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Volumn 59, Issue 2, 2014, Pages 265-271

Dolutegravir: A next-generation integrase inhibitor for treatment of HIV infection

Author keywords

INSTI

Indexed keywords

ATAZANAVIR PLUS RITONAVIR; BOCEPREVIR; CREATININE; DARUNAVIR PLUS RITONAVIR; DOLUTEGRAVIR; EFAVIRENZ; ELVITEGRAVIR; ETRAVIRINE; FOSAMPRENAVIR PLUS RITONAVIR; LOPINAVIR PLUS RITONAVIR; OMEPRAZOLE; PREDNISONE; RALTEGRAVIR; RIFABUTIN; RIFAMPICIN; RILPIVIRINE; RITONAVIR PLUS TIPRANAVIR; TELAPREVIR; FUSED HETEROCYCLIC RINGS; INTEGRASE INHIBITOR;

EID: 84903997841     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/ciu221     Document Type: Review
Times cited : (42)

References (45)
  • 1
    • 74049164246 scopus 로고    scopus 로고
    • Life expectancy after HIV diagnosis based on national HIV surveillance data from 25 states, United States
    • Harrison KM, Song R, Zhang X. Life expectancy after HIV diagnosis based on national HIV surveillance data from 25 states, United States. J Acquir Immune Defic Syndr 2010; 53:124-30.
    • (2010) J Acquir Immune Defic Syndr , vol.53 , pp. 124-130
    • Harrison, K.M.1    Song, R.2    Zhang, X.3
  • 2
    • 80052905594 scopus 로고    scopus 로고
    • Long-term treatment with raltegravir or efavirenz combined with tenofovir/emtricitabine for treatment-naive human immunodeficiency virus-1 co-infected patients: 156-week results from STARTMRK
    • Rockstroh JK, Lennox JL, DeJesus E, et al. Long-term treatment with raltegravir or efavirenz combined with tenofovir/emtricitabine for treatment-naive human immunodeficiency virus-1 co-infected patients: 156-week results from STARTMRK. Clin Infect Dis. 2011; 53:807-16.
    • (2011) Clin Infect Dis. , vol.53 , pp. 807-816
    • Rockstroh, J.K.1    Lennox, J.L.2    Dejesus, E.3
  • 3
    • 84879799713 scopus 로고    scopus 로고
    • Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: Final results of two randomised, placebo-controlled trials
    • Eron JJ, Cooper DA, Steigbigel RT, et al. Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: Final results of two randomised, placebo-controlled trials. Lancet Infect Dis. 2013; 13:587-96.
    • (2013) Lancet Infect Dis. , vol.13 , pp. 587-596
    • Eron, J.J.1    Cooper, D.A.2    Steigbigel, R.T.3
  • 4
    • 84862876886 scopus 로고    scopus 로고
    • Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: A randomised, double-blind, phase 3 trial, analysis of results after 48 weeks
    • Sax PE, DeJesus E, Mills A, et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: A randomised, double-blind, phase 3 trial, analysis of results after 48 weeks. Lancet 2012; 379:2439-48.
    • (2012) Lancet , vol.379 , pp. 2439-2448
    • Sax, P.E.1    Dejesus, E.2    Mills, A.3
  • 5
    • 84862843404 scopus 로고    scopus 로고
    • Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: A randomised, double-blind, phase 3, non-inferiority trial
    • DeJesus E, Rockstroh JK, Henry K, et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: A randomised, double-blind, phase 3, non-inferiority trial. Lancet 2012; 379:2429-38.
    • (2012) Lancet , vol.379 , pp. 2429-2438
    • Dejesus, E.1    Rockstroh, J.K.2    Henry, K.3
  • 6
    • 51549116289 scopus 로고    scopus 로고
    • Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants
    • Marinello J, Marchand C, Mott BT, Bain A, Thomas CJ, Pommier Y. Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants. Biochemistry 2008; 47:9345-54.
    • (2008) Biochemistry , vol.47 , pp. 9345-9354
    • Marinello, J.1    Marchand, C.2    Mott, B.T.3    Bain, A.4    Thomas, C.J.5    Pommier, Y.6
  • 7
    • 37849002059 scopus 로고    scopus 로고
    • Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
    • Shimura K, Kodama E, Sakagami Y, et al. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol 2008; 82:764-74.
