Icariin induced B16 melanoma tumor cells apoptosis, suppressed tumor growth and metastasis

Iranian Journal of Public Health

Volumn 43, Issue 6, 2014, Pages 847-848

  Li, Xiuying ^a   Sun, Jinfan ^b   Hu, Shunqin ^c   Liu, Jiaxin ^a  

^a KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b LaoBoYunTang Medicine Co Ltd   (China)

^c KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84903530705     PISSN: 22516085     EISSN: 22516093     Source Type: Journal    
DOI: None     Document Type: Letter

References (7)

1. Tsao H, Chin L, Garraway LA, Fisher DE (2012). Melanoma: from mutations to medicine. Genes Dev, 26 (11): 1131-55.
2. Li S, Dong P, Wang J, Zhang J, Gu J, Wu X, Wu W, Fei X, Zhang Z, Wang Y, Quan Z, Liu Y (2010). Icariin, a natural flavonol glycoside, in-duces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway. Cancer Lett, 298 (2): 222-30.
3. Wang Y, Dong H, Zhu M, Ou Y, Zhang J, Luo H, Luo R, Wu J, Mao M, Liu X, Zhang J, Wei L (2010). Icariin exterts negative effects on hu-man gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway. Eur J Pharmacol, 635: 40-48.
4. Lowe SW, Lin AW (2000). Apoptosis in cancer. Carcinogenesis, 21: 485-495.
5. Fesik SW (2005). Promoting apoptosis as a strat-egy for cancer drug discovery. Nat Rev Cancer, 5: 876-85.
6. Ghobrial IM, Witzig TE, Adjei AA (2005). Targeting apoptosis pathways in cancer ther-apy. CA Cancer J Clin, 55: 178-194.
7. Liang HR, Vuorela P, Vuorela H, Hiltunen R (1997). Isolation and immunomodulatory ef-fect of flavonol glycosides from Epimedium hunanense. Planta Med, 63: 316-9.