Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: Comparison with celecoxib

Toxicology and Applied Pharmacology

Volumn 279, Issue 2, 2014, Pages 129-140

  Darwish, Hebatallah A ^a   Arab, Hany H ^a   Abdelsalam, Rania M ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Apoptosis; Celecoxib; Chrysin; Inflammation; Rheumatoid arthritis; Testicular dysfunction

Indexed keywords

CASPASE 3; CELECOXIB; CHRYSIN; CYCLOOXYGENASE 2; FAS LIGAND; FOLLITROPIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LUTEINIZING HORMONE; MYELOPEROXIDASE; NITRIC OXIDE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RHEUMATOID ARTHRITIS; TESTIS INJURY; TESTOSTERONE BLOOD LEVEL;

APOPTOSIS; CELECOXIB; CHRYSIN; INFLAMMATION; RHEUMATOID ARTHRITIS; TESTICULAR DYSFUNCTION;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; ARTHRITIS, EXPERIMENTAL; CASPASE 3; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FAS LIGAND PROTEIN; FLAVONOIDS; FOLLICLE STIMULATING HORMONE; INFLAMMATION; INFLAMMATION MEDIATORS; LUTEINIZING HORMONE; MALE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PEROXIDASE; PHOSPHOPROTEINS; PYRAZOLES; RATS; RATS, WISTAR; RNA, MESSENGER; SPERMATOGENESIS; SULFONAMIDES; TESTIS; TESTOSTERONE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84903650172     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.05.018     Document Type: Article

References (52)

