A randomized noninferiority trial of standard versus enhanced risk reduction and adherence counseling for individuals receiving post-exposure prophylaxis following sexual exposures to HIV

Clinical Infectious Diseases

Volumn 53, Issue 1, 2011, Pages 76-83

  Roland, Michelle E ^a,d   Neilands, Torsten B ^b   Krone, Melissa R ^c   Coates, Thomas J ^d   Franses, Karena ^a   Chesney, Margaret A ^d   Kahn, James S ^a   Martin, Jeffrey N ^a,b,c  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATL CENTER FOR INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIDANOSINE; DIDANOSINE PLUS STAVUDINE; LAMIVUDINE PLUS STAVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; STAVUDINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HIGH RISK PATIENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PATIENT COUNSELING; POST EXPOSURE PROPHYLAXIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK REDUCTION; SEROCONVERSION; SEXUAL BEHAVIOR; UNSAFE SEX;

ADULT; DIRECTIVE COUNSELING; FEMALE; HIV INFECTIONS; HUMANS; MALE; PATIENT COMPLIANCE; POST-EXPOSURE PROPHYLAXIS; RISK REDUCTION BEHAVIOR; UNSAFE SEX;

EID: 79958836497     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cir333     Document Type: Article

References (34)

1. Office of National AIDS Policy. National HIV/AIDS Strategy for the United States. Washington, DC: The White House, 2010.
2. Centers for Disease Control and Prevention. Antiretroviral postexposure prophylaxis after sexual, injection drug use, or other nonoccupational exposure to HIV in the United States. Recommendations from the U.S. Department of Health and Human Services. MMWR Jan 21, 2005; 54 (No. RR-2).
3. Cardo DM, Culver DH, Ciesielski CA, et al. A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group. N Engl J Med 1997; 337:1485-90. (Pubitemid 27495773)
4. Roland ME, Neilands TB, Krone MR, et al. Seroconversion following nonoccupational postexposure prophylaxis against HIV. Clin Infect Dis 2005; 41:1507-13. (Pubitemid 41579997)
5. Kahn JO, Martin JN, Roland ME, et al. Feasibility of postexposure prophylaxis (PEP) against human immunodeficiency virus infection after sexual or injection drug use exposure: the San Francisco PEP Study. J Infect Dis 2001; 183:707-14. (Pubitemid 32171744)
6. Martin JN, Roland ME, Neilands TB, et al. Use of postexposure prophylaxis against HIV infection following sexual exposure does not lead to increases in high-risk behavior. AIDS 2004; 18:787-92. (Pubitemid 38535007)
7. Kamb ML, Fishbein M, Douglas JM, et al. Efficacy of risk-reduction counseling to prevent human immunodeficiency virus and sexually transmitted diseases: a randomized controlled trial. Project RESPECT Study Group. JAMA 1998; 280:1161-7. (Pubitemid 28457806)
8. Bandura A. Social cognitive theory and exercise of control over HIV infection. In: DiClemente RJ PJ. ed: Preventing AIDS: theories and methods of behavioral interventions. New York: Plenum, 1994; 25-59.
9. Miller WR, Rollnick S. Motivational interviewing: preparing people to change addictive behavior. New York: Guilford Press, 1991.
10. Chesney MA, Chambers DB, Taylor JM, Johnson LM, Folkman S. Coping effectiveness training for men living with HIV: results from a randomized clinical trial testing a group-based intervention. Psychosom Med 2003; 65:1038-46. (Pubitemid 38057805)
11. Fisher JD. Possible effects of reference group-based social influence on AIDS-risk behavior and AIDS prevention. Am Psychol 1988; 43:914-20.
12. Friedman LM, Furberg C, DeMets DL. Fundamentals of clinical trials, 3rd ed. New York: Springer-Verlag New York, Inc., 1998.
13. Landovitz RJ, Combs KB, Currier JS. Availability of HIV postexposure prophylaxis services in Los Angeles County. Clin Infect Dis 2009; 48:1624-7.
14. Landovitz RJ, Currier JS. Clinical practice. Postexposure prophylaxis for HIV infection. N Engl J Med 2009; 361:1768-75.
15. Bryant J, Baxter L, Hird S. Non-occupational postexposure prophylaxis for HIV: a systematic review. Health Technol Assess 2009; 13 iii, ix-x, 1-60.
