Antibiotic rotation strategies to reduce antimicrobial resistance in Gram-negative bacteria in European intensive care units: Study protocol for a cluster-randomized crossover controlled trial

Trials

Volumn 15, Issue 1, 2014, Pages

  van Duijn, Pleun J ^a   Bonten, Marc J M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; PIPERACILLIN PLUS TAZOBACTAM; ANTIINFECTIVE AGENT;

ACINETOBACTER; ANTIBIOTIC CYCLING; ANTIBIOTIC MIXING; ANTIBIOTIC RESISTANCE; ANTIBIOTIC ROTATION; ANTIBIOTIC THERAPY; ARTICLE; BELGIUM; CASE MIX; CONTROLLED STUDY; CROSSOVER PROCEDURE; ENTEROBACTERIACEAE; FRANCE; GERMANY; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; HOSPITAL INFECTION; HUMAN; INFECTION PREVENTION; INTENSIVE CARE UNIT; LENGTH OF STAY; MORTALITY; MULTICENTER STUDY; OPEN STUDY; OROPHARYNX; OUTCOME ASSESSMENT; PERINEUM; PORTUGAL; PREVALENCE; PSEUDOMONAS AERUGINOSA; RANDOMIZED CONTROLLED TRIAL; REDUCTION; SLOVENIA; CLINICAL PROTOCOL; CLINICAL TRIAL; CLUSTER ANALYSIS; DRUG ADMINISTRATION; DRUG SUBSTITUTION; EUROPE; GRAM-NEGATIVE BACTERIAL INFECTIONS; INTENSIVE CARE; METHODOLOGY; MICROBIOLOGY; PROCEDURES; TIME; TRANSMISSION; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; CLINICAL PROTOCOLS; CLUSTER ANALYSIS; CROSS-OVER STUDIES; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE, BACTERIAL; DRUG SUBSTITUTION; EUROPE; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; INTENSIVE CARE; INTENSIVE CARE UNITS; PREVALENCE; RESEARCH DESIGN; TIME FACTORS; TREATMENT OUTCOME;

EID: 84903856941     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/1745-6215-15-277     Document Type: Article

References (38)

1. Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y, Reinhart K. International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009, 302:2323-2329.
2. Sarraf-Yazdi S, Sharpe M, Bennett KM, Dotson TL, Anderson DJ, Vaslef SN. A 9-Year retrospective review of antibiotic cycling in a surgical intensive care unit. J Surg Res 2012, 176:e73-e78.
3. Gerding DN, Larson TA, Hughes RA, Weiler M, Shanholtzer C, Peterson LR. Aminoglycoside resistance and aminoglycoside usage: ten years of experience in one hospital. Antimicrob Agents Chemother 1991, 35:1284-1290.
4. Cadena J, Taboada CA, Burgess DS, Ma JZ, Lewis JS, Freytes CO, Patterson JE. Antibiotic cycling to decrease bacterial antibiotic resistance: a 5-year experience on a bone marrow transplant unit. Bone Marrow Transplant 2007, 40:151-155.
5. van Loon HJ, Vriens MR, Fluit AC, Troelstra A, van der Werken C, Verhoef J, Bonten MJ. Antibiotic rotation and development of gram-negative antibiotic resistance. Am J Respir Crit Care Med 2005, 171:480-487.
6. Craig M, Cumpston AD, Hobbs GR, Devetten MP, Sarwari AR, Ericson SG. The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a hematological malignancy and transplantation unit. Bone Marrow Transplant 2007, 39:477-482.
7. Martinez JA, Nicolas JM, Marco F, Horcajada JP, Garcia-Segarra G, Trilla A, Codina C, Torres A, Mensa J. Comparison of antimicrobial cycling and mixing strategies in two medical intensive care units. Crit Care Med 2006, 34:329-336.
8. Warren DK, Hill HA, Merz LR, Kollef MH, Hayden MK, Fraser VJ, Fridkin SK. Cycling empirical antimicrobial agents to prevent emergence of antimicrobial-resistant Gram-negative bacteria among intensive care unit patients. Crit Care Med 2004, 32:2450-2456.
9. Ginn AN, Wiklendt AM, Gidding HF, George N, O'Driscoll JS, Partridge SR, O'Toole BI, Perri RA, Faoagali J, Gallagher JE, Lipman J, Iredell JR. The ecology of antibiotic use in the ICU: homogeneous prescribing of cefepime but not tazocin selects for antibiotic resistant infection. PLoS One 2012, 7:e38719.
10. Sandiumenge A, Lisboa T, Gomez F, Hernandez P, Canadell L, Rello J. Effect of antibiotic diversity on ventilator-associated pneumonia caused by ESKAPE Organisms. Chest 2011, 140:643-651.
11. Toltzis P, Dul MJ, Hoyen C, Salvator A, Walsh M, Zetts L, Toltzis H. The effect of antibiotic rotation on colonization with antibiotic-resistant bacilli in a neonatal intensive care unit. Pediatrics 2002, 110:707-711.
12. Nijssen S, Fluit A, van de Vijver D, Top J, Willems R, Bonten MJ. Effects of reducing beta-lactam antibiotic pressure on intestinal colonization of antibiotic-resistant gram-negative bacteria. Intensive Care Med 2010, 36:512-519.
13. Raymond DP, Pelletier SJ, Crabtree TD, Gleason TG, Hamm LL, Pruett TL, Sawyer RG. Impact of a rotating empiric antibiotic schedule on infectious mortality in an intensive care unit. Crit Care Med 2001, 29:1101-1108.
14. Sandiumenge A, Diaz E, Rodriguez A, Vidaur L, Canadell L, Olona M, Rue M, Rello J. Impact of diversity of antibiotic use on the development of antimicrobial resistance. J Antimicrob Chemother 2006, 57:1197-1204.
15. Bennett KM, Scarborough JE, Sharpe M, Dodds-Ashley E, Kaye KS, Hayward TZ, Vaslef SN. Implementation of antibiotic rotation protocol improves antibiotic susceptibility profile in a surgical intensive care unit. J Trauma 2007, 63:307-311.
16. Evans HL, Milburn ML, Hughes MG, Smith RL, Chong TW, Raymond DP, Pelletier SJ, Pruett TL, Sawyer RG. Nature of gram-negative rod antibiotic resistance during antibiotic rotation. Surg Infect (Larchmt) 2005, 6:223-231.
17. Hedrick TL, Schulman AS, McElearney ST, Smith RL, Swenson BR, Evans HL, Truwit JD, Scheld WM, Sawyer RG. Outbreak of resistant Pseudomonas aeruginosa infections during a quarterly cycling antibiotic regimen. Surg Infect (Larchmt) 2008, 9:139-152.
18. Dominguez EA, Smith TL, Reed E, Sanders CC, Sanders WE. A pilot study of antibiotic cycling in a hematology-oncology unit. Infect Control Hosp Epidemiol 2000, 21(1 Suppl):S4-S8.
