Lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) causes hyperactivity in male rat pups by aberrant increase in dopamine and its receptor

Environmental Toxicology

Volumn 29, Issue 8, 2014, Pages 876-883

  Lesmana, Ronny ^a,b   Shimokawa, Noriaki ^a   Takatsuru, Yusuke ^a   Iwasaki, Toshiharu ^a   Koibuchi, Noriyuki ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b PADJADJARAN UNIVERSITY   (Indonesia)

Author keywords

Dopamine; Dopamine receptor; Hydroxylated PCB 106; Hyperactivity; Postnatal PCB exposure; Rats

Indexed keywords

AMINES; ANTHROPOMETRY; HYDROXYLATION; NEUROPHYSIOLOGY; ORGANIC POLLUTANTS; RATING; RATS;

DOPAMINE; DOPAMINE RECEPTOR; HYDROXYLATED-PCB 106; HYPERACTIVITY; POSTNATAL PCB-EXPOSURE;

POLYCHLORINATED BIPHENYLS;

4 HYDROXY 2',3,3',4',5' PENTACHLOROBIPHENYL; CORN OIL; DOPAMINE; DOPAMINE 2 RECEPTOR; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG;

ABNORMALITY; BEHAVIORAL RESPONSE; BIOACTIVITY; BIOCHEMISTRY; CIRCADIAN RHYTHM; ECOTOXICOLOGY; HORMONE; LACTATION; LOCOMOTION; MILK; PCB; POLLUTION EFFECT; POLLUTION EXPOSURE; RODENT; YOUNG POPULATION;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR CHANGE; BEHAVIOR CONTROL; BODY WEIGHT; BREAST MILK; CIRCADIAN RHYTHM; COORDINATION; CORPUS STRIATUM; EXPLORATORY BEHAVIOR; FEEDING; FEMALE; HYPERACTIVITY; LACTATION; LOCOMOTION; MALE; NEUROTOXICITY; NEWBORN; NONHUMAN; PERINATAL DRUG EXPOSURE; PHYSICAL ACTIVITY; PHYSICAL DEVELOPMENT; POLLUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

RATTUS; ZEA MAYS;

DOPAMINE; DOPAMINE RECEPTOR; HYDROXYLATED-PCB 106; HYPERACTIVITY; POSTNATAL PCB-EXPOSURE; RATS;

ANIMALS; ANIMALS, NEWBORN; CORPUS STRIATUM; DOPAMINE; ENVIRONMENTAL POLLUTANTS; FEMALE; HYDROXYLATION; LACTATION; LOCOMOTION; MALE; MOTOR ACTIVITY; POLYCHLORINATED BIPHENYLS; RATS, WISTAR; RECEPTORS, DOPAMINE; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D5;

EID: 84903819205     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.21815     Document Type: Article

References (27)

