-
1
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against her2 for metastatic breast cancer that overexpresses HER2
-
DOI 10.1056/NEJM200103153441101
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344:783-92. (Pubitemid 32222155)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
2
-
-
62649116580
-
The role of Neuregulin-1 beta/ErbB signaling in the heart
-
Pentassuglia L, Sawyer DB. The role of Neuregulin-1 beta/ErbB signaling in the heart. Exp Cell Res. 2009;315:627-37.
-
(2009)
Exp Cell Res
, vol.315
, pp. 627-637
-
-
Pentassuglia, L.1
Sawyer, D.B.2
-
3
-
-
0028827104
-
Multiple essential functions of neuregulin in development
-
Meyer D, Birchmeier C. Multiple essential functions of neuregulin in development. Nature. 1995;378:386-90.
-
(1995)
Nature
, vol.378
, pp. 386-390
-
-
Meyer, D.1
Birchmeier, C.2
-
4
-
-
0028884413
-
Requirement for neuregulin receptor erbB2 in neural and cardiac development
-
Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature. 1995;378:394-8.
-
(1995)
Nature
, vol.378
, pp. 394-398
-
-
Lee, K.F.1
Simon, H.2
Chen, H.3
Bates, B.4
Hung, M.C.5
Hauser, C.6
-
5
-
-
42749093499
-
ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium
-
Fuller SJ, Sivarajah K, Sugden PH. ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium. J Mol Cell Cardiol. 2008;44:831-54.
-
(2008)
J Mol Cell Cardiol
, vol.44
, pp. 831-854
-
-
Fuller, S.J.1
Sivarajah, K.2
Sugden, P.H.3
-
6
-
-
0037429649
-
Neuregulins: Functions, forms, and signaling strategies
-
DOI 10.1016/S0014-4827(02)00102-7
-
Falls DL. Neuregulins: functions, forms, and signaling strategies. Exp Cell Res. 2003;284:14-30. (Pubitemid 36335807)
-
(2003)
Experimental Cell Research
, vol.284
, Issue.1
, pp. 14-30
-
-
Falls, D.L.1
-
7
-
-
0028785406
-
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
-
Gassmann M, Casagranda F, Orioli D, et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature. 1995;378:390-4.
-
(1995)
Nature
, vol.378
, pp. 390-394
-
-
Gassmann, M.1
Casagranda, F.2
Orioli, D.3
-
8
-
-
0036677402
-
Neuregulin-1 promotes formation of the murine cardiac conduction system
-
Rentschler S, Zander J, Meyers K, et al. Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc Natl Acad Sci U S A. 2002;99:10464-9.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 10464-10469
-
-
Rentschler, S.1
Zander, J.2
Meyers, K.3
-
9
-
-
0036099675
-
ErbB2 is essential in the prevention of dilated cardiomyopathy
-
DOI 10.1038/nm0502-459
-
Crone SA, Zhao YY, Fan L, et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002;8:459-65. (Pubitemid 34546747)
-
(2002)
Nature Medicine
, vol.8
, Issue.5
, pp. 459-465
-
-
Crone, S.A.1
Zhao, Y.-Y.2
Fan, L.3
Gu, Y.4
Minamisawa, S.5
Liu, Y.6
Peterson, K.L.7
Chen, J.8
Kahn, R.9
Condorelli, G.10
Ross Jr., J.11
Chien, K.R.12
Lee, K.-F.13
-
10
-
-
0037007076
-
Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: Potential mechanism for trastuzumab-induced cardiotoxicity
-
DOI 10.1161/01.CIR.0000013839.41224.1C
-
Sawyer DB, Zuppinger C, Miller TA, Eppenberger HM, Suter TM. Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity. Circulation. 2002;105:1551-4. (Pubitemid 34297631)
-
(2002)
Circulation
, vol.105
, Issue.13
, pp. 1551-1554
-
-
Sawyer, D.B.1
Zuppinger, C.2
Miller, T.A.3
Eppenberger, H.M.4
