메뉴 건너뛰기




Volumn 15, Issue 7, 2014, Pages 826-831

Vemurafenib and panitumumab combination tailored therapy in BRAF-mutated metastatic colorectal cancer: A case report

Author keywords

BRAF; Colorectal cancer; Cutaneous toxicity; EGFR; Panitumumab; Personalized medicine; Target therapy; Vemurafenib

Indexed keywords

ANTINEOPLASTIC AGENT; B RAF KINASE; BEVACIZUMAB; CA 19-9 ANTIGEN; CAPECITABINE; CARCINOEMBRYONIC ANTIGEN; CETUXIMAB; CHLOROPLAST DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; K RAS PROTEIN; OXALIPLATIN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; SORAFENIB; VEMURAFENIB; BRAF PROTEIN, HUMAN; INDOLE DERIVATIVE; MONOCLONAL ANTIBODY; SULFONAMIDE;

EID: 84903828105     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.28878     Document Type: Article
Times cited : (18)

References (31)
  • 1
    • 84883430683 scopus 로고    scopus 로고
    • The role of personalized medicine in metastatic colorectal cancer: An evolving landscape
    • PMID:24003339
    • Moorcraft SY, Smyth EC, Cunningham D. The role of personalized medicine in metastatic colorectal cancer: an evolving landscape. Therap Adv Gastroenterol 2013; 6:381-95; PMID:24003339; http://dx.doi.org/10.1177/1756283X13491797
    • (2013) Therap Adv Gastroenterol , vol.6 , pp. 381-395
    • Moorcraft, S.Y.1    Smyth, E.C.2    Cunningham, D.3
  • 5
    • 80052210041 scopus 로고    scopus 로고
    • KRAS and colorectal cancer: Ethical and pragmatic issues in effecting real-time change in oncology clinical trials and practice
    • NCI GI Steering Committee Colon Cancer Task Force, PMID:21737577
    • Blanke CD, Goldberg RM, Grothey A, Mooney M, Roach N, Saltz LB, Welch JJ, Wood WA, Meropol NJ; NCI GI Steering Committee Colon Cancer Task Force. KRAS and colorectal cancer: ethical and pragmatic issues in effecting real-time change in oncology clinical trials and practice. Oncologist 2011; 16:1061-8; PMID:21737577; http://dx.doi.org/10.1634/theoncologist.2011-0011
    • (2011) Oncologist , vol.16 , pp. 1061-1068
    • Blanke, C.D.1    Goldberg, R.M.2    Grothey, A.3    Mooney, M.4    Roach, N.5    Saltz, L.B.6    Welch, J.J.7    Wood, W.A.8    Meropol, N.J.9
  • 6
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
    • PMID:20100961
    • Bardelli A, Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol 2010; 28:1254-61; PMID:20100961; http://dx.doi.org/10.1200/JCO.2009.24.6116
    • (2010) J Clin Oncol , vol.28 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2
  • 7
    • 73349114941 scopus 로고    scopus 로고
    • KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial
    • PMID:19884549
    • Richman SD, Seymour MT, Chambers P, Elliott F, Daly CL, Meade AM, Taylor G, Barrett JH, Quirke P. KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J Clin Oncol 2009; 27:5931-7; PMID:19884549; http://dx.doi.org/10.1200/JCO.2009.22.4295
    • (2009) J Clin Oncol , vol.275 , pp. 931-937
    • Richman, S.D.1    Seymour, M.T.2    Chambers, P.3    Elliott, F.4    Daly, C.L.5    Meade, A.M.6    Taylor, G.7    Barrett, J.H.8    Quirke, P.9
  • 10
    • 84861863158 scopus 로고    scopus 로고
    • EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib
    • PMID:22448344
    • Corcoran RB, Ebi H, Turke AB, Coffee EM, Nishino M, Cogdill AP, Brown RD, Della Pelle P, Dias-Santagata D, Hung KE, et al. EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov 2012; 2:227-35; PMID:22448344; http://dx.doi.org/10.1158/2159-8290.CD-11-0341
    • (2012) Cancer Discov , vol.2 , pp. 227-235
