Selective immunoproteasome inhibitors with non-peptide scaffolds identified from structure-based virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 15, 2014, Pages 3614-3617

  Kasam, Vinod ^a   Lee, Na Ra ^a   Kim, Kyung Bo ^a   Zhan, Chang Guo ^a  

^a University of Kentucky   (United States)

Author keywords

Immunoproteasome; Inhibitor identification; Non peptide scaffold; Selective inhibitor

Indexed keywords

EPOXOMICIN; IMMUNOPROTEASOME INHIBITOR; MOLECULAR SCAFFOLD; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG; IMMUNOPROTEASOME BETA5I; PROTEASOME;

ARTICLE; CHEMICAL STRUCTURE; COVALENT BOND; DRUG DESIGN; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; ELECTROPHILICITY; EUKARYOTIC CELL; HYDROGEN BOND; HYDROPHILICITY; IMMUNOCOMPETENT CELL; MOLECULAR DYNAMICS; PROTEIN EXPRESSION; VIRTUAL REALITY; BINDING AFFINITY; CHEMICAL INTERACTION; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; PHARMACOPHORE; X RAY BONE DENSITOMETER; CHEMISTRY; CONFORMATION; DOSE RESPONSE; IMMUNOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

EUKARYOTA;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904035914     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.05.025     Document Type: Article

References (19)

1. A.L. Goldberg Nature 426 2003 895
2. A.F. Kisselev, and A.L. Goldberg Chem. Biol. 8 2001 739
3. A. McBride, and P.Y. Ryan Expert Rev. Anticancer Ther. 13 2013 339
4. D. Chen, M. Frezza, S. Schmitt, J. Kanwar, and Q.P. Dou Cur. Cancer Drug Targets 11 2011 239
5. P.G. Richardson, B. Barlogie, J. Berenson, S. Singhal, S. Jagannath, D. Irwin, S.V. Rajkumar, G. Srkalovic, M. Alsina, R. Alexanian, D. Siegel, R.Z. Orlowski, D. Kuter, S.A. Limentani, S. Lee, T. Hideshima, D.L. Esseltine, M. Kauffman, J. Adams, D.P. Schenkein, and K.C. Anderson N. Engl. J. Med. 348 2003 2609
6. D.S. Siegel, T. Martin, M. Wang, R. Vij, A.J. Jakubowiak, S. Lonial, S. Trudel, V. Kukreti, N. Bahlis, M. Alsina, A. Chanan-Khan, F. Buadi, F.J. Reu, G. Somlo, J. Zonder, K. Song, A.K. Stewart, E. Stadtmauer, L. Kunkel, S. Wear, A.F. Wong, R.Z. Orlowski, and S. Jagannath Blood 2012
7. K.L. Rock, and A.L. Goldberg Annu. Rev. Immunol. 17 1999 739
8. F. Parlati, S.J. Lee, M. Aujay, E. Suzuki, K. Levitsky, J.B. Lorens, D.R. Micklem, P. Ruurs, C. Sylvain, Y. Lu, K.D. Shenk, and M.K. Bennett Blood 114 2009 3439
9. P. Vlieghe, V. Lisowski, J. Martinez, and M. Khrestchatisky Drug Discovery Today 15 2010 40
10. B. Lei, M.D.M. AbdulHameed, A. Hamza, M. Wehenkel, J.L. Muzyka, X.-J. Yao, K.-B. Kim, and C.-G. Zhan J. Phys. Chem. B 114 2010 12333
11. B. Lei, A. Hamza, and C.-G. Zhan Theor. Chem. Acc. 131 2012 1203
12. D. Wei, B. Lei, M. Tang, and C.-G. Zhan J. Am. Chem. Soc. 134 2012 10436
13. W. Yang, M.D.M. AbdulHameed, A. Hamza, and C.-G. Zhan Bioorg. Med. Chem. Lett. 22 2012 1629
14. A. Hamza, X. Zhao, M. Tong, H.H. Tai, and C.G. Zhan Bioorg. Med. Chem. 19 2011 6077
15. M.R. McGann, H.R. Almond, A. Nicholls, J.A. Grant, and F.K. Brown Biopolymers 68 2003 76
16. D.A. Case, T.E. Cheatham, T. Darden, H. Gohlke, R. Luo, K.M. Merz, A. Onufriev, C. Simmerling, B. Wang, and R.J. Woods J. Comput. Chem. 26 2005 1668
17. Y.K. Ho, P. Bargagna-Mohan, M. Wehenkel, R. Mohan, and K.-B. Kim Chem. Biol. 14 2007 419
18. A.F. Kisselev, and A.L. Goldberg Methods Enzymol. 398 2005 364
19. M. Naim, S. Bhat, K.N. Rankin, S. Dennis, S.F. Chowdhury, I. Siddiqi, P. Drabik, T. Sulea, C.I. Bayly, A. Jakalian, and E.O. Purisima J. Chem. Inf. Model. 47 2007 122