The hidden price of repeated traumatic exposure

Stress

Volumn 17, Issue 4, 2014, Pages 343-351

  Levy Gigi, Einat ^a   Richter Levin, Gal ^a,b,c  

^a Institute for the Study of Affective Neuroscience   (Israel)

^b Department of Psychology ^*  (Israel)

^c UNIVERSITY OF HAIFA   (Israel)

Author keywords

Context; Firefighters; First responders; Hippocampus; Repeated exposure to trauma; Reversal learning

Indexed keywords

ADULT; ANXIETY; ARTICLE; ASSOCIATION; BECK DEPRESSION INVENTORY; BRAIN SIZE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; CUE CONTEXT REVERSAL PARADIGM; DEPRESSION; FEMALE; FIRE FIGHTER; FOLLOW UP; HIPPOCAMPAL DEFICIT; HUMAN; INTELLIGENCE QUOTIENT; LEARNING; MALE; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; OCCUPATIONAL EXPOSURE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SELF REPORT; STATE TRAIT ANXIETY INVENTORY; STIMULUS RESPONSE; TASK PERFORMANCE; AGED; HIPPOCAMPUS; LIFE EVENT; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL RATING SCALE;

ADULT; AGED; CUES; FEMALE; HIPPOCAMPUS; HUMANS; LEARNING; LIFE CHANGE EVENTS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; STRESS DISORDERS, POST-TRAUMATIC;

EID: 84903704193     PISSN: 10253890     EISSN: 16078888     Source Type: Journal    
DOI: 10.3109/10253890.2014.923397     Document Type: Article

References (56)

