The impact of a structured pharmacist intervention on the appropriateness of prescribing in older hospitalized patients

Drugs and Aging

Volumn 31, Issue 6, 2014, Pages 471-481

  O'Sullivan, David ^a   O'Mahony, Denis ^b   O'Connor, Marie N ^b   Gallagher, Paul ^b   Cullinan, Shane ^a   O'Sullivan, Richard ^a   Gallagher, James ^a   Eustace, Joseph ^b   Byrne, Stephen ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b University College Cork and INFANT Centre   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ABBREVIATED MENTAL TEST SCORE; AGED; AGED HOSPITAL PATIENT; ARTICLE; BARTHEL INDEX; CLINICAL PROTOCOL; COMPUTERIZED DECISION SUPPORT SYSTEM; CONTROLLED STUDY; CUMULATIVE ILLNESS RATING SCORE; DRUG RELATED PROBLEMS; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HUMAN; INAPPROPRIATE PRESCRIBING; LENGTH OF STAY; MAJOR CLINICAL STUDY; MEDICAL DECISION MAKING; MEDICATION THERAPY MANAGEMENT; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; PHARMACEUTICAL CARE; PHARMACIST; PRIORITY JOURNAL; PROSPECTIVE STUDY; STRUCTURED PHARMACIST REVIEW OF MEDICATION; AGE; DECISION SUPPORT SYSTEM; DRUG SURVEILLANCE PROGRAM; DRUG USE; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; ELECTRONIC PRESCRIBING; HOSPITAL PHARMACY; IRELAND; MALE; PREVALENCE; PROCEDURES; PROFESSIONAL STANDARD; STANDARDS; STATISTICS AND NUMERICAL DATA; TEACHING HOSPITAL; VERY ELDERLY;

ADVERSE DRUG REACTION REPORTING SYSTEMS; AGE FACTORS; AGED; AGED, 80 AND OVER; DECISION SUPPORT SYSTEMS, CLINICAL; DRUG UTILIZATION REVIEW; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; ELECTRONIC PRESCRIBING; FEMALE; HOSPITALS, TEACHING; HUMANS; INAPPROPRIATE PRESCRIBING; IRELAND; MALE; PHARMACISTS; PHARMACY SERVICE, HOSPITAL; PREVALENCE; PROFESSIONAL ROLE; PROSPECTIVE STUDIES;

EID: 84903754854     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.1007/s40266-014-0172-6     Document Type: Article

References (55)

