Early propranolol administration to severely injured patients can improve bone marrow dysfunction

Journal of Trauma and Acute Care Surgery

Volumn 77, Issue 1, 2014, Pages 54-60

  Bible, Letitia E ^a   Pasupuleti, Latha V ^a   Alzate, Walter D ^a   Gore, Amy V ^a   Song, Kim J ^a   Sifri, Ziad C ^a   Livingston, David H ^a   Mohr, Alicia M ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

anemia; Bone marrow; G CSF; hemoglobin; blockade

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; HEMOGLOBIN; PROPRANOLOL;

ADULT; ANEMIA; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BLAST FORMING UNIT ERYTHROID CELL; BLOOD SAMPLING; BONE MARROW DEPRESSION; CLINICAL ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; DEMOGRAPHY; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG SAFETY; EMERGENCY HEALTH SERVICE; ERYTHROID CELL; FEMALE; HEART RATE; HEMATOPOIETIC STEM CELL; HEMOGLOBIN BLOOD LEVEL; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; INJURY SCALE; INJURY SEVERITY; INTENSIVE CARE; LENGTH OF STAY; MALE; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESUSCITATION; RETICULOCYTE COUNT; STEM CELL MOBILIZATION; TACHYCARDIA; TREATMENT OUTCOME; VITAL SIGN;

ADULT; BONE MARROW; FEMALE; HEART RATE; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; INJURY SEVERITY SCORE; MALE; PROPRANOLOL; PROSPECTIVE STUDIES; WOUNDS AND INJURIES;

EID: 84903756394     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000264     Document Type: Article

References (30)

