PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a

Chemico-Biological Interactions

Volumn 219, Issue , 2014, Pages 159-167

  Al Anati, Lauy ^a   Kadekar, Sandeep ^a   Högberg, Johan ^a   Stenius, Ulla ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Benzo a pyrene; Estradiol; FoxO3a; p53 Mediated interactions; Persistent organic pollutants; PP2A

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BENZO[A]PYRENE; DIBENZO[A,L]PYRENE; ESTRADIOL; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN 14 3 3; PROTEIN P53; SMALL INTERFERING RNA; THREONINE; TRANSCRIPTION FACTOR FKHRL1; POLYCYCLIC AROMATIC HYDROCARBON; 2,4,5,2',4',5'-HEXACHLOROBIPHENYL; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; POLYCHLORINATED BIPHENYL;

APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; NUCLEOCYTOPLASMIC TRANSPORT; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; CYTOPLASM; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; FLOW CYTOMETRY; HEPG2 CELL LINE; IMMUNOHISTOCHEMISTRY; LIVER; METABOLISM; PHOSPHORYLATION; WESTERN BLOTTING;

14-3-3 PROTEINS; APOPTOSIS; BENZO(A)PYRENE; BLOTTING, WESTERN; ESTRADIOL; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HEP G2 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; PHOSPHORYLATION; POLYCHLORINATED BIPHENYLS; RNA, SMALL INTERFERING; TETRACHLORODIBENZODIOXIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84903851554     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.06.007     Document Type: Article

References (39)

