Pharmacokinetics of Single-Dose Dolutegravir in HIV-Seronegative Subjects With Moderate Hepatic Impairment Compared to Healthy Matched Controls

Clinical Pharmacology in Drug Development

Volumn 2, Issue 4, 2013, Pages 342-348

  Song, Ivy H ^a   Borland, Julie ^a   Savina, Paul M ^a   Chen, Shuguang ^a   Patel, Parul ^a   Wajima, Toshihiro ^b   Peppercorn, Amanda F ^a   Piscitelli, Stephen C ^a  

^a GLAXOSMITHKLINE   (United States)

^b SHIONOGI AND CO LTD   (Japan)

Author keywords

Dolutegravir; Hepatic impairment; Pharmacokinetics; Protein binding

Indexed keywords

ALBUMIN; DOLUTEGRAVIR;

ABDOMINAL DISTENSION; ABNORMAL LABORATORY RESULT; ADULT; AGED; ALBUMIN BLOOD LEVEL; AREA UNDER THE CURVE; ARTICLE; BODY MASS; CHILD PUGH SCORE; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERANCE; FEMALE; HEADACHE; HUMAN; LIVER FAILURE; MALE; MAXIMUM PLASMA CONCENTRATION; NOSE OBSTRUCTION; OPEN STUDY; OROPHARYNX PAIN; OTALGIA; PRIORITY JOURNAL; SENSORY DYSFUNCTION; SERODIAGNOSIS; SIDE EFFECT; SINGLE DRUG DOSE; SOMNOLENCE; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 84885896032     PISSN: 2160763X     EISSN: 21607648     Source Type: Journal    
DOI: 10.1002/cpdd.55     Document Type: Article

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