Suter, T.M.5
-
11
-
-
10944236872
-
Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling
-
DOI 10.1074/jbc.M408662200
-
Kuramochi Y, Cote GM, Guo XX, et al. Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1 beta/erbB4 signaling. J Biol Chem. 2004;279:51141-7. (Pubitemid 40017856)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.49
, pp. 51141-51147
-
-
Kuramochi, Y.1
Cote, G.M.2
Guo, X.3
Lebrasseur, N.K.4
Cui, L.5
Liao, R.6
Sawyer, D.B.7
-
12
-
-
0037405153
-
Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle
-
Lebrasseur NK, Cote GM, Miller TA, Fielding RA, Sawyer DB. Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle. Am J Physiol Cell Physiol. 2003;284:C1149-55. (Pubitemid 36457395)
-
(2003)
American Journal of Physiology - Cell Physiology
, vol.284
, Issue.5
-
-
Lebrasseur, N.K.1
Cote, G.M.2
Miller, T.A.3
Fielding, R.A.4
Sawyer, D.B.5
-
14
-
-
0037149539
-
Herceptin acts as an anti-angiogenic cocktail
-
Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK. Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature. 2002;416:279-80. (Pubitemid 34260234)
-
(2002)
Nature
, vol.416
, Issue.6878
, pp. 279-280
-
-
Izumi, Y.1
Xu, L.2
Di, T.E.3
Fukumura, D.4
Jain, R.K.5
-
15
-
-
79958163104
-
Trastuzumab has anti-metastatic and anti-angiogenic activity in a spontaneous metastasis xenograft model of esophageal adenocarcinoma
-
Lange T, Nentwich MF, Luth M, Yekebas E, Schumacher U. Trastuzumab has anti-metastatic and anti-angiogenic activity in a spontaneous metastasis xenograft model of esophageal adenocarcinoma. Cancer Lett. 2011;308:54-61.
-
(2011)
Cancer Lett
, vol.308
, pp. 54-61
-
-
Lange, T.1
Nentwich, M.F.2
Luth, M.3
Yekebas, E.4
Schumacher, U.5
-
16
-
-
67650133506
-
Serum Neuregulin-1beta as a Biomarker of Cardiovascular Fitness
-
Moondra V, Sarma S, Buxton T, et al. Serum Neuregulin-1beta as a Biomarker of Cardiovascular Fitness. Open Biomark J. 2009;2:1-5.
-
(2009)
Open Biomark J
, vol.2
, pp. 1-5
-
-
Moondra, V.1
Sarma, S.2
Buxton, T.3
-
17
-
-
84903635036
-
Circulating Neuregulin-1 beta in Human Heart Failure
-
Ky B, Kimmel SE, Safa R, et al. Circulating Neuregulin-1 beta in Human Heart Failure. Circulation. 2009;119:E312-3.
-
(2009)
Circulation
, vol.119
-
-
Ky, B.1
Kimmel, S.E.2
Safa, R.3
-
18
-
-
81855175973
-
Circulating neuregulin-1beta levels vary according to the angiographic severity of coronary artery disease and ischemia
-
This small retrospective observational cohort study discovered that plasma NRG-1 inversely correlated with severity of coronary artery disease and that NRG-1 was statisitcally higher in patients with stress tests that were positive for ischemia. The study has led to other work examining the role of NRG-1 as a biomarkerof cardiovascular health
-
• Geisberg CA, Wang G, Safa RN, et al. Circulating neuregulin-1beta levels vary according to the angiographic severity of coronary artery disease and ischemia. Coron Artery Dis. 2011;22:577-82. This small retrospective observational cohort study discovered that plasma NRG-1 inversely correlated with severity of coronary artery disease and that NRG-1 was statisitcally higher in patients with stress tests that were positive for ischemia. The study has led to other work examining the role of NRG-1 as a biomarkerof cardiovascular health.