19. Gruson D, Hilbert G, Vargas F, Valentino R, Bebear C, Allery A, Gbikpi-Benissan G, Cardinaud JP. Rotation and restricted use of antibiotics in a medical intensive care unit: impact on the incidence of ventilator-associated pneumonia caused by antibiotic-resistant gram-negative bacteria. Am J Respir Crit Care Med 2000, 162(3 Pt 1):837-843.
20. Raineri E, Crema L, Dal Zoppo S, Acquarolo A, Pan A, Carnevale G, Albertario F, Candiani A. Rotation of antimicrobial therapy in the intensive care unit: impact on incidence of ventilator-associated pneumonia caused by antibiotic-resistant Gram-negative bacteria. Eur J Clin Microbiol Infect Dis 2010, 29:1015-1024.
21. Damas P, Canivet JL, Ledoux D, Monchi M, Melin P, Nys M, De Mol P. Selection of resistance during sequential use of preferential antibiotic classes. Intensive Care Med 2006, 32:67-74.
22. Gruson D, Hilbert G, Vargas F, Valentino R, Bui N, Pereyre S, Bebear C, Bebear CM, Gbikpi-Benissan G. Strategy of antibiotic rotation: long-term effect on incidence and susceptibilities of Gram-negative bacilli responsible for ventilator-associated pneumonia. Crit Care Med 2003, 31:1908-1914.
23. Takesue Y, Nakajima K, Ichiki K, Ishihara M, Wada Y, Takahashi Y, Tsuchida T, Ikeuchi H. Impact of a hospital-wide programme of heterogeneous antibiotic use on the development of antibiotic-resistant Gram-negative bacteria. J Hosp Infect 2010, 75:28-32.
24. Nijssen S, Bootsma M, Bonten M. Potential confounding in evaluating infection-control interventions in hospital settings: changing antibiotic prescription. Clin Infect Dis 2006, 43:616-623.
25. Campbell MK, Piaggio G, Elbourne DR, Altman DG. Consort 2010 statement: extension to cluster randomised trials. BMJ 2012, 345:e5661.
26. de Smet AM, Kluytmans JA, Blok HE, Mascini EM, Benus RF, Bernards AT, Kuijper EJ, Leverstein-van Hall MA, Jansz AR, de Jongh BM, van Asselt GJ, Thijsen SF, Conijn SN, Kaan JA, Arends JP, Sturm PD, Bootsma MC, Bonten MJ. Selective digestive tract decontamination and selective oropharyngeal decontamination and antibiotic resistance in patients in intensive-care units: an open-label, clustered group-randomised, crossover study. Lancet Infect Dis 2011, 11:372-380.
27. Gerding DN. Antimicrobial cycling: lessons learned from the aminoglycoside experience. Infect Control Hosp Epidemiol 2000, 21(1 Suppl):S12-S17.
28. Bonhoeffer S, Lipsitch M, Levin BR. Evaluating treatment protocols to prevent antibiotic resistance. Proc Natl Acad Sci U S A 1997, 94:12106-12111.
29. Bergstrom CT, Lo M, Lipsitch M. Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals. Proc Natl Acad Sci U S A 2004, 101:13285-13290.
30. Magee JT. The resistance ratchet: theoretical implications of cyclic selection pressure. J Antimicrob Chemother 2005, 56:427-430.
31. Reluga TC. Simple models of antibiotic cycling. Math Med Biol 2005, 22:187-208.
32. Chow K, Wang X, Curtiss R, Castillo-Chavez C. Evaluating the efficacy of antimicrobial cycling programmes and patient isolation on dual resistance in hospitals. J Biol Dyn 2011, 5:27-43.
33. Sun HR, Lu X, Ruan S. Qualitative analysis of models with different treatment protocols to prevent antibiotic resistance. Math Biosci 2010, 227:56-67.
34. Beardmore RE, Pena-Miller R. Rotating antibiotics selects optimally against antibiotic resistance, in theory. Math Biosci Eng 2010, 7:527-552.
35. Bonhoeffer S, Wiesch PA, Kouyos RD. Rotating antibiotics does not minimize selection for resistance. Math Biosci Eng 2010, 7:919-922.
36. Beardmore RE, Pena-Miller R. Antibiotic cycling versus mixing: the difficulty of using mathematical models to definitively quantify their relative merits. Math Biosci Eng 2010, 7:923-933.
37. Kouyos RD, Abel Zur Wiesch P, Bonhoeffer S. Informed switching strongly decreases the prevalence of antibiotic resistance in hospital wards. PLoS Comput Biol 2011, 7:e1001094.
38. ClinicalTrials.gov. http://clinicaltrials.gov/.