Folic acid supplementation for prevention of mood disorders in young people at familial risk: A randomised, double blind, placebo controlled trial

Journal of Affective Disorders

Volumn 167, Issue , 2014, Pages 306-311

  Sharpley, Ann L ^a   Hockney, Rena ^a   McPeake, Lily ^a   Geddes, John R ^a   Cowen, Philip J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Clinical trial; Familial risk; Folic acid; Mood disorders; Prevention; Young people

Indexed keywords

FOLIC ACID; PLACEBO;

ADOLESCENT; ADULT; ARTICLE; BIPOLAR I DISORDER; BIPOLAR II DISORDER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG TOLERABILITY; DSM-IV; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MEDICATION COMPLIANCE; MOOD AND FEELING QUESTIONNAIRE; MOOD DISORDER; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; OUTCOME ASSESSMENT; PARALLEL DESIGN; PRIMARY PREVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE; SURVIVAL TIME; TREATMENT DURATION; BIPOLAR DISORDER; DEPRESSIVE DISORDER, MAJOR; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOUBLE BLIND PROCEDURE; GENETIC PREDISPOSITION; GENETICS; INCIDENCE; PSYCHOLOGY; RISK;

BIPOLAR DISORDER; DEPRESSIVE DISORDER, MAJOR; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FOLIC ACID; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INCIDENCE; MALE; RISK;

EID: 84903941551     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2014.06.011     Document Type: Article

References (30)

1. O.P. Almeida, K. Marsh, H. Alfonso, L. Flicker, T.M. Davis, and G.J. Hankey B-vitamins reduce the long-term risk of depression after stroke: the VITATOPS-DEP trial Ann. Neurol. 68 2010 503 510
2. E.G. Altman, D. Hedaker, and J.L. Peterson The Altman self-rating mania scale Biol. Psychiatry 42 1997 948 955
3. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed. 2000 American Psychiatric Association Washington, DC (text revision)
4. N.C. Andreasen, J. Rice, J. Endicott, T. Reich, and W. Coryell The family history approach to diagnosis. How useful is it? Arch. Gen. Psychiatry 43 1986 421 429
5. J. Angst Course and prognosis of mood disorders M.G. Gelder, J. Lopez-Ibor, N. Andreasen, New Oxford Textbook of Psychiatry 2000 Oxford University Press Oxford 1134 1141
6. W.R. Beardslee, E.M. Versage, and T.R.G. Gladstone Children of affectively ill parents: a review of the past 10 years J. Am. Acad. Child Adolesc. Psychiatry 37 1998 1134 1141
7. Z. Bhagwagar, and P.J. Cowen It's not over when it's over". Persistent neurobiological abnormalities in recovered depressed patients Psychol. Med. 38 2008 307 313
8. I. Bjelland, G.S. Tell, and S.E. Vollset Folate, vitamin B12, homocysteine, and the MTHFR677C-T polymorphism in anxiety and depression Arch. Gen. Psychiatry 60 2003 618 626
9. P.C. Broderick, and C. Krteland A prospective study of rumination and depression in early adolescence Clin. Child Psychol. Psychiatry 9 2004 383 394
10. A. Coppen, and J. Bailey Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial J. Affect. Disord. 60 2000 121 130
11. M.P. Delbello, and B. Geller Review of studies of child and adolescent off-spring of bipolar parents Bipolar Disord. 3 2001 325 334
12. H.J. Eysenck, and S.B.G. Eysenck Manual of the Eysenck Personality Questionnaire 1975 Hodder and Stoughton Educational Great Britain
13. S. Gilbody, T. Lightfoot, and T. Sheldon Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity J. Epidemiol. Community Health 61 2007 631 637
14. J.F. Greden The burden of recurrent depression: causes, consequences, and future prospects J. Clin. Psychiatry 62 Suppl. 22 2001 S5 S9
15. R. Harrington, and B. Dubicka Natural history of mood disorders in children and adolescents I.M. Goodyer, The Depressed Child and Adolescent 2001 Cambridge University Press Cambridge 353 380
16. J.M. Hettema, M.C. Neale, J.M. Myers, C.A. Prescott, and K.S. Kendler A population-based twin study of the relationship between neuroticism and internalizing disorders Am. J. Psychiatry 163 2006 857 864
17. M. Hoffman Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress Med. Hypothesis 77 2011 1088 1093
18. C. Kuehner, and I. Weber Responses to depression in unipolar depressed patients: an investigation of Nolen-Hoeksema's response styles theory Psychol. Med. 29 1999 1323 1333
19. S.J. Lewis, D.A. Lawlor, G. Davey Smith, R. Araya, N. Timpson, and I.N.M. Day The thermolable variant of MTHFR is associated with depression in the British Womens Heart and Health Study and meta-analysis Mol. Psychiatry 11 2006 352 360
20. M.P. Mattson, and T.B. Shea Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders Trends Neurosci. 26 2003 137 146
21. A.P. Morrison, P. Hutton, D. Shiers, and D. Turkington Antipsychotics: is it time to introduce patient choice? Br. J. Psychiatry 201 2012 83 84
22. Nolen-Hoeksema Responses to depression and their effects on the duration of the depressive episode J. Abnorm. Psychol. 100 1991 569 582
23. S. Nolen-Hoeksema, J.S. Girgus, and M.E. Seligman Learned helplessness in children: a longitudinal study of depression, achievement, and explanatory style J. Pers. Soc. Psychol. 51 1986 435 442
24. A. Pablos-Méndez, R. Barr, and S. Shea Run-in periods in randomized trials: implications for the application of results in clinical practice J. Am. Med. Assoc. 279 1998 222 225
25. P. Ramchandani A question of balance: how safe are the medicines that are prescribed to children? Nature 430 2004 401 402
26. S.B. Roberts, and K.S. Kendler Neuroticism and self esteem as indices of the vulnerability to major depression in women Psychol. Med. 29 1999 1101 1109
27. M. Thompson, N.J. Kaslow, B. Weiss, and S. Nolen-Hoeksema Children's attributional style questionnaire revised: psychometric examination Psychol. Assess. 10 1998 166 170
28. R. Venkatasubramanian, C.N. Kumar, and R.S. Pandey A randomized double-blind comparison of fluoxetine augmentation by high and low dosage folic acid in patients with depressive episodes J. Affect. Disord. 150 2013 644 648
29. N.J. Wald, M.R. Law, J.K. Morris, and D.S. Wald Quantifying the effect of folic acid Lancet 358 2001 2069 2073
30. A. Wood, L. Kroll, A. Moore, and R. Harrington Properties of the mood and feelings questionnaire in adolescent psychiatric outpatients: a research note J. Child Psychol. Psychiatry 36 1995 327 334