-
(2011)
Coron Artery Dis
, vol.22
, pp. 577-582
-
-
Geisberg, C.A.1
Wang, G.2
Safa, R.N.3
-
19
-
-
34548336833
-
Molecular and cellular mechanisms of anthracycline cardiotoxicity
-
DOI 10.1007/s12012-007-0005-5
-
Chen B, Peng X, Pentassuglia L, Lim CC, Sawyer DB. Molecular and cellular mechanisms of anthracycline cardiotoxicity. Cardiovasc Toxicol. 2007;7:114-21. (Pubitemid 47339857)
-
(2007)
Cardiovascular Toxicology
, vol.7
, Issue.2
, pp. 114-121
-
-
Chen, B.1
Peng, X.2
Pentassuglia, L.3
Lim, C.C.4
Sawyer, D.B.5
-
20
-
-
74949138296
-
Anthracycline cardiomyopathy ismediated by depletion of the cardiac stemcell pool and is rescued by restoration of progenitor cell function
-
De Angelis A, Piegari E, Cappetta D, et al. Anthracycline cardiomyopathy ismediated by depletion of the cardiac stemcell pool and is rescued by restoration of progenitor cell function. Circulation. 2010;121:276-92.
-
(2010)
Circulation
, vol.121
, pp. 276-292
-
-
De Angelis, A.1
Piegari, E.2
Cappetta, D.3
-
21
-
-
22544471568
-
The cardiotoxicology of anthracycline chemotherapeutics: Translating molecular mechanism into preventative medicine
-
DOI 10.1124/mi.5.3.6
-
Peng XY, Chen B, Lim CC, Sawyer DB. The cardiotoxicology of anthracycline chemotherapeutics: Translating molecular mechanism into preventative medicine. Mol Interv. 2005;5:163-71. (Pubitemid 41018273)
-
(2005)
Molecular Interventions
, vol.5
, Issue.3
, pp. 163-171
-
-
Peng, X.1
Chen, B.2
Lim, C.C.3
Sawyer, D.B.4
-
22
-
-
0344924865
-
Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt
-
DOI 10.1016/j.yjmcc.2003.09.012
-
Fukazawa R, Miller TA, Kuramochi Y, et al. Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt. J Mol Cell Cardiol. 2003;35:1473-9. (Pubitemid 37491190)
-
(2003)
Journal of Molecular and Cellular Cardiology
, vol.35
, Issue.12
, pp. 1473-1479
-
-
Fukazawa, R.1
Miller, T.A.2
Kuramochi, Y.3
Frantz, S.4
Kim, Y.-D.5
Marchionni, M.A.6
Kelly, R.A.7
Sawyer, D.B.8
-
23
-
-
33748929841
-
Neuregulin-1/erbB-Activation Improves Cardiac Function and Survival in Models of Ischemic, Dilated, and Viral Cardiomyopathy
-
DOI 10.1016/j.jacc.2006.05.057, PII S0735109706017980
-
Liu X, Gu X, Li Z, et al. Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J Am Coll Cardiol. 2006;48:1438-47. (Pubitemid 44436803)
-
(2006)
Journal of the American College of Cardiology
, vol.48
, Issue.7
, pp. 1438-1447
-
-
Liu, X.1
Gu, X.2
Li, Z.3
Li, X.4
Li, H.5
Chang, J.6
Chen, P.7
Jin, J.8
Xi, B.9
Chen, D.10
Lai, D.11
Graham, R.M.12
Zhou, M.13
-
24
-
-
78650412123
-
Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses
-
This was a small singlearm phase I study investigating the safety, tolerability, and hemodynamic effect of a 12-hour infusion of recombinant NRG-1 in stable chronic heart failure patients. The study reveled that this form of recombinant NRG-1 was well-tolerated and produced favorable acute and chronic hemodynamic effects in patients with stable CHF
-
• Jabbour A, Hayward CS, Keogh AM, et al. Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses. Eur J Heart Fail. 2011;13:83-92. This was a small singlearm phase I study investigating the safety, tolerability, and hemodynamic effect of a 12-hour infusion of recombinant NRG-1 in stable chronic heart failure patients. The study reveled that this form of recombinant NRG-1 was well-tolerated and produced favorable acute and chronic hemodynamic effects in patients with stable CHF.
