High prevalence of hypovitaminosis D in Sicilian children affected by growth hormone deficiency and its improvement after 12 months of replacement treatment

Journal of Endocrinological Investigation

Volumn 37, Issue 7, 2014, Pages 631-638

  Ciresi, A ^a   Ciccio F ^a   Giordano, C ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

GH deficiency; GH treatment; Growth hormone; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE BONE ISOENZYME; CALCIUM; GROWTH HORMONE; PARATHYROID HORMONE; PHOSPHATE; SOMATOMEDIN C; VITAMIN D; HUMAN GROWTH HORMONE;

ALKALINE PHOSPHATASE BLOOD LEVEL; AREA UNDER THE CURVE; ARTICLE; BEDTIME DOSAGE; BODY HEIGHT; CALCIUM BLOOD LEVEL; CHILD; CONTROLLED STUDY; FEMALE; FOLLOW UP; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PREPUBERTY; PREVALENCE; PROSPECTIVE STUDY; SEASONAL VARIATION; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; WAIST CIRCUMFERENCE; ADOLESCENT; COMORBIDITY; DEFICIENCY; DWARFISM, PITUITARY; INFANT; PRESCHOOL CHILD; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; COMORBIDITY; DWARFISM, PITUITARY; FEMALE; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; INFANT; MALE; PREVALENCE; TREATMENT OUTCOME; VITAMIN D DEFICIENCY; YOUNG ADULT;

EID: 84903717151     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-014-0084-7     Document Type: Article

References (38)

