Weighted-incidence syndromic combination antibiograms to guide empiric treatment of critical care infections: A retrospective cohort study

Critical Care

Volumn 18, Issue 3, 2014, Pages

  Randhawa, Varinder ^a   Sarwar, Syed ^b   Walker, Sandra ^c,d   Elligsen, Marion ^c   Palmay, Lesley ^c   Daneman, Nick ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b Canada   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTAZIDIME; CEFTRIAXONE; CIPROFLOXACIN; CLOXACILLIN; ERTAPENEM; LINEZOLID; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; TOBRAMYCIN; VANCOMYCIN; ANTIINFECTIVE AGENT;

ADULT; AGED; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; ARTIFICIAL VENTILATION; CATHETER INFECTION; COHORT ANALYSIS; CRITICALLY ILL PATIENT; FEMALE; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MORTALITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; VENTILATOR ASSOCIATED PNEUMONIA; WEIGHTED INCIDENCE SYNDROMIC COMBINATION ANTIBIOGRAM; ADVERSE EFFECTS; BACTEREMIA; CATHETERIZATION; CROSS INFECTION; MICROBIAL SENSITIVITY TEST; MIDDLE AGED; PNEUMONIA, VENTILATOR-ASSOCIATED; PROCEDURES; TREATMENT OUTCOME;

ADULT; AGED; ANTI-BACTERIAL AGENTS; BACTEREMIA; CATHETERIZATION; CRITICAL CARE; CROSS INFECTION; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; PNEUMONIA, VENTILATOR-ASSOCIATED; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84903640384     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13901     Document Type: Article

References (25)

1. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Kumar A, Cheang M. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006, 34:1589-1596. 10.1097/01.CCM.0000217961.75225.E9, 16625125.
2. Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 2002, 122:262-268. 10.1378/chest.122.1.262, 12114368.
3. Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 1999, 115:462-474. 10.1378/chest.115.2.462, 10027448.
4. Kaki R, Elligsen M, Walker S, Simor A, Palmay L, Daneman N. Impact of antimicrobial stewardship in critical care: a systematic review. J Antimicrob Chemother 2011, 66:1223-1230. 10.1093/jac/dkr137, 21460369.
5. Hebert C, Ridgway J, Vekhter B, Brown EC, Weber SG, Robicsek A. Demonstration of the weighted-incidence syndromic combination antibiogram: an empiric prescribing decision aid. Infect Control Hosp Epidemiol 2012, 33:381-388. 10.1086/664768, 22418634.
6. Critical Care Secretariat Health Quality Ontario- Information about Patient Safety Quality Indicators 2012, [http://www.hqontario.ca/public-reporting/patient-safety/information-about-patient-safety-quality-indicators], Critical Care Secretariat.
7. Nolte FS, Williams JM, Jerris RC, Morello JA, Leitch CD, Matushek S, Schwabe LD, Dorigan F, Kocka FE. Multicenter clinical evaluation of a continuous monitoring blood culture system using fluorescent-sensor technology (BACTEC 9240). J Clin Microbiol 1993, 31:552-557. 262818, 8458950.
8. Elligsen M, Walker S, Simor A, Daneman N. Prospective Audit and Feedback of Antimicrobial Stewardship in Critical Care: Program Implementation, Experience, and Challenges. Can J Hosp Pharm 2012, 65:31-36. 3282196, 22479110.
9. Rotstein C, Evans G, Born A, Grossman R, Light RB, Magder S, McTaggart B, Weiss K, Zhanel GG. Clinical practice guidelines for hospital-acquired pneumonia and ventilator-associated pneumonia in adults. Can J Infect Dis Med Microbiol 2008, 19:19-53. 2610276, 19145262.
10. Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'Grady NP, Raad II, Rijnders BJ, Sherertz RJ, Warren DK. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis 2009, 49:1-45. 10.1086/599376, 4039170, 19489710.
11. Sievert DM, Ricks P, Edwards JR, Schneider A, Patel J, Srinivasan A, Kallen A, Limbago B, Fridkin S. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010. Infect Control Hosp Epidemiol 2013, 34:1-14. 10.1086/668770, 23221186.
12. Zhanel GG, DeCorby M, Laing N, Weshnoweski B, Vashisht R, Tailor F, Nichol KA, Wierzbowski A, Baudry PJ, Karlowsky JA, Lagace-Wiens P, Walkty A, McCracken M, Mulvey MR, Johnson J, Hoban DJ. Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. Antimicrob Agents Chemother 2008, 52:1430-1437. 10.1128/AAC.01538-07, 2292546, 18285482.
13. Garnacho-Montero J, bo-Pallas T, Garnacho-Montero C, Cayuela A, Jimenez R, Barroso S, Ortiz-Leyba C. Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis. Crit Care 2006, 10:R111. 10.1186/cc4995, 1751000, 16859504.
14. Gaieski DF, Mikkelsen ME, Band RA, Pines JM, Massone R, Furia FF, Shofer FS, Goyal M. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010, 38:1045-1053. 10.1097/CCM.0b013e3181cc4824, 20048677.
15. Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Horton JM, Studnek JR, Kline JA, Jones AE. Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med 2011, 39:2066-2071. 10.1097/CCM.0b013e31821e87ab, 3158284, 21572327.
16. Corona A, Bertolini G, Lipman J, Wilson AP, Singer M. Antibiotic use and impact on outcome from bacteraemic critical illness: the BActeraemia Study in Intensive Care (BASIC). J Antimicrob Chemother 2010, 65:1276-1285. 10.1093/jac/dkq088, 20335186.
17. Eachempati SR, Hydo LJ, Shou J, Barie PS. The pathogen of ventilator-associated pneumonia does not influence the mortality rate of surgical intensive care unit patients treated with a rotational antibiotic system. Surg Infect (Larchmt) 2010, 11:13-20. 10.1089/sur.2008.025, 20163258.
18. Piskin N, Aydemir H, Oztoprak N, Akduman D, Comert F, Kokturk F, Celebi G. Inadequate treatment of ventilator-associated and hospital-acquired pneumonia: risk factors and impact on outcomes. BMC Infect Dis 2012, 12:268. 10.1186/1471-2334-12-268, 3511218, 23095664.
19. Hranjec T, Rosenberger LH, Swenson B, Metzger R, Flohr TR, Politano AD, Riccio LM, Popovsky KA, Sawyer RG. Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study. Lancet Infect Dis 2012, 12:774-780. 10.1016/S1473-3099(12)70151-2, 3462590, 22951600.
20. Melsen WG, Rovers MM, Groenwold RH, Bergmans DC, Camus C, Bauer TT, Hanisch EW, Klarin B, Koeman M, Krueger WA, Lacherade JC, Lorente L, Memish ZA, Morrow LE, Nardi G, van Nieuwenhoven CA, O'Keefe GE, Nakos G, Scannapieco FA, Seguin P, Staudinger T, Topeli A, Ferrer M, Bonten MJ. Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies. Lancet Infect Dis 2013, 13:665-671. 10.1016/S1473-3099(13)70081-1, 23622939.
21. Klompas M. Interobserver variability in ventilator-associated pneumonia surveillance. Am J Infect Control 2010, 38:237-239. 10.1016/j.ajic.2009.10.003, 20171757.
22. Dotson RG, Pingleton SK. The effect of antibiotic therapy on recovery of intracellular bacteria from bronchoalveolar lavage in suspected ventilator-associated nosocomial pneumonia. Chest 1993, 103:541-546. 10.1378/chest.103.2.541, 8432151.
23. Torres A, el-Ebiary M, Padro L, Gonzalez J, de La Bellacasa JP, Ramirez J, Xaubet A, Ferrer M, Rodriguez-Roisin R. Validation of different techniques for the diagnosis of ventilator-associated pneumonia. Comparison with immediate postmortem pulmonary biopsy. Am J Respir Crit Care Med 1994, 149:324-331. 10.1164/ajrccm.149.2.8306025, 8306025.
24. Klompas M. Does this patient have ventilator-associated pneumonia?. JAMA 2007, 297:1583-1593. 10.1001/jama.297.14.1583, 17426278.
25. Rea-Neto A, Youssef NC, Tuche F, Brunkhorst F, Ranieri VM, Reinhart K, Sakr Y. Diagnosis of ventilator-associated pneumonia: a systematic review of the literature. Crit Care 2008, 12:R56. 10.1186/cc6877, 2447611, 18426596.