, A Y ^e  

^a GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CONNECTICUT   (United States)

^e SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antiretroviral medications; HIV; Medication adherence; Pre exposure prophylaxis (PrEP); Preventive therapy; Review

Indexed keywords

CONTRACEPTIVE AGENT; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

BLOOD PRESSURE MONITORING; DIRECTLY OBSERVED THERAPY; HEALTH CARE COST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERLIPIDEMIA; HYPERTENSION; INFECTION PREVENTION; LATENT TUBERCULOSIS; MALARIA; MALARIA CONTROL; MEDICATION COMPLIANCE; OSTEOPOROSIS; PATIENT EDUCATION; POST EXPOSURE PROPHYLAXIS; PRE EXPOSURE PROPHYLAXIS; PRIMARY PREVENTION; PRIORITY JOURNAL; REVIEW; SECONDARY PREVENTION; SYSTEMATIC REVIEW; HEALTH PROMOTION; HIV INFECTIONS; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ANTI-HIV AGENTS; HEALTH PROMOTION; HIV INFECTIONS; HUMANS; MEDICATION ADHERENCE; PRIMARY PREVENTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84904038605     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/hiv.12132     Document Type: Review

References (73)

1. (UNAIDS) JUNPoHA. Global report: UNAIDS report on the global AIDS epidemic 2012. In; 2012.
2. Grant RM, Lama JR, Anderson PL etal. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 2010; 363: 2587-2599.
3. Baeten JM, Donnell D, Ndase P etal. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med 2012; 367: 399-410.
4. Thigpen MC, Kebaabetswe PM, Paxton LA etal. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med 2012; 367: 423-434.
5. Abdool Karim Q, Abdool Karim SS, Frohlich JA etal. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010; 329: 1168-1174.
6. Van Damme L, Corneli A, Ahmed K etal. Preexposure prophylaxis for HIV infection among African women. N Engl J Med 2012; 367: 411-422.
7. Marrazzo J, Ramjee G, Nair G etal. Pre-exposure prophylaxis for HIV in women: daily oral tenofovir, oral tenofovir/emtricitabine, or vaginal tenofovir gel int he VOICE study (MTN 003). 20th Conference on Retroviruses and Opportunistic Infections. Atlanta, GA, 2013.
8. Rueda S, Park-Wyllie LY, Bayoumi AM etal. Patient support and education for promoting adherence to highly active antiretroviral therapy for HIV/AIDS. Cochrane Database Syst Rev 2006; (3)CD001442.
9. Koenig LJ, Lyles C, Smith DK. Adherence to antiretroviral medications for HIV pre-exposure prophylaxis: lessons learned from trials and treatment studies. Am J Prev Med 2013; 44: S91-S98.
10. Amico KR, Harman JJ, Johnson BT. Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials, 1996 to 2004. J Acquir Immune Defic Syndr 2006; 41: 285-297.
11. Simoni JM, Pearson CR, Pantalone DW, Marks G, Crepaz N. Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load. A meta-analytic review of randomized controlled trials. J Acquir Immune Defic Syndr 2006; 43 (Suppl 1): S23-S35.
12. Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2008; 2: CD000011.
13. McDonald HP, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication prescriptions: scientific review. JAMA 2002; 288: 2868-2879.
14. Viswanathan M, Golin CE, Jones CD etal. Interventions to improve adherence to self-administered medications for chronic diseases in the United States: a systematic review. Ann Intern Med 2012; 157: 785-795.
15. Stirratt MJ, Gordon CM. Adherence to biomedical HIV prevention methods: considerations drawn from HIV treatment adherence research. Curr HIV/AIDS Rep 2008; 5: 186-192.
16. Tangmunkongvorakul A, Chariyalertsak S, Amico KR etal. Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand. AIDS Care 2012; 25: 961-967.