1. Agha A.M., Gad M.Z. Lipid peroxidation and lysosomal integrity in different inflammatory models in rats: the effects of indomethacin and naftazone. Pharmacol. Res. 1995, 32:279-285.
2. Ahn J.H., Park S.M., Cho H.S., Lee M.S., Yoon J.B., Vilcek J., Lee T.H. Non-apoptotic signaling pathways activated by soluble Fas ligand in serum-starved human fibroblasts. Mitogen-activated protein kinases and NF-kappaB-dependent gene expression. J. Biol. Chem. 2001, 276:47100-47106.
3. Ali N., Rashid S., Nafees S., Hasan S.K., Sultana S. Beneficial effects of chrysin against methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis. Mol. Cell. Biochem. 2014, 385:215-223.
4. Arab H.H., El-Sawalhi M.M. Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators. Toxicol. Appl. Pharmacol. 2013, 268:241-248.
5. Bain J. The many faces of testosterone. Clin. Interv. Aging 2007, 2:567-576.
6. Bove R. Autoimmune diseases and reproductive aging. Clin. Immunol. 2013, 149:251-264.
7. Breikaa R.M., Mosli H.A., Nagy A.A., Abdel-Naim A.B. Adverse testicular effects of Botox in mature rats. Toxicol. Appl. Pharmacol. 2014, 275:182-188.
8. Bruot B.C., Clemens J.W. Regulation of testosterone production in the adjuvant-induced arthritic rat. J. Androl. 1992, 13:87-92.
9. Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods Enzymol. 1978, 52:302-310.
10. Buvat J., Maggi M., Guay A., Torres L.O. Testosterone deficiency in men: systematic review and standard operating procedures for diagnosis and treatment. J. Sex. Med. 2013, 10:245-284.
11. Chandra J., Samali A., Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 2000, 29:323-333.
12. Ciftci O., Ozdemir I., Aydin M., Beytur A. Beneficial effects of chrysin on the reproductive system of adult male rats. Andrologia 2012, 44:181-186.
13. Clemens J.W., Bruot B.C. Testicular dysfunction in the adjuvant-induced arthritic rat. J. Androl. 1989, 10:419-424.
14. Cutolo M., Balleari E., Giusti M., Intra E., Accardo S. Androgen replacement therapy in male patients with rheumatoid arthritis. Arthritis Rheum. 1991, 34:1-5.
15. Cutolo M., Seriolo B., Villaggio B., Pizzorni C., Craviotto C., Sulli A. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann. N. Y. Acad. Sci. 2002, 966:131-142.
16. Cutolo M., Sulli A., Pizzorni C., Craviotto C., Straub R.H. Hypothalamic-pituitary-adrenocortical and gonadal functions in rheumatoid arthritis. Ann. N. Y. Acad. Sci. 2003, 992:107-117.
17. Dhawan K., Kumar S., Sharma A. Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats. J. Med. Food 2002, 5:43-48.
18. Eiserich J.P., Hristova M., Cross C.E., Jones A.D., Freeman B.A., Halliwell B., van der Vliet A. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 1998, 391:393-397.
19. Ernestam S., Hafstrom I., Werner S., Carlstrom K., Tengstrand B. Increased DHEAS levels in patients with rheumatoid arthritis after treatment with tumor necrosis factor antagonists: evidence for improved adrenal function. J. Rheumatol. 2007, 34:1451-1458.
20. Fernandes-Alnemri T., Litwack G., Alnemri E.S. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J. Biol. Chem. 1994, 269:30761-30764.
21. Gambelunghe C., Rossi R., Sommavilla M., Ferranti C., Ciculi C., Gizzi S., Micheletti A., Rufini S. Effects of chrysin on urinary testosterone levels in human males. J. Med. Food 2003, 6:387-390.
22. Gordon D., Beastall G.H., Thomson J.A., Sturrock R.D. Androgenic status and sexual function in males with rheumatoid arthritis and ankylosing spondylitis. Q. J. Med. 1986, 60:671-679.
23. Hall G.M., Larbre J.P., Spector T.D., Perry L.A., Da Silva J.A. A randomized trial of testosterone therapy in males with rheumatoid arthritis. Br. J. Rheumatol. 1996, 35:568-573.
24. Jacobo P.V., Fass M., Perez C.V., Jarazo-Dietrich S., Lustig L., Theas M.S. Involvement of soluble Fas ligand in germ cell apoptosis in testis of rats undergoing autoimmune orchitis. Cytokine 2012, 60:385-392.
25. Jana K., Yin X., Schiffer R.B., Chen J.J., Pandey A.K., Stocco D.M., Grammas P., Wang X. Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells. J. Endocrinol. 2008, 197:315-323.
26. Jimenez-Balderas F.J., Tapia-Serrano R., Fonseca M.E., Arellano J., Beltran A., Yanez P., Camargo-Coronel A., Fraga A. High frequency of association of rheumatic/autoimmune diseases and untreated male hypogonadism with severe testicular dysfunction. Arthritis Res. 2001, 3:362-367.
27. Jurcovicova J., Svik K., Scsukova S., Bauerova K., Rovensky J., Stancikova M. Methotrexate treatment ameliorated testicular suppression and anorexia related leptin reduction in rats with adjuvant arthritis. Rheumatol. Int. 2009, 29:1187-1191.
