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Volumn 351, Issue 1, 2014, Pages 6-12

Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of central nerve system metastases from non-small cell lung cancer

Author keywords

Brain metastasis; EGFR TKI; NSCLC

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB;

EID: 84903723265     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.04.019     Document Type: Review
Times cited : (58)

References (65)
  • 1
    • 33847241812 scopus 로고    scopus 로고
    • Clinical predictors of metastatic disease to the brain from non-small cell lung carcinoma: primary tumor size, cell type, and lymph node metastases
    • Mujoomdar A., Austin J.H., Malhotra R., Powell C.A., Pearson G.D., Shiau M.C., et al. Clinical predictors of metastatic disease to the brain from non-small cell lung carcinoma: primary tumor size, cell type, and lymph node metastases. Radiology 2007, 242(3):882-888. 10.1148/radiol.2423051707.
    • (2007) Radiology , vol.242 , Issue.3 , pp. 882-888
    • Mujoomdar, A.1    Austin, J.H.2    Malhotra, R.3    Powell, C.A.4    Pearson, G.D.5    Shiau, M.C.6
  • 2
    • 4344694453 scopus 로고    scopus 로고
    • Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the metropolitan detroit cancer surveillance system
    • Barnholtz-Sloan J.S., Sloan A.E., Davis F.G., Vigneau F.D., Lai P., Sawaya R.E. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the metropolitan detroit cancer surveillance system. J. Clin. Oncol. 2004, 22(14):2865-2872. 10.1200/JCO.2004.12.149.
    • (2004) J. Clin. Oncol. , vol.22 , Issue.14 , pp. 2865-2872
    • Barnholtz-Sloan, J.S.1    Sloan, A.E.2    Davis, F.G.3    Vigneau, F.D.4    Lai, P.5    Sawaya, R.E.6
  • 3
    • 0029740191 scopus 로고    scopus 로고
    • Brain metastases. Histology, multiplicity, surgery, and survival
    • Nussbaum E.S., Djalilian H.R., Cho K.H., Hall W.A. Brain metastases. Histology, multiplicity, surgery, and survival. Cancer 1996, 78(8):1781-1788.
    • (1996) Cancer , vol.78 , Issue.8 , pp. 1781-1788
    • Nussbaum, E.S.1    Djalilian, H.R.2    Cho, K.H.3    Hall, W.A.4
  • 4
    • 0029803306 scopus 로고    scopus 로고
    • Final results of the Royal College of Radiologists trial comparing two different radiotherapy schedules in the treatment of cerebral metastases
    • Priestman T.J., Dunn J., Brada M., Rampling R., Baker P.G. Final results of the Royal College of Radiologists trial comparing two different radiotherapy schedules in the treatment of cerebral metastases. Clin. Oncol. (R. Coll. Radiol.) 1996, 8(5):308-315.
    • (1996) Clin. Oncol. (R. Coll. Radiol.) , vol.8 , Issue.5 , pp. 308-315
    • Priestman, T.J.1    Dunn, J.2    Brada, M.3    Rampling, R.4    Baker, P.G.5
  • 5
    • 2442713678 scopus 로고    scopus 로고
    • Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    • Andrews D.W., Scott C.B., Sperduto P.W., Flanders A.E., Gaspar L.E., Schell M.C., et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 2004, 363(9422):1665-1672. 10.1016/S0140-6736(04)16250-8.
    • (2004) Lancet , vol.363 , Issue.9422 , pp. 1665-1672
    • Andrews, D.W.1    Scott, C.B.2    Sperduto, P.W.3    Flanders, A.E.4    Gaspar, L.E.5    Schell, M.C.6
  • 6
    • 0027217452 scopus 로고
    • Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery?
    • Vecht C.J., Haaxma-Reiche H., Noordijk E.M., Padberg G.W., Voormolen J.H., Hoekstra F.H., et al. Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery?. Ann. neurol. 1993, 33(6):583-590. 10.1002/ana.410330605.
    • (1993) Ann. neurol. , vol.33 , Issue.6 , pp. 583-590
    • Vecht, C.J.1    Haaxma-Reiche, H.2    Noordijk, E.M.3    Padberg, G.W.4    Voormolen, J.H.5    Hoekstra, F.H.6
  • 7
    • 33846201188 scopus 로고    scopus 로고
    • Up-front chemotherapy and radiation treatment in newly diagnosed nonsmall cell lung cancer with brain metastases: survey by outcome research network for evaluation of treatment results in oncology
    • Moscetti L., Nelli F., Felici A., Rinaldi M., De Santis S., D'Auria G., et al. Up-front chemotherapy and radiation treatment in newly diagnosed nonsmall cell lung cancer with brain metastases: survey by outcome research network for evaluation of treatment results in oncology. Cancer 2007, 109(2):274-281. 10.1002/cncr.2239.