1. Acheson DT, Gresack JE, Risbrough VB. (2012). Hippocampal dysfunction effects on context memory: possible etiology for post-traumatic stress disorder. Neuropharmacology 62:674-85.
2. Beck AT, Steer RA, Brown GK. (1996). Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation.
3. Brown AD, Root JC, Romano TA, Chang LJ, Bryant RA, Hirst W. (2013). Overgeneralized autobiographical memory and future thinking in combat veterans with post-traumatic stress disorder. J Behav Ther Exp Psychiatry 44:129-34.
4. Buchel C, Dolan RJ, Armony JL, Friston KJ. (1999). Amygdalahippocampal involvement in human aversive trace conditioning revealed through event-related fMRI. J Neurosci 19:10869-76. (Pubitemid 30235731)
5. Chang CM, Lee LC, Connor KM, Davidson JR, Lai TJ. (2008). Modification effects of coping on post-traumatic morbidity among earthquake rescuers. Psychiatry Res 158:164-71.
6. Davachi L. (2006). Item, context and relational episodic encoding in humans. Curr Opin Neurobiol 16:693-700.
7. Del Ben KS, Scotti JR, Chen Y, Fortson BL. (2006). Prevalence of posttraumatic stress disorder symptoms in firefighters. Work Stress 20:37-48. (Pubitemid 43995256)
8. Diana RA, Yonelinas AP, Ranganath C. (2012). Adaptation to cognitive context and item information in the medial temporal lobes. Neuropsychologia 50:3062-9.
9. Dickerson BC, Eichenbaum H. (2010). The episodic memory system: neurocircuitry and disorders. Neuropsychopharmacology 35:86-104.
10. Fani N, Tone EB, Phifer J, Norrholm SD, Bradley B, Ressler KJ, Kamkwalala A, Jovanovic T. (2012). Attention bias toward threat is associated with exaggerated fear expression and impaired extinction in PTSD. Psychol Med 42:533-43.
11. Fellows LK, Farah MJ. (2003). Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm. Brain 126:1830-7. (Pubitemid 36917342)
12. First MB, Gibbon M, Spitzer RL, Williams JBW. (1996). User's Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders-Research Version. New York: Biometrics Research Department, New York State Psychiatric.
13. Foerde K, Shohamy D. (2011). Feedback timing modulates brain systems for learning in humans. J Neurosci 31:13157-67.
14. Fushimi M. (2012). Posttraumatic stress in professional firefighters in japan: rescue efforts after the Great East Japan Earthquake (higashi nihon dai-shinsai). Prehosp Disaster Med 27:416-18.
15. Giachero M, Calfa GD, Molina VA. (2013). Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning. Learn Mem 20:611-16.
16. Goosens KA. (2011). Hippocampal regulation of aversive memories. Curr Opin Neurobiol 21:460-6.
17. Guthrie RM, Bryant RA. (2006). Extinction learning before trauma and subsequent posttraumatic stress. Psychosom Med 68:307-11. (Pubitemid 43740136)
18. Hockley WE. (2008). The effects of environmental context on recognition memory and claims of remembering. J Exp Psychol Learn Mem Cogn 34:1412-29.
19. Isarida T, Isarin TK. (2007). Environmental context effects of background color in free recall. Mem Cognit 35:1620-9. (Pubitemid 350106127)
20. Karl A, Schaefer M, Malta LS, Dorfel D, Rohleder N, Werner A. (2006). A meta analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev 30:1004-31. (Pubitemid 44308647)
21. Kitayama N, Vaccarino V, Kutner M, Weiss P, Bremner JD. (2005). Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis. J Affect Disord 88:79-86. (Pubitemid 41160417)
22. Kleim B, Ehring T, Ehlers A. (2012). Perceptual processing advantages for trauma-related visual cues in post-traumatic stress disorder. Psychol Med 42:173-81.
23. LaBar KS, Cabeza R. (2006). Cognitive neuroscience of emotional memory. Nat Rev Neurosci 7:54-64. (Pubitemid 41828931)
24. Lang S, Kroll A, Lipinski SJ, Wessa M, Ridder S, Christmann C, Schad LR, Flor H. (2009). Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex. Eur J Neurosci 29:823-32.
25. Levy-Gigi E, Kelemen O, Gluck MA, Ke'ri S. (2011). Impaired context reversal learning, but not cue reversal learning, in patients with amnestic mild cognitive impairment. Neuropsychologia 49:3320-6.
26. Levy-Gigi E, Ke'ri S. (2012). Falling out of time: enhanced memory for scenes presented at behaviorally irrelevant points in time in Posttraumatic Stress Disorder (PTSD). PLoS One 7:e42502.
27. Levy-Gigi E, Ke'ri S, Myers CE, Lencovsky Z, Sharvit-Benbaji H, Orr SP, Gilbertson MW, et al. (2012). Individuals with post-traumatic stress disorder show a selective deficit in generalization of associative learning. Neuropsychology 26:758-67.
28. Levy-Gigi E, Szabo C, Richter-Levin G, Kéri S. (2014). Reduced hippocampal volume is associated with impaired generalization of negative context in individuals with PTSD. [Epub ahead of print].
29. Macken WJ. (2002). Environmental context and recognition: the role of recollection and familiarity. J Exp Psychol Learn Memory Cogn 28: 153-61.