    • (2008) J Virol , vol.82 , pp. 764-774
    • Shimura, K.1    Kodama, E.2    Sakagami, Y.3
  • 8
    • 73849124557 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of S/GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers
    • Min S, Song I, Borland J, et al. Pharmacokinetics and safety of S/GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers. Antimicrob Agents Chemother 2010; 54:254-8.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 254-258
    • Min, S.1    Song, I.2    Borland, J.3
  • 9
    • 84880268976 scopus 로고    scopus 로고
    • Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans
    • Castellino S, Moss L, Wagner D, et al. Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans. Antimicrob Agents Chemother 2013; 57:3536-46.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 3536-3546
    • Castellino, S.1    Moss, L.2    Wagner, D.3
  • 10
    • 84891881368 scopus 로고    scopus 로고
    • Pharmacokinetics of dolutegravir in HIV-seronegative subjects with severe renal impairment
    • Weller S, Borland J, Chen S, et al. Pharmacokinetics of dolutegravir in HIV-seronegative subjects with severe renal impairment. Eur J Clin Pharmacol 2014; 70:29-35.
    • (2014) Eur J Clin Pharmacol , vol.70 , pp. 29-35
    • Weller, S.1    Borland, J.2    Chen, S.3
  • 12
    • 84863115993 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of the integrase inhibitor dolutegravir
    • Song I, Borland J, Chen S, et al. Effect of food on the pharmacokinetics of the integrase inhibitor dolutegravir. Antimicrob Agents Chemother 2012; 56:1627-9.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 1627-1629
    • Song, I.1    Borland, J.2    Chen, S.3
  • 13
    • 84885896032 scopus 로고    scopus 로고
    • Pharmacokinetics of single dose dolutegravir in HIV seronegative subjects with moderate hepatic impairment compared to healthy matched controls
    • Song IH, Borland J, Savina PM, et al. Pharmacokinetics of single dose dolutegravir in HIV seronegative subjects with moderate hepatic impairment compared to healthy matched controls. Clin Pharmacol Drug Dev 2013; 2:342-8.
    • (2013) Clin Pharmacol Drug Dev , vol.2 , pp. 342-348
    • Song, I.H.1    Borland, J.2    Savina, P.M.3
  • 14
    • 79959244325 scopus 로고    scopus 로고
    • Effects of etravirine alone and with ritonavir-boosted protease inhibitors on the pharmacokinetics of dolutegravir
    • Song I, Borland J, Min S, et al. Effects of etravirine alone and with ritonavir-boosted protease inhibitors on the pharmacokinetics of dolutegravir. Antimicrob Agents Chemother 2011; 55:3517-21.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 3517-3521
    • Song, I.1    Borland, J.2    Min, S.3
  • 15
    • 79958719816 scopus 로고    scopus 로고
    • Effect of atazanavir and atazanavir/ritonavir on the pharmacokinetics of the next generation HIV integrase inhibitor, S/GSK1349572
    • Song I, Borland J, Chen S, et al. Effect of atazanavir and atazanavir/ritonavir on the pharmacokinetics of the next generation HIV integrase inhibitor, S/GSK1349572. Br J Clin Pharmacol 2011; 72:103-8.
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 103-108
    • Song, I.1    Borland, J.2    Chen, S.3
  • 16
    • 84896835559 scopus 로고    scopus 로고
    • Effect of fosamprenavir/ritonavir on the pharmacokinetics of the integrase inhibitor, dolutegravir, in healthy subjects [abstract A1-1727]
    • Chicago, IL
    • Song I, Borland J, Chen S. Effect of fosamprenavir/ritonavir on the pharmacokinetics of the integrase inhibitor, dolutegravir, in healthy subjects [abstract A1-1727]. In: 51st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 2011.
    • (2011) 51st Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Song, I.1    Borland, J.2    Chen, S.3
  • 17
    • 84899110511 scopus 로고    scopus 로고
    • Effects of enzyme inducers, tipranavir and efavirenz, on the pharmacokinetics of the integrase inhibitor, dolutegravir (S/GSK1349572)
    • Miami, FL
    • Song I, Borland J, Lou Y, et al. Effects of enzyme inducers, tipranavir and efavirenz, on the pharmacokinetics of the integrase inhibitor, dolutegravir (S/GSK1349572). In: 12th International Workshop on Clinical Pharmacology of HIV Therapy, Miami, FL, 2011:13-5.
