Cardiovascular support for low birth weight infants and cerebral hemodynamics: A randomized, blinded, clinical trial

Pediatrics

Volumn 115, Issue 6, 2005, Pages 1501-1512

  Pellicer, Adelina ^a   Valverde, Eva ^a   Elorza, María Dolores ^a   Madero, Rosario ^a   Gayá, Francisco ^a   Quero, José ^a   Cabañas, Fernando ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Cerebral hemodynamics; Dopamine; Epinephrine; Hypotension; Low birth weight infants; Near infrared spectroscopy

Indexed keywords

ADRENALIN; DEOXYHEMOGLOBIN; DOPAMINE; INOTROPIC AGENT; OXYHEMOGLOBIN; CARBON DIOXIDE; CARDIOTONIC AGENT; HEMOGLOBIN; OXYGEN;

ARTICLE; BRAIN CIRCULATION; CARDIOVASCULAR SYSTEM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GESTATIONAL AGE; HEART RATE; HEMATOLOGY; HUMAN; HYPOTENSION; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; NEAR INFRARED SPECTROSCOPY; NEWBORN; OXYGEN SATURATION; OXYGENATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSCUTANEOUS CARBON DIOXIDE MONITORING; TRANSCUTANEOUS OXYGEN MONITORING; ULTRASOUND; BLOOD; BLOOD PRESSURE; COMPARATIVE STUDY; ECHOENCEPHALOGRAPHY; HEMODYNAMICS; INSTRUMENTATION; OXIDATION REDUCTION REACTION; OXIMETRY; PREMATURITY; TREATMENT OUTCOME;

BLOOD PRESSURE; CARBON DIOXIDE; CARDIOTONIC AGENTS; CEREBROVASCULAR CIRCULATION; DOPAMINE; DOUBLE-BLIND METHOD; ECHOENCEPHALOGRAPHY; EPINEPHRINE; FEMALE; GESTATIONAL AGE; HEART RATE; HEMODYNAMIC PROCESSES; HEMOGLOBINS; HUMANS; HYPOTENSION; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; MALE; OXIDATION-REDUCTION; OXIMETRY; OXYGEN; OXYHEMOGLOBINS; TREATMENT OUTCOME;

EID: 27744540115     PISSN: 00314005     EISSN: 00314005     Source Type: Journal    
DOI: 10.1542/peds.2004-1396     Document Type: Article

References (48)