16. Herida M, Larsen C, Lot F, Laporte A, Desenclos JC, Hamers FF. Costeffectiveness of HIV post-exposure prophylaxis in France. AIDS 2006; 20:1753-61. (Pubitemid 44299367)
17. Lunding S, Katzenstein TL, Kronborg G, et al. The Danish PEP registry: experience with the use of postexposure prophylaxis (PEP) following sexual exposure to HIV from 1998 to 2006. Sex Transm Dis 2010; 37:49-52.
18. Merchant RC, Mayer KH, Becker BM, Delong AK, Hogan JW. Predictors of the initiation of HIV postexposure prophylaxis in Rhode Island emergency departments. AIDS Patient Care STDS 2008; 22:41-52.
19. Roedling S, Reeves I, Copas AJ, et al. Changes in the provision of postexposure prophylaxis for HIV after sexual exposure following introduction of guidelines and publicity campaigns. Int J STD AIDS 2008; 19:241-2. (Pubitemid 351738773)
20. Schechter M, do Lago RF, Mendelsohn AB, Moreira RI, Moulton LH, Harrison LH. Behavioral impact, acceptability, and HIV incidence among homosexual men with access to postexposure chemoprophylaxis for HIV. J Acquir Immune Defic Syndr 2004; 35:519-25. (Pubitemid 38420661)
21. Sonder GJ, Prins JM, Regez RM, et al. Comparison of two HIV postexposure prophylaxis regimens among men who have sex with men in Amsterdam: adverse effects do not influence compliance. Sex Transm Dis 2010; 37:681-686.
22. Sonder GJ, van den Hoek A, Regez RM, et al. Trends in HIV postexposure prophylaxis prescription and compliance after sexual exposure in Amsterdam, 2000-2004. Sex Transm Dis 2007; 34:288-93. (Pubitemid 46707481)
23. Korner H, Hendry O, Kippax S. Safe sex after post-exposure prophylaxis for HIV: intentions, challenges and ambivalences in narratives of gay men. AIDS Care 2006; 18:879-87. (Pubitemid 44521841)
24. Pinkerton SD, Martin JN, Roland ME, Katz MH, Coates TJ, Kahn JO. Cost-effectiveness of HIV postexposure prophylaxis following sexual or injection drug exposure in 96 metropolitan areas in the United States. AIDS 2004; 18:2065-73. (Pubitemid 39463360)
25. Pinkerton SD, Martin JN, Roland ME, Katz MH, Coates TJ, Kahn JO. Cost-effectiveness of postexposure prophylaxis after sexual or injection-drug exposure to human immunodeficiency virus. Arch Intern Med 2004; 164:46-54. (Pubitemid 38067388)
26. Roland ME. Enhancing the potential benefits of HIV post-exposure prophylaxis. AIDS 2006; 20:1889-90. (Pubitemid 44358908)
27. Liu AY, Kittredge PV, Vittinghoff E, et al. Limited knowledge and use of HIV post- and pre-exposure prophylaxis among gay and bisexual men. J Acquir Immune Defic Syndr 2008; 47:241-7. (Pubitemid 351172193)
28. Nodin N, Carballo-Dieguez A, Ventuneac AM, Balan IC, Remien R. Knowledge and acceptability of alternative HIV prevention bio-medical products among MSM who bareback. AIDS Care 2008; 20:106-15. (Pubitemid 351264545)
29. Rey D, Bouhnik AD, Peretti-Watel P, Obadia Y, Spire B. Awareness of non-occupational HIV postexposure prophylaxis among French people living with HIV: the need for better targeting. AIDS 2007; 21: (Suppl 1):S71-76. (Pubitemid 44967418)
30. Waldo CR, Stall RD, Coates TJ. Is offering post-exposure prevention for sexual exposures to HIV related to sexual risk behavior in gay men? AIDS 2000; 14:1035-9. (Pubitemid 30336065)
31. Mayer KH, Mimiaga MJ, Cohen D, et al. Tenofovir DF plus lamivudine or emtricitabine for nonoccupational postexposure prophylaxis (NPEP) in a Boston community health Center. J Acquir Immune Defic Syndr 2008; 47:494-9. (Pubitemid 351366963)
32. Bassett IV, Freedberg KA, Walensky RP. Two drugs or three? Balancing efficacy, toxicity, and resistance in postexposure prophylaxis for occupational exposure to HIV. Clin Infect Dis 2004; 39:395-401. (Pubitemid 39050489)
33. Dodds C. Positive benefits: preventive impact of post-exposure prophylaxis awareness among those with diagnosed HIV. Sex Transm Infect 2008; 84:92-3. (Pubitemid 351497915)
34. Rey D, Bouhnik AD, Peretti-Watel P, Obadia Y, Spire B. Awareness of non-occupational HIV postexposure prophylaxis among French people living with HIV: the need for better targeting. AIDS 2007; 21: (Suppl 1):S71-S76. (Pubitemid 44967418)