    • (2011) 12th International Workshop on Clinical Pharmacology of HIV Therapy , pp. 13-15
    • Song, I.1    Borland, J.2    Lou, Y.3
  • 18
    • 84872084395 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of the HIV integrase inhibitor dolutegravir given twice daily with rifampin or once daily with rifabutin: Results of a phase 1 study among healthy subjects
    • Dooley KE, Sayre P, Borland J, et al. Safety, tolerability, and pharmacokinetics of the HIV integrase inhibitor dolutegravir given twice daily with rifampin or once daily with rifabutin: Results of a phase 1 study among healthy subjects. J Acquir Immune Defic Syndr 2013; 62:21-7.
    • (2013) J Acquir Immune Defic Syndr , vol.62 , pp. 21-27
    • Dooley, K.E.1    Sayre, P.2    Borland, J.3
  • 19
    • 79551709965 scopus 로고    scopus 로고
    • The effect of lopinavir/ritonavir and darunavir/ritonavir on the HIV integrase inhibitor S/GSK1349572 in healthy participants
    • Song I, Min SS, Borland J, et al. The effect of lopinavir/ritonavir and darunavir/ritonavir on the HIV integrase inhibitor S/GSK1349572 in healthy participants. J Clin Pharmacol 2011; 51:237-42.
    • (2011) J Clin Pharmacol , vol.51 , pp. 237-242
    • Song, I.1    Min, S.S.2    Borland, J.3
  • 20
    • 84885934539 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between rilpivirine and integrase inhibitors dolutegravir and GSK1265744
    • Ford SL, Gould E, Chen S, et al. Lack of pharmacokinetic interaction between rilpivirine and integrase inhibitors dolutegravir and GSK1265744. Antimicrob Agents Chemother 2013; 57:5472-7.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 5472-5477
    • Ford, S.L.1    Gould, E.2    Chen, S.3
  • 21
    • 78049297410 scopus 로고    scopus 로고
    • Lack of interaction between the HIV integrase inhibitor S/GSK1349572 and tenofovir in healthy subjects
    • Song I, Min SS, Borland J, et al. Lack of interaction between the HIV integrase inhibitor S/GSK1349572 and tenofovir in healthy subjects. J Acquir Immune Defic Syndr 2010; 55:365-7.
    • (2010) J Acquir Immune Defic Syndr , vol.55 , pp. 365-367
    • Song, I.1    Min, S.S.2    Borland, J.3
  • 24
    • 79958856040 scopus 로고    scopus 로고
    • Pharmacokinetics of the HIV integrase inhibitor S/GSK1349572 co-Administered with acid-reducing agents and multivitamins in healthy volunteers
    • Patel P, Song I, Borland J, et al. Pharmacokinetics of the HIV integrase inhibitor S/GSK1349572 co-Administered with acid-reducing agents and multivitamins in healthy volunteers. J Antimicrob Chemother 2011; 66:1567-72.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 1567-1572
    • Patel, P.1    Song, I.2    Borland, J.3
  • 25
    • 84877620605 scopus 로고    scopus 로고
    • Dolutegravir has no effect on pharmacokinetics of methadone or oral contraceptives with norgestimate and ethinyl estradiol [poster abstract 535]
    • Atlanta, GA
    • Song I. Dolutegravir has no effect on pharmacokinetics of methadone or oral contraceptives with norgestimate and ethinyl estradiol [poster abstract 535]. In: 20th Conference on Retroviruses and Opportunistic Infections, Atlanta, GA, 2013.
    • (2013) 20th Conference on Retroviruses and Opportunistic Infections
    • Song, I.1
  • 26
    • 84887018042 scopus 로고    scopus 로고
    • Dolutegravir does not affect methadone pharmacokinetics in opioid-dependent, HIV-seronegative subjects
    • Song I, Mark S, Chen S, et al. Dolutegravir does not affect methadone pharmacokinetics in opioid-dependent, HIV-seronegative subjects. Drug Alcohol Depend 2013; 133:781-4.
    • (2013) Drug Alcohol Depend , vol.133 , pp. 781-784
    • Song, I.1    Mark, S.2    Chen, S.3
  • 27
    • 78751697293 scopus 로고    scopus 로고
    • In vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor
    • Kobayashi M, Yoshinaga T, Seki T, et al. In vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor. Antimicrob Agents Chemothe 2011; 55:813-21.
