Cognitive and autonomic dysfunction in presymptomatic and early Huntington's disease

Journal of Neurology

Volumn 261, Issue 6, 2014, Pages 1119-1125

  Kobal, Jan ^a   Melik, Ziva ^b   Cankar, Ksenija ^b   Strucl, Martin ^b  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Cardiovascular autonomic tests; Cognitive dsyfunction; Huntington's disease; Laser Doppler fluxmetry

Indexed keywords

ADULT; ARTICLE; ASYMPTOMATIC DISEASE; AUTONOMIC DYSFUNCTION; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD PRESSURE MONITOR; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIGIT SYMBOL SUBSTITUTION TEST; DOPPLER FLOWMETER; EARLY HUNTINGTON DISEASE; ELECTROCARDIOGRAM; HEART RATE; HETEROZYGOTE; HUMAN; HUNTINGTON CHOREA; LASER DOPPLER FLOWMETRY; MENTAL ARITHMETIC; MICROVASCULARIZATION; MOTOR PERFORMANCE; PRIORITY JOURNAL; REST; SYSTOLIC BLOOD PRESSURE; UNIFIED HUNTINGTON DISEASE RATING SCALE; ANALYSIS OF VARIANCE; AUTONOMIC NERVOUS SYSTEM DISEASES; BLOOD PRESSURE; COGNITION DISORDERS; COMPLICATION; DISABILITY; FEMALE; MALE; MATHEMATICS; NEUROLOGIC EXAMINATION; NEUROPSYCHOLOGICAL TEST; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL;

ADULT; ANALYSIS OF VARIANCE; ASYMPTOMATIC DISEASES; AUTONOMIC NERVOUS SYSTEM DISEASES; BLOOD PRESSURE; COGNITION DISORDERS; DISABILITY EVALUATION; FEMALE; HEART RATE; HUMANS; HUNTINGTON DISEASE; LINEAR MODELS; MALE; MATHEMATICS; NEUROLOGIC EXAMINATION; NEUROPSYCHOLOGICAL TESTS; SEVERITY OF ILLNESS INDEX;

EID: 84903625583     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-014-7319-6     Document Type: Article

References (39)