28. Karagiannis A., Harsoulis F. Gonadal dysfunction in systemic diseases. Eur. J. Endocrinol. 2005, 152:501-513.
29. Khan R., Khan A.Q., Qamar W., Lateef A., Tahir M., Rehman M.U., Ali F., Sultana S. Chrysin protects against cisplatin-induced colon. Toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. Toxicol. Appl. Pharmacol. 2012, 258:315-329.
30. Khayyal M.T., El-Ghazaly M.A., Abdallah D.M., Okpanyi S.N., Kelber O., Weiser D. Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Arzneimittelforschung 2005, 55:677-687.
31. Krawisz J.E., Sharon P., Stenson W.F. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 1984, 87:1344-1350.
32. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408.
33. Malek H.A., Saleh D.M. Cyclooxygenase-2 inhibitor celecoxib in a rat model of hindlimb ischemia reperfusion. Can. J. Physiol. Pharmacol. 2009, 87:353-359.
34. Matsuno H., Yudoh K., Watanabe Y., Nakazawa F., Aono H., Kimura T. Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand. J. Rheumatol. 2001, 28:22-28.
35. Miranda K.M., Espey M.G., Wink D.A. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001, 5:62-71.
36. Morton D., Weisbrode S.E., Wyder W.E., Maurer J.K., Capen C.C. Spermatid giant cells, tubular hypospermatogenesis, spermatogonial swelling, cytoplasmic vacuoles, and tubular dilatation in the testes of normal rabbits. Vet. Pathol. 1986, 23:176-183.
37. Nagata S. Fas ligand-induced apoptosis. Annu. Rev. Genet. 1999, 33:29-55.
38. Ozturk H., Terzi E.H., Bugdayci G., Duran A. Interleukin 10 reduces testicular damage in experimental testicular ischemia/reperfusion injury. Urology 2013, 10.1016/j.urology.2013.09.027.
39. Page S.T., Plymate S.R., Bremner W.J., Matsumoto A.M., Hess D.L., Lin D.W., Amory J.K., Nelson P.S., Wu J.D. Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolites. Am. J. Physiol. Endocrinol. Metab. 2006, 290:E856-E863.
40. Perez C.V., Theas M.S., Jacobo P.V., Jarazo-Dietrich S., Guazzone V.A., Lustig L. Dual role of immune cells in the testis: protective or pathogenic for germ cells?. Spermatogenesis 2013, 3:e23870.
41. Pushpavalli G., Kalaiarasi P., Veeramani C., Pugalendi K.V. Effect of chrysin on hepatoprotective and antioxidant status in d-galactosamine-induced hepatitis in rats. Eur. J. Pharmacol. 2010, 631:36-41.
42. Rehman M.U., Tahir M., Khan A.Q., Khan R., Lateef A., Oday O.H., Qamar W., Ali F., Sultana S. Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-kappaB. Toxicol. Lett. 2013, 216:146-158.
43. Selmanoglu G., Kockaya E.A., Akay M.T., Kismet K. Subacute toxicity of celecoxib on thyroid and testis of rats: hormonal and histopathological changes. Environ. Toxicol. Pharmacol. 2006, 22:85-89.
44. Steinbach G., Lynch P.M., Phillips R.K., Wallace M.H., Hawk E., Gordon G.B., Wakabayashi N., Saunders B., Shen Y., Fujimura T., Su L.K., Levin B., Godio L., Patterson S., Rodriguez-Bigas M.A., Jester S.L., King K.L., Schumacher M., Abbruzzese J., DuBois R.N., Hittelman W.N., Zimmerman S., Sherman J.W., Kelloff G. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N. Engl. J. Med. 2000, 342:1946-1952.
45. Taneli F., Vatansever S., Ulman C., Yilmaz O., Giray G., Genc A., Taneli C. The effect of spermatic vessel ligation on testicular nitric oxide levels and germ cell-specific apoptosis in rat testis. Acta Histochem. 2005, 106:459-466.
46. Tengstrand B., Carlstrom K., Hafstrom I. Bioavailable testosterone in men with rheumatoid arthritis-high frequency of hypogonadism. Rheumatology (Oxford) 2002, 41:285-289.
47. Vaithinathan S., Saradha B., Mathur P.P. Methoxychlor induces apoptosis via mitochondria- and FasL-mediated pathways in adult rat testis. Chem. Biol. Interact. 2010, 185:110-118.
48. Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 2007, 39:44-84.
49. Wang X., Shen C.L., Dyson M.T., Eimerl S., Orly J., Hutson J.C., Stocco D.M. Cyclooxygenase-2 regulation of the age-related decline in testosterone biosynthesis. Endocrinology 2005, 146:4202-4208.
50. Wang R.S., Yeh S., Tzeng C.R., Chang C. Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice. Endocr. Rev. 2009, 30:119-132.
51. Winnall W.R., Muir J.A., Liew S., Hirst J.J., Meachem S.J., Hedger M.P. Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-treated rats. Int. J. Androl. 2009, 32:542-555.
52. Woo K.J., Jeong Y.J., Inoue H., Park J.W., Kwon T.K. Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Lett. 2005, 579:705-711.