CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish

Blood

Volumn 124, Issue 1, 2014, Pages 70-78

  Bresciani, Erica ^a   Carrington, Blake ^a   Wincovitch, Stephen ^a   Jones, Marypat ^a   Gore, Aniket V ^b   Weinstein, Brant M ^b   Sood, Raman ^a   Liu, P Paul ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 1,3 DIHYDRO 5 (2 PYRROLYL) 2H 1,4 BENZODIAZEPIN 2 ONE; NOTCH RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CBF BETA; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG; CCAAT BINDING FACTOR; ZEBRAFISH PROTEIN;

AORTA GONAD MESONEPHROS; ARTICLE; EMBRYO; GENE LOSS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HETEROZYGOTE; MESONEPHROS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ZEBRA FISH; ANIMAL; GENE INACTIVATION; GENETICS; IN SITU HYBRIDIZATION; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CCAAT-BINDING FACTOR; CORE BINDING FACTOR ALPHA 2 SUBUNIT; GENE KNOCKOUT TECHNIQUES; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; IN SITU HYBRIDIZATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84903952953     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-10-531988     Document Type: Article

References (39)

1. Detrich HW III, Kieran MW, Chan FY, et al. Intraembryonic hematopoietic cell migration during vertebrate development. Proc Natl Acad Sci USA. 1995;92(23):10713-10717.
2. Herbomel P, Thisse B, Thisse C. Ontogeny and behaviour of early macrophages in the zebrafish embryo. Development. 1999;126(17):3735-3745. (Pubitemid 29440473)
3. Sood R, Liu P. Novel insights into the genetic controls of primitive and definitive hematopoiesis from zebrafish models. Adv Hematol. 2012;2012: 830703.
4. Paik EJ, Zon LI. Hematopoietic development in the zebrafish. Int J Dev Biol. 2010;54(6-7): 1127-1137.
5. Bertrand JY, Chi NC, Santoso B, Teng S, Stainier DY, Traver D. Haematopoietic stem cells derive directly from aortic endothelium during development. Nature. 2010;464(7285):108-111.
6. Kissa K, Herbomel P. Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature. 2010;464(7285):112-115.
7. Kissa K, Murayama E, Zapata A, et al. Live imaging of emerging hematopoietic stem cells and early thymus colonization. Blood. 2008;111(3): 1147-1156. (Pubitemid 351213395)
8. Murayama E, Kissa K, Zapata A, et al. Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development. Immunity. 2006;25(6):963-975. (Pubitemid 44894947)
9. Bertrand JY, Kim AD, Violette EP, Stachura DL, Cisson JL, Traver D. Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Development. 2007;134(23):4147-4156.
10. Ogawa E, Inuzuka M, Maruyama M, et al. Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology. 1993;194(1):314-331.
11. Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol. 1993;13(6):3324-3339. (Pubitemid 23157270)
12. Sasaki K, Yagi H, Bronson RT, et al. Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta. Proc Natl Acad Sci USA. 1996;93(22): 12359-12363. (Pubitemid 26367148)
13. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84(2):321-330. (Pubitemid 26042836)
14. Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA. 1996; 93(8):3444-3449. (Pubitemid 26125639)
15. Wang Q, Stacy T, Miller JD, et al. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell. 1996;87(4):697-708. (Pubitemid 26386943)
16. Ito Y. RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. Adv Cancer Res. 2008;99:33-76. (Pubitemid 350148068)
17. Mangan JK, Speck NA. RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making. Crit Rev Oncog. 2011;16(1-2):77-91.
18. North T, Gu TL, Stacy T, et al. Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development. 1999;126(11):2563-2575. (Pubitemid 29299024)
19. Chen MJ, Yokomizo T, Zeigler BM, Dzierzak E, Speck NA. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature. 2009;457(7231):887-891.
20. Jin H, Sood R, Xu J, et al. Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI. Development. 2009;136(4):647-654.
21. Sood R, English MA, Belele CL, et al. Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation. Blood. 2010;115(14):2806-2809.
22. Chen MJ, Li Y, De Obaldia ME, et al. Erythroid/ myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells. Cell Stem Cell. 2011;9(6):541-552.
23. Blake T, Adya N, Kim CH, et al. Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood. 2000;96(13):4178-4184.
24. Westerfield M. The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Danio rerio). Eugene, OR: University of Oregon Press; 1995.
25. Bertrand JY, Kim AD, Teng S, Traver D. CD411 cmyb1 precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Development. 2008;135(10):1853-1862.
26. Lin HF, Traver D, Zhu H, et al. Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood. 2005;106(12): 3803-3810. (Pubitemid 41739016)
27. Wang Y, Kaiser MS, Larson JD, et al. Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis. Development. 2010; 137(18):3119-3128.
28. Jiang YJ, Brand M, Heisenberg CP, et al. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development. 1996;123:205-216. (Pubitemid 27056748)
29. Scheer N, Campos-Ortega JA. Use of the Gal4- UAS technique for targeted gene expression in the zebrafish. Mech Dev. 1999;80(2):153-158. (Pubitemid 29125426)
30. Sood R, Carrington B, Bishop K, et al. Efficient methods for targeted mutagenesis in zebrafish using zinc-finger nucleases: data from targeting of nine genes using CompoZr or CoDA ZFNs. PLoS ONE. 2013;8(2):e57239.
31. Thisse C, Thisse B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc. 2008;3(1):59-69.
32. Meng X, Noyes MB, Zhu LJ, Lawson ND, Wolfe SA. Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases. Nat Biotechnol. 2008;26(6):695-701. (Pubitemid 351809594)
33. Doyon Y, McCammon JM, Miller JC, et al. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat Biotechnol. 2008;26(6):702-708. (Pubitemid 351809597)
34. Burns CE, Traver D, Mayhall E, Shepard JL, Zon LI. Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev. 2005;19(19):2331-2342. (Pubitemid 41396910)
35. Gering M, Patient R. Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev Cell. 2005;8(3):389-400. (Pubitemid 40309809)
36. Koudijs MJ, den Broeder MJ, Keijser A, et al. The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway. PLoS Genet. 2005;1(2):e19.
37. Cunningham L, Finckbeiner S, Hyde RK, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFb interaction. Proc Natl Acad Sci USA. 2012; 109(36):14592-14597.
38. Nakagawa M, Ichikawa M, Kumano K, et al. AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis. Blood. 2006; 108(10):3329-3334.
39. Zhang Y, Jin H, Li L, Qin FX, Wen Z. cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis. Blood. 2011;118(15):4093-4101.