    • Corcoran, R.B.1    Ebi, H.2    Turke, A.B.3    Coffee, E.M.4    Nishino, M.5    Cogdill, A.P.6    Brown, R.D.7    Della Pelle, P.8    Dias-Santagata, D.9    Hung, K.E.10
  • 12
    • 84885135736 scopus 로고    scopus 로고
    • The economic evaluation of personalised oncology medicines: Ethical challenges
    • PMID:24099207
    • Lewis JR, Lipworth WL, Kerridge IH, Day RO. The economic evaluation of personalised oncology medicines: ethical challenges. Med J Aust 2013; 199:471-3; PMID:24099207; http://dx.doi.org/10.5694/mja13.10046
    • (2013) Med J Aust , vol.199 , pp. 471-473
    • Lewis, J.R.1    Lipworth, W.L.2    Kerridge, I.H.3    Day, R.O.4
  • 14
    • 84876953788 scopus 로고    scopus 로고
    • B-Raf and the inhibitors: From bench to bedside
    • PMID:23617957
    • Huang T, Karsy M, Zhuge J, Zhong M, Liu D. B-Raf and the inhibitors: from bench to bedside. J Hematol Oncol 2013; 6:30; PMID:23617957; http://dx.doi.org/10.1186/1756-8722-6-30
    • (2013) J Hematol Oncol , vol.6 , pp. 30
    • Huang, T.1    Karsy, M.2    Zhuge, J.3    Zhong, M.4    Liu, D.5
  • 15
    • 84887497121 scopus 로고    scopus 로고
    • The quest to overcome resistance to EGFR-targeted therapies in cancer
    • PMID:24202392
    • Chong CR, Jänne PA. The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat Med 2013; 19:1389-400; PMID:24202392; http://dx.doi.org/10.1038/nm.3388
    • (2013) Nat Med , vol.19 , pp. 1389-1400
    • Chong, C.R.1    Jänne, P.A.2
  • 17
    • 84887478023 scopus 로고    scopus 로고
    • Tumor adaptation and resistance to RAF inhibitors
    • PMID:24202393
    • Lito P, Rosen N, Solit DB. Tumor adaptation and resistance to RAF inhibitors. Nat Med 2013; 19:1401-9; PMID:24202393; http://dx.doi.org/10.1038/ nm.3392
    • (2013) Nat Med , vol.19 , pp. 1401-1409
    • Lito, P.1    Rosen, N.2    Solit, D.B.3
  • 18
    • 78651418282 scopus 로고    scopus 로고
    • Mutant BRAF melanomas-dependence and resistance
    • PMID:21251612
    • Poulikakos PI, Rosen N. Mutant BRAF melanomas-dependence and resistance. Cancer Cell 2011; 19:11-5; PMID:21251612; http://dx.doi.org/10.1016/j.ccr.2011. 01.008
    • (2011) Cancer Cell , vol.19 , pp. 11-15
    • Poulikakos, P.I.1    Rosen, N.2
  • 19
    • 84869067183 scopus 로고    scopus 로고
    • Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas
    • PMID:23153539
    • Lito P, Pratilas CA, Joseph EW, Tadi M, Halilovic E, Zubrowski M, Huang A, Wong WL, Callahan MK, Merghoub T, et al. Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas. Cancer Cell 2012; 22:668-82; PMID:23153539; http://dx.doi.org/10.1016/j.ccr.2012.10.009
    • (2012) Cancer Cell , vol.22 , pp. 668-682
    • Lito, P.1    Pratilas, C.A.2    Joseph, E.W.3    Tadi, M.4    Halilovic, E.5    Zubrowski, M.6    Huang, A.7    Wong, W.L.8    Callahan, M.K.9    Merghoub, T.10
  • 20
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
    • PMID:21107323
    • Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 2010; 468:973-7; PMID:21107323; http://dx.doi.org/10.1038/nature09626
    • (2010) Nature , vol.468 , pp. 973-977
    • Nazarian, R.1    Shi, H.2    Wang, Q.3    Kong, X.4    Koya, R.C.5    Lee, H.6    Chen, Z.7    Lee, M.K.8    Attar, N.9    Sazegar, H.10
  • 21
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • PMID:20179705
    • Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010; 464:427-30; PMID:20179705; http://dx.doi.org/10.1038/nature08902
    • (2010) Nature , vol.464 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5
  • 22
    • 84863115580 scopus 로고    scopus 로고
    • Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation
    • PMID:22205714
    • Su F, Bradley WD, Wang Q, Yang H, Xu L, Higgins B, Kolinsky K, Packman K, Kim MJ, Trunzer K, et al. Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation. Cancer Res 2012; 72:969-78; PMID:22205714; http://dx.doi.org/10.1158/0008-5472.CAN-11-1875
    • (2012) Cancer Res , vol.72 , pp. 969-978
    • Su, F.1    Bradley, W.D.2    Wang, Q.3    Yang, H.4    Xu, L.5    Higgins, B.6    Kolinsky, K.7    Packman, K.8    Kim, M.J.9    Trunzer, K.10
  • 23
    • 78650008177 scopus 로고    scopus 로고
    • Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
    • PMID:21156289
    • Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis M, Cipolla AK, Wubbenhorst B, Xu X, Gimotty PA, Kee D, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 2010; 18:683-95; PMID:21156289; http://dx.doi.org/10.1016/j.ccr.2010.11.023
    • (2010) Cancer Cell , vol.18 , pp. 683-695
    • Villanueva, J.1    Vultur, A.2    Lee, J.T.3    Somasundaram, R.4    Fukunaga-Kalabis, M.5    Cipolla, A.K.6    Wubbenhorst, B.7    Xu, X.8    Gimotty, P.A.9    Kee, D.10
  • 25
    • 84880100858 scopus 로고    scopus 로고
    • Off-label use of cetuximab plus sorafenib and panitumumab plus regorafenib to personalize therapy for a patient with V600E BRAFmutant metastatic colon cancer
    • PMID:23792568
    • Al-Marrawi MY, Saroya BS, Brennan MC, Yang Z, Dykes TM, El-Deiry WS. Off-label use of cetuximab plus sorafenib and panitumumab plus regorafenib to personalize therapy for a patient with V600E BRAFmutant metastatic colon cancer. Cancer Biol Ther 2013; 14:703-10; PMID:23792568; http://dx.doi.org/10.4161/cbt. 25191
    • (2013) Cancer Biol Ther , vol.14 , pp. 703-710
    • Al-Marrawi, M.Y.1    Saroya, B.S.2    Brennan, M.C.3    Yang, Z.4    Dykes, T.M.5    El-Deiry, W.S.6
  • 26
    • 84877924804 scopus 로고    scopus 로고
    • Dermatological adverse events from BRAF inhibitors: A growing problem
    • PMID:23463215
    • Belum VR, Fischer A, Choi JN, Lacouture ME. Dermatological adverse events from BRAF inhibitors: a growing problem. Curr Oncol Rep 2013; 15:249-59; PMID:23463215; http://dx.doi.org/10.1007/s11912-013-0308-6
    • (2013) Curr Oncol Rep , vol.15 , pp. 249-259
    • Belum, V.R.1    Fischer, A.2    Choi, J.N.3    Lacouture, M.E.4
  • 28
    • 84873360893 scopus 로고    scopus 로고
    • Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents
    • PMID:23251002
    • Mao M, Tian F, Mariadason JM, Tsao CC, Lemos R Jr., Dayyani F, Gopal YN, Jiang ZQ, Wistuba II, Tang XM, et al. Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clin Cancer Res 2013; 19:657-67; PMID:23251002; http://dx.doi.org/10. 1158/1078-0432.CCR-11-1446
    • (2013) Clin Cancer Res , vol.19 , pp. 657-667
    • Mao, M.1    Tian, F.2    Mariadason, J.M.3    Tsao, C.C.4    Lemos Jr., R.5    Dayyani, F.6    Gopal, Y.N.7    Jiang, Z.Q.8    Wistuba, I.I.9    Tang, X.M.10
  • 29
    • 84880254869 scopus 로고    scopus 로고
    • Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors
    • PMID:23614898
    • Morris EJ, Jha S, Restaino CR, Dayananth P, Zhu H, Cooper A, Carr D, Deng Y, Jin W, Black S, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov 2013; 3:742-50; PMID:23614898; http://dx.doi.org/10.1158/2159-8290.CD-13-0070
    • (2013) Cancer Discov , vol.3 , pp. 742-750
    • Morris, E.J.1    Jha, S.2    Restaino, C.R.3    Dayananth, P.4    Zhu, H.5    Cooper, A.6    Carr, D.7    Deng, Y.8    Jin, W.9    Black, S.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.