1. Malone DL, Dunne J, Tracy JK, Putnam AT, Scalea TM, Napolitano LM. Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma. 2003;54:898-905.
2. Fonseca RB, Mohr AM, Wang L, Clinton E, Sifri ZC, Rameshwar P, Livingston DH. Adrenergic modulation of erythropoiesis following severe injury is mediated through bone marrow stroma. Surg Infect. 2004;5: 385-393. (Pubitemid 40458364)
3. Cook KM, Sifri ZC, Baranski GM, Mohr AM, Livingston DH. The role of plasma granulocyte colony stimulating factor and bone marrow dysfunction after severe trauma. J Am Coll Surg. 2013;216:57-64.
4. Katayama Y, Battista M, Kao W, Hidalgo A, Peired AJ, Thomas SA, Frenette PS. Signals from the sympathetic nervous system regulate he-matopoietic stem cell egress from bone marrow. Cell. 2006;124:407-421. (Pubitemid 43121987)
5. Livingston DH, Anjaria D, Wu J, Hauser CJ, Chang V, Deitch EA, Rameshwar P. Bone marrow failure following severe injury in humans. Ann Surg. 2003;238:748-753. (Pubitemid 38182268)
6. Mohr AM, Elhassan IO, Hannoush EJ, Sifri ZC, Offin MD, Alzate WD, Rameshwar P, Livingston DH. Does beta blockade post injury prevent bone marrow suppression? J Trauma. 2011;70:1043-1050.
7. Bateman AP, McArdle F, Walsh TS.Time courseofanemia duringsix months follow up following intensive care discharge and factors associated with impaired recovery of erythropoiesis. Crit Care Med. 2009;37:1906-1912.
8. Woolf PD, McDonald JV, Feliciano DV, Kelly MM, Nichols D, Cox C. The catecholamine response to multisystem trauma. Arch Surg. 1992;127: 899-903.
9. Goodall MC, Stone C, Haynes BW Jr. Urinary output of adrenaline and noradrenaline in severe thermal burns. Ann Surg. 1957;145:479-487.
10. Wilmore DW, Aulick LH. Metabolic changes in burned patients. Surg Clin North Am. 1978;58:1173-1187. (Pubitemid 9106731)
11. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. High circulating adrenaline levels at admission predict increased mortality after trauma. J Trauma Acute Care Surg. 2012;72:428-436.
12. Fonseca RB, Mohr AM, Wang L, Sifri ZC, Rameshwar P, Livingston DH. The impact of a hypercatecholamine state on erythropoiesis following severe injury and the role of IL-6. J Trauma. 2005;59:884-889.
13. Penn A, Mohr AM, Shah SG, Sifri ZC, Kaiser VL, Rameshwar P, Livingston DH. Dose-response relationship between norepinephrine and erythropoiesis: evidence for a critical threshold. J Surg Res. 2010;163: e85-e90.
14. Baranski GM, Offin MD, Sifri ZC, Elhassan IO, Hannoush EJ, Alzate WD, Rameshwar P, Livingston DH, Mohr AM. A-blockade protection of bone marrow following trauma: the role of G-CSF. J Surg Res. 2011;170: 325-331.
15. Elhassan IO, Hannoush EJ, Sifri ZC, Jones E, Alzate WD, Rameshwar P, Livingston DH, Mohr AM. Beta-blockade prevents hematopoietic progenitor cell suppression after hemorrhagic shock. Surg Infect. 2011;12: 273-278.
16. Friese RS, Barber R, McBride D, Bender J, Gentilello LM. Could beta blockade improve outcomes after injury by modulating inflammatory profiles? J Trauma. 2008;64:1061-1068. (Pubitemid 351521900)
17. Arbabi S, Campion EM, Hemmila MR, Barker M, Dimo M, Ahrns KS, Niederbichler AD, Ipaktchi K, Wahl WL. Beta-blocker useisassociated with improved outcomes in adult trauma patients. J Trauma. 2007;62:56-62.
18. Song H, Vita M, Sallam H, Tehranchi R, Nilsson C, Sidén A, Hassan Z. Effect of Cdk-inhibitor roscovitine on mouse hematopoietic progenitors in vivo and in vitro. Cancer Chemother Pharmacol. 2007;60:841-849. (Pubitemid 47389390)
19. Bryan RM Jr. Cerebral blood flow and energy metabolism during stress. Am J Physiol. 1990;259:J269-J280.
20. Herndon DN, Barrow RE, Rutan TC, Minifee P, Jahoor F, Wolfe RR. Effect of propranolol administration on hemodynamic and metabolic responses of burned pediatric patients. Ann Surg. 1988;208:484-492. (Pubitemid 18266464)
21. Kaufamn TM, Horton JW. Characterization of cardiac beta-adrenergic receptors in the guinea pig heart: application to study of beta-adrenergic receptors in shock models. J Surg Res. 1993;55:516-523. (Pubitemid 23355521)
22. Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR. Reversal of catabolism by beta-blockade after severe burns. N Engl J Med. 2001; 345:1223-1229. (Pubitemid 34951485)
23. Arbabi S, Ahrns KS, Wahl WL, Hemmila MR, Wang SC, Brandt MM, Taheri PA. Beta-blocker use is associated with improved survival in adult burn patients. J Trauma. 2004;56:265-269.
24. Beiermeister KA, Keck BM, Sifri ZC, ElHassan IO, Hannoush EJ, Alzate WD, Rameshwar P, Livingston DH, Mohr AM. Hematopoietic progenitor cell mobilization is mediated through beta-2 and beta-3 receptors after injury. J Trauma. 2010;69:338-343.
25. Baranski GM, Pasupuleti LV, Sifri ZC, Cook KM, Alzate WD, Rameshwar P, Livingston DH, Mohr AM. Beta blockade protection of bone marrow following injury: a critical link between heart rate and immunomodulation. J Bone Marrow Res. 2013;1:124.
26. Finnerty CC, Herndon DN, Chinkes DL, Jeschke MG. Serum cytokine differences is severely burned children with and without sepsis. Shock. 2007;27:4-9. (Pubitemid 44968003)
27. Shander A, Gandhi NR, Goodnough LT. Anemia, erythropoietin, and the trauma patient. ITACCS. 2008;18:29-34.
28. Vincent JL, Baron JF, Reinhart K, Gattinoni L, Thijs L, Webb A, MeierHellmann A, Nollet G, Peres-Bota D. Anemia and blood transfusion in critically ill patients. JAMA. 2002;288:1499-1507.
29. Marque S, Cariou A, Chiche JD, Mallet VO, Pene F, Mira JP, Dhainaut JF, Claessens YE. Risk factors for post-ICU red blood cell transfusion: a prospective study. Crit Care. 2006;10:R129.
30. Otterman ML, Nijboer JM, van der Horst IC, van Meurs M, ten Duis HJ, Nijsten MW. Reticulocyte counts and their relation to hemoglobin levels in trauma patients. J Trauma. 2009;67:121-124.