Cerebral Circulation and Hypotension in the Premature Infant: Diagnosis and Treatment

Neonatology: Questions and Controversies Series: Neurology

Volumn , Issue , 2008, Pages 3-26

  McLean, Claire W ^a,b,c   Cayabyab, Rowena G ^a   Noori, Shahab ^d   Seri, Istvan ^a,b,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c WOMEN S AND CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84903858151     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4160-3157-4.10002-1     Document Type: Chapter

References (88)

1. Perlman JM, McMenamin JB, Volpe JJ Fluctuating cerebral blood flow velocity in respiratory distress syndrome. Relation to the development of intraventricular hemorrhage. N Engl J Med 1983, 309(4):204-209.
2. Van Bel F, Van de Bor M, Stijnen T, et al. Aetiological role of cerebral blood flow alterations in development and extension of peri-intraventricular hemorrhage. Dev Med Child Neurol 1987, 29(5):601-614.
3. Miall-Allen VM, de Vries LS, Whitelaw AG Mean arterial pressure and neonatal cerebral lesions. Arch Dis Child 1987, 62:1068-1069.
4. Bada HS, Korones SB, Perry EH, et al. Mean arterial blood pressure changes in premature infants and those at risk for intraventricular hemorrhage. J Pediatr 1990, 117:607-614.
5. Tsuji M, Saul PJ, duPlessis A, et al. Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics 2000, 106:625.
6. Hunt R, Evans N, Rieger I, et al. Low superior vena cava flow and neurodevelopment at 3 years in very preterm infants. J Pediatr 2004, 145:588-592.
7. Goldstein RF, Thompson RJ, Oehler JM, et al. Influence of acidosis, hypoxemia, and hypotension on neurodevelopmental outcome in very low birth weight infants. Pediatrics 1995, 95:238-243.
8. Damman O, Allred EN, Kuban KCK, et al. Systemic hypotension and white matter damage in preterm infants. Dev Med Child Neurol 2002, 44:82-90.
9. Nuntnarumit P, Yang W, Bada-Ellzey HS Blood pressure measurements in the newborn. Clin Perinat 1999, 26(4):981-996.
10. Development of audit measures and guidelines for good practice in the management of neonatal respiratory distress syndrome. Arch Dis Child 1992, 67:1221-1227. Report of a Joint Working Group of the British Association of Perinatal Medicine and the Research Unit of the Royal College of Physicians.
11. Engle WD Blood pressure in the very low birth weight neonate. Early Human Dev 2001, 62:97-130.
12. Seri I Circulatory support of the sick newborn infant. Semin Neonatol 2001, 6:85-95.
13. Greisen G Autoregulation of cerebral blood flow in newborn babies. Early Human Dev 2005, 81:423-428.
14. Milligan DWA Failure of autoregulation and intraventricular haemorrhage in preterm infants. Lancet 1980, i:896-899.
15. Munro MJ, Walker AM, Barfield CP Hypotensive extremely low birth weight infants have reduced cerebral blood flow. Pediatrics 2004, 114:1591.
16. Kissack CM, Garr R, Wardle SP, Weindling AM Cerebral fractional oxygen extraction is inversely correlated with oxygen delivery in the sick, newborn preterm infant. J Cerebr Blood Flow Metab 2005, 25:545-553.
17. Weindling AM, Victor NM Definition of hypotension in very low birth weight infants during the immediate neonatal period. NeoReviews 2007, 8(1):c32-c43.
18. Victor S, Marson AG, Appleton RE, et al. Relationship between blood pressure, cerebral electrical activity, cerebral fractional oxygen extraction and peripheral blood flow in very low birth weight newborn infants. Pediatr Res 2006, 59:314-319.
19. Victor S, Appleton RE, Beirne M, et al. The relationship between cardiac output, cerebral electrical activity, cerebral fractional oxygen extraction and peripheral blood flow in premature newborn infants. Pediatr Res 2006, 60:1-5.
20. Kluckow M, Evans N Low superior vena cava flow and intraventricular haemorrhage in preterm infants. Arch Dis Child 2000, 82:188-194.
21. Kluckow M, Evans N Relationship between blood pressure and cardiac output in preterm infants requiring mechanical ventilation. J Pediatr 1996, 129:506.
