Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection

Journal of Experimental Medicine

Volumn 211, Issue 7, 2014, Pages 1289-1296

  Min Oo, Gundula ^a   Bezman, Natalie A ^a   Madera, Sharline ^c   Sun, Joseph C ^c   Lanier, Lewis L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CD11B ANTIGEN; CD27 ANTIGEN; CELL THERAPY AGENT; INTERLEUKIN 12; INTERLEUKIN 15; STAT4 PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL EXPANSION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS INFECTION; DEGRANULATION; MEMORY T LYMPHOCYTE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INDUCTION; T LYMPHOCYTE SUBPOPULATION; WILD TYPE;

ANIMALS; ANTIGENS, DIFFERENTIATION; ANTIGENS, VIRAL; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; HERPESVIRIDAE INFECTIONS; IMMUNOLOGIC MEMORY; KILLER CELLS, NATURAL; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUROMEGALOVIRUS; PROTO-ONCOGENE PROTEINS;

EID: 84903780487     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20132459     Document Type: Article

References (28)

1. Bezman, N.A., C.C. Kim, J.C. Sun, G. Min-Oo, D.W. Hendricks, Y. Kamimura, J.A. Best, A.W. Goldrath, and L.L. Lanier; Immunological Genome Project Consortium. 2012. Molecular definition of the identity and activation of natural killer cells. Nat. Immunol. 13:1000-1009. http://dx.doi.org/10.1038/ni.2395
2. Bouillet, P., and L.A. O'Reilly. 2009. CD95, BIM and T cell homeostasis. Nat. Rev. Immunol. 9:514-519. http://dx.doi.org/10.1038/nri2570
3. Bouillet, P., D. Metcalf, D.C. Huang, D.M. Tarlinton, T.W. Kay, F. Köntgen, J.M. Adams, and A. Strasser. 1999. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 286:1735-1738. http://dx.doi.org/10.1126/science.286.5445.1735
4. Brown, M.G., A.O. Dokun, J.W. Heusel, H.R. Smith, D.L. Beckman, E.A. Blattenberger, C.E. Dubbelde, L.R. Stone, A.A. Scalzo, and W.M. Yokoyama. 2001. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science. 292:934-937. http://dx.doi.org/10.1126/science.1060042
5. Chiossone, L., J. Chaix, N. Fuseri, C. Roth, E. Vivier, and T. Walzer. 2009. Maturation of mouse NK cells is a 4-stage developmental program. Blood. 113:5488-5496. http://dx.doi.org/10.1182/blood-2008-10-187179
6. Cooper, M.A., J.E. Bush, T.A. Fehniger, J.B. VanDeusen, R.E. Waite, Y. Liu, H.L. Aguila, and M.A. Caligiuri. 2002. In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells. Blood. 100:3633-3638. http://dx.doi.org/10.1182/blood-2001-12-0293
7. Cooper, M.A., J.M. Elliott, P.A. Keyel, L. Yang, J.A. Carrero, and W.M. Yokoyama. 2009. Cytokine-induced memory-like natural killer cells. Proc. Natl. Acad. Sci. USA. 106:1915-1919. http://dx.doi.org/10.1073/pnas.0813192106
8. Gumá, M., A. Angulo, C. Vilches, N. Gómez-Lozano, N. Malats, and M. López-Botet. 2004. Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood. 104:3664-3671. http://dx.doi.org/10.1182/blood-2004-05-2058
9. Hildeman, D.A., Y. Zhu, T.C. Mitchell, P. Bouillet, A. Strasser, J. Kappler, and P. Marrack. 2002. Activated T cell death in vivo mediated by proapoptotic Bcl-2 family member Bim. Immunity. 16:759-767. http://dx.doi.org/10.1016/S1074-7613(02)00322-9
10. Huntington, N.D., H. Puthalakath, P. Gunn, E. Naik, E.M. Michalak, M.J. Smyth, H. Tabarias, M.A. Degli-Esposti, G. Dewson, S.N. Willis, et al. 2007. Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat. Immunol. 8:856-863. http://dx.doi.org/10.1038/ni1487
11. Jay, D.C., D.M. Mitchell, and M.A. Williams. 2013. Bim mediates the elimination of functionally unfit Th1 responders from the memory pool. PLoS ONE. 8:e67363. http://dx.doi.org/10.1371/journal.pone.0067363