    • (2007) Cancer , vol.109 , Issue.2 , pp. 274-281
    • Moscetti, L.1    Nelli, F.2    Felici, A.3    Rinaldi, M.4    De Santis, S.5    D'Auria, G.6
  • 9
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2004, 350(21):2129-2139. 10.1056/NEJMoa040938.
    • (2004) N. Engl. J. Med. , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 10
    • 79960702788 scopus 로고    scopus 로고
    • Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS)
    • Fukuoka M., Wu Y.L., Thongprasert S., Sunpaweravong P., Leong S.S., Sriuranpong V., et al. Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J. Clin. Oncol. 2011, 29(21):2866-2874. 10.1200/JCO.2010.33.4235.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.21 , pp. 2866-2874
    • Fukuoka, M.1    Wu, Y.L.2    Thongprasert, S.3    Sunpaweravong, P.4    Leong, S.S.5    Sriuranpong, V.6
  • 11
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
    • Zhou C., Wu Y.L., Chen G., Feng J., Liu X.Q., Wang C., et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011, 12(8):735-742. 10.1016/S1470-2045(11)70184-X.
    • (2011) Lancet Oncol. , vol.12 , Issue.8 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3    Feng, J.4    Liu, X.Q.5    Wang, C.6
  • 12
    • 79952268212 scopus 로고    scopus 로고
    • Brain metastases from lung cancer responding to erlotinib: the importance of EGFR mutation
    • Porta R., Sanchez-Torres J.M., Paz-Ares L., Massuti B., Reguart N., Mayo C., et al. Brain metastases from lung cancer responding to erlotinib: the importance of EGFR mutation. Eur. Respir. J. 2011, 37(3):624-631. 10.1183/09031936.00195609.
    • (2011) Eur. Respir. J. , vol.37 , Issue.3 , pp. 624-631
    • Porta, R.1    Sanchez-Torres, J.M.2    Paz-Ares, L.3    Massuti, B.4    Reguart, N.5    Mayo, C.6
  • 13
    • 84865197331 scopus 로고    scopus 로고
    • Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation
    • Park S.J., Kim H.T., Lee D.H., Kim K.P., Kim S.W., Suh C., et al. Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation. Lung Canc. (Amsterdam, Netherlands). 2012, 77(3):556-560. 10.1016/j.lungcan.2012.05.09.
    • (2012) Lung Canc. (Amsterdam, Netherlands). , vol.77 , Issue.3 , pp. 556-560
    • Park, S.J.1    Kim, H.T.2    Lee, D.H.3    Kim, K.P.4    Kim, S.W.5    Suh, C.6
  • 14
    • 0022642587 scopus 로고
    • Principles of brain tumor chemotherapy
    • Shapiro W.R., Shapiro J.R. Principles of brain tumor chemotherapy. Semin. Oncol. 1986, 13(1):56-69.
    • (1986) Semin. Oncol. , vol.13 , Issue.1 , pp. 56-69
    • Shapiro, W.R.1    Shapiro, J.R.2
  • 15
    • 0025316477 scopus 로고
    • Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat
    • Greig N.H., Soncrant T.T., Shetty H.U., Momma S., Smith Q.R., Rapoport S.I. Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat. Cancer Chemother. Pharmacol. 1990, 26(4):263-268.
    • (1990) Cancer Chemother. Pharmacol. , vol.26 , Issue.4 , pp. 263-268
    • Greig, N.H.1    Soncrant, T.T.2    Shetty, H.U.3    Momma, S.4    Smith, Q.R.5    Rapoport, S.I.6
  • 17
    • 79959914514 scopus 로고    scopus 로고
    • Erlotinib accumulation in brain metastases from non-small cell lung cancer: visualization by positron emission tomography in a patient harboring a mutation in the epidermal growth factor receptor
    • Weber B., Winterdahl M., Memon A., Sorensen B.S., Keiding S., Sorensen L., et al. Erlotinib accumulation in brain metastases from non-small cell lung cancer: visualization by positron emission tomography in a patient harboring a mutation in the epidermal growth factor receptor. J. Thoracic Oncol.: Off. Publ. Int. Assoc. Study Lung Canc. 2011, 6(7):1287-1289. 10.1097/JTO.0b013e318219ab87.
