Mouse models of mantle cell lymphoma, complex changes in gene expression and phenotype of engrafted MCL cells: Implications for preclinical research

Laboratory Investigation

Volumn 94, Issue 7, 2014, Pages 806-817

  Klanova, Magdalena ^a   Soukup, Tomas ^a   Jaksa, Radek ^a   Molinsky, Jan ^a   Lateckova, Lucie ^a   Maswabi, Bokang C L ^a   Prukova, Dana ^a   Brezinova, Jana ^b   Michalova, Kyra ^b   Vockova, Petra ