The cardioprotective effect of protocatechuic acid on myocardial ischemia/reperfusion injury

Journal of Pharmacological Sciences

Volumn 125, Issue 2, 2014, Pages 176-183

  Tang, Xi Lan ^a,b   Liu, Jian Xun ^a   Dong, Wei ^b   Li, Peng ^a   Li, Lei ^a   Lin, Cheng Ren ^a   Zheng, Yong Qiu ^a   Cong, Wei Hong ^a   Hou, Jin Cai ^a  

^a XIYUAN HOSPITAL   (China)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Inflammatory response; Myocardial ischemia reperfusion injury; Platelet aggregation; Protocatechuic acid

Indexed keywords

CASPASE 3; CLOPIDOGREL; DILTIAZEM; PROTEIN KINASE B; PROTOCATECHUIC ACID; TUMOR NECROSIS FACTOR ALPHA; CARDIOTONIC AGENT; HYDROXYBENZOIC ACID DERIVATIVE; TUMOR NECROSIS FACTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; ENZYME MODIFICATION; ENZYME PHOSPHORYLATION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IN VIVO STUDY; MALE; NEWBORN; NONHUMAN; PRIMARY CELL CULTURE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REOXYGENATION; REPERFUSION INJURY; THROMBOCYTE AGGREGATION; UPREGULATION; ANIMAL; BLOOD; CARDIAC MUSCLE CELL; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; SPRAGUE DAWLEY RAT; WISTAR RAT;

ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; CASPASE 3; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HYDROXYBENZOATES; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PLATELET AGGREGATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84903945226     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13247FP     Document Type: Article

References (36)

1. Dongó E, Hornyák I, Benkõ Z, Kiss L. The cardioprotective potential of hydrogen sulfide in myocardial ischemia/reperfusion injury. Acta Physiol Hung. 2011;98:369-381.
2. Turer AT, Hill JA. Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol. 2010;106: 360-368.
3. Chen X, Kotani A, Hakamata H, Wang J, Du S, Kusu F. Three-channel column-switching high-performance liquid chromatography with electrochemical detection for determining bioactive redox components in Salvia miltiorrhiza. J Chromatogr A. 2012;1256:105-113.
4. Li X, Zhang YF, Yang L, Feng Y, Liu YM, Zeng X. [Studies of phenolic acid constituents from the whole plant of Sarcandra glabra]. Traditional Chinese Drug Research and Clinical Pharmacology. 2012;23:295-298. (text in Chinese with English abstract)
5. Kim K, Bae ON, Lim KM, Noh JY, Kang S, Chung KY, et al. Novel antiplatelet activity of protocatechuic acid through the inhibition of high shear stress-induced platelet aggregation. J Pharmacol Exp Ther. 2012;343:704-711.
6. Lin HH, Chen JH, Wang CJ. Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne. Curr Med Chem. 2011;18:1245-1254.
7. Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr. 2005;81:317S-325S.
8. Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal. 2013;18:1818-1892.
9. Yin MC, Lin CC, Wu HC, Tsao SM, Hsu CK. Apoptotic effects of protocatechuic acid in human breast, lung, liver, cervix, and prostate cancer cells: potential mechanisms of action. J Agric Food Chem. 2009;57:6468-6473.
10. Shui G, Bao YM, Bo J, An LJ. Protective effect of protocatechuic acid from Alpinia oxyphylla on hydrogen peroxide-induced oxidative PC12 cell death. Eur J Pharmacol. 2006;538:73-79.
11. Lende AB, Kshirsagar AD, Deshpande AD, Muley MM, Patil RR, Bafna PA, et al. Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice. Inflammopharmacology. 2011;19:255-263.
12. Wang DL, Wei XY, Yan X, Jin TR, Ling WH. Protocatechuic acid, a metabolite of anthocyanins, inhibits monocyte adhesion and reduces atherosclerosis in apolipoprotein E-deficient mice. J Agric Food Chem. 2010;58:12722-12728.
13. Rao MR, Liu GY, Gao CZ, Liang MD, Zhu SH. [Effects of protocatechuic acid and propranolol on myocardial metabolism and infarct size in dogs with acute myocardial infarction]. Zhongguo Yao Li Xue Bao. 1988;9:27-30. (text in Chinese with English abstract)
14. Zhong H, Xin H, Wu LX, Zhu YZ. Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway. J Pharmacol Sci. 2010;114:399-408.
15. Tang XL, Liu JX, Dong W, Li P, Li L, Lin CR, et al. The cardioprotective effects of citric acid and L-malic acid on myocardial ischemia/reperfusion injury. Evid Based Complement Alternat Med. 2013;2013:820695.
16. Born GVR, Cross MJ. The aggregation of blood platelets. J Physiol. 1963;168:178-195.
17. Li P, Fu JH, Wang JK, Ren JG, Liu JX. Extract of paris polyphylla simth protects cardiomyocytes from anoxia-reoxia injury through inhibition of calcium overload. Chin J Integr Med. 2011;17:283-289.
18. Sun YG, Zhang Y, Yan M, Wu YB, Zheng XX. B-type natriuretic peptide-induced cardioprotection against reperfusion is associated with attenuation of mitochondrial permeability transition. Biol Pharm Bull. 2009;32:1545-1551.
19. Kleinbongard P, Heusch G, Schulz R. TNF-α in atherosclerosis, myocardial ischemia/reperfusion and heart failure. Pharmacol Ther. 2010;127:295-314.
20. Klinkhardt U, Bauersachs R, Adams J, Graff J, Lindhoff-Last E, Harder S. Clopidogrel but not aspirin reduces P-selectin expression and formation of platelet-leukocyte aggregates in patients with atherosclerotic vascular disease. Clin Pharmacol Ther. 2003;73:232-241. (Pubitemid 36269674)
21. Galla JM, Lincoff AM. The role of clopidogrel in the management of ischemic heart disease. Curr Opin Cardiol. 2007;22:273-279. (Pubitemid 46897277)
22. Djukanovic N, Todorovic Z, Obradovic S, Zamaklar-Trifunovic D, Njegomirovic S, Milic NM, et al. Abrupt cessation of oneyear clopidogrel treatment is not associated with thrombotic events. J Pharmacol Sci. 2011;117:12-18.
23. Tanaka T, Kojima T, Suzui M, Mori H. Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid: suppressing effects on tumor development and biomarkers expression of colon tumorigenesis. Cancer Res. 1993;53:3908-3913. (Pubitemid 23267687)
24. Cai WT, Liu L, Chen Y, Han FM. [The pharmacokinetics of protocatechuic acid in rat plasma for intragastric administration]. Journal of Hubei University (Natural Science). 2010;32:98-111. (text in Chinese with English abstract)
25. Stanely Mainzen Prince P, Rajakumar S, Dhanasekar K. Protective effects of vanillic acid on electrocardiogram, lipid peroxidation, antioxidants, proinflammatory markers and histopathology in isoproterenol induced cardiotoxic rats. Eur J Pharmacol. 2011; 668:233-240.
26. Akhlaghi M, Bandy B. Mechanisms of flavonoid protection against myocardial ischemia-reperfusion injury. J Mol Cell Cardiol. 2009;46:309-317.
27. Hofer A, Kozek-Langenecker S, Schaden E, Panholzer M, Gombotz H. Point-of-care assessment of platelet aggregation in paediatric open heart surgery. Br J Anaesth. 2011;107:587-592.
28. Antoniades C, Bakogiannis C, Tousoulis D, Antonopoulos AS, Stefanadis C. The CD40/CD40 ligand system: linking inflammation with atherothrombosis. J Am Coll Cardiol. 2009;54:669-677.
29. Stumpf C, Fan QL, Hintermann C, Raaz D, Kurfürst I, Losert S, et al. Anti-inflammatory effects of danshen on human vascular endothelial cells in culture. Am J Chin Med. 2013;41:1065-1077.
30. Ji LL, Fu F, Zhang LH, Liu WC, Cai XQ, Zhang L, et al. Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress. Am J Physiol Endocrinol Metab. 2010;298:E871-E880.
31. Ishihara Y, Shimamoto N. Sulfaphenazole attenuates myocardial cell apoptosis accompanied with cardiac ischemia-reperfusion by suppressing the expression of BimEL and Noxa. J Pharmacol Sci. 2012;119:251-259.
32. Guan S, Ge D, Liu TQ, Ma XH, Cui ZF. Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells. Toxicol In Vitro. 2009;23:201-208.
33. Deng JS, Lee SD, Kuo WW, Fan MJ, Lin YM, Hu WS, et al. Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts. Chem Biol Interact. 2014;209:77-84.
34. Oshima Y, Ouchi N, Sato K, Izumiya Y, Pimentel DR, Walsh K. Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart. Circulation. 2008;117:3099-3108.
35. Bhuiyan MS, Fukunaga K. Cardioprotection by vanadium compounds targeting Akt-mediated signaling. J Pharmacol Sci. 2009;110:1-13.
36. Mullonkal CJ, Toledo-Pereyra LH. Akt in ischemia and reperfusion. J Invest Surg. 2007;20:195-203. (Pubitemid 47050383)