    • (2011) J. Thoracic Oncol.: Off. Publ. Int. Assoc. Study Lung Canc. , vol.6 , Issue.7 , pp. 1287-1289
    • Weber, B.1    Winterdahl, M.2    Memon, A.3    Sorensen, B.S.4    Keiding, S.5    Sorensen, L.6
  • 19
    • 84866364723 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer
    • Togashi Y., Masago K., Masuda S., Mizuno T., Fukudo M., Ikemi Y., et al. Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer. Cancer Chemother. Pharmacol. 2012, 70(3):399-405. 10.1007/s00280-012-1929-4.
    • (2012) Cancer Chemother. Pharmacol. , vol.70 , Issue.3 , pp. 399-405
    • Togashi, Y.1    Masago, K.2    Masuda, S.3    Mizuno, T.4    Fukudo, M.5    Ikemi, Y.6
  • 20
    • 84875235273 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentrations of gefitinib in patients with lung adenocarcinoma
    • Zhao J., Chen M., Zhong W., Zhang L., Li L., Xiao Y., et al. Cerebrospinal fluid concentrations of gefitinib in patients with lung adenocarcinoma. Clin. Lung Canc. 2013, 14(2):188-193. 10.1016/j.cllc.2012.06.004.
    • (2013) Clin. Lung Canc. , vol.14 , Issue.2 , pp. 188-193
    • Zhao, J.1    Chen, M.2    Zhong, W.3    Zhang, L.4    Li, L.5    Xiao, Y.6
  • 21
    • 77954427100 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI-420 in patients with central nervous system metastases of non-small cell lung cancer
    • Togashi Y., Masago K., Fukudo M., Terada T., Fujita S., Irisa K., et al. Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI-420 in patients with central nervous system metastases of non-small cell lung cancer. J. Thoracic Oncol.: Off. Publ. Int. Assoc. Study Lung Canc. 2010, 5(7):950-955. 10.1097/JTO.0b013e3181e2138b.
    • (2010) J. Thoracic Oncol.: Off. Publ. Int. Assoc. Study Lung Canc. , vol.5 , Issue.7 , pp. 950-955
    • Togashi, Y.1    Masago, K.2    Fukudo, M.3    Terada, T.4    Fujita, S.5    Irisa, K.6
  • 22
    • 79959614287 scopus 로고    scopus 로고
    • Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy
    • Masuda T., Hattori N., Hamada A., Iwamoto H., Ohshimo S., Kanehara M., et al. Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy. Cancer Chemother. Pharmacol. 2011, 67(6):1465-1469. 10.1007/s00280-011-1555-6.
    • (2011) Cancer Chemother. Pharmacol. , vol.67 , Issue.6 , pp. 1465-1469
    • Masuda, T.1    Hattori, N.2    Hamada, A.3    Iwamoto, H.4    Ohshimo, S.5    Kanehara, M.6
  • 23
    • 84887018157 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic study of Gefitinib in a mouse model of non-small-cell lung carcinoma with brain metastasis
    • Chen Y., Wang M., Zhong W., Zhao J. Pharmacokinetic and pharmacodynamic study of Gefitinib in a mouse model of non-small-cell lung carcinoma with brain metastasis. Lung Canc. (Amsterdam, Netherlands). 2013, 10.1016/j.lungcan.2013.08.01.
    • (2013) Lung Canc. (Amsterdam, Netherlands).
    • Chen, Y.1    Wang, M.2    Zhong, W.3    Zhao, J.4
  • 24
    • 27744506881 scopus 로고    scopus 로고
    • Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01
    • Lassman A.B., Rossi M.R., Raizer J.J., Abrey L.E., Lieberman F.S., Grefe C.N., et al. Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01. Clin. Canc. Res.: Off. J. Am. Assoc. Canc. Res. 2005, 11(21):7841-7850. 10.1158/1078-0432.ccr-05-0421.
    • (2005) Clin. Canc. Res.: Off. J. Am. Assoc. Canc. Res. , vol.11 , Issue.21 , pp. 7841-7850
    • Lassman, A.B.1    Rossi, M.R.2    Raizer, J.J.3    Abrey, L.E.4    Lieberman, F.S.5    Grefe, C.N.6
  • 25
    • 84856304068 scopus 로고    scopus 로고
    • "Pulsatile" high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer
    • Grommes C., Oxnard G.R., Kris M.G., Miller V.A., Pao W., Holodny A.I., et al. "Pulsatile" high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer. Neuro-Oncology 2011, 13(12):1364-1369. 10.1093/neuonc/nor121.
