Mechanism of the toxicity induced by natural humic acid on human vascular endothelial cells

Environmental Toxicology

Volumn 29, Issue 8, 2014, Pages 916-925

  Kihara, Yusuke ^a   Yustiawati, ^a   Tanaka, Masato ^a   Gumiri, Sulmin ^b   Ardianor, ^b   Hosokawa, Toshiyuki ^a   Tanaka, Shunitz ^a   Saito, Takeshi ^a   Kurasaki, Masaaki ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF PALANGKA RAYA   (Indonesia)

Author keywords

Apoptosis; Endothelial cell; Humic acid; Oxidative stress; Tropical peatland

Indexed keywords

BIOLOGICAL MATERIALS; CELL DEATH; CYTOTOXICITY; HEAVY METALS; ORGANIC ACIDS; OXIDATIVE STRESS; WETLANDS;

EXPERIMENTAL SYSTEM; HIGH MOLECULAR WEIGHT; HUMAN VASCULAR ENDOTHELIAL CELLS; HUMIC ACID; HUMIC SUBSTANCES; MITOCHONDRIAL PATHWAYS; PEATLAND; VASCULAR ENDOTHELIAL CELLS;

ENDOTHELIAL CELLS;

ASCORBIC ACID; CASPASE 6; CASPASE 9; HUMIC ACID;

APOPTOSIS; BIOLOGICAL UPTAKE; CYTOLOGY; ECOTOXICOLOGY; ENVIRONMENTAL STRESS; ENZYME ACTIVITY; HEALTH IMPACT; HUMIC ACID; PEATLAND; PHYSIOLOGICAL RESPONSE; PUBLIC HEALTH; RISK FACTOR;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INDONESIA; OXIDATIVE STRESS; PEATLAND; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BORNEO; INDONESIA; KALIMANTAN;

APOPTOSIS; ENDOTHELIAL CELL; HUMIC ACID; OXIDATIVE STRESS; TROPICAL PEATLAND;

ASCORBIC ACID; CASPASES; CELL SURVIVAL; DEFEROXAMINE; GLUTATHIONE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HUMIC SUBSTANCES; HYDROGEN PEROXIDE; INDONESIA; IRON; IRON CHELATING AGENTS; L-LACTATE DEHYDROGENASE; OXIDATIVE STRESS; RIVERS; SOIL POLLUTANTS; VITAMINS; WATER POLLUTANTS;

EID: 84903819768     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.21819     Document Type: Article

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