30. Maren S, Phan KL, Liberzon I. (2013). The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat Rev Neurosci 14:417-28.
31. Mayes AR, MacDonald C, Donlan L, Pears J, Meudell PR. (1992). Amnesics have a disproportionately severe memory deficit for interactive context. Q J Exp Psychol 45:265-97.
32. Meyer EC, Zimering R, Daly E, Knight J, Kamholz BW, Gulliver SB. (2012). Predictors of posttraumatic stress disorder and other psychological symptoms in trauma-exposed firefighters. Psychol Serv 9: 1-15.
33. Moustafa AA, Gilbertson MW, Orr SP, Herzallah MM, Servatius RJ, Myers CE. (2013). A model of amygdala-hippocampal-prefrontal interaction in fear conditioning and extinction in animals. Brain Cogn 81:29-43.
34. Murnane K, Phelps M, Malmberg K. (1999). Context-dependent recognition memory: the ICE theory. J Exp Psychol 128:403-15.
35. Orr SP, Lasko NB, Macklin ML, Pineles SL, Chang Y, Pitman RK. (2012). Predicting post-trauma stress symptoms from pre-trauma psychophysiologic reactivity, personality traits and measures of psychopathology. Biol Mood Anxiety Disord 2:8. doi: 10.1186/ 2045-5380-2-8.
36. Phelps EA, O'Connor KJ, Gatenby JC, Gore JC, Grillon C, Davis M. (2001). Activation of the left amygdala to a cognitive representation of fear. Nat Neurosci 4:437-41. (Pubitemid 32260122)
37. Pole N, Neylan TC, Otte C, Henn-Hasse C, Metzler TJ, Marmar CR. (2009). Prospective prediction of posttraumatic stress disorder symptoms using fear potentiated auditory startle responses. Biol Psychiatry 65:235-40.
38. Rogers RD, Andrews TC, Grasby PM, Brooks DJ, Robbins TW. (2000). Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans. J Cogn Neurosci 12:142-62. (Pubitemid 30142790)
39. Rau V, DeCola JP, Fanselow MS. (2005). Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder. Neurosci Biobehav Rev 29:1207-23. (Pubitemid 41446896)
40. Rau V, Fanselow MS. (2009). Exposure to a stressor produces a long lasting enhancement of fear learning in rats. Stress 12:125-33.
41. Rudy JW. (2009). Context representations, context functions, and the parahippocampale-hippocampal system. Learn Mem 16:573-85.
42. Rutherford A. (2004). Environmental context-dependent recognition memory effects: an examination of ICE model and cue-overload hypotheses. Q J Exp Psychol A 57:107-27.
43. Smith AP, Henson RN, Dolan RJ, Rugg MD. (2004). fMRI correlates of the episodic retrieval of emotional contexts. Neuroimage 22:868-78. (Pubitemid 38759451)
44. Smith AP, Stephan KE, Rugg MD, Dolan RJ. (2006). Task and content modulate amygdala-hippocampal connectivity in emotional retrieval. Neuron 49:631-8. (Pubitemid 43221896)
45. Smith ME. (2005). Bilateral hippocampal volume reduction in adults with posttraumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus 15:798-807.
46. Soo J, Webber MP, Gustave J, Lee R, Hall CB, Cohen HW, Kelly KJ, Prezant DJ. (2011). Trends in probable PTSD in firefighters exposed to the World Trade Center disaster, 2001-2010. Disaster Med Public Health Prep 2:197-203.
47. Spielberger CD, Gorsuch RL, Lushene RE, Vagg PR. (1983). State-Trait Anxiety Inventory (STAI). Bib 2010:180.
48. Spitzer RL, Williams JB, Gibbon M, First MB. (1990). User's guide for the structured clinical interview for DSM-III-R: SCID. Washington, DC: American Psychiatric Press.
49. Spreen OA. Compendium of neuropsychological tests: administration, norms, and commentary. NY: Oxford University Press; 1998.
50. Stevens JS, Jovanovic T, Fani N, Ely TD, Glover EM, Bradley B, Ressler KJ. (2013). Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder. J Psychiatr Res 47:1469-78.
51. Tsoory MM, Guterman A, Richter-Levin G. (2010). "Juvenile stress" alters maturation-related changes in expression of the neural cell adhesion molecule L1 in the limbic system: relevance for stressrelated psychopathologies. J Neurosci Res 88:369-80.
52. Tversky A, Kahneman D, Choice R. (1981). The framing of decisions. Science 211:453-8.
53. Vythilingam M, Blair KS, McCaffrey D, Scaramozza M, Jones M, Nakic M, Mondillo K, et al. (2007). Biased emotional attention in post traumatic stress disorder: a help as well as a hindrance? Psychol Med 37:1445-55.
54. Wald I, Degnan KA, Gorodetsky E, Charney DS, Fox NA, Fruchter E, Goldman D, et al. (2013). Attention to threats and combat-related posttraumatic stress symptoms: prospective associations and moderation by the serotonin transporter gene. JAMA Psychiatry 70:401-8.
55. Wechsler D. (1997). Wechsler Adult Intelligence Scale -Third addition. San Antonio: The Psychological Corporation.
56. Woon FL, Sood S, Hedges DW. (2010). Hippocampal volume deficits associated with exposure to psychological trauma and post-traumatic stress disorder in adults: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 34:1181-8.