    • (2011) Neuro-Oncology , vol.13 , Issue.12 , pp. 1364-1369
    • Grommes, C.1    Oxnard, G.R.2    Kris, M.G.3    Miller, V.A.4    Pao, W.5    Holodny, A.I.6
  • 26
    • 33749046899 scopus 로고    scopus 로고
    • Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib
    • Jackman D.M., Holmes A.J., Lindeman N., Wen P.Y., Kesari S., Borras A.M., et al. Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib. J. Clin. Oncol. 2006, 24(27):4517-4520. 10.1200/JCO.2006.06.6126.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.27 , pp. 4517-4520
    • Jackman, D.M.1    Holmes, A.J.2    Lindeman, N.3    Wen, P.Y.4    Kesari, S.5    Borras, A.M.6
  • 27
    • 77956060394 scopus 로고    scopus 로고
    • High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer
    • Clarke J.L., Pao W., Wu N., Miller V.A., Lassman A.B. High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer. J. Neurooncol. 2010, 99(2):283-286. 10.1007/s11060-010-0128-6.
    • (2010) J. Neurooncol. , vol.99 , Issue.2 , pp. 283-286
    • Clarke, J.L.1    Pao, W.2    Wu, N.3    Miller, V.A.4    Lassman, A.B.5
  • 28
    • 74949110711 scopus 로고    scopus 로고
    • Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
    • Jackman D., Pao W., Riely G.J., Engelman J.A., Kris M.G., Janne P.A., et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J. Clin. Oncol. 2010, 28(2):357-360. 10.1200/JCO.2009.24.7049.
    • (2010) J. Clin. Oncol. , vol.28 , Issue.2 , pp. 357-360
    • Jackman, D.1    Pao, W.2    Riely, G.J.3    Engelman, J.A.4    Kris, M.G.5    Janne, P.A.6
  • 29
    • 68949086799 scopus 로고    scopus 로고
    • Carcinomatous meningitis in non-small-cell lung cancer: response to high-dose erlotinib
    • Dhruva N., Socinski M.A. Carcinomatous meningitis in non-small-cell lung cancer: response to high-dose erlotinib. J. Clin. Oncol. 2009, 27(22):e31-e32. 10.1200/JCO.2008.21.0963.
    • (2009) J. Clin. Oncol. , vol.27 , Issue.22
    • Dhruva, N.1    Socinski, M.A.2
  • 30
    • 80054730405 scopus 로고    scopus 로고
    • Efficacy of increased-dose erlotinib for central nervous system metastases in non-small cell lung cancer patients with epidermal growth factor receptor mutation
    • Togashi Y., Masago K., Fukudo M., Tsuchido Y., Okuda C., Kim Y.H., et al. Efficacy of increased-dose erlotinib for central nervous system metastases in non-small cell lung cancer patients with epidermal growth factor receptor mutation. Cancer Chemother. Pharmacol. 2011, 68(4):1089-1092. 10.1007/s00280-011-1691-z.
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , Issue.4 , pp. 1089-1092
    • Togashi, Y.1    Masago, K.2    Fukudo, M.3    Tsuchido, Y.4    Okuda, C.5    Kim, Y.H.6
  • 31
    • 79951745868 scopus 로고    scopus 로고
    • High-dose erlotinib for refractory brain metastases in a patient with relapsed non-small cell lung cancer
    • Hata A., Kaji R., Fujita S., Katakami N. High-dose erlotinib for refractory brain metastases in a patient with relapsed non-small cell lung cancer. J. Thoracic Oncol.: Off. Publ. Int. Assoc. Study Lung Canc. 2011, 6(3):653-654. 10.1097/JTO.0b013e3181d899bb.
    • (2011) J. Thoracic Oncol.: Off. Publ. Int. Assoc. Study Lung Canc. , vol.6 , Issue.3 , pp. 653-654
    • Hata, A.1    Kaji, R.2    Fujita, S.3    Katakami, N.4
  • 32
    • 33747886041 scopus 로고    scopus 로고
    • A phase I/II study of weekly high-dose erlotinib in previously treated patients with nonsmall cell lung cancer
    • Milton D.T., Azzoli C.G., Heelan R.T., Venkatraman E., Gomez J.E., Kris M.G., et al. A phase I/II study of weekly high-dose erlotinib in previously treated patients with nonsmall cell lung cancer. Cancer 2006, 107(5):1034-1041. 10.1002/cncr.22088.
    • (2006) Cancer , vol.107 , Issue.5 , pp. 1034-1041
    • Milton, D.T.1    Azzoli, C.G.2    Heelan, R.T.3    Venkatraman, E.4    Gomez, J.E.5    Kris, M.G.6
  • 33
    • 70449584901 scopus 로고    scopus 로고
    • Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenocarcinoma who showed initial good response to gefitinib
    • Katayama T., Shimizu J., Suda K., Onozato R., Fukui T., Ito S., et al. Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenocarcinoma who showed initial good response to gefitinib. J. Thoracic Oncol.: Off. Publ. Int. Assoc. Study Lung Canc. 2009, 4(11):1415-1419. 10.1097/JTO.0b013e3181b62572.