1. Central Statistic Office. Population and Labour Force Projections 2016-2046. Dublin: Government of Ireland; 2013. p. 2013.
2. Richardson K, Moore P, Peklar J, Galvin R, Bennett K, Kenny RA. Polypharmacy in adults over 50 in Ireland: Opportunities for cost saving and improved healthcare. Dublin: Trinity College Dublin; 2012.
3. Spinewine A, Swine C, Dhillon S, et al. Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trial. J Am Geriatr Soc. 2007;55(5):658-65. (Pubitemid 46668957)
4. Spinewine A, Dhillon S, Mallet L, et al. Implementation of ward-based clinical pharmacy services in Belgium - description of the impact on a geriatric unit. Ann Pharmacother. 2006;40(4):720-8.
5. Quelennec B, Beretz L, Paya D, et al. Potential clinical impact of medication discrepancies at hospital admission. Eur J Intern Med. 2013.
6. Galvin M, Jago-Byrne MC, Fitzsimons M, et al. Clinical pharmacist's contribution to medication reconciliation on admission to hospital in Ireland. Int J Clin Pharm. 2013;35(1):14-21.
7. Cornish PL, Knowles SR, Marchesano R, et al. Unintended medication discrepancies at the time of hospital admission. Arch Intern Med. 2005;165(4):424-9. (Pubitemid 40280198)
8. Grimes TC, Duggan CA, Delaney TP, et al. Medication details documented on hospital discharge: cross-sectional observational study of factors associated with medication non-reconciliation. Br J Clin Pharmacol. 2011;71(3):449-57.
9. Mueller SK, Sponsler KC, Kripalani S, et al. Hospital-based medication reconciliation practices: a systematic review. Arch Intern Med. 2012;172(14):1057-69.
10. Bergkvist A, Midlov P, Hoglund P, et al. A multi-intervention approach on drug therapy can lead to a more appropriate drug use in the elderly. LIMM-Landskrona Integrated Medicines Management. J Eval Clin Pract. 2009;15(4):660-7.
11. O'Connor MN, Gallagher P, O'Mahony D. Inappropriate prescribing: criteria, detection and prevention. Drugs Aging. 2012;29(6):437-52.
12. Gallagher PF, O'Connor MN, O'Mahony D. Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria. Clin Pharmacol Ther. 2011;89(6):845-54.
13. Routledge PA, O'Mahony MS, Woodhouse KW. Adverse drug reactions in elderly patients. Br J Clin Pharmacol. 2004;57(2):121-6. (Pubitemid 38223523)
14. Resar R, Midelfort L. Medication reconciliation review. Boston: Institute for Healthcare Improvement; 2004.
15. World Health Organisation (WHO). Assuring Medication Accuracy at Transitions in Care. Geneva: World Health Organisation (WHO), 2007.
16. Caglar S, Henneman PL, Blank FS, Smithline HA, Henneman EA. Emergency department medication lists are not accurate. J Emerg Med. 2011;40:613-6.
17. Hanlon JT, Schmader KE, Samsa GP, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol. 1992;45(10):1045-51.
18. Wenger NS, Shekelle PG. Assessing care of vulnerable elders: ACOVE project overview. Ann Intern Med. 2001;135(8 Pt 2):642-6. (Pubitemid 33015477)
19. Fick DM, Cooper JW, Wade WE, et al. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med. 2003 Dec 8-22;163(22):2716-24. (Pubitemid 37517412)
20. Gallagher P, Ryan C, Byrne S, et al. STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72-83. (Pubitemid 351233792)
21. Holt S, Schmiedl S, Thurmann PA. Potentially inappropriate medications in the elderly: the PRISCUS list. Deutsches Arzteblatt Int. 2010;107(31-32):543- 51.
22. Spinewine A, Fialova D, Byrne S. The role of the pharmacist in optimizing pharmacotherapy in older people. Drugs Aging. 2012;29(6):495-510.
23. Cherubini A, Ruggiero C, Gasperini B, et al. The prevention of adverse drug reactions in older subjects. Current Drug Metabol. 2011;12(7):652-7.
24. Kaur S, Mitchell G, Vitetta L, et al. Interventions that can reduce inappropriate prescribing in the elderly: a systematic review. Drugs Aging. 2009;26(12):1013-28.
25. Campbell F, Karnon J, Czoski-Murray C, Jones R. A systematic review of the effectiveness and costeffectiveness of interventions aimed at preventing medication error (medicines reconciliation) at hospital admission. Shellfield: The University of Sheffield, School of Health and Related Research (ScHARR); 2007.
26. Gillespie U, Alassaad A, Henrohn D, et al. A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial. Arch Intern Med. 2009;169(9):894-900.
27. Spinewine A, Schmader KE, Barber N, et al. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet. 2007;370(9582):173-84. (Pubitemid 47049724)
28. Drenth-van Maanen AC, Spee J, van Hensbergen L, et al. Structured history taking of medication use reveals iatrogenic harm due to discrepancies in medication histories in hospital and pharmacy records. J Am Geriatr Soc. 2011;59(10):1976-7.
29. Martin J. British National Formulary. London; 2011.
