Vesicular nucleotide transport: A brief history and the vesicular nucleotide transporter as a target for drug development

Current Pharmaceutical Design

Volumn 20, Issue 16, 2014, Pages 2745-2749

  Hiasa, Miki ^a   Togawa, Natsuko ^a   Moriyama, Yoshinori ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

ADP; ATP; Drug target; Purinergic chemical transmission; Secretory granules; Synaptic vesicles; Vesicular nucleotide transporter

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; NUCLEOTIDE TRANSPORTER; ORGANIC ANION TRANSPORTER; SYNAPTOTAGMIN; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 2; VESICULAR GLUTAMATE TRANSPORTER 3; VESICULAR NEUROTRANSMITTER TRANSPORTER; VESICULAR NUCLEOTIDE TRANSPORTER; NUCLEOTIDE;

ACTIVE TRANSPORT; ARTICLE; CHROMAFFIN GRANULE; DRUG DEVELOPMENT; GAP JUNCTION; INTESTINE INNERVATION; NONHUMAN; NUCLEOTIDE TRANSPORT; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; PROTEIN TRANSPORT; SECRETORY GRANULE; SECRETORY VESICLE; SIGNAL TRANSDUCTION; SYNAPSE VESICLE; ANIMAL; DRUG DELIVERY SYSTEM; HUMAN; METABOLISM; PHYSIOLOGY; PROCEDURES; TRANSPORT AT THE CELLULAR LEVEL; TRENDS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL TRANSPORT; DRUG DELIVERY SYSTEMS; DRUG DISCOVERY; HUMANS; NUCLEOTIDE TRANSPORT PROTEINS; NUCLEOTIDES; SECRETORY VESICLES;

EID: 84903707492     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990574     Document Type: Article

References (52)

1. Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 2007; 87: 659-797.
2. Winkler H, Carmichael SW In The Secretory granule. eds Poisner AM, Trifaro JM (Elsevier Biomedical, Amsterdam), 1982, pp 1-415.
3. Njus D, Kelley PM, Harnadek GJ. Bioenergetics of secretory vesicles. Biochim Biophys Acta 1986; 853: 237-65.
4. Johnson RG. Accumulation of biological amines into chromaffin granules: a model for hormone and neurotransmitter transport. Physiol Rev 1988; 68: 232-307.
5. Zimmermann H. Signalling via ATP in the nervous system. Trend Neurosci 1994; 17: 420-6.
6. Hutton JC, Penn EJ, Peshavaria M. Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate. Biochem J 1983; 210: 297-305.
7. Suckale J, Solimena M. The insulin secretory granule as a signaling hub. Trends Endocrinol Metab 2010; 21: 599-609.
8. Castle JD, Cameron RS, Arvan P, von Zastrow M, Rudnick G. Similarities and differences among neuroendocrine, exocrine, and endocytic vesicles. Ann N Y Acad Sci 1987; 493: 448-60.
9. Omote H, Miyaji T, Juge N, Moriyama Y. Vesicular neurotransmitter transporter: bioenergetics and regulation of glutamate transport. Biochemistry 2011; 50: 5558-65.
10. Kostron H, Winkler H, Peer LJ, König P. Uptake of adenosine triphosphate by isolated adrenal chromaffin granules: a carriermediated transport. Neuroscience 1977; 2: 159-66.
11. Weber A, Winkler H. Specificity and mechanism of nucleotide uptake by adrenal chromaffin granules. Neuroscience 1981; 6: 2269-76.
12. Weber A, Westhead EW, Winkler H. Specificity and properties of the nucleotide carrier in chromaffin granules from bovine adrenal medulla. Biochem J 1983; 210: 789-94.
13. Grüninger HA, Apps DK, Phillips JH. Adenine nucleotide and phosphoenolpyruvate transport by bovine chromaffin granule "ghosts". Neuroscience 1983; 9: 917-24.
14. Bankston LA, Guidotti G. Characterization of ATP transport into chromaffin granule ghosts. Synergy of ATP and serotonin accumulation in chromaffin granule ghosts. J Biol Chem 1996; 271: 17132-8.
15. Hnasko TS, Chuhma N, Zhang H, et al. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron 2010; 65: 643-56.
16. Gualix J, Fideu MD, Pintor J, Rotllán P, García-Carmona F, Miras-Portugal MT. Characterization of diadenosine polyphosphate transport into chromaffin granules from adrenal medulla. FASEB J 1997; 11: 981-90.
17. Gualix J, Pintor J, Miras-Portugal MT. Characterization of nucleotide transport into rat brain synaptic vesicles. J Neurochem 1999; 73: 1098-104.
18. Zalk R, Shoshan-Barmatz V. Characterization of DIDS-sensitive ATP accumulation in brain synaptic vesicles. FEBS Lett 2006; 580: 5894-8.
19. Santos TG, Souza DO, Tasca CI. GTP uptake into rat brain synaptic vesicles. Brain Res 2006; 1070: 71-6.
20. Rudnick G. Vesicular ATP transport is a hard (V)NUT to crack. Proc Natl Acad Sci USA 2008; 105: 5949-50.
21. Stadler H, Fenwick EM. Cholinergic synaptic vesicles from Torpedo marmorata contain an atractyloside-binding protein related to the mitochondrial ADP/ATP carrier. Eur J Biochem 1983; 136: 377-82.
22. Lee DA, Witzemann V. Photoaffinity labeling of a synaptic vesicle specific nucleotide transport system from Torpedo marmorata. Biochemistry 1983; 22: 6123-30.
23. Sawada K, Echigo N, Juge N, et al. Identification of a vesicular nucleotide transporter. Proc Natl Acad Sci USA 2008; 105: 5683-6.
24. Iharada M, et al. Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl--dependent urate exporter. J Biol Chem 2010; 285: 26107-13.
25. Jutabha P, Anzai N, Kitamura K, et al. Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem 2010; 285: 35123-32.
26. +/phosphate co-transporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol electronic version
27. Miyaji T, Echigo N, Hiasa M, Senoh S, Omote H, Moriyama Y. Identification of a vesicular aspartate transporter. Proc Natl Acad Sci USA 2008; 105: 11720-4.
28. Morin P, Sagné C, Gasnier B. Functional characterization of wildtype and mutant human sialin. EMBO J 2004; 23: 4560-70.
29. Moriyama Y, Yamamoto A. Glutamatergic chemical transmission: look! Here, there, and anywhere. J Biochem 2004; 135: 155-63.
30. Fremeau RT Jr, Voglmaier S, Seal RP, Edwards RH. VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Trends Neurosci 2004; 27: 98-103.
31. Miyaji T, Sawada K, Omote H, Moriyama Y. Divalent cation transport by vesicular nucleotide transporter. J Biol Chem 2011; 286: 42881-7.
32. Bodin P, Burnstock G. Purinergic signalling: ATP release. Neurochem Res 2001; 26: 959-69.
33. Jedlitschky G, et al. The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood 2004; 104: 3603-10.
34. Jedlitschky G, Tirschmann K, Lubenow LE, et al. Role of MRP4 (ABCC4) in platelet adenine nucleotide-storage: evidence from patients with delta-storage pool deficiencies. Am J Pathol 2010; 176: 1097-103.
35. Schuldiner S, Avron M. On the mechanism of the energydependent quenching of atebrin fluorescence in isolated chloroplasts. FEBS Lett 1971; 14: 233-6.
36. Ohkuma S, Poole B. Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances. J Cell Biol 1981; 90: 656-64.
37. Pangrsic T, Potokar M, Stenovec M, et al. Exocytotic release of ATP from cultured astrocytes. J Biol Chem 2007; 282: 28749-58.
38. Moriyama Y, Takano T, Ohkuma S. Acridine orange as a fluorescent probe for lysosomal proton pump. J Biochem 1982; 92: 1333-6.
39. Larsson M, Sawada K, Morland C, et al. Functional and anatomical identification of a vesicular transporter mediating neuronal ATP release. Cereb Cortex 2012; 22: 1203-14.
40. Ohta Y, Nishikawa K, Hiroaki Y, Fujiyoshi Y. Electron tomographic analysis of gap junctions in lateral giant fibers of crayfish. J Struct Biol 2011; 175: 49-61.
41. Coco S, Calegari F, Pravettoni E, et al. Storage and release of ATP from astrocytes in culture. J Biol Chem 2003; 278: 1354-62.
42. Zhang Z, Chen G, Zhou W, et al. Regulated ATP release from astrocytes through lysosome exocytosis. Nat Cell Biol 2007; 9: 945-53.
43. Iwatsuki K, Ichikawa R, Hiasa M, Moriyama Y, Torii K, Uneyama H. Identification of the vesicular nucleotide transporter (VNUT) in taste cells. Biochem Biophys Res Commun 2009; 388: 1-5.
44. Mihara H, Boudaka A, Sugiyama T, Moriyama Y, Tominaga M. Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. J Physiol 2011; 589: 3471-82.
45. Wolf-Johnston AS, Hanna-Mitchell AT, Buffington CA, et al. Alterations in the non-neuronal acetylcholine synthesis and release machinery in esophageal epithelium. Life Sci 2012 electronic version
46. Vessey KA, Fletcher EL. Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse. PLoS One 2012; 7: e29990.
47. Haanes KA, Novak I. ATP storage and uptake by isolated pancreatic zymogen granules. Biochem J 2010; 429: 303-11.
48. Tokunaga A, Tsukimoto M, Harada H, Moriyama Y, Kojima S. Involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation. J Biol Chem 2010; 285: 17406-16.
49. Mutafova-Yambolieva VN, Hwang SJ, Hao X, et al. Betanicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle. Proc Natl Acad Sci USA 2007; 104: 16359-64.
50. Hwang SJ, Durnin L, Dwyer L, et al. β-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons. Gastroenterology 2011; 140: 608-617. e6.
51. Thompson CM, Davis E, Carrigan CN, Cox HD, Bridges RJ, Gerdes JM. Inhibitor of the glutamate vesicular transporter (VGLUT). Curr Med Chem 2005; 12: 2041-56.
52. Juge N, Gray JA, Omote H, et al. Metabolic control of vesicular glutamate transport and release. Neuron 2010; 68: 99-112.