    • (2009) J. Thoracic Oncol.: Off. Publ. Int. Assoc. Study Lung Canc. , vol.4 , Issue.11 , pp. 1415-1419
    • Katayama, T.1    Shimizu, J.2    Suda, K.3    Onozato, R.4    Fukui, T.5    Ito, S.6
  • 34
    • 17144371349 scopus 로고    scopus 로고
    • Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva)
    • Chinnaiyan P., Huang S., Vallabhaneni G., Armstrong E., Varambally S., Tomlins S.A., et al. Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva). Cancer Res. 2005, 65(8):3328-3335. 10.1158/0008-5472.CAN-04-3547.
    • (2005) Cancer Res. , vol.65 , Issue.8 , pp. 3328-3335
    • Chinnaiyan, P.1    Huang, S.2    Vallabhaneni, G.3    Armstrong, E.4    Varambally, S.5    Tomlins, S.A.6
  • 35
    • 0036795061 scopus 로고    scopus 로고
    • Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa)
    • Bianco C., Tortora G., Bianco R., Caputo R., Veneziani B.M., Caputo R., et al. Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa). Clin. Canc. Res.: Off. J. Am. Assoc. Canc. Res. 2002, 8(10):3250-3258.
    • (2002) Clin. Canc. Res.: Off. J. Am. Assoc. Canc. Res. , vol.8 , Issue.10 , pp. 3250-3258
    • Bianco, C.1    Tortora, G.2    Bianco, R.3    Caputo, R.4    Veneziani, B.M.5    Caputo, R.6
  • 36
    • 0036681995 scopus 로고    scopus 로고
    • Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa)
    • Huang S.M., Li J., Armstrong E.A., Harari P.M. Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Cancer Res. 2002, 62(15):4300-4306.
    • (2002) Cancer Res. , vol.62 , Issue.15 , pp. 4300-4306
    • Huang, S.M.1    Li, J.2    Armstrong, E.A.3    Harari, P.M.4
  • 37
    • 0026501854 scopus 로고
    • Quantitative study of blood-brain barrier permeability changes after experimental whole-brain radiation
    • d'Avella D., Cicciarello R., Albiero F., Mesiti M., Gagliardi M.E., Russi E., et al. Quantitative study of blood-brain barrier permeability changes after experimental whole-brain radiation. Neurosurgery 1992, 30(1):30-34.
    • (1992) Neurosurgery , vol.30 , Issue.1 , pp. 30-34
    • d'Avella, D.1    Cicciarello, R.2    Albiero, F.3    Mesiti, M.4    Gagliardi, M.E.5    Russi, E.6
  • 39
    • 0141450250 scopus 로고    scopus 로고
    • Influence of radiation on the blood-brain barrier and optimum time of chemotherapy, Zhongguo Yi, Xue Ke, Xue Yuan, Xue Bao
    • D. Qin, R. Zheng, J. Ma, J. Xiao, Z. Tang, Influence of radiation on the blood-brain barrier and optimum time of chemotherapy, Zhongguo Yi, Xue Ke, Xue Yuan, Xue Bao, 21 (4) (1999) 307-310.
    • (1999) , vol.21 , Issue.4 , pp. 307-310
    • Qin, D.1    Zheng, R.2    Ma, J.3    Xiao, J.4    Tang, Z.5
  • 40
    • 0031005544 scopus 로고    scopus 로고
    • Effect of brain irradiation on blood-CSF barrier permeability of chemotherapeutic agents
    • Qin D., Ma J., Xiao J., Tang Z. Effect of brain irradiation on blood-CSF barrier permeability of chemotherapeutic agents. Am. J. Clin. Oncol. 1997, 20(3):263-265.
    • (1997) Am. J. Clin. Oncol. , vol.20 , Issue.3 , pp. 263-265
    • Qin, D.1    Ma, J.2    Xiao, J.3    Tang, Z.4
  • 41
    • 0035889349 scopus 로고    scopus 로고
    • Improved efficacy of chemotherapy for glioblastoma by radiation-induced opening of blood-brain barrier: clinical results
    • Qin D., Ou G., Mo H., Song Y., Kang G., Hu Y., et al. Improved efficacy of chemotherapy for glioblastoma by radiation-induced opening of blood-brain barrier: clinical results. Int. J. Radiat. Oncol. Biol. Phys. 2001, 51(4):959-962.