-
(2011)
Eur J Heart Fail
, vol.13
, pp. 83-92
-
-
Jabbour, A.1
Hayward, C.S.2
Keogh, A.M.3
-
25
-
-
77952317892
-
A Phase II, randomized, doubleblind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure
-
This study demonstrated that in a small randomized control trial of recombinant NRG-1 that a 12 hour infusion for 10-days slightly improved left ventricular ejection fraction and significantly improved ventricular volumes at 90-days suggesting that short-term treatment with rhNRG-1 results in a long-term reversal of remodeling
-
• Gao R, Zhang J, Cheng L, et al. A Phase II, randomized, doubleblind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure. J Am Coll Cardiol. 2010;55:1907-14. This study demonstrated that in a small randomized control trial of recombinant NRG-1 that a 12 hour infusion for 10-days slightly improved left ventricular ejection fraction and significantly improved ventricular volumes at 90-days suggesting that short-term treatment with rhNRG-1 results in a long-term reversal of remodeling.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 1907-1914
-
-
Gao, R.1
Zhang, J.2
Cheng, L.3
-
26
-
-
84896702497
-
Safety And Tolerability Of Glial Growth Factor 2 In PatientsWith Chronic Heart Failure: A Phase I Single Dose Escalation Study
-
This was a phase I single-dose escalation study investigating the safety and tolerability of a 20-minute infusion of a different form of recombinant NRG-1 (Glial Growth Factor, GGF2). The study showed that this form of recombinant NRG-1 was safe and well-tolerated, and showed a trend toward improvement in ventricular ejection fraction at four weeks. Further development of GGF2 as a treatment for systolic heart failure is warranted
-
• Lenihan D, Geisberg C, Caggiano A et al. Safety And Tolerability Of Glial Growth Factor 2 In PatientsWith Chronic Heart Failure: A Phase I Single Dose Escalation Study. JACC 2013;61. This was a phase I single-dose escalation study investigating the safety and tolerability of a 20-minute infusion of a different form of recombinant NRG-1 (Glial Growth Factor, GGF2). The study showed that this form of recombinant NRG-1 was safe and well-tolerated, and showed a trend toward improvement in ventricular ejection fraction at four weeks. Further development of GGF2 as a treatment for systolic heart failure is warranted
-
(2013)
JACC
, vol.61
-
-
Lenihan, D.1
Geisberg, C.2
Caggiano, A.3
-
27
-
-
84871853849
-
Higher baseline NRG levels were observed in those with the greatest decline in LVEF, supporting the continued investigation of NRG as a potential prognostic marker in early-stage HF
-
This was a small prospective study of breast cancer patients who underwent serial measurement of cardiac function and biomarkers. More than 20% of women experienced cardiac dysfunction, detected by decline in LVEF, and were reclassified as stage B or C HF. Plasma NRG-1 levels were reduced after exposure to cardiotoxic chemotherapy, suggesting a loss in cardioprotective growth factor
-
• Geisberg CA, Abdallah WM, da Silva M, et al. This was a small prospective study of breast cancer patients who underwent serial measurement of cardiac function and biomarkers. More than 20% of women experienced cardiac dysfunction, detected by decline in LVEF, and were reclassified as stage B or C HF. Plasma NRG-1 levels were reduced after exposure to cardiotoxic chemotherapy, suggesting a loss in cardioprotective growth factor. Higher baseline NRG levels were observed in those with the greatest decline in LVEF, supporting the continued investigation of NRG as a potential prognostic marker in early-stage HF. J Card Fail. 2013;19:10-5.
-
(2013)
J Card Fail
, vol.19
, pp. 10-15
-
-
Geisberg, C.A.1
Abdallah, W.M.2
Da Silva, M.3
-
28
-
-
63049089461
-
Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes
-
Pentassuglia L, Graf M, Lane H, et al. Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes. Exp Cell Res. 2009;315:1302-12.
-
(2009)
Exp Cell Res
, vol.315
, pp. 1302-1312
-
-
Pentassuglia, L.1
Graf, M.2
Lane, H.3
|