22. Kluckow M, Evans N Superior vena cava flow in newborn infant: a novel marker of systemic blood flow. Arch Dis Child Fetal Neonatal Ed 2000, 82:182-187.
23. Kissack CM, Garr R, Wardle SP, et al. Cerebral fractional oxygen extraction in very low birth weight infants is high when there is low left ventricular output and hypocarbia but is unaffected by hypotension. Pediatr Res 2004, 55:400-405.
24. Seri I Hemodynamics during the first two postnatal days and neurodevelopment in preterm neonates. J Pediatr 2004, 145:573-575.
25. Greisen G Cerebral blood flow in preterm infants during the first week of life. Acta Paediatr Scand 1986, 75:43-51.
26. Pryds O, Andersen E, Hansen BF Cerebral blood flow reactivity in spontaneously breathing infants shortly after birth. Acta Paediatr Scand 1990, 79:391-396.
27. 2 and haemoglobin concentration on day to day variation of CBF in preterm neonates. Acta Paediatr Scand 1989, 360:33-36.
28. 2 changes and visual evoked potentials in mechanically ventilated preterm infants. Acta Paediatr Scand 1987, 76:394-400.
29. Altman DI, Powers WJ, Perlman JM, et al. Cerebral blood flow requirement for brain viability in newborn infants is lower than in adults. Ann Neurol 1988, 24:218-226.
30. Kluckow M, Evans N Low systemic blood flow and hyperkalemia in preterm infants. J Pediatr 2001, 139:227-232.
31. Osborn D, Evans N, Kluckow M Randomised trial of dopamine and dobutamine in preterm infants with low systemic blood flow. J Pediatr 2002, 140:183-191.
32. Kehrer M, Blumenstock G, Ehehalt S, et al. Development of cerebral blood flow volume in preterm neonates during the first two weeks of life. Pediatr Res 2005, 58:927-930.
33. Osborn D, Evans N, Kluckow M Clinical detection of low upper body blood flow in very premature infants using blood pressure, capillary refill time and central peripheral temperature difference. Arch Dis Child Fetal Neonatal Ed 2004, 89:168-173.
34. Evans N, Iyer P Longitudinal changes in the diameter of the ductus arteriosus in ventilated preterm infants: correlation with respiratory outcomes. Arch Dis Child Fetal Neonatal Ed 1995, 72:F156-F161.
35. West CR, Groves AM, Williams CE, et al. Early low cardiac output is associated with compromised electroencephalographic activity in very preterm infants. Pediatr Res 2006, 59:610-615.
36. Kluckow M, Seri I, Evans N Functional echocardiography: an emerging clinical tool for the neonatologist. J Pediatr 2007, 150(2):125-130.
37. Gilbert RD, Pearce WJ, Ashwal S, Longo LD Effects of hypoxia on contractility of isolated fetal lamb cerebral arteries. J Dev Physiol 1990, 13:199-203.
38. Hansen NB, Stonestreet BS, Rosenkrantz TS, Oh W Validity of Doppler measurements of anterior cerebral artery blood flow velocity: correlation with brain blood flow in piglets. Pediatrics 1983, 72:526-531.
39. 133xenon clearance. J Pediatr 1984, 104:411-418.
40. Raju TN Cerebral Doppler studies in the fetus and the newborn infant. J Pediatr 1991, 119:165-174.
41. van der Linden J, Wesslen O, Ekroth R, et al. Transcranial Doppler-estimated versus thermodilution-estimated cerebral blood flow during cardiac operations. Influence of temperature and arterial carbon dioxide tension. J Thorac Cardiovasc Surg 1991, 102:95-102.
42. Bassan H, Gauvreau K, Newburger JW, et al. Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery. Pediatr Res 2005, 57:35-41.
43. Brazy JE, Lewis DV, Mitnisk MH, et al. Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observation. Pediatrics 1985, 75:217-225.
44. Patel J, Marks K, Roberts I, et al. Measurement of cerebral blood flow in newborn infants using near infrared spectroscopy with indocyanine green. Pediatr Res 1998, 43:34-39.