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.51 , Issue.4 , pp. 959-962
    • Qin, D.1    Ou, G.2    Mo, H.3    Song, Y.4    Kang, G.5    Hu, Y.6
  • 42
    • 0024338963 scopus 로고
    • Radiation-induced dementia in patients cured of brain metastases
    • DeAngelis L.M., Delattre J.Y., Posner J.B. Radiation-induced dementia in patients cured of brain metastases. Neurology 1989, 39(6):789-796.
    • (1989) Neurology , vol.39 , Issue.6 , pp. 789-796
    • DeAngelis, L.M.1    Delattre, J.Y.2    Posner, J.B.3
  • 43
    • 67651102970 scopus 로고    scopus 로고
    • Phase I study of concurrent whole brain radiotherapy and erlotinib for multiple brain metastases from non-small-cell lung cancer
    • Lind J.S., Lagerwaard F.J., Smit E.F., Senan S. Phase I study of concurrent whole brain radiotherapy and erlotinib for multiple brain metastases from non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 2009, 74(5):1391-1396. 10.1016/j.ijrobp.2008.10.026.
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.74 , Issue.5 , pp. 1391-1396
    • Lind, J.S.1    Lagerwaard, F.J.2    Smit, E.F.3    Senan, S.4
  • 44
    • 67449122414 scopus 로고    scopus 로고
    • Treatment of brain metastasis from non-small cell lung cancer with whole brain radiotherapy and Gefitinib in a Chinese population
    • Ma S., Xu Y., Deng Q., Yu X. Treatment of brain metastasis from non-small cell lung cancer with whole brain radiotherapy and Gefitinib in a Chinese population. Lung Canc. (Amsterdam, Netherlands) 2009, 65(2):198-203. 10.1016/j.lungcan.2008.10.02.
    • (2009) Lung Canc. (Amsterdam, Netherlands) , vol.65 , Issue.2 , pp. 198-203
    • Ma, S.1    Xu, Y.2    Deng, Q.3    Yu, X.4
  • 45
    • 84875720245 scopus 로고    scopus 로고
    • Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer
    • Welsh J.W., Komaki R., Amini A., Munsell M.F., Unger W., Allen P.K., et al. Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer. J. Clin. Oncol. 2013, 31(7):895-902. 10.1200/JCO.2011.40.1174.
    • (2013) J. Clin. Oncol. , vol.31 , Issue.7 , pp. 895-902
    • Welsh, J.W.1    Komaki, R.2    Amini, A.3    Munsell, M.F.4    Unger, W.5    Allen, P.K.6
  • 48
    • 84871679394 scopus 로고    scopus 로고
    • Gefitinib alone or with concomitant whole brain radiotherapy for patients with brain metastasis from non-small-cell lung cancer: a retrospective study
    • Zeng Y.D., Zhang L., Liao H., Liang Y., Xu F., Liu J.L., et al. Gefitinib alone or with concomitant whole brain radiotherapy for patients with brain metastasis from non-small-cell lung cancer: a retrospective study. Asian Pac. J. Cancer Prev. 2012, 13(3):909-914.
    • (2012) Asian Pac. J. Cancer Prev. , vol.13 , Issue.3 , pp. 909-914
    • Zeng, Y.D.1    Zhang, L.2    Liao, H.3    Liang, Y.4    Xu, F.5    Liu, J.L.6
  • 49
    • 84875239644 scopus 로고    scopus 로고
    • A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: radiation therapy oncology group 0320
    • Sperduto P.W., Wang M., Robins H.I., Schell M.C., Werner-Wasik M., Komaki R., et al. A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: radiation therapy oncology group 0320. Int. J. Radiat. Oncol. Biol. Phys. 2013, 85(5):1312-1318. 10.1016/j.ijrobp.2012.11.042.
    • (2013) Int. J. Radiat. Oncol. Biol. Phys. , vol.85 , Issue.5 , pp. 1312-1318
    • Sperduto, P.W.1    Wang, M.2    Robins, H.I.3    Schell, M.C.4    Werner-Wasik, M.5    Komaki, R.6
  • 50
    • 84885224003 scopus 로고    scopus 로고
    • Phase II study of whole brain radiotherapy with or without erlotinib in patients with multiple brain metastases from lung adenocarcinoma
    • Zhuang H., Yuan Z., Wang J., Zhao L., Pang Q., Wang P. Phase II study of whole brain radiotherapy with or without erlotinib in patients with multiple brain metastases from lung adenocarcinoma. Drug Des. Dev. Ther. 2013, 7:1179-1186. 10.2147/dddt.s53011.
