Local infusion of citalopram into the basolateral amygdala decreased conditioned fear of rats through increasing extracellular serotonin levels

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 54, Issue , 2014, Pages 216-222

  Kitaichi, Yuji ^a   Inoue, Takeshi ^a   Nakagawa, Shin ^a   Omiya, Yuki ^a   Song, Ning ^a   An, Yan ^a   Chen, Chong ^a   Kusumi, Ichiro ^a   Koyama, Tsukasa ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Amygdala; Citalopram; Conditioned fear stress; Dopamine; Serotonin

Indexed keywords

CITALOPRAM; DOPAMINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; BASOLATERAL AMYGDALA; CONDITIONING; CONTROLLED STUDY; DRUG RESEARCH; EXTRACELLULAR SPACE; FEAR; FREEZING; MALE; MENTAL STRESS; NONHUMAN; RAT; TRANQUILIZING ACTIVITY; ANIMAL; CATALEPSY; DOSE RESPONSE; DRUG EFFECTS; DRUG THERAPY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BASOLATERAL NUCLEAR COMPLEX; CITALOPRAM; CONDITIONING (PSYCHOLOGY); DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SPACE; FEAR; FREEZING REACTION, CATALEPTIC; MALE; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; STRESS, PSYCHOLOGICAL;

EID: 84903543459     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2014.05.018     Document Type: Article

References (33)

1. Abraham A.D., Neve K.A., Lattal K.M. Dopamine and extinction: a convergence of theory with fear and reward circuitry. Neurobiol Learn Mem 2014, 108:65-77.
2. Bandelow B., Zohar J., Hollander E., Kasper S., Möller H.J. WFSBP Task Force on Treatment Guidelines for Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disoders. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision. World J Biol Psychiatry 2008, 9:248-312.
3. Bechara A., Tranel D., Damasio H., Adolphs R., Rockland C., Damasio A.R. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 1995, 269:1115-1118.
4. 2 subtypes of dopamine receptors in rat brain. J Neurosci 1986, 6:3177-3188.
5. 2C receptor antagonist. Biol Psychiatry 2007, 62:1111-1118.
6. 2c receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress. Biol Psychiatry 2010, 67:339-345.
7. Erikkson E., Humble M. Serotonin in psychiatric pathophysiology. A review of data from experimental and clinical research. Progress in basic clinical pharmacology 1990, 66-119. Karger, Basel. R. Pohl, S. Gershon (Eds.).
8. Fadok J.P., Dickerson T.M., Palmiter R.D. Dopamine is necessary for cue-dependent fear conditioning. J Neurosci 2009, 29:11089-11097.
9. Fanselow M.S. Conditioned and unconditioned components of post shock freezing. Pavlov J Biol Sci 1980, 15:177-182.
10. Fuller R.W. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci 1994, 55:163-167.
11. 1 receptor-rich main and paracapsular intercalated nerve cell groups of the rat amygdala: relationship to the dopamine innervation. Neuroscience 2003, 119:733-746.
12. Greenwood B.N., Strong P.V., Brooks L., Fleshner M. Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise. Psychopharmacology (Berl) 2008, 199:209-222.
13. 1 dopamine receptor involvement in Pavlovian fear conditioning. Brain Res 1999, 827:28-40.
14. 2 dopamine receptor antagonist on Pavlovian fear conditioning. Behav Neurosci 2000, 114:647-651.
15. Hashimoto S., Inoue T., Koyama T. Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats. Psychopharmacology (Berl) 1996, 123:182-186.
16. 1 receptor antagonist, SHC23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning. Neurobiol Learn Mem 2008, 90:217-222.
17. Inoue T., Hashimoto S., Tsuchiya K., Izumi T., Ohmori T., Koyama T. Effect of citalopram, a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing. Eur J Pharmacol 1996, 311:1-6.
18. Inoue T., Li X.B., Abekawa T., Kitaichi Y., Izumi T., Nakagawa S., et al. Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala. Eur J Pharmacol 2004, 497:311-316.
19. Inoue T., Kitaichi Y., Koyama T. SSRIs and conditioned fear. Prog Neuropsychopharmacol Biol Psychiatry 2011, 35:1810-1819.
20. Izumi T., Inoue T., Kitaichi Y., Nakagawa S., Koyama T. Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor. Eur J Pharmacol 2006, 534:129-132.
21. Kessler R.C., Berglund P., Demler O., Jin R., Merikangas K.R., Walters E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replocation. Arch Gen Psychiatry 2005, 62:593-602.
22. Kitaichi Y., Inoue T., Nakagawa S., Izumi T., Koyama T. Effect of co-administration of subchronic lithium pretreatment and acute MAO inhibitors on extracellular monoamine and the expression of contextual conditioned fear in rats. Eur J Pharmacol 2006, 532:236-245.
23. LeBar K.S., LeDoux J.E. Partial distribution of fear conditioning in rats with unilateral amygdala damage: correspondence with unilateral temporal lobectomy in humans. Behav Neurosci 1996, 110:991-997.
24. LeDoux J.E. The amygdala and emotion: a view though fear. The amygdala: a functional analysis 2000, 289-310. Oxford Univ Press, Oxford. 2nd ed. J.P. Aggleton (Ed.).
25. 2C receptors in the amygdala of mice. Neuropharmacology 2012, 62:474-484.
26. Maren S., Fanselow M.S. Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. J Neurosci 1995, 15:7548-7564.
27. 2 receptor mRNAs in rat brain. Neuropsychopharmacology 1991, 5:231-242.
28. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1997, Academic Press, San Diego. 3rd ed.
29. Pezze M.A., Feldon J. Mesolimbic dopaminergic pathways in fear conditioning. Prog Neurobiol 2004, 74:301-320.
30. Pozzi L., Invernizzi R., Garavaglia C., Samanin R. Fluoxetine increases extracellular dopamine in the prefrontal cortex by a mechanism not dependent on serotonin: a comparison with citalopram. J Neurochem 1999, 73:1051-1057.
31. Radja F., Laporte A.M., Daval G., Vergé D., Gozlan H., Hamon M. Autoradiography of serotonin receptor subtypes in the central nervous system. Neurochem Int 1991, 18:1-15.
32. 2 receptor subtype mRNAs in rat brain. J Comp Neurol 1995, 351:357-373.
33. Zohar J., Westenberg H.G. Anxiety disorders: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Acta Psychiatr Scand Suppl 2000, 403:39-49.