17. Anderson PL, Lama JR, Buchbinder S etal. Interpreting detection rates of intracellular FTC-DP and TFV-DP: the iPrEx trial. 18th Conference on Retroviruses and Opportunistic Infections. Boston, MA, 2011.
18. Van Damme L, Corneli A, Ahmed K etal. Preexposure prophylaxis for HIV infection among African women. N Engl J Med 2012; 367: 411-422.
19. Ware NC, Wyatt MA, Haberer JE etal. What's love got to do with it? Explaining adherence to oral antiretroviral pre-exposure prophylaxis for HIV-serodiscordant couples. J Acquir Immune Defic Syndr 2012; 59: 463-468.
20. Wu YP, Roberts MC. A meta-analysis of interventions to increase adherence to medication regimens for pediatric otitis media and streptococcal pharyngitis. J Pediatr Psychol 2008; 33: 789-796.
21. Johnson SS, Driskell MM, Johnson JL etal. Transtheoretical model intervention for adherence to lipid-lowering drugs. Dis Manag 2006; 9: 102-114.
22. Salleras Sanmarti L, Alcaide Megias J, Altet Gomez MN etal. Evaluation of the efficacy of health education on the compliance with antituberculosis chemoprophylaxis in school children. A randomized clinical trial. Tuber Lung Dis 1993; 74: 28-31.
23. Chin-Quee D, Otterness C, Wedderburn M, McDonald O, Janowitz B. One versus multiple packs for women starting oral contraceptive pills: a comparison of two distribution regimens. Contraception 2009; 79: 369-374.
24. Morisky DE, Malotte CK, Choi P etal. A patient education program to improve adherence rates with antituberculosis drug regimens. Health Educ Q 1990; 17: 253-267.
25. Jay MS, DuRant RH, Shoffitt T, Linder CW, Litt IF. Effect of peer counselors on adolescent compliance in use of oral contraceptives. Pediatrics 1984; 73: 126-131.
26. Guthrie RM. The effects of postal and telephone reminders on compliance with pravastatin therapy in a national registry: results of the first myocardial infarction risk reduction program. Clin Ther 2001; 23: 970-980.
27. Kirscht JP, Kirscht JL, Rosenstock IM. A test of interventions to increase adherence to hypertensive medical regimens. Health Educ Q 1981; 8: 261-272.
28. Deijen JB, Kornaat H. The influence of type of information, somatization, and locus of control on attitude, knowledge, and compliance with respect to the triphasic oral contraceptive Tri-Minulet. Contraception 1997; 56: 31-41.
29. Magid DJ, Ho PM, Olson KL etal. A multimodal blood pressure control intervention in 3 healthcare systems. Am J Manag Care 2011; 17: e96-103.
30. Binstock ML, Franklin KL. A comparison of compliance techniques on the control of high blood pressure. Am J Hypertens 1988; 1: 192S-194S.
31. Morisky DE, Malotte CK, Ebin V etal. Behavioral interventions for the control of tuberculosis among adolescents. Public Health Rep 2001; 116: 568-574.
32. McKenney JM, Munroe WP, Wright JT, Jr. Impact of an electronic medication compliance aid on long-term blood pressure control. J Clin Pharmacol 1992; 32: 277-283.
33. Hanna KM. Effect of nurse-client transaction on female adolescents' oral contraceptive adherence. Image J Nurs Sch 1993; 25: 285-290.
34. Ollivier L, Romand O, Marimoutou C etal. Use of short message service (SMS) to improve malaria chemoprophylaxis compliance after returning from a malaria endemic area. Malar J 2009; 8: 236.
35. Tulsky JP, Pilote L, Hahn JA etal. Adherence to isoniazid prophylaxis in the homeless: a randomized controlled trial. Arch Intern Med 2000; 160: 697-702.
36. Chaisson RE, Barnes GL, Hackman J etal. A randomized, controlled trial of interventions to improve adherence to isoniazid therapy to prevent tuberculosis in injection drug users. Am J Med 2001; 110: 610-615.
37. Pilote L, Tulsky JP, Zolopa AR, Hahn JA, Schecter GF, Moss AR. Tuberculosis prophylaxis in the homeless. A trial to improve adherence to referral. Arch Intern Med 1996; 156: 161-165.