1. Bemis JC, Seegal RF.2004.PCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content.Toxicol Sci80:288-295.
2. Dreiem A, Okoniewski RJ, Brosch KO, Miller VM, Seegal RF.2010.Polychlorinated biphenyls and polybrominated diphenyl ethers alter striatal dopamine neurochemistry in synaptosomes from developing rats in an additive manner.Toxicol Sci118:150-159.
3. Erickson MD.2001. Introduction: PCB properties, uses, occurrence, and regulatory history. In: Robertson LW, Hansen LG, editors.PCBs.Lexington:The University Press of Kentucky. ppxi-xxx.
4. Faroon O, Jones D, de Rosa C.2001.Effects of polychlorinated biphenyls on the nervous system.Toxicol Ind Health16:305-333.
5. 3H]dopa in various regions of the brain.J Neurochem13:655-669.
6. Holene E, Nafstad I, Skaare JU, Bernhoft A, Engen P, Sagvolden T.1995.Behavioral effects of pre and postnatal exposure to individual polychlorinated biphenyl congeners in rats.Environ Toxicol Chem14:967-976.
7. Holene E, Nafstad I, Skaare JU, Sagvolden T.1998.Behavioral hyperactivity in rats following postnatal exposure to sub-toxic doses of polychlorinated biphenyl congeners 153 and 126.Behav Brain Res94:213-224.
8. 2+ entry, and cAMP responsive element binding protein phosphorylation in developing cortical cells following exposure to polychlorinated biphenyls.J Pharmacol Exp Ther297:762-773.
9. Kang JH, Jeong W, Park Y, Lee SY, Chung MW, Lim HK, Park IS, Choi KH, Chung SY, Kim DS, Park CS, Hwang O, Kim J.2002.Aroclor 1254-induced cytotoxicity in catecholaminergic CATH.a cells related to the inhibition of NO production.Toxicology177:157-166.
10. Kang JH, Park IS, Oh WY, Lim HK, Wang SY, Lee SY, Choi KH, Kim JI, Jung SY, Suh CK, Kim DS.2004.Inhibition of aroclor 1254-induced depletion of stored calcium prevents the cell death in catecholaminergic cells.Toxicology200:93-101.
11. Karadaghy AA, Lasak JM, Chomchai JS, Khan KM, Drescher MJ, Drescher DG.1997.Quantitative analysis of dopamine receptor messages in the mouse cochlea.Brain Res Mol Brain Res44:151-156.
12. Lilienthal H, Winnecke G.1991.Sensitive periods for behavioral toxicity of polychlorinated biphenyls: Determination by cross-fostering in rats.Fundam Appl Toxicol17:368-375.
13. 2+ oscillations and alterations of membrane potential in cultured cortical cells.J Appl Toxicol30:334-342.
14. Mariussen E, Fonnum F.2001.The effect of polychlorinated biphenyls on the high affinity uptake of the neurotransmitters dopamine, serotonin, glutamate and GABA, into rat brain synaptosomes.Toxicology159:11-21.
15. Miyazaki W, Iwasaki T, Takeshita A, Kuroda Y, Koibuchi N.2004.Polychlorinated biphenyls suppress thyroid hormone receptor-mediated transcription through a novel mechanism.J Biol Chem279:18195-18202.
16. Okada J, Shimokawa N, Koibuchi N.2005.Polychlorinated biphenyl (PCB) alters acid-sensitivity of cultured neurons derived from the medulla oblongata.Int J Biochem Cell Biol37:1368-1374.
17. Safe SH.1994.Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment.Crit Rev Toxicol24:87-149.
18. Schantz SL, Moshtaghian J, Ness DK.1995.Spatial learning deficits in adult rats exposed to ortho-substituted PCB congeners during gestation and lactation.Fundam Appl Toxicol26:117-126.
19. Seegal RF, Okoniewski RJ, Brosch KO, Bemis JC.2002.Polychlorinated biphenyls alter extraneuronal but not tissue dopamine concentrations in adult rat striatum: An in vivo microdialysis study.Environ Health Perspect110:1113-1117.
20. Seegal RF, Marek KL, Seibyl JP, Jennings DL, Molho ES, Higgins DS, Factor SA, Fitzgerald EF, Hills EA, Korrick SA, Wolff MS, Haase RF, Todd AC, Parsons P, McCaffrey RJ.2010.Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: A beta-CIT imaging study.Neurobiol Dis38:219-225.
21. Seeman P, Schwarz J, Chen JF, Szechtman H, Perreault M, McKnight GS, Roder JC, Quirion R, Boksa P, Srivastava LK, Yanai K, Weinshenker D, Sumiyoshi T.2006.Psychosis pathways converge via D2high dopamine receptors.Synapse60:319-346
22. Shimokawa N, Miyazaki W, Iwasaki T, Koibuchi N.2006.Low dose hydroxylated PCB induces c-Jun expression in PC12 cells.Neurotoxicology27:176-183.
23. Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I.2010.CIN85 regulates dopamine receptor endocytosis and governs behavior in mice.EMBO J29:2421-2432.
24. Tilson HA, Kodavanti PR.1997.Neurochemical effects of polychlorinated biphenyls: An overview and identification of research needs.Neurotoxicology18:727-743.
25. Tilson HA, Kodavanti PR.1998.The neurotoxicity of polychlorinated biphenyls.Neurotoxicology19:517-525.
26. Wong PW, Garcia EF, Pessah IN.2001.Ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism.J Neurochem76:450-463.
27. Yao WD, Spealman RD, Zhang J.2008.Dopaminergic signaling in dendritic spines.Biochem Pharmacol75:2055-2069.