Intrathecal administration of mesenchymal stem cells reduces the reactive oxygen species and pain behavior in neuropathic rats

Korean Journal of Pain

Volumn 27, Issue 3, 2014, Pages 239-245

  Zhang, En Ji ^a   Song, Chang Hwa ^a   Ko, Young Kwon ^a   Lee, Won Hyung ^a  

^a Chungnam National University   (South Korea)

Author keywords

Mesenchymal stem cells; Neuropathic pain; Reactive oxygen species

Indexed keywords

HYDROETHIDINE; REACTIVE OXYGEN METABOLITE;

ADULT; ALLODYNIA; ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; IN VIVO STUDY; INTRATHECAL STEM CELL TRANSPLANTATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NEUROMODULATION; NEUROPATHIC PAIN; NONHUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; RAT; SPINAL CORD DORSAL HORN; SPINAL NERVE LIGATION INJURY; SPRAGUE DAWLEY RAT; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME; VON FREY TEST; WITHDRAWAL REFLEX;

EID: 84903717488     PISSN: 20059159     EISSN: 20930569     Source Type: Journal    
DOI: 10.3344/kjp.2014.27.3.239     Document Type: Article

References (28)

1. Gilron I, Watson CP, Cahill CM, Moulin DE. Neuropathic pain: a practical guide for the clinician. CMAJ 2006; 175: 265-75.
2. Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, Pittenger MF. Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 2000; 275: 9645-52.
3. Conget PA, Minguell JJ. Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells. J Cell Physiol 1999; 181: 67-73.
4. Lu L, Zhao C, Liu Y, Sun X, Duan C, Ji M, et al. Therapeutic benefit of TH-engineered mesenchymal stem cells for Parkinson's disease. Brain Res Brain Res Protoc 2005; 15: 46-51.
5. Yang LY, Huang TH, Ma L. Bone marrow stromal cells express neural phenotypes in vitro and migrate in brain after transplantation in vivo. Biomed Environ Sci 2006; 19: 329-35.
6. Le Blanc K, Pittenger M. Mesenchymal stem cells: progress toward promise. Cytotherapy 2005; 7: 36-45.
7. Kim HK, Park SK, Zhou JL, Taglialatela G, Chung K, Coggeshall RE, et al. Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain 2004; 111: 116-24.
8. Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, et al. A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther 2004; 309: 869-78.
9. Valle-Prieto A, Conget PA. Human mesenchymal stem cells efficiently manage oxidative stress. Stem Cells Dev 2010; 19: 1885-93.
10. Tal M, Bennett GJ. Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve. Pain 1994; 57: 375-82.
11. Soleimani M, Nadri S. A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow. Nat Protoc 2009; 4: 102-6.
12. Yang CC, Shih YH, Ko MH, Hsu SY, Cheng H, Fu YS. Transplantation of human umbilical mesenchymal stem cells from Wharton's jelly after complete transection of the rat spinal cord. PLoS One 2008; 3: e3336.
13. Papir-Kricheli D, Frey J, Laufer R, Gilon C, Chorev M, Selinger Z, et al. Behavioural effects of receptor-specific substance P agonists. Pain 1987; 31: 263-76.
14. Harraz MM, Marden JJ, Zhou W, Zhang Y, Williams A, Sharov VS, et al. SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest 2008; 118: 659-70.
15. Kumar S, Ruchi R, James SR, Chidiac EJ. Gene therapy for chronic neuropathic pain: how does it work and where do we stand today? Pain Med 2011; 12: 808-22.
16. Marchand F, Perretti M, McMahon SB. Role of the immune system in chronic pain. Nat Rev Neurosci 2005; 6: 521-32.
17. Hill RG. Molecular basis for the perception of pain. Neuroscientist 2001; 7: 282-92.
18. Scholz J, Woolf CJ. The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci 2007; 10: 1361-8.
19. Reichling DB, Levine JD. Critical role of nociceptor plasticity in chronic pain. Trends Neurosci 2009; 32: 611-8.
20. Kim D, You B, Jo EK, Han SK, Simon MI, Lee SJ. NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci U S A 2010; 107: 14851-6.
21. Siniscalco D, Giordano C, Rossi F, Maione S, de Novellis V. Role of neurotrophins in neuropathic pain. Curr Neuropharmacol 2011; 9: 523-9.
22. Wagers AJ, Weissman IL. Plasticity of adult stem cells. Cell 2004; 116: 639-48.
23. Siniscalco D, Giordano C, Galderisi U, Luongo L, Alessio N, Di Bernardo G, et al. Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic mice. Cell Mol Life Sci 2010; 67: 655-69.
24. Savitz SI, Dinsmore JH, Wechsler LR, Rosenbaum DM, Caplan LR. Cell therapy for stroke. NeuroRx 2004; 1: 406-14.
25. Levy YS, Bahat-Stroomza M, Barzilay R, Burshtein A, Bulvik S, Barhum Y, et al. Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson's disease. Cytotherapy 2008; 10: 340-52.
26. Zurita M, Vaquero J. Functional recovery in chronic paraplegia after bone marrow stromal cells transplantation. Neuroreport 2004; 15: 1105-8.
27. Kim CH, Kim YW, Jang SH, Chang CH, Jung JH, Kim SH. Motor function recovery after adipose tissue derived mesenchymal stem cell therapy in rats with cerebral infarction. J Korean Neurosurg Soc 2006; 40: 267-72.
28. Park ES, Gao X, Chung JM, Chung K. Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons. Neurosci Lett 2006; 391: 108-11.