    • (2013) Drug Des. Dev. Ther. , vol.7 , pp. 1179-1186
    • Zhuang, H.1    Yuan, Z.2    Wang, J.3    Zhao, L.4    Pang, Q.5    Wang, P.6
  • 51
    • 63449122814 scopus 로고    scopus 로고
    • Establishment and characterization of a model of acquired resistance to epidermal growth factor receptor targeting agents in human cancer cells
    • Benavente S., Huang S., Armstrong E.A., Chi A., Hsu K.T., Wheeler D.L., et al. Establishment and characterization of a model of acquired resistance to epidermal growth factor receptor targeting agents in human cancer cells. Clin. Canc. Res.: Off. J. Am. Assoc. Canc. Res. 2009, 15(5):1585-1592. 10.1158/1078-0432.CCR-08-2068.
    • (2009) Clin. Canc. Res.: Off. J. Am. Assoc. Canc. Res. , vol.15 , Issue.5 , pp. 1585-1592
    • Benavente, S.1    Huang, S.2    Armstrong, E.A.3    Chi, A.4    Hsu, K.T.5    Wheeler, D.L.6
  • 52
    • 84876758037 scopus 로고    scopus 로고
    • Association between EGFR-TKI resistance and efficacy of radiotherapy for brain metastases from EGFR-mutant lung adenocarcinoma
    • Hirata H., Nakamura K., Kunitake N., Shioyama Y., Sasaki T., Ohga S., et al. Association between EGFR-TKI resistance and efficacy of radiotherapy for brain metastases from EGFR-mutant lung adenocarcinoma. Anticancer Res. 2013, 33(4):1649-1655.
    • (2013) Anticancer Res. , vol.33 , Issue.4 , pp. 1649-1655
    • Hirata, H.1    Nakamura, K.2    Kunitake, N.3    Shioyama, Y.4    Sasaki, T.5    Ohga, S.6
  • 53
    • 80054766947 scopus 로고    scopus 로고
    • Continuous EGFR-TKI administration following radiotherapy for non-small cell lung cancer patients with isolated CNS failure
    • Shukuya T., Takahashi T., Naito T., Kaira R., Ono A., Nakamura Y., et al. Continuous EGFR-TKI administration following radiotherapy for non-small cell lung cancer patients with isolated CNS failure. Lung Canc (Amsterdam, Netherlands). 2011, 74(3):457-461. 10.1016/j.lungcan.2011.04.00.
    • (2011) Lung Canc (Amsterdam, Netherlands). , vol.74 , Issue.3 , pp. 457-461
    • Shukuya, T.1    Takahashi, T.2    Naito, T.3    Kaira, R.4    Ono, A.5    Nakamura, Y.6
  • 54
    • 34548049302 scopus 로고    scopus 로고
    • Gefitinib as palliative therapy for lung adenocarcinoma metastatic to the brain
    • Wu C., Li Y.L., Wang Z.M., Li Z., Zhang T.X., Wei Z. Gefitinib as palliative therapy for lung adenocarcinoma metastatic to the brain. Lung Canc (Amsterdam, Netherlands). 2007, 57(3):359-364. 10.1016/j.lungcan.2007.03.01.
    • (2007) Lung Canc (Amsterdam, Netherlands). , vol.57 , Issue.3 , pp. 359-364
    • Wu, C.1    Li, Y.L.2    Wang, Z.M.3    Li, Z.4    Zhang, T.X.5    Wei, Z.6
  • 55
    • 4944226682 scopus 로고    scopus 로고
    • Effect of gefitinib ('Iressa', ZD1839) on brain metastases in patients with advanced non-small-cell lung cancer
    • Hotta K., Kiura K., Ueoka H., Tabata M., Fujiwara K., Kozuki T., et al. Effect of gefitinib ('Iressa', ZD1839) on brain metastases in patients with advanced non-small-cell lung cancer. Lung Canc (Amsterdam, Netherlands) 2004, 46(2):255-261. 10.1016/j.lungcan.2004.04.03.
    • (2004) Lung Canc (Amsterdam, Netherlands) , vol.46 , Issue.2 , pp. 255-261
    • Hotta, K.1    Kiura, K.2    Ueoka, H.3    Tabata, M.4    Fujiwara, K.5    Kozuki, T.6
  • 56
    • 7444234824 scopus 로고    scopus 로고
    • Gefitinib in patients with brain metastases from non-small-cell lung cancer: review of 15 clinical cases
    • Namba Y., Kijima T., Yokota S., Niinaka M., Kawamura S., Iwasaki T., et al. Gefitinib in patients with brain metastases from non-small-cell lung cancer: review of 15 clinical cases. Clin. Lung Canc. 2004, 6(2):123-128. 10.3816/CLC.2004.n.026.