12. Koenen, P., S. Heinzel, E.M. Carrington, L. Happo, W.S. Alexander, J.-G. Zhang, M.J. Herold, C.L. Scott, A.M. Lew, A. Strasser, and P.D. Hodgkin. 2013. Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals. Nat Commun. 4:1735. http://dx.doi.org/10.1038/ncomms2719
13. Kurtulus, S., P. Tripathi, J.T. Opferman, and D.A. Hildeman. 2010. Contracting the 'mus cells'-does down-sizing suit us for diving into the memory pool? Immunol. Rev. 236:54-67. http://dx.doi.org/10.1111/j.1600-065X.2010.00920.x
14. Lee, S.H., S. Girard, D. Macina, M. Busà, A. Zafer, A. Belouchi, P. Gros, and S.M. Vidal. 2001. Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat. Genet. 28:42-45. http://dx.doi.org/10.1038/ng0501-42
15. Li, Q., C. Eppolito, K. Odunsi, and P.A. Shrikant. 2006. IL-12-programmed long-term CD8+ T cell responses require STAT4. J. Immunol. 177:7618-7625. http://dx.doi.org/10.4049/jimmunol.177.11.7618
16. Lopez-Vergès, S., J.M. Milush, B.S. Schwartz, M.J. Pando, J. Jarjoura, V.A. York, J.P. Houchins, S. Miller, S.-M. Kang, P.J. Norris, et al. 2011. Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection. Proc. Natl. Acad. Sci. USA. 108:14725-14732. http://dx.doi.org/10.1073/pnas.1110900108
17. Min-Oo, G., Y. Kamimura, D.W. Hendricks, T. Nabekura, and L.L. Lanier. 2013. Natural killer cells: walking three paths down memory lane. Trends Immunol. 34:251-258. http://dx.doi.org/10.1016/j.it.2013.02.005
18. O'Connor, L., A. Strasser, L.A. O'Reilly, G. Hausmann, J.M. Adams, S. Cory, and D.C. Huang. 1998. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 17:384-395. http://dx.doi.org/10.1093/emboj/17.2.384
19. Paust, S., and U.H. von Andrian. 2011. Natural killer cell memory. Nat. Immunol. 12:500-508. http://dx.doi.org/10.1038/ni.2032
20. Paust, S., H.S. Gill, B.-Z. Wang, M.P. Flynn, E.A. Moseman, B. Senman, M. Szczepanik, A. Telenti, P.W. Askenase, R.W. Compans, and U.H. von Andrian. 2010. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat. Immunol. 11:1127-1135. http://dx.doi.org/10.1038/ni.1953
21. Prlic, M., and M.J. Bevan. 2008. Exploring regulatory mechanisms of CD8+ T cell contraction. Proc. Natl. Acad. Sci. USA. 105:16689-16694. http://dx.doi.org/10.1073/pnas.0808997105
22. Prlic, M., B.R. Blazar, M.A. Farrar, and S.C. Jameson. 2003. In vivo survival and homeostatic proliferation of natural killer cells. J. Exp. Med. 197:967-976. http://dx.doi.org/10.1084/jem.20021847
23. Strasser, A. 2005. The role of BH3-only proteins in the immune system. Nat. Rev. Immunol. 5:189-200. http://dx.doi.org/10.1038/nri1568
24. Strasser, A., A.W. Harris, D.C. Huang, P.H. Krammer, and S. Cory. 1995. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14:6136-6147.
25. Sun, J.C., and L.L. Lanier. 2011. NK cell development, homeostasis and function: parallels with CD8+ T cells. Nat. Rev. Immunol. 11:645-657. http://dx.doi.org/10.1038/nri3044
26. Sun, J.C., J.N. Beilke, and L.L. Lanier. 2009. Adaptive immune features of natural killer cells. Nature. 457:557-561. http://dx.doi.org/10.1038/nature07665
27. Sun, J.C., J.N. Beilke, N.A. Bezman, and L.L. Lanier. 2011. Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection. J. Exp. Med. 208:357-368. http://dx.doi.org/10.1084/jem.20100479
28. Sun, J.C., S. Madera, N.A. Bezman, J.N. Beilke, M.H. Kaplan, and L.L. Lanier. 2012. Proinflammatory cytokine signaling required for the generation of natural killer cell memory. J. Exp. Med. 209:947-954. http://dx.doi.org/10.1084/jem.20111760