30. Cunningham G, Dodd TR, Grant DJ, et al. Drug-related problems in elderly patients admitted to Tayside hospitals, methods for prevention and subsequent reassessment. Age Ageing. 1997;26(5):375-82. (Pubitemid 27448382)
31. Hanlon JT, Weinberger M, Samsa GP, et al. A randomized, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy. Am J Med. 1996;100(4):428-37. (Pubitemid 26115198)
32. Schmader KE, Hanlon JT, Pieper CF, et al. Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. Am J Med. 2004;116(6):394-401. (Pubitemid 38299484)
33. Hume AL, Quilliam BJ, Goldman R, et al. Alternatives to potentially inappropriate medications for use in e-prescribing software: triggers and treatment algorithms. BMJ Qual Saf. 2011;20(10):875-84.
34. Raebel MA, Charles J, Dugan J, et al. Randomized trial to improve prescribing safety in ambulatory elderly patients. J Am Geriatr Soc. 2007;55(7):977-85. (Pubitemid 47024602)
35. Tamblyn R, Huang A, Perreault R, et al. The medical office of the 21st century (MOXXI): effectiveness of computerized decision-making support in reducing inappropriate prescribing in primary care. CMAJ Canadian Med Assoc J J l'Assoc Med Canadienne. 2003;169(6):549-56. (Pubitemid 37174595)
36. Kuijpers MA, van Marum RJ, Egberts AC, et al. Relationship between polypharmacy and underprescribing. Br J Clin Pharmacol. 2008;65(1):130-3. (Pubitemid 350265160)
37. van den Heuvel PM, Los M, van Marum RJ, et al. Polypharmacy and underprescribing in older adults: rational underprescribing by general practitioners. J Am Geriatr Soc. 2011;59(9):1750-2.
38. Higashi T, Shekelle PG, Solomon DH, et al. The quality of pharmacologic care for vulnerable older patients. Ann Intern Med. 2004;140(9):714-20.
39. Dunn RL, Harrison D, Ripley TL. The Beers criteria as an outpatient screening tool for potentially inappropriate medications. Consult Pharm J Am Soc Consult Pharm. 2011;26(10):754-63.
40. Gallagher P, O'Mahony D. STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions): application to acutely ill elderly patients and comparison with Beers' criteria. Age Ageing. 2008;37(6):673-9.
41. Hellstrom LM, Bondesson A, Hoglund P, et al. Errors in medication history at hospital admission: prevalence and predicting factors. BMC Clin Pharmacol. 2012;12:9.
42. Lessard S, DeYoung J, Vazzana N. Medication discrepancies affecting senior patients at hospital admission. Am J Health System Pharm AJHP Off J Am Soc Health System Pharm. 2006;63(8):740-3.
43. Schnipper JL, Hamann C, Ndumele CD, et al. Effect of an electronic medication reconciliation application and process redesign on potential adverse drug events: a cluster-randomized trial. Arch Intern Med. 2009;169(8):771-80.
44. O'Sullivan DP, O'Mahony D, Parsons C, et al. A prevalence study of potentially inappropriate prescribing in Irish long-term care residents. Drugs Aging. 2013;30(1):39-49.
45. Dalleur O, Spinewine A, Henrard S, et al. Inappropriate prescribing and related hospital admissions in frail older persons according to the STOPP and START criteria. Drugs Aging. 2012;29(10):829-37.
46. Gallagher P, Lang PO, Cherubini A, et al. Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals. Eur J Clin Pharmacol. 2011;67(11):1175-88.
47. Conejos Miquel MD, Sánchez Cuervo M, Delgado Silveira E, et al. Potentially inappropriate drug prescription in older subjects across health care settings. Eur Geriatr Med. 2010;1(1):9-14.
48. Hamilton H, Gallagher P, Ryan C, et al. Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. Arch Intern Med. 2011;171(11):1013-9.
49. Villanyi D, Fok M, Wong RY. Medication reconciliation: identifying medication discrepancies in acutely ill hospitalized older adults. Am J Geriatr Pharmacother. 2011;9(5):339-44.
50. Cornu P, Steurbaut S, Leysen T, et al. Effect of medication reconciliation at hospital admission on medication discrepancies during hospitalization and at discharge for geriatric patients. Ann Pharmacother. 2012;46(4):484-94.
51. Milos V, Rekman E, Bondesson A, et al. Improving the quality of pharmacotherapy in elderly primary care patients through medication reviews: a randomised controlled study. Drugs Aging. 2013;30(4):235-46.
52. Miller D, Garcia D, Kreys T, Phan S, Vandenberg A, Garrison K. Evaluating the quality of performance of medication reconciliation on hospital admission. Hospital Pharm. 2012;47(7):526-31.
53. Gillespie U, Alassaad A, Henrohn D, et al. A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial. Arch Intern Med. 2009;169(9):894-900.
54. Fialova D, Onder G. Medication errors in elderly people: contributing factors and future perspectives. Br J Clin Pharmacol. 2009;67(6):641-5.
55. Bond CA, Raehl CL, Patry R. Evidence-based core clinical pharmacy services in United States hospitals in 2020: services and staffing. Pharmacotherapy. 2004;24(4):427-40. (Pubitemid 38420529)