    • (2011) Antimicrob Agents Chemothe , vol.55 , pp. 813-821
    • Kobayashi, M.1    Yoshinaga, T.2    Seki, T.3
  • 28
    • 77953587761 scopus 로고    scopus 로고
    • HIV-1 resistance patterns to integrase inhibitors in antiretroviral- experienced patients with virological failure on raltegravir-containing regimens
    • Da Silva D, Van Wesenbeeck L, Breilh D, et al. HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containing regimens. J Antimicrob Chemother 2010; 65:1262-9.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 1262-1269
    • Da Silva, D.1    Van Wesenbeeck, L.2    Breilh, D.3
  • 29
    • 80052847538 scopus 로고    scopus 로고
    • Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572)
    • Hare S, Smith SJ, Metifiot M, et al. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol 2011; 80:565-72.
    • (2011) Mol Pharmacol , vol.80 , pp. 565-572
    • Hare, S.1    Smith, S.J.2    Metifiot, M.3
  • 31
    • 80051818332 scopus 로고    scopus 로고
    • A meta-Analysis to assess the FDA DAVP's TLOVR algorithm in HIV submissions
    • Smith F, Hammerstrom T, Soon G, et al. A meta-Analysis to assess the FDA DAVP's TLOVR algorithm in HIV submissions. Drug Informat J 2011; 45:291-300.
    • (2011) Drug Informat J , vol.45 , pp. 291-300
    • Smith, F.1    Hammerstrom, T.2    Soon, G.3
  • 32
    • 84903959380 scopus 로고    scopus 로고
    • Phase 3 assessment of dolutegravir (DTG) 50 mg twice daily in HIV-1-infected subjects with raltegravir (RAL) and/or elvitegravir (EVG) resistance in VIKING-3: Week 24 results of all 183 patients enrolled [abstract TULBPE19]
    • Kuala Lumpur, Malaysia, June 30-July 3
    • Nichols G, Lazzarin A, Maggiolo F. Phase 3 assessment of dolutegravir (DTG) 50 mg twice daily in HIV-1-infected subjects with raltegravir (RAL) and/or elvitegravir (EVG) resistance in VIKING-3: Week 24 results of all 183 patients enrolled [abstract TULBPE19]. In: 7th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention, Kuala Lumpur, Malaysia, June 30-July 3, 2013.
    • (2013) 7th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention
    • Nichols, G.1    Lazzarin, A.2    Maggiolo, F.3
  • 33
    • 84873658141 scopus 로고    scopus 로고
    • Antiviral activity of dolutegravir in subjects with failure on an integrase inhibitor-based regimen: Week 24 phase 3 results from VIKING-3
    • Nichols G, Mills A, Grossberg R, et al. Antiviral activity of dolutegravir in subjects with failure on an integrase inhibitor-based regimen: Week 24 phase 3 results from VIKING-3. J Int AIDS Soc 2012; 15 (suppl 4):18112.
    • (2012) J Int AIDS Soc , vol.15 , Issue.SUPPL.4 , pp. 18112
    • Nichols, G.1    Mills, A.2    Grossberg, R.3
  • 34
    • 0042454476 scopus 로고    scopus 로고
    • US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research. Center for Drug Evaluation and Research, 2002. Accessed 10 January
    • US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research. Guidance for industry: Antiretroviral drugs using plasma HIV RNA measurements- clinical considerations for accelerated and traditional approval. Center for Drug Evaluation and Research, 2002. Available at: Http://www.fda. gov/downloads/Drugs/ GuidanceComplianceRegulatoryInformation/ Guidances/ucm070968.pdf. Accessed 10 January 2014.
    • (2014) Guidance for Industry: Antiretroviral Drugs Using Plasma HIV RNA Measurements- Clinical Considerations for Accelerated and Traditional Approval
  • 35
    • 84879874721 scopus 로고    scopus 로고
    • Dolutegravir in antiretroviralnaive adults with HIV-1: 96-week results from a randomized doseranging study
    • Stellbrink HJ, Reynes J, Lazzarin A, et al. Dolutegravir in antiretroviralnaive adults with HIV-1: 96-week results from a randomized doseranging study. AIDS 2013; 27:1771-8.
    • (2013) AIDS , vol.27 , pp. 1771-1778
    • Stellbrink, H.J.1    Reynes, J.2    Lazzarin, A.3
  • 36
    • 84887052771 scopus 로고    scopus 로고
    • Dolutegravir plus abacavirlamivudine for the treatment of HIV-1 infection
    • Walmsley SL, Antela A, Clumeck N, et al. Dolutegravir plus abacavirlamivudine for the treatment of HIV-1 infection. N Engl J Med 2013; 369:1807-18.