1. U. Ghosh, J.R. Zimmerman, and R.G. Luthy PCB and PAH speciation among particle types in contaminated harbor sediments and effects on PAH bioavailability Environ. Sci. Technol. 37 10 2003 2209 2217 (Pubitemid 36593044)
2. R. Godschalk et al. Benzo[a]pyrene enhances lipid peroxidation induced DNA damage in aorta of apolipoprotein E knockout mice Free Radic. Res. 37 12 2003 1299 1305 (Pubitemid 37441713)
3. R. Ishaq et al. PCBs, PCNs, PCDD/Fs, PAHs and Cl-PAHs in air and water particulate samples - patterns and variations Chemosphere 50 9 2003 1131 1150 (Pubitemid 36192825)
4. R.C. James et al. Polychlorinated biphenyl exposure and human disease J. Occup. Med. 35 2 1993 136 148 (Pubitemid 23064289)
5. B.H. Robinson E-waste: an assessment of global production and environmental impacts Sci. Total Environ. 408 2 2009 183 191
6. H. Bartsch DNA adducts in human carcinogenesis: etiological relevance and structure-activity relationship Mutat. Res. 340 2-3 1996 67 79 (Pubitemid 126657368)
7. K. Schneider et al. Cancer risk assessment for oral exposure to PAH mixtures J. Appl. Toxicol. 22 1 2002 73 83 (Pubitemid 34126624)
8. G. Boysen, and S.S. Hecht Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods Mutat. Res. 543 1 2003 17 30 (Pubitemid 36050911)
9. M. Ueno et al. Thioredoxin-dependent redox regulation of p53-mediated p21 activation J. Biol. Chem. 274 50 1999 35809 35815 (Pubitemid 129512885)
10. M. Ramet et al. P53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines Carcinogenesis 16 9 1995 2117 2124
11. J.G. Teodoro, S.K. Evans, and M.R. Green Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome J. Mol. Med. (Berl.) 85 11 2007 1175 1186 (Pubitemid 47622219)
12. K.H. Vousden P53: death star Cell 103 5 2000 691 694
13. H. Hemming, S. Flodstrom, and L. Warngard Enhancement of altered hepatic foci in rat liver and inhibition of intercellular communication in vitro by the pyrethroid insecticides fenvalerate, flucythrinate and cypermethrin Carcinogenesis 14 12 1993 2531 2535 (Pubitemid 24016591)
14. J. Strathmann et al. PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors Toxicol. Sci. 93 1 2006 34 40 (Pubitemid 44288247)
15. L. Al-Anati, J. Hogberg, and U. Stenius Non-dioxin-like PCBs interact with benzo[a]pyrene-induced p53-responses and inhibit apoptosis Toxicol. Appl. Pharmacol. 249 2 2010 166 177
16. D.R. Green, and G. Kroemer Cytoplasmic functions of the tumour suppressor p53 Nature 458 7242 2009 1127 1130
17. E.R. Schuur et al. Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family J. Biol. Chem. 276 36 2001 33554 33560
18. D. Menendez, A. Inga, and M.A. Resnick Potentiating the p53 network Discov. Med. 10 50 2010 94 100
19. S.C. Kang, and B.M. Lee Effect of estrogen receptor (ER) on benzo[a]pyrene-DNA adduct formation in human breast cancer cells J. Toxicol. Environ. Health A 68 21 2005 1833 1840 (Pubitemid 41783259)
20. S.V. Singh et al. Gender-related differences in susceptibility of A/J mouse to benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis Cancer Lett. 128 2 1998 197 204 (Pubitemid 28318736)
21. Z. Chen et al. Estrogen promotes benzo[a]pyrene-induced lung carcinogenesis through oxidative stress damage and cytochrome c-mediated caspase-3 activation pathways in female mice Cancer Lett. 308 1 2011 14 22
22. W.J. Crinnion The CDC fourth national report on human exposure to environmental chemicals: what it tells us about our toxic burden and how it assist environmental medicine physicians Altern. Med. Rev. 15 2 2010 101 109
23. E. Aries, D.R. Anderson, and R. Fisher Exposure assessment of workers to airborne PCDD/Fs, PCBs and PAHs at an electric arc furnace steelmaking plant in the UK Ann. Occup. Hyg. 52 4 2008 213 225 (Pubitemid 351832998)
24. K. Jackson et al. Assessment of exposure to PCDD/F, PCB, and PAH at a basic oxygen steelmaking (BOS) and an iron ore sintering plant in the UK Ann. Occup. Hyg. 56 1 2012 37 48
25. M. Stenberg, and P.L. Andersson Selection of non-dioxin-like PCBs for in vitro testing on the basis of environmental abundance and molecular structure Chemosphere 71 10 2008 1909 1915
26. M. Lippman, G. Bolan, and K. Huff The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture Cancer Res. 36 12 1976 4595 4601
27. T. Mikkola et al. Effect of physiological concentrations of estradiol on PGI2 and NO in endothelial cells Maturitas 25 2 1996 141 147 (Pubitemid 26336679)
28. Y. Zhang et al. Estrogen and androgen protection of human neurons against intracellular amyloid beta1-42 toxicity through heat shock protein 70 J. Neurosci. 24 23 2004 5315 5321 (Pubitemid 38747672)
29. M. Tampio et al. Induction of PUMA-alpha and down-regulation of PUMA-beta expression is associated with benzo(a)pyrene-induced apoptosis in MCF-7 cells Toxicol. Lett. 188 3 2009 214 222
30. A. Singh et al. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT Mol. Biol. Cell 21 6 2010 1140 1152
31. K. Ueda et al. Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation Arterioscler. Thromb. Vasc. Biol. 33 8 2013 1837 1843
32. G. Tzivion, M. Dobson, and G. Ramakrishnan FoxO transcription factors; regulation by AKT and 14-3-3 proteins Biochim. Biophys. Acta 1813 11 2011 1938 1945
33. W. Fu et al. MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation J. Biol. Chem. 284 21 2009 13987 14000
34. H.Y. Yang et al. 14-3-3 sigma positively regulates p53 and suppresses tumor growth Mol. Cell Biol. 23 20 2003 7096 7107
35. F. Wang et al. Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53 J. Mol. Biol. 384 3 2008 590 603
36. H. You, K. Yamamoto, and T.W. Mak Regulation of transactivation- independent proapoptotic activity of p53 by FOXO3a Proc. Natl. Acad. Sci. U.S.A. 103 24 2006 9051 9056 (Pubitemid 43902531)
37. S. Clavel et al. Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cells Mol. Cell Biol. 30 2 2010 470 480
38. Q. Liu et al. PP2A-dependent control of transcriptionally active FOXO3a in CD8(+) central memory lymphocyte survival requires p47(phox) Cell Death Dis. 3 2012 e375
39. J.D. Amaral et al. The role of p53 in apoptosis Discov. Med. 9 45 2010 145 152