Impact of stromal cell components of tumor microenvironment on epithelial-mesenchymal transition in breast cancer cells

Experimental Oncology

Volumn 36, Issue 2, 2014, Pages 72-78

  Bezdenezhnykh, N ^a   Semesiuk, N ^a   Lykhova, O ^a   Zhylchuk, V ^b,c   Kudryavets, Y ^a  

^a R E KAVETSKY INSTITUTE OF EXPERIMENTAL PATHOLOGY   (Ukraine)

^b Rivne Region Oncology Hospital   (Ukraine)

^c DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY   (Ukraine)

Author keywords

Bone marrow; Breast cancer; Co cultivation; Epithelial mesenchymal transition; Microenvironment

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; KI 67 ANTIGEN; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR SLUG; UVOMORULIN; VIMENTIN; BIOLOGICAL MARKER;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW BIOPSY; BREAST CANCER; BREAST CANCER CELL LINE; CANCER CELL; CANCER GROWTH; CANCER REGRESSION; CELL COMPONENT; CELL GROWTH; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MCF 7 CELL LINE; NONHUMAN; PHENOTYPIC VARIATION; RAT; STROMA CELL; TUMOR MICROENVIRONMENT; ANIMAL; BREAST TUMOR; CELL COMMUNICATION; CELL SURVIVAL; FEMALE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; BIOLOGICAL MARKERS; BREAST NEOPLASMS; CELL COMMUNICATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COCULTURE TECHNIQUES; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; MCF-7 CELLS; RATS; STROMAL CELLS; TUMOR MICROENVIRONMENT;

EID: 84903773679     PISSN: 18129269     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Castaco Z, Tracy K, McAllister SS. The tumor macroenvironment and systemic regulation of breast cancer progression. Int J Dev Biol 2011; 55: 889-97.
2. Schiavoni G, Gabriele L, Mattei F. The tumor microenvironment: a pitch for multiple players Front Oncol 2013; 3: 90.
3. Witz IP. The tumor microenvironment: the making of a paradigm cancer microenvironment. Cancer Microenviron 2009; 2: 9-17.
4. Tran-Thanh D, Done SJ. The role of stromal factors in breast tumorigenicity. Am J Pathol 2010; 176: 1072-74.
5. Castells M, Thibault B, Delord J-P, et al. Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death. Int J Mol Sci 2012; 13: 9545-71.
6. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-28.
7. Ben-Baruch A. Host microenvironment in breast cancer development: inflammatory cells, cytokines and chemokines in breast cancer progression: reciprocal tumor-microenvironment interactions. Breast Cancer Res 2003; 5: 31-6. (Pubitemid 36553576)
8. Semesiuk N, Zhylchuk A, Bezdenezhnykh N, et al. Disseminated tumor cells and enhanced level of some cytokines in bone marrow and peripheral blood of breast cancer patients as predictive factors of tumor progression. Exp Oncol 2013; 35: 295-302.
9. Strell C, Rundovist H, Ostman A. Fibroblasts - a key host cell type in tumor initiation, progression and metastasis. Upsala J Med Sci 2012; 117: 187-195.
10. Li AP, Bode C, Sakai Y. A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells. Chem-Biol Interact 2004; 150: 129-36. (Pubitemid 39441299)
11. Trahtenberg MI, Kudryavets Yu, Marchenko ML, et al. Improved model of multiorgan system toxicity of xenobio tics from co-cultivation human cells in vitro. Such Probl Toksykol 2011; 1-2: 60-4 (in Ukrainian).
12. Semesiuk NI, Zhylchuk AV, Bezdenezhnykh NO, et al. Tumor necrosis factor in peripheral blood and bone marrow of breast cancer patients as a marker of the tumor progression. Onkologiya 2012; 4: 293-7 (in Ukrainian).
13. Semesiuk NI, Zhylchuk AV, Bezdenezhnykh NO, et al. Colony stimulating activity in peripheral blood and bone marrow breast cancer patients and its prognostic value. Zbirnyk. Hematol Perelyv Krovi 2012; 36: 232-7 (in Ukrainian).
14. Kudryavets YuI, Bezdenezhnykh NO, Trehubova ON, et al. The new model of experimental oncology: cell line MRS from spontaneous rat breast cancer tends to modulate the transformed phenotype. XI congress of oncologists Ukraine. Sudak, 2006, 29 p.
15. Kudryavets YuI, Bezdenezhnykh NO, Kovaleva OA, et al. Cell line MRS from breast adenocarcinoma rat as a model to study mechanisms of epithelial- mesenchymal transition of tumor cells. Klin Onkol 2011; 2: 218 (in Ukrainian).
16. Vega-Avila E, Pugsley KM. An overview of colorimetric assay methods used to assess survival or proliferation of mammalian cells. Proc West Pharmacol Soc 2011; 54: 10-4.
17. Bezdenezhnykh NO, Semesiuk NI, Lykhova OO, et al. Modification of epithelial-mesenchymal transition in breast cancer cells by means of their co-cultivation with fibroblasts and bone marrow cells. Onkologiya 2013; 15: 191-6 (in Ukrainian).
18. - phenotype with poor prognosis in early-stage breast cancer. Neoplasia 2009; 11: 987-1002.
19. Khodarev NN, Yu J, Labay E, et al. Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells. J Cell Sci 2002; 116: 1013-22. (Pubitemid 36395612)
20. Krishnamurthy S, Cristofanilli M, Singh B, et al. Detection of minimal residual disease in blood and bone marrow in early stage breast cancer. Cancer 2010; 116: 3330-7.
21. Bischoff J, Rosenberg R, Dahm M, et al. Minimal residual disease in bone marrow and peripheral blood of patients with metastatic breast cancer. Recent Res Cancer Res 2003; 162: 135-40.
22. Diel IJ, Cote RJ. Bone marrow and lymph node assessment for minimal residual disease in patients with breast cancer. Cancer Treat Rev 2000; 26: 53-65. (Pubitemid 30102800)
23. Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 2009; 9: 400-14.
24. Onder TT, Gupta PB, Mani SA, et al. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 2008; 68:3645-54.
25. Gilles C, Polette M, Zahm J-M, et al. Vimentin contributes to human mammary epithelial cell migration. J Cell Sci 1999; 112: 4615-25. (Pubitemid 30034810)
26. Mendez MG, Kojima S-I, Goldman RD. Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J 2010; 24: 1838-51.
27. de Neergaard M, Kim J, Villadsen R, et al. Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment. Am J Pathol 2010; 176: 1229-40.
28. Nielsen HL, Ronnov-Jessen L, Villadsen R, et al. Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer. Genom 2002; 79: 703-10. (Pubitemid 34499486)
29. - phenotype is enriched in basal-like breast tumours. Breast Cancer Res 2008; 10: R53.