    • (2013) N Engl J Med , vol.369 , pp. 1807-1818
    • Walmsley, S.L.1    Antela, A.2    Clumeck, N.3
  • 37
    • 84903760207 scopus 로고    scopus 로고
    • Once-daily dolutegravir (DTG) is superior to darunavir/ritonavir (DRV/r) in antiretroviral naive adults: 48 week results from FLAMINGO (ING114915) [abstract H-1464a]
    • Denver, CO
    • Feinberg J, Clotet B, Khuong MA. Once-daily dolutegravir (DTG) is superior to darunavir/ritonavir (DRV/r) in antiretroviral naive adults: 48 week results from FLAMINGO (ING114915) [abstract H-1464a]. In: 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Denver, CO, 2013.
    • (2013) 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Feinberg, J.1    Clotet, B.2    Khuong, M.A.3
  • 38
    • 84885948765 scopus 로고    scopus 로고
    • Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, doubleblind, non-inferiority trial
    • Raffi F, Jaeger H, Quiros-Roldan E, et al. Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, doubleblind, non-inferiority trial. Lancet Infect Dis. 2013; 13:927-35.
    • (2013) Lancet Infect Dis. , vol.13 , pp. 927-935
    • Raffi, F.1    Jaeger, H.2    Quiros-Roldan, E.3
  • 39
    • 84874411899 scopus 로고    scopus 로고
    • Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study
    • Raffi F, Rachlis A, Stellbrink HJ, et al. Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study. Lancet 2013; 381:735-43.
    • (2013) Lancet , vol.381 , pp. 735-743
    • Raffi, F.1    Rachlis, A.2    Stellbrink, H.J.3
  • 40
    • 84882912698 scopus 로고    scopus 로고
    • Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: Week 48 results from the randomised, double-blind, non-inferiority SAILING study
    • Cahn P, Pozniak AL, Mingrone H, et al. Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: Week 48 results from the randomised, double-blind, non-inferiority SAILING study. Lancet 2013; 382:700-8.
    • (2013) Lancet , vol.382 , pp. 700-708
    • Cahn, P.1    Pozniak, A.L.2    Mingrone, H.3
  • 41
    • 84873633830 scopus 로고    scopus 로고
    • Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study
    • Eron JJ, Clotet B, Durant J, et al. Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study. J Infect Dis. 2013; 207:740-8.
    • (2013) J Infect Dis. , vol.207 , pp. 740-748
    • Eron, J.J.1    Clotet, B.2    Durant, J.3
  • 42
    • 84856226017 scopus 로고    scopus 로고
    • Once daily dolutegravir (S/ GSK1349572) in combination therapy in antiretroviral-naive adults with HIV: Planned interim 48 week results from SPRING-1, a doseranging, randomised, phase 2b trial
    • van LJ, Maggiolo F, Arribas JR, et al. Once daily dolutegravir (S/ GSK1349572) in combination therapy in antiretroviral-naive adults with HIV: Planned interim 48 week results from SPRING-1, a doseranging, randomised, phase 2b trial. Lancet Infect Dis. 2012; 12:111-8.
    • (2012) Lancet Infect Dis. , vol.12 , pp. 111-118
    • Van, L.J.1    Maggiolo, F.2    Arribas, J.R.3
  • 43
    • 84874431501 scopus 로고    scopus 로고
    • A phase 1 study to evaluate the effect of dolutegravir on renal function via measurement of iohexol and paraaminohippurate clearance in healthy subjects
    • Koteff J, Borland J, Chen S, et al. A phase 1 study to evaluate the effect of dolutegravir on renal function via measurement of iohexol and paraaminohippurate clearance in healthy subjects. Br J Clin Pharmacol 2013; 75:990-6.
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 990-996
    • Koteff, J.1    Borland, J.2    Chen, S.3
  • 44
    • 84904019819 scopus 로고    scopus 로고
    • Panel on antiretroviral guidelines for adults and adolescents: Recommendation on integrase inhibitor use in antiretroviral treatment-naive HIV infected individuals
    • Accessed 14 January 2014
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. Recommendation on integrase inhibitor use in antiretroviral treatment-naive HIV infected individuals. Department of Health and Human Services, 2013. Available at: Http://aidsinfo.nih.gov/ contentfiles/AdultARV-INSTIRecommendations.pdf. Accessed 14 January 2014.
    • (2013) Department of Health and Human Services


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