1. Gutekunst CA, Norflus F, Hersch SM (2002) The neuropathology of Huntington's disease. In: Bates G, Harper PS, Jones L (eds) Huntington's disease. Oxford University Press, New York, pp 251-275
2. Den Heijer JC, Bollen WL, Reulenm JP (1988) Autonomic nervous function in Huntington's disease. Arch Neurol 45:309-312
3. Kobal J, Meglic B, Mesec A et al (2004) Early sympathetic hyperactivity in Huntington's disease. Eur J Neurol 11:842-848
4. Kremer B (2002) Clinical neurology of Huntington's disease. Diversity in unity, unity in diversity. In: Bates G, Harper PS, Jones L (eds) Huntington's disease. Oxford University Press, New York, pp 28-61
5. Kirkwood SC, Siemers E, Hodes ME et al (2000) Subtle changes among presymptomatic carriers of the Huntington's disease gene. J Neurol Neurosurg Psychiatry 69:773-779
6. Begeti F, Tan AYK, Cummins GA et al (2013) The Addenbrooke's cognitive examination-revised accurately detects cognitive decline in Huntington's disease. J Neurol 260:2777-2785
7. Wolf RC, Sambataro F, Vasic N et al (2008) Altered frontostriatal coupling in pre-manifest Huntington's disease: effects of increasing cognitive load. Eur J Neurol 15:1180-1190
8. Paulsen JS, Zimbelman JL, Hinton SC et al (2004) fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's disease. Am J Neuroradiol 25:1715-1721
9. Rosas HD, Salat DH, Lee SY et al (2008) Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity. Brain 131:1057-1068
10. Rosas HD, Hevelone ND, Zaleta AK et al (2005) Regional cortical thinning in preclinical Huntington disease and its relationship to cognition. Neurology 65:745-747
11. Wolf RC, Vasic N, Schönfeldt-Lecuona C et al (2007) Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI. Brain 130:2845-2857
12. Aziz NA, Anguelova GV, Marinus J et al (2010) Autonomic symptoms in patients and pre-manifest mutation carriers of Huntington's disease. Eur J Neurol 17:1068-1074
13. Andrich J, Schmitz T, Saft C et al (2002) Autonomic nervous system function in Huntington's disease. J Neurol Neurosurg Psychiatry 72:726-731
14. Kobal J, Melik Z, Cankar K et al (2010) Autonomic dysfunction in presymptomatic and early symptomatic Huntington's disease. Acta Neurol Scand 121:392-399
15. Melik Z, Kobal J, Cankar K et al (2012) Microcirculation response to local cooling in patients with Huntington's disease. J Neurol 295:921-928
16. Bennaroch EE (1993) The central autonomic network: functional organisation, dysfunction and perspective. Mayo Clin Proc 68:988-1001
17. Aylward EH, Nopoulos PC, Ross CA et al (2011) Longitudinal change in regional brain volumes in prodromal Huntington's disease. J Neurol Neurosurg Psychiatry 82:405-410
18. Peckerman A, la Manca JJ, Smith SL (2000) Cardiovascular stress responses and their relation to symptoms of gulf war veterans with fatiguing illness. Psychosom Med 62:509-516
19. Rupp J, Blekher T, Jackson J et al (2010) Progression in prediagnostic Huntington disease. J Neurol Neurosurg Psychiatry 81:379-384
20. Huntington Study Group (1996) Unified Huntington's disease rating scale: reliability and consistency. Mov Disord 11:135-142
21. Yvonne-Tee GB, Rasool AH, Halim AS et al (2006) Noninvasive assessment of cuteneous vascular function in vivo using capillaroscopy, pletismography and Laser-Doppler instruments; its strengths and weaknesses. Clin Hemorheol Microcirc 34:457-473
22. Snowden JS, Craufurd D, Thompson J et al (2002) Psychomotor, executive and memory function in preclinical Huntington's disease. J Clin Exp Neuropsychol 24:133-145
23. Paulsen JS, Smith MM, Long JD, the PREDICT investigators and coordinators of the Huntington Study Group (2013) Cognitive decline in prodromal Huntington Disease: implications for clinical trials. J Neurol Neurosurg Psychiatry 84:1233-1239
24. The Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72:971-983
25. Tonkin AL, Frewin DB (2002) Drugs, chemicals and toxins that alter autonomic function. In: Mathias CJ, Bannister R (eds) Autonomic failure. Oxford University Press, Oxford, pp 527-533
26. Low PA, Pfeiffer MA (1993) Standardization of clinical tests for practice and clinical trials. In: Low PA (ed) Clinical autonomic disorders: evaluation and management. Little Brown, Boston, pp 728-745
27. Malik M (1996) Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation 93:1043-1065
28. Stein PK, Kleiger RE (1999) Insights from the study of heart rate variability. Annu Rev Med 50:249-261
29. Parati G, Di Renzo M, Mancia G (2000) How to measure baroreflex sensitivity: from the cardiovascular laboratory to daily life. J Hypertens 18:7-19
30. Ostergren J, Kahan T, Hjemdahl P et al (1992) Effects of sympatho-adrenal activation on the finger microcirculation in mild hypertension. J Hum Hypertens 6:169-173
31. Thomaides TN, Zoukos Y, Chauhuri KR et al (1993) Physiological assessment of aspects of autonomic function in patients secondary progressive multiple sclerosis. J Neurol 240:139-143
32. Jänig W, Häbler HJ (2003) Neurophysiological analysis of target-related sympathetic pathways - from animal to human: similarities and differences. Acta Physiol Scand 177:255-274
33. Paulsen JS, Nopopulos PC, Aylward E et al (2010) Striatal and white matter predictors of estimated diagnosis for Huntington disease. Brain Res Bull 82:201-207
34. Rosas HD, Reuter M, Doros G et al (2011) A tale of two factors: what determines rate of progression in Huntington disease? A longitudinal MRI study. Mov Disord 26:1691-1697
35. Squitieri F, Cannella M, Giallonardo P et al (2001) Onset and pre-onset studies to define the Huntington's disease natural history. Brain Res Bull 56:233-238
36. Sprengelmeyer R, Orth M, Müller HP et al (2013) The neuroanatomy of subthreshold depressive symptoms in Huntington's disease: a combined diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) study. Psychol Med 7:1-12 [Epub ahead of print]
37. Li SH, Li XJ (2004) Huntingtin and its role in neuronal degeneration. Neuroscientist 10:467-475
38. Griffioen KJ, Wan R, Brown TR et al (2012) Aberrant heart rate and brainstem BDNF signaling in a mouse model of Huntington's disease. Neurobiol Aging. doi: 10.1016/j.neurobiolaging.2011.11.030
39. Pattison JS, Robbins J (2008) Protein misfolding and cardiac disease: establishing cause and effect. Autophagy 4:821-823