    • (2004) Clin. Lung Canc. , vol.6 , Issue.2 , pp. 123-128
    • Namba, Y.1    Kijima, T.2    Yokota, S.3    Niinaka, M.4    Kawamura, S.5    Iwasaki, T.6
  • 57
    • 10444237217 scopus 로고    scopus 로고
    • Gefitinib is active in patients with brain metastases from non-small cell lung cancer and response is related to skin toxicity
    • Chiu C.H., Tsai C.M., Chen Y.M., Chiang S.C., Liou J.L., Perng R.P. Gefitinib is active in patients with brain metastases from non-small cell lung cancer and response is related to skin toxicity. Lung Canc (Amsterdam, Netherlands). 2005, 47(1):129-138. 10.1016/j.lungcan.2004.05.01.
    • (2005) Lung Canc (Amsterdam, Netherlands). , vol.47 , Issue.1 , pp. 129-138
    • Chiu, C.H.1    Tsai, C.M.2    Chen, Y.M.3    Chiang, S.C.4    Liou, J.L.5    Perng, R.P.6
  • 58
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    • Paez J.G., Janne P.A., Lee J.C., Tracy S., Greulich H., Gabriel S., et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science (New York, NY). 2004, 304(5676):1497-1500. 10.1126/science.109931.
    • (2004) Science (New York, NY). , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 61
    • 77954586493 scopus 로고    scopus 로고
    • Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis
    • Benedettini E., Sholl L.M., Peyton M., Reilly J., Ware C., Davis L., et al. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. The Am. J. Pathol. 2010, 177(1):415-423. 10.2353/ajpath.2010.090863.
    • (2010) The Am. J. Pathol. , vol.177 , Issue.1 , pp. 415-423
    • Benedettini, E.1    Sholl, L.M.2    Peyton, M.3    Reilly, J.4    Ware, C.5    Davis, L.6
  • 62
    • 68049140927 scopus 로고    scopus 로고
    • Caveolin-1 expression in lung carcinoma varies according to tumour histotype and is acquired de novo in brain metastases
    • Cassoni P., Daniele L., Maldi E., Righi L., Tavaglione V., Novello S., et al. Caveolin-1 expression in lung carcinoma varies according to tumour histotype and is acquired de novo in brain metastases. Histopathology 2009, 55(1):20-27. 10.1111/j.1365-2559.2009.03326.x.
    • (2009) Histopathology , vol.55 , Issue.1 , pp. 20-27
    • Cassoni, P.1    Daniele, L.2    Maldi, E.3    Righi, L.4    Tavaglione, V.5    Novello, S.6
  • 63
    • 84887023536 scopus 로고    scopus 로고
    • Phase II trial of gefitinib alone without radiation therapy for Japanese patients with brain metastases from EGFR-mutant lung adenocarcinoma
    • Iuchi T., Shingyoji M., Sakaida T., Hatano K., Nagano O., Itakura M., et al. Phase II trial of gefitinib alone without radiation therapy for Japanese patients with brain metastases from EGFR-mutant lung adenocarcinoma. Lung Canc (Amsterdam, Netherlands). 2013, 10.1016/j.lungcan.2013.08.01.
    • (2013) Lung Canc (Amsterdam, Netherlands).
    • Iuchi, T.1    Shingyoji, M.2    Sakaida, T.3    Hatano, K.4    Nagano, O.5    Itakura, M.6
  • 64
    • 84857088535 scopus 로고    scopus 로고
    • The retrospective analysis of the frequency of EGFR mutations and efficacy of gefitinib in NSCLC patients with brain metastases
    • e18065
    • Li Z., Lu J., Zhao Y., Guo H. The retrospective analysis of the frequency of EGFR mutations and efficacy of gefitinib in NSCLC patients with brain metastases. J. Clin. Oncol. 2011, 29. e18065.
    • (2011) J. Clin. Oncol. , vol.29
    • Li, Z.1    Lu, J.2    Zhao, Y.3    Guo, H.4
  • 65
    • 80053519935 scopus 로고    scopus 로고
    • Rates of central nervous system (CNS) metastases in patients with advanced non-small cell lung cancer (NSCLC) and somatic EGFR mutations initially treated with gefitinib or erlotinib versus chemotherapy
    • Heon S., Yeap B., Lindeman N., Rabin M., Jackman D., Johnson B. Rates of central nervous system (CNS) metastases in patients with advanced non-small cell lung cancer (NSCLC) and somatic EGFR mutations initially treated with gefitinib or erlotinib versus chemotherapy. J. Clin. Oncol. 2011, 29:7607.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 7607
    • Heon, S.1    Yeap, B.2    Lindeman, N.3    Rabin, M.4    Jackman, D.5    Johnson, B.6


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