38. Schousboe JT, DeBold RC, Kuno LS, Weiss TW, Chen Y, Abbott TA. Education and phone follow-up in postmenopausal women at risk for osteoporosis. Dis Manage Health Outcomes 2005; 13: 395-404.
39. Hovell MF, Sipan CL, Blumberg EJ etal. Increasing Latino adolescents' adherence to treatment for latent tuberculosis infection: a controlled trial. Am J Public Health 2003; 93: 1871-1877.
40. Santschi V, Rodondi N, Bugnon O, Burnier M. Impact of electronic monitoring of drug adherence on blood pressure control in primary care: a cluster 12-month randomised controlled study. Eur J Intern Med 2008; 19: 427-434.
41. Roland ME, Neilands TB, Krone MR etal. A randomized noninferiority trial of standard versus enhanced risk reduction and adherence counseling for individuals receiving post-exposure prophylaxis following sexual exposures to HIV. Clin Infect Dis 2011; 53: 76-83.
42. Westhoff C, Heartwell S, Edwards S etal. Initiation of oral contraceptives using a quick start compared with a conventional start: a randomized controlled trial. Obstet Gynecol 2007; 109: 1270-1276.
43. Tulsky JP, Hahn JA, Long HL etal. Can the poor adhere? Incentives for adherence to TB prevention in homeless adults. Int J Tuberc Lung Dis 2004; 8: 83-91.
44. Wetzels GE, Nelemans PJ, Schouten JS etal. Electronic monitoring of adherence as a tool to improve blood pressure control. A randomized controlled trial. Am J Hypertens 2007; 20: 119-125.
45. Schroeder K, Fahey T, Hollinghurst S, Peters TJ. Nurse-led adherence support in hypertension: a randomized controlled trial. Fam Pract 2005; 22: 144-151.
46. Hacihasanoglu R, Gozum S. The effect of patient education and home monitoring on medication compliance, hypertension management, healthy lifestyle behaviours and BMI in a primary health care setting. J Clin Nurs 2011; 20: 692-705.
47. Christensen A, Christrup LL, Fabricius PE etal. The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy: a randomized controlled trial. J Hypertens 2010; 28: 194-200.
48. Ruppar TM. Randomized pilot study of a behavioral feedback intervention to improve medication adherence in older adults with hypertension. J Cardiovasc Nurs 2010; 25: 470-479.
49. Friedman RH, Kazis LE, Jette A etal. A telecommunications system for monitoring and counseling patients with hypertension. Impact on medication adherence and blood pressure control. Am J Hypertens 1996; 9: 285-292.
50. Marquez Contreras E, Vegazo Garcia O, Claros NM etal. Efficacy of telephone and mail intervention in patient compliance with antihypertensive drugs in hypertension. ETECUM-HTA study. Blood Press 2005; 14: 151-158.
51. Amado Guirado E, Pujol Ribera E, Pacheco Huergo V, Borras JM. Knowledge and adherence to antihypertensive therapy in primary care: results of a randomized trial. Gac Sanit 2011; 25: 62-67.
52. Stacy JN, Schwartz SM, Ershoff D, Shreve MS. Incorporating tailored interactive patient solutions using interactive voice response technology to improve statin adherence: results of a randomized clinical trial in a managed care setting. Popul Health Manage 2009; 12: 241-254.
53. Nielsen D, Ryg J, Nielsen W, Knold B, Nissen N, Brixen K. Patient education in groups increases knowledge of osteoporosis and adherence to treatment: a two-year randomized controlled trial. Patient Educ Couns 2010; 81: 155-160.
54. Guilera M, Fuentes M, Grifols M, Ferrer J, Badia X. Does an educational leaflet improve self-reported adherence to therapy in osteoporosis? The OPTIMA study. Osteoporos Int 2006; 17: 664-671.