45. Dullenkopf A, Kolarova A, Schulz G, et al. Reproducibility of cerebral oxygenation measurement in neonates and infants in the clinical setting using the NIRO 300 oximeter. Pediatr Crit Care Med 2005, 6:344-347.
46. Boas DA, Gaudette T, Strangman G, et al. The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics. NeuroImage 2001, 13:276-290.
47. 133xenon clearance for estimation of cerebral blood flow in critically ill preterm infants. Pediatr Res 1993, 33:56-60.
48. Toet MC, Hellstrom-Westas L, Groenendaal F, et al. Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 1999, 81:F19-F23.
49. Hellstrom-Westas L Comparison between taper-recorded and amplitude-integrated EEG monitoring in sick newborn infants. Acta Paediatr 1992, 81:812-819.
50. Toet MC, van der Mei W, de Vries LS, et al. Comparison between simultaneously recorded amplitude-integrated electroencephalogram (cerebral function monitor) and standard electroencephalogram in neonates. Pediatrics 2002, 109:772-779.
51. Ter Horst HJ, Sommer C, Bergman KA, et al. Prognostic significance of amplitude-integrated EEG during the first 72 hours after birth in severely asphyxiated neonates. Pediatr Res 2004, 55:1026-1033.
52. Shalak LF, Laptook AR, Velaphi SC, et al. Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathy. Pediatrics 2003, 111:351-357.
53. Greisen G, Pryds O Low CBF, discontinuous EEG activity, and periventricular brain injury in ill, preterm neonates. Brain Dev 1989, 11:164-168.
54. Hellstrom-Westas L, Klette H, Thorngren-Jerneck K, et al. Early prediction of outcome with aEEG in preterm infants with large intraventricular hemorrhages. Neuropediatrics 2001, 32:319-324.
55. Olischar M, Klebermass K, Kuhle S, et al. Reference values for amplitude-integrated electroencephalographic activity in preterm infants younger than 30 weeks' gestational age. Pediatrics 2004, 113:e61-e66.
56. Klebermass K, Kuhle S, Olischar M, et al. Intra-and extrauterine maturation of amplitude-integrated electroencephalographic activity in preterm infants younger than 30 weeks of gestation. Biol Neonate 2006, 89:120-125.
57. Woodward LJ, Anderson PJ, Austin NC, et al. Neonatal MRI to predict neurodevelopmental outcomes in preterm infants. N Engl J Med 2006, 255:685-694.
58. Miller SP, Ferriero DM, Leonard C, et al. Early brain injury in premature newborns detected with magnetic resonance imaging is associated with adverse early neurodevelopmental outcome. J Pediatr 2005, 147:609-616.
59. Pellicer A, Valverde E, Elorza MD, et al. Cardiovascular support for low birth weight infants and cerebral hemodynamics: a randomized blinded clinical trial. Pediatrics 2005, 115:1501.
60. Fanaroff JM, Wilson-Costello DE, Newman NS, et al. Treated hypotension is associated with neonatal morbidity and hearing loss in extremely low birth weight infants. Pediatrics 2006, 117:1131-1135.
61. Pryds O, Greisen G, Lou H, et al. Heterogeneity of cerebral vasoreactivity in preterm infants supported by mechanical ventilation. J Pediatr 1982, 115:638-644.
62. Seri I, Abbasi S, Wood DC, et al. Regional hemodynamic effects of dopamine in the sick preterm neonate. J Pediatr 1998, 133:728-734.
63. Pryds O, Andersen GE, Friis-Hansen B Cerebral blood flow reactivity in spontaneously breathing, preterm infants shortly after birth. Acta Paediatr Scand 1990, 79:391-396.
64. Boylan GB, Young K, Panerai RB, et al. Dynamic cerebral autoregulation in sick newborn infants. Pediatr Res 2000, 48:12-17.
65. Seri I, Rudas G, Bors Z, et al. Effects of low dose dopamine infusion on cardiovascular and renal functions, cerebral blood flow and plasma catecholamine levels in sick preterm neonates. Pediatr Res 1993, 34:742-749.
66. Evans N, Moorcraft J Effect of patency of the ductus arteriosus on blood pressure in very preterm infants. Arch Dis Child 1992, 67:1169.
