Engineering D-helix of antithrombin in alpha-1-proteinase inhibitor confers antiinflammatory properties on the chimeric serpin

Thrombosis and Haemostasis

Volumn 112, Issue 1, 2014, Pages 164-175

  Yang, Likui ^a   Dinarvand, Peyman ^a   Qureshi, Shabir H ^a   Rezaie, Alireza R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antithrombin; Coagulation inhibitors; Endothelial cells; Inflammation; SERPINs

Indexed keywords

ALPHA 1 ANTITRYPSIN; ANTITHROMBIN; CASPASE 8; HEPARIN; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; SERINE PROTEINASE INHIBITOR; THROMBIN; HEPARIN PROTEOGLYCAN; PROTEOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL MEMBRANE PERMEABILITY; CELL PROTECTION; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOLOGY; HUMAN; HUMAN CELL; LEUKOCYTE MIGRATION; MALE; MORTALITY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPECTROPHOTOMETRY; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL MODEL; BLOOD CLOTTING; CELL CULTURE; CELL MOTION; ENDOTHELIUM CELL; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN ENGINEERING; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION;

ALPHA 1-ANTITRYPSIN; ANIMALS; ANTITHROMBINS; BLOOD COAGULATION; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIAL CELLS; HEPARIN; HUMANS; INFLAMMATION; MICE; MODELS, ANIMAL; MUTATION; NF-KAPPA B; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEOGLYCANS; SIGNAL TRANSDUCTION;

EID: 84903758950     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-12-1029     Document Type: Article

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