55. Bednarek PH, Nichols MD, Carlson N etal. Effect of 'observed start' vs. traditional 'Sunday start' on hormonal contraceptive continuation rates after medical abortion. Contraception 2008; 78: 26-30.
56. Delmas PD, Vrijens B, Eastell R etal. Effect of monitoring bone turnover markers on persistence with risedronate treatment of postmenopausal osteoporosis. J Clin Endocrinol Metab 2007; 92: 1296-1304.
57. Riesen WF, Noll G, Dariolo R. Impact of enhanced compliance initiatives on the efficacy of rosuvastatin in reducing low density lipoprotein cholesterol levels in patients with primary hypercholesterolaemia. Swiss Med Wkly 2008; 138: 420-426.
58. Hou MY, Hurwitz S, Kavanagh E, Fortin J, Goldberg AB. Using daily text-message reminders to improve adherence with oral contraceptives: a randomized controlled trial. Obstet Gynecol 2010; 116: 633-640.
59. Waalen J, Bruning AL, Peters MJ, Blau EM. A telephone-based intervention for increasing the use of osteoporosis medication: a randomized controlled trial. Am J Manag Care 2009; 15: e60-e70.
60. Clowes JA, Peel NF, Eastell R. The impact of monitoring on adherence and persistence with antiresorptive treatment for postmenopausal osteoporosis: a randomized controlled trial. J Clin Endocrinol Metab 2004; 89: 1117-1123.
61. Takala J, Niemela N, Rosti J, Sievers K. Improving compliance with therapeutic regimens in hypertensive patients in a community health center. Circulation 1979; 59: 540-543.
62. Schectman G, Hiatt J, Hartz A. Telephone contacts do not improve adherence to niacin or bile acid sequestrant therapy. Ann Pharmacother 1994; 28: 29-35.
63. Marquez Contreras E, Martel Claros N, Gil Guillen V etal. Non-pharmacological intervention as a strategy to improve antihypertensive treatment compliance. Aten Primaria 2009; 41: 501-510.
64. Marquez Contreras E, Casado Martinez JJ, Corchado Albalat Y etal. [Efficacy of an intervention to improve treatment compliance in hyperlipidemias]. Aten Primaria 2004; 33: 443-450.
65. Sclar DA, Chin A, Skaer TL, Okamoto MP, Nakahiro RK, Gill MA. Effect of health education in promoting prescription refill compliance among patients with hypertension. Clin Ther 1991; 13: 489-495.
66. Marquez Contreras E, Casado Martinez JJ, Lopez de Andres M etal. [Therapeutic compliance in dyslipidemias. A trial of the efficacy of health education]. Aten Primaria 1998; 22: 79-84.
67. Marquez Contreras E, Casado Martinez JJ, Celotti Gomez B etal. Treatment compliance in arterial hypertension. A 2-year intervention trial through health education. Aten Primaria 2000; 26: 5-10.
68. van Onzenoort HA, Verberk WJ, Kessels AG etal. Assessing medication adherence simultaneously by electronic monitoring and pill count in patients with mild-to-moderate hypertension. Am J Hypertens 2010; 23: 149-154.
69. Pladevall M, Brotons C, Gabriel R etal. Multicenter cluster-randomized trial of a multifactorial intervention to improve antihypertensive medication adherence and blood pressure control among patients at high cardiovascular risk (the COM99 study). Circulation 2010; 122: 1183-1191.
70. Roland ME, Elbeik TA, Kahn JO etal. HIV RNA testing in the context of nonoccupational postexposure prophylaxis. J Infect Dis 2004; 190: 598-604.
71. Consumer Health Information USFaDA. First Rapid Home-Use HIV Kit Approved for Self Testing. In; 2012.
72. Muchomba FM, Gearing RE, Simoni JM, El-Bassel N. State of the science of adherence in pre-exposure prophylaxis and microbicide trials. J Acquir Immune Defic Syndr 2012; 61: 490-498.
73. Amico KR, Mansoor LE, Corneli A, Torjesen K, van der Straten A. Adherence support approaches in biomedical HIV prevention trials: experiences, insights and future directions from four multisite prevention trials. AIDS Behav 2013; 17: 2143-2155.