67. Kluckow M, Evans N Early echocardiographic prediction of symptomatic patent ductus arteriosus in preterm infants undergoing mechanical ventilation. J Pediatr 1995, 127:774-779.
68. Osborn DA, Evans N, Kluckow M Effect of early, targeted indomethacin on the ductus arteriosus and blood flow to the upper body and brain in the preterm infant. Arch Dis Child Fetal Neonatal Ed 2003, 88:477-482.
69. Yanowitz TD, Yao AC, Werner JC, et al. Effects of prophylactic low-dose indomethacin on hemodynamics in very low birth weight infants. J Pediatr 1998, 132:28-34.
70. Thomas RL, Parker GC, Van Overmeire B, et al. A meta-analysis of ibuprofen versus indomethacin for closure of patent ductus arteriosus. Eur J Pediatr 2005, 164:135-140.
71. Seri I Cardiovascular, renal and endocrine actions of dopamine in neonates and children. J Pediatr 1995, 126:333-344.
72. Lundstrom K, Pryds O, Greisen G The haemodynamic effects of dopamine and volume expansion in sick preterm infants. Early Hum Dev 2000, 57:157-163.
73. Chang AC, Atz A, Wernovsky G, et al. Milrinone: systemic and pulmonary hemodynamic effects in neonates after cardiac surgery. Crit Care Med 1995, 23:1907-1911.
74. Hoffman TM, Wernovsky G, Atz AM, et al. Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation 2003, 107:996-1002.
75. Paradisis M, Evans N, Kluckow M, et al. Pilot study of milrinone for low systemic blood flow in very preterm infants. J Pediatr 2006, 148:306-313.
76. Roze JC, Tohier C, Maingureneau C, et al. Response to dobutamine and dopamine in the hypotensive very preterm infant. Arch Dis Child 1993, 69:59-63.
77. Noori S, Friedlich P, Seri I Cardiovascular and renal effects of dobutamine in the neonate. NeoReviews 2004, 5:E22-E26.
78. Ng PC, Lee CH, Lam CWK, et al. Transient adrenocortical insufficiency of prematurity and systemic hypotension in very low birth weight infants. Arch Dis Child Fetal Neonatal Ed 2004, 89:F119-F126.
79. Fernandez E, Schrader R, Watterberg Prevalence of low cortisol values in term and near-term infants with vasopressor-resistant hypotension. J Perinatol 2005, 25:114-118.
80. Seri I, Tan R, Evans J The effect of hydrocortisone on blood pressure in preterm neonates with pressor-resistant hypotension. Pediatrics 2001, 107:1070-1074.
81. Noori S, Friedlich P, Wong P, et al. Hemodynamic changes after low-dose hydrocortisone administration in vasopressor-treated preterm and term neonates. Pediatrics 2006, 118:1456-1466.
82. Niijima S, Shortland DB, Levene MI, et al. Transient hyperoxia and cerebral blood flow velocity in infants born prematurely and at full term. Arch Dis Child 1988, 63:1126-1130.
83. Tyszczuk L, Meek J, Elwell C, et al. Cerebral blood flow is independent of mean arterial blood pressure in preterm infants undergoing intensive care. Pediatrics 1998, 102:337-341.
84. Victor S, Appleton RE, Beirne M, et al. Effect of carbon dioxide on background cerebral electrical activity and fractional oxygen extraction in very low birth weight infants just after birth. Pediatr Res 2005, 58:579-585.
85. Murase M, Ishida A Early hypocarbia of preterm infants: its relationship to periventricular leukomalacia and cerebral palsy, and its perinatal risk factors. Acta Paediatr 2005, 94:85-91.
86. Kaiser JR, Gauss CH, Williams DK The effects of hypercapnia on cerebral autoregulation in ventilated very low birth weight infants. Pediatr Res 2005, 58:931-935.
87. van Alfen-van der Velden AAEM, Hopman JCW, Klaessens JHGM, et al. Effects of midazolam and morphine on cerebral oxygenation and hemodynamics in ventilated premature infants. Biol Neonate 2006, 90:197-202.
88. Roll C, Huning B, Kaunicke M, et al. Umbilical artery catheter blood sampling volume and velocity: impact on cerebral blood volume and oxygenation in very-low-birthweight infants. Acta Paediatr 2006, 95:68-73.