1. Hegyi T, Carbone MT, Anwar M, et al. Blood pressure ranges in premature infants, I: the first hours of life. J Pediatr. 1994;124:627-633
2. Zubrow AB, Hulman S, Kushner H, Falkner B. Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. J Perinatol. 1995;15:470-479
3. Nuntnarumit P, Yang W, Bada-Ellzey HS. Blood pressure measurements in the newborn. Clin Perinatol. 1999;26:981-996
4. Cunningham S, Symon AG, Elton RA, Zhu C, McIntosh N. Intra-arterial blood pressure reference ranges, death and morbidity in very low birthweight infants during the first seven days of life. Early Hum Dev. 1999;56:151-165
5. Miall-Allen VM, de Vries LS, Dubowitz LMS, Whitelaw AGL. Blood pressure fluctuation and intraventricular hemorrhage in the preterm infant of less than 31 weeks' gestation. Pediatrics. 1989;83:657-661
6. Bada HS, Korones SB, Perry EH, et al. Mean arterial blood pressure changes in premature infants and those at risk for intraventricular hemorrhage. J Pediatr. 1990;117:607-614
7. Wakins AM, West CR, Cooke RW. Blood pressure and cerebral hemorrhage and ischemia in very low birth weight infants. Early Hum Dev. 1989;19:103-110
8. Goldstein RF, Thompson RJ, Oehler JM, Brazy JE. Influence of acidosis, hypoxemia, and hypotension on neurodevelopmental outcome in very low birth weight infants. Pediatrics. 1995;95:238-243
9. Meek JH, Tyszczuk L, Elwell CE, Wyatt JS. Low cerebral blood flow is a risk factor for severe intraventricular haemorrhage. Arch Dis Child Fetal Neonatal Ed. 1999;81:F15-F18
10. Lou HC. Hypoxic-hemodynamic pathogenesis of brain lesions in the newborn. Brain Dev. 1994;16:423-431
11. Pryds O. Low neonatal oxygen delivery is associated with brain injury in preterm infants. Acta Paediatr. 1994;83:1233-1236
12. Perlman JM, McMenamin JB, Volpe JJ. Fluctuating cerebral blood flow velocity in respiratory distress syndrome. N Engl J Med. 1983;309:204-209
13. Tsuji M, Saul JP, du Plessis A, et al. Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics. 2000;106:625-632
14. Rozè JC, Tohier C, Maingueneau C, Lefèvre M, Mouzard A. Response to dobutamine and dopamine in the hypotensive very preterm infant. Arch Dis Child. 1993;69:59-63
15. Klarr JM, Faix RG, Pryce CJE, Bhatt-Mehta V. Randomized, blind trial of dopamine versus dobutamine for treatment of hypotension in preterm infants with respiratory distress syndrome. J Pediatr. 1994;125:117-122
16. Osborn D, Evans N, Kluckow M. Randomized trial of dobutamine versus dopamine in preterm infants with low systemic blood flow. J Pediatr. 2002;140:183-191
17. Ruelas-Orozco G, Varga-Origel A. Assessment of therapy for arterial hypotension in critically ill preterm infants. Am J Perinatol. 2000;17:95-99
18. Zhang J, Penny DJ, Kim NS, Yu VYH, Smolich JJ. Mechanisms of blood pressure increase induced by dopamine in hypotensive preterm neonates. Arch Dis Child Fetal Neonatal Ed. 1999;81:F99-F104
19. Barrington K, Chan W. The circulatory effects of epinephrine infusion in the anesthetized piglet. Pediatr Res. 1993;33:190-194
20. Barrington KJ, Dewald J, Allen RG. The renal vascular effects of epinephrine infusion in the halothane anesthetized piglet. Can J Physiol Pharmacol. 1994;72:394-396
21. Bigam DL, Barrington KJ, Jirsch DW, Cheung PY. Effects of a continuous epinephrine infusion on regional blood flow in awake newborn piglets. Biol Neonate. 1998;73:198-206
22. Phillipos EZ, Barrington KJ, Robertson MA. Dopamine versus epinephrine for inotropic support in the neonate: a randomized double blinded controlled trial. Pediatr Res. 1996;39:238A
23. Phillipos EZ, Barrington KJ, Robertson MA. The effects of dopamine versus epinephrine on the pulmonary circulation in the sick newborn: a randomized double blinded controlled trial. Pediatr Res. 1996;39:238A
24. Jobsis FF. Noninvasive infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science. 1977;198:1264-1267
25. Cope M, Delpy DT. A system for the long-term measurement of cerebral blood and tissue oxygenation in newborn infants by near infrared transillumination. Med Biol Eng Comput. 1988;26:289-294
26. Wray S, Cope M, Delpy DT, Wyatt JS, Reynolds EOR. Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for non-invasive monitoring of cerebral oxygenation. Biochim Biophys Acta. 1988;933:184-192
27. Pellicer A, Gayá F, Stiris TA, Quero J, Cabañas F. Cerebral haemodynamics in preterm infants after exposure to dexamethasone. Arch Dis Child. 1998;79:F123-F128
28. Pellicer A, Gayá F, Madero R, Quero J, Cabañas F. Noninvasive continuous monitoring of the effects of head position on brain hemodynamics in ventilated infants. Pediatrics. 2002;109:434-440
29. Wyatt JS, Cope M, Delpy DT. Measurement of optical path length for cerebral near-infrared spectroscopy in newborn infants. Dev Neurosci. 1990;12:140-144
30. Wyatt JS, Edwards AD, Cope M, et al. Response of cerebral blood volume to changes in arterial carbon dioxide tension in preterm and term infants. Pediatr Res. 1991;29:553-557
31. Lammertsma AA, Brooks DJ, Bearney RP. In vivo measurement of regional cerebral hematocrit using positron emission tomography. J Cereb Blood Flow Metab. 1984;4:317-322
32. Tsuji M, duPlessis A, Taylor G, Crocker R, Volpe JJ. Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets. Pediatr Res. 1998;44:591-595
33. Soul JS, Taylor GA, Wypij D, duPlessis AJ, Volpe JJ. Noninvasive detection of changes in cerebral blood flow by near infrared spectroscopy in a piglet model of hydrocephalus. Pediatr Res. 2000;48:445-449
34. Pellicer A, Cabañas F, García-Alix A, Pérez Rodríguez J, Quero J. Natural history of ventricular dilatation in preterm infants: prognostic significance. Pediatr Neurol. 1993;9:108-114
35. Volpe JJ. Intracranial hemorrhage: germinal matrix-intraventricular hemorrhage of the premature infant. In: Volpe JJ, ed. Neurology of the Newborn. 4th ed. Philadelphia, PA: WB Saunders; 2001:428-493
36. Levene MI. Measurement of the growth of the lateral ventricles in preterm infants with real time ultrasound. Arch Dis Child. 1981;56:900-904
37. Seri I, Tan R, Evans J. Cardiovascular effects of hydrocortisone in preterm infants with pressor-resistant hypotension. Pediatrics. 2001;107:1070-1074
38. Pellicer A, Valverde E, Gayá F, Quero J, Cabañas F. Postnatal adaptation of brain circulation in preterm infants. Pediatr Neurol. 2001;24:103-109
39. Rennie JM. Cerebral blood flow velocity variability after cardiovascular support in premature babies. Arch Dis Child. 1989;64:897-901
40. Seri I, Rudas G, Bors Z, Kanyicska B, Tulassay T. Effects of low-dose dopamine infusion on cardiovascular and renal functions, cerebral blood flow, and plasma catecholamine levels in sick preterm neonates. Pediatr Res. 1993;34:742-749
41. Seri I, Abbasi S, Wood DC, Gerdes JS. Regional hemodynamic effects of dopamine in the sick preterm neonate. J Pediatr. 1998;133:728-734
42. Lundström K, Pryds O, Greisen G. The haemodynamic effects of dopamine and volume expansion in sick preterm infants. Early Hum Dev. 2000;57:157-163
43. Skov L, Pryds O. Capillary recruitment for preservation of cerebral glucose influx in hypoglycemic, preterm newborns: evidence for a glucose sensor? Pediatrics. 1992;90:193-195
44. Seri I. Cardiovascular, renal, and endocrine actions of dopamine in neonates and children. J Pediatr. 1995;126:333-344
45. 2-adrenoceptor stimulation in conscious fasted rabbits. Fundam Clin Pharmacol. 1991;5:663-676
46. van der Hoeven MAHBM, Maertzdorf WJ, Blanco CE. Continuous central venous oxygen saturation (Scvo2) measurement using a fibre optic catheter in newborn infants. Arch Dis Child Fetal Neonatal Ed. 1996;74:F177-F181
47. O'Connor TA, Hall RT. Mixed venous oxygenation in critically ill neonates. Crit Care Med. 1994;22:343-346
48. Lee J, Wright F, Barber R, et al. Central venous oxygen saturation in shock. Anesthesiology. 1972;36:472-478