Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications

Biometrical Journal

Volumn 56, Issue 4, 2014, Pages 614-630

  Graf, Alexandra C ^a,b   Bauer, Peter ^a   Glimm, Ekkehard ^c   Koenig, Franz ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF BREMEN   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Conditional error function; Interim analysis; Maximum type 1 error; Sample size reassessment; Treatment selection

Indexed keywords

ERROR ANALYSIS; ERROR STATISTICS; SAMPLING;

CONDITIONAL ERROR FUNCTION; ERROR RATE; ERROR-FUNCTION; INTERIM ANALYSIS; MAXIMUM TYPE 1 ERROR; MAXIMUM TYPES; SAMPLE SIZE REASSESSMENT; SAMPLE SIZES; SIZE MODIFICATION; TREATMENT SELECTION;

STATISTICAL TESTS;

BIOMETRY; CLINICAL TRIAL (TOPIC); DECISION MAKING; HUMAN; METHODOLOGY; PROCEDURES; SAMPLE SIZE;

BIOMETRY; CLINICAL TRIALS AS TOPIC; DECISION MAKING; HUMANS; RESEARCH DESIGN; SAMPLE SIZE;

EID: 84903637900     PISSN: 03233847     EISSN: 15214036     Source Type: Journal    
DOI: 10.1002/bimj.201300153     Document Type: Article

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