1. Johansen JS, Pedersen SA, Jørgensen JO, Riis BJ, Christiansen C, Christiansen JS, Skakkebaek NE (1990) Effects of growth hormone (GH) on plasma bone Gla protein in GH-deficient adults. J Clin Endocrinol Metab 70(4):916-919
2. Binnerts A, Swart GR, Wilson JH, Hoogerbrugge N, Pols HA, Birkenhager JC, Lamberts SW (1992) The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clin Endocrinol (Oxf) 37(1):79-87
3. Schlemmer A, Johansen JS, Pedersen SA, Jørgensen JO, Hassager C, Christiansen C (1991) The effect of growth hormone (GH) therapy on urinary pyridinoline cross-links in GH-deficient adults. Clin Endocrinol (Oxf) 35(6):471-476
4. Henry HL (2011) Regulation of vitamin D metabolism. Best Pract Res Clin Endocrinol Metab 25(4):531-541
5. Bianda T, Hussain MA, Glatz Y, Bouillon R, Froesch ER, Schmid C (1997) Effects of short-term insulin-like growth factor-I or growth hormone treatment on bone turnover, renal phosphate reabsorption and 1,25 dihydroxyvitamin D3 production in healthy man. J Intern Med 241(2):143-150 (Pubitemid 27092903)
6. Marcus R, Butterfield G, Holloway L, Gilliland L, Baylink DJ, Hintz RL, Sherman BM (1990) Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab 70(2):519-527
7. Kamenický P, Blanchard A, Gauci C, Salenave S, Letierce A, Lombès M, Brailly-Tabard S, Azizi M, Prié D, Souberbielle JC, Chanson P (2012) Pathophysiology of renal calcium handling in acromegaly: what lies behind hypercalciuria? J Clin Endocrinol Metab 97(6):2124-2133
8. Amato G, Izzo G, La Montagna G, Bellastella A (1996) Low dose recombinant human growth hormone normalizes bone metabolism and cortical bone density and improves trabecular bone density in growth hormone deficient adults without causing adverse effects. Clin Endocrinol (Oxf) 45(1):27-32 (Pubitemid 26248928)
9. Wei S, Tanaka H, Seino Y (1998) Local action of exogenous growth hormone and insulin-like growth factor-I on dihydroxyvitamin D production in LLC-PK1 cells. Eur J Endocrinol 139(4):454-460
10. Ameri P, Giusti A, Boschetti M, Bovio M, Teti C, Leoncini G, Ferone D, Murialdo G, Minuto F (2013) Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency. Eur J Endocrinol 169(6):767-772
11. Soliman AT, Al Khalaf F, Alhemaidi N, Al Ali M, Al Zyoud M, Yakoot K (2008) Linear growth in relation to the circulating concentrations of insulin-like growth factor I, parathyroid hormone, and 25-hydroxy vitamin D in children with nutritional rickets before and after treatment: endocrine adaptation to vitamin D deficiency. Metab Clin Exp 57:95-102 (Pubitemid 350234979)
12. Marshall WA, Tanner JM (1969) Variations in pattern of pubertal changes in girls. Arch Dis Child 44(235):230-291
13. Growth Hormone Research Society (2000) Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab 85:3990-3993
14. Norman AW, Bouillon R, Whiting SJ, Vieth R, Lips P (2007) 13th workshop consensus for vitamin D nutritional guidelines. J Steroid Biochem Mol Biol 103:204-205 (Pubitemid 46420528)
15. McKenna MJ, Freaney R (1998) Secondary hyperparathyroidism in the elderly: means to defining hypovitaminosis D. Osteoporos Int 8(Suppl 2):S3-S6 (Pubitemid 28416848)
16. Arabi A, El Rassi R, El-Hajj Fuleihan G (2010) Hypovitaminosis D in developing countries-prevalence, risk factors and outcomes. Nat Rev Endocrinol 6(10):550-561
17. Guillemant J, Taupin P, Le HT, Taright N, Allemandou A, Pérès G, Guillemant S (1999) Vitamin D status during puberty in French healthy male adolescents. Osteoporos Int 10(3):222-225 (Pubitemid 29458717)
18. Lehtonen-Veromaa M, Möttönen T, Irjala K, Kärkkäinen M, Lamberg-Allardt C, Hakola P, Viikari J (1999) Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-year-old Finnish girls. Eur J Clin Nutr 53(9):746-751 (Pubitemid 29424006)
19. Guillemant J, Allemandou A, Cabrol S, Pérès G, Guillemant S (1998) Vitamin D status in the adolescent: seasonal variations and effects of winter supplementation with vitamin D3. Arch Pediatr 5(11):1211-1215
20. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J, IOF Committee of Scientific Advisors (CSA), Nutrition Working Group (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20(11):1807-1820
21. Prentice A (2008) Vitamin D deficiency: a global perspective. Nutr Rev 66(10 Suppl 2):S153-S164
22. Bouillon R, Carmeliet G, Daci E, Segaert S, Verstuyf A (1998) Vitamin D metabolism and action. Osteoporos Int 8(Suppl 2):S13-S19 (Pubitemid 28416850)
23. Norman AW (2008) From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 88(2):491S-499S
24. Halhali A, Díaz L, Sánchez I, Garabédian M, Bourges H, Larrea F (1999) Effects of IGF-I on 1,25-dihydroxyvitamin D(3) synthesis by human placenta in culture. Mol Hum Reprod 5(8):771-776 (Pubitemid 29366876)
25. Ameri P, Giusti A, Boschetti M, Murialdo G, Minuto F, Ferone D (2013) Interactions between vitamin D and IGF-I: from physiology to clinical practice. Clin Endocrinol (Oxf) 79(4):457-463
26. Giustina A, Mazziotti G, Canalis E (2008) Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 29(5):535-559
27. Parkinson C, Kassem M, Heickendorff L, Flyvbjerg A, Trainer PJ (2003) Pegvisomant-induced serum insulin-like growth factor-I normalization in patients with acromegaly returns elevated markers of bone turnover to normal. J Clin Endocrinol Metab 88(12):5650-5655 (Pubitemid 38033029)
28. Wei S, Tanaka H, Kubo T, Ono T, Kanzaki S, Seino Y (1997) Growth hormone increases serum 1,25-dihydroxyvitamin D levels and decreases 24,25-dihydroxyvitamin D levels in children with growth hormone deficiency. Eur J Endocrinol 136(1):45-51 (Pubitemid 27090679)
29. Saggese G, Baroncelli GI, Bertelloni S, Cinquanta L, Di Nero G (1993) Effects of long-term treatment with growth hormone on bone and mineral metabolism in children with growth hormone deficiency. J Pediatr 122(1):37-45 (Pubitemid 23010681)
30. Hansen TB, Brixen K, Vahl N, Jørgensen JO, Christiansen JS, Mosekilde L, Hagen C (1996) Effects of 12 months of growth hormone (GH) treatment on calciotropic hormones, calcium homeostasis, and bone metabolism in adults with acquired GH deficiency: a double blind, randomized, placebo-controlled study. J Clin Endocrinol Metab 81(9):3352-3359 (Pubitemid 26296215)
31. El-Hajj Fuleihan G, Nabulsi M, Choucair M, Salamoun M, Hajj Shahine C, Kizirian A, Tannous R (2001) Hypovitaminosis D in healthy schoolchildren. Pediatrics 107(4):E53
32. Carnevale V, Modoni S, Pileri M, Di Giorgio A, Chiodini I, Minisola S, Vieth R, Scillitani A (2001) Longitudinal evaluation of vitamin D status in healthy subjects from southern Italy: seasonal and gender differences. Osteoporos Int 12(12): 1026-1030 (Pubitemid 34105973)
33. Wright NM, Papadea N, Wentz B, Hollis B, Willi S, Bell NH (1997) Increased serum 1,25-dihydroxyvitamin D after growth hormone administration is not parathyroid hormone-mediated. Calcif Tissue Int 61(2):101-103 (Pubitemid 27315220)
34. Ahmad AM, Thomas J, Clewes A, Hopkins MT, Guzder R, Ibrahim H, Durham BH, Vora JP, Fraser WD (2003) Effects of growth hormone replacement on parathyroid hormone sensitivity and bone mineral metabolism. J Clin Endocrinol Metab 88(6):2860-2868 (Pubitemid 36724468)
35. Lombardi G, Di Somma C, Vuolo L, Guerra E, Scarano E, Colao A (2010) Role of IGF-I on PTH effects on bone. J Endocrinol Invest 33(7 Suppl):22-26
36. Bianda T, Glatz Y, Bouillon R, Froesch ER, Schmid C (1998) Effects of short-term insulin-like growth factor-I (IGF-I) or growth hormone (GH) treatment on bone metabolism and on production of 1,25-dihydroxycholecalciferol in GH-deficient adults. J Clin Endocrinol Metab 83(1):81-87 (Pubitemid 28498314)
37. Beshyah SA, Thomas E, Kyd P, Sharp P, Fairney A, Johnston DG (1994) The effect of growth hormone replacement therapy in hypopituitary adults on calcium and bone metabolism. Clin Endocrinol (Oxf) 40(3):383-391 (Pubitemid 24194634)
38. Savić L, Savić D (2008) Serum calcium and phosphorus concentration and alkaline phosphatase activity in healthy children during growth and development. Med Pregl 61(7-8):393-399