Revised NMR data for 9-O-demethylgalanthine: An alkaloid from Zephyranthes robusta (Amaryllidaceae) and its biological activity

Natural Product Communications

Volumn 9, Issue 6, 2014, Pages 787-788

  Šafratová, Marcela ^a   Novák, Zdeněk ^b   Kulhánková, Andrea ^a   Kuneš, Jiří ^b   Hrabinová, Martina ^c   Jun, Daniel ^d   Macáková, Kateřina ^a   Opletal, Lubomír ^a   Cahlíková, Lucie ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^d UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

9 O demethylgalanthine; Amaryllidaceae; Prolyl oligopeptidase inhibition activity; Zephyranthes robusta

Indexed keywords

9 O DEMETHYLGALANTHINE; ACETYLCHOLINESTERASE; ALKALOID DERIVATIVE; CHOLINESTERASE; PROLYL ENDOPEPTIDASE; PROLYL ENDOPEPTIDASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ACTIVITY; DRUG ISOLATION; ENZYME INHIBITION; HETERONUCLEAR MULTIPLE BOND CORRELATION; IC 50; MEDICINAL PLANT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; ZEPHYRANTHES ROBUSTA;

AMARYLLIDACEAE ALKALOIDS; CHOLINESTERASE INHIBITORS; LILIACEAE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PHENANTHRIDINES;

EID: 84903603373     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1400900614     Document Type: Article

References (9)

1. (a) Cahlíková L, Kulhánková A, Urbanová K, Macáková K, Kuneš J. (2010) Analysis of Amaryllidaceae alkaloids from Zephyranthes robusta and their cholinesterase activity. Natural Product Communications, 5, 1201-1204;
2. (b) Kulhánková A, Cahlíková L, Novák Z, Macáková K, Kuneš J, Opletal L. (2013) Alkaloids from Zephyranthes robusta Baker and their acetylcholinesterase- and butyrylcholinesterase-inhibitory activity. Chemistry & Biodiversity, 10, 1120-1127;
3. (c) Kobayashi S, Ishikawa H, Kihara M, Shingu T, Hashimoto T. (1977) Isolation of carinatine and pretazettine from the bulbs of Zephyranthes carinata Herb. (Amaryllidaceae). Chemical & Pharmaceutical Bulletin, 25, 2244-2248.
4. (a) Jitsuno M, Yokosuka A, Sakagami H, Mimaki Y. (2009) Chemical constituents of the bulbs of Habranthus brachyandrus and their cytotoxic activities. Chemical & Pharmaceutical Bulletin, 57, 1153-1157;
5. (b) Li H, Wang H, Chen JH, Wang LH, Zhang HS, Fan Y. (2003) Determination of amino acid neurotransmitters in cerebral cortex of rats administered with baicalin prior to cerebral ischemia by capillary electrophoresis-laser-induced fluorescence detection. Journal of Chromatography B, 788, 93-101;
6. (c) Lee H, Yang LL, Wang CC, Hu SY, Chang SF, Lee YH. (2003) Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. Brain Research, 986, 103-113;
7. (d) Toide K, Shinoda M, Fujiwara T, Iwamoto Y. (1997) Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and central cholinergic neurons in aged rats. Pharmacology, Biochemistry and Behavior, 56, 427-434.
8. (a) Tarragó T, Kichik N, Claasen B, Prades R, Teixidó M, Giralt E. (2008) Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorganic & Medicinal Chemistry, 16, 7516-7524;
9. (b) Cahlíková L, Hrabinová M, Kulhá nková A, Benešová N, Chlebek J, Jun D, Novák Z, Macáková K, Kuneš J, Kuča K, Opletal L. (2013) Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyloligopeptidase activities. Natural Product Communications, 8, 1541-1544.