Only high levels of dabigatran attenuate catheter thrombosis in vitro and in rabbits

Thrombosis and Haemostasis

Volumn 112, Issue 1, 2014, Pages 79-86

  Yau, Jonathan W ^a   Liao, Peng ^a   Fredenburgh, James C ^a   Roberts, Robin S ^a   Weitz, Jeffrey I ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Catheter thrombosis; Dabigatran; Heparin; Rabbits; Thrombin generation

Indexed keywords

DABIGATRAN; HEPARIN; THROMBIN; ANTITHROMBIN; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING TIME; CATHETER OCCLUSION; CATHETER THROMBOSIS; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG MEGADOSE; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; THROMBIN TIME; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; CATHETER; CATHETER OBSTRUCTION; COMPARATIVE STUDY; DOSE CALCULATION; HEART VALVE REPLACEMENT; HUMAN; IN VITRO STUDY; METABOLISM; POSTOPERATIVE COMPLICATIONS; THROMBOEMBOLISM; THROMBOSIS;

ANIMALS; ANTITHROMBINS; BENZIMIDAZOLES; BETA-ALANINE; CATHETER OBSTRUCTION; CATHETERS; DRUG DOSAGE CALCULATIONS; HEART VALVE PROSTHESIS IMPLANTATION; HEPARIN; HUMANS; IN VITRO TECHNIQUES; MALE; MODELS, ANIMAL; POSTOPERATIVE COMPLICATIONS; RABBITS; THROMBIN; THROMBOEMBOLISM; THROMBOSIS;

EID: 84903788509     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-12-1047     Document Type: Article

References (28)

1. Yusuf S, Mehta SR, Chrolavicius S, et al. Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. J Am Med Assoc 2006; 295: 1519-1530.
2. Yusuf S, Mehta SR, Chrolavicius S, et al. Comparison of fondaparinux and enoxaparin in acute coronary syndromes. N Engl J Med 2006; 354: 1464-1476.
3. Eikelboom JW, Connolly SJ, Brueckmann M, et al. Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med 2013; 369: 1206-1214.
4. Hylek EM. Dabigatran and mechanical heart valves--not as easy as we hoped. N Engl J Med 2013; 369: 1264-1266.
5. Yau JW, Stafford AR, Liao P, et al. Mechanism of catheter thrombosis: comparison of the antithrombotic activities of fondaparinux, enoxaparin, and heparin in vitro and in vivo. Blood 2011; 118: 6667-6674.
6. Steg PG, Jolly SS, Mehta SR, et al. Low-dose vs standard-dose unfractionated heparin for percutaneous coronary intervention in acute coronary syndromes treated with fondaparinux: the FUTURA/OASIS-8 randomized trial. J Am Med Assoc 2010; 304: 1339-1349.
7. Kretz CA, Cuddy KK, Stafford AR, et al. HD1, a thrombin-and prothrombinbinding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions. Thromb Haemost 2010; 103: 83-93.
8. Lau A, Berry LR, Mitchell LG, et al. Effect of substrate and fibrin polymerization inhibitor on determination of plasma thrombin generation in vitro. Thromb Res 2007; 119: 667-677.
9. Du YJ, Klement P, Berry LR, et al. In vivo rabbit acute model tests of polyurethane catheters coated with a novel antithrombin-heparin covalent complex. Thromb Haemost 2005; 94: 366-372.
10. Yau JW, Stafford AR, Liao P, et al. Corn trypsin inhibitor coating attenuates the prothrombotic properties of catheters in vitro and in vivo. Acta Biomater 2012; 8: 4092-4100.
11. Wienen W, Stassen JM, Priepke H, et al. Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis. J Thromb Haemost 2007; 5: 1237-1242.
12. Schiele F, van Ryn J, Canada K, et al. A specific antidote for dabigatran: functional and structural characterization. Blood 2013; 121: 3554-3562.
13. van Ryn J, Stangier J, Haertter S, et al. Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010; 103: 1116-1127.
14. Stangier J, Feuring M. Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran. Blood Coagul Fibrinolysis 2012; 23: 138-143.
15. Teien AN, Lie M. Evaluation of an amidolytic heparin assay method: increased sensitivity by adding purified antithrombin III. Thromb Res 1977; 10: 399-410.
16. Cheng SS, Nordenholz K, Matero D, et al. Standard subcutaneous dosing of unfractionated heparin for venous thromboembolism prophylaxis in surgical ICU patients leads to subtherapeutic factor Xa inhibition. Intensive Care Med 2012; 38: 642-648.
17. Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361: 1139-1151.
18. Schulman S, Kearon C, Kakkar AK, et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009; 361: 2342-2352.
19. Schulman S, Kakkar AK, Goldhaber SZ, et al. Treatment of Acute Venous Thromboembolism with Dabigatran or Warfarin and Pooled Analysis. Circulation 2013; 129: 764-772.
20. Hankey GJ, Eikelboom JW. Dabigatran etexilate: a new oral thrombin inhibitor. Circulation 2011; 123: 1436-1450.
21. Mega JL, Braunwald E, Wiviott SD, et al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med 2012; 366: 9-19.
22. Lee AY, Kamphuisen PW. Epidemiology and prevention of catheter-related thrombosis in patients with cancer. J Thromb Haemost 2012; 10: 1491-1499.
23. Vranckx P, Verheugt FW, de Maat MP, et al. A randomised study of dabigatran in elective percutaneous coronary intervention in stable coronary artery disease patients. EuroIntervention 2013; 8: 1052-1060.
24. Matafonov A, Leung PY, Gailani AE, et al. Factor XII inhibition reduces thrombus formation in a primate thrombosis model. Blood 2014; Epub ahead of print.
25. de Maat S, van Dooremalen S, de Groot PG, et al. A nanobody-based method for tracking factor XII activation in plasma. Thromb Haemost 2013; 110: 458-468.
26. Woodruff RS, Xu Y, Layzer J, et al. Inhibiting the intrinsic pathway of coagulation with a factor XII-targeting RNA aptamer. J Thromb Haemost 2013; 11: 1364-1373.
27. Revenko AS, Gao D, Crosby JR, et al. Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding. Blood 2011; 118: 5302-5311.
28. Yau JW, Liao P, Fredenburgh JC, et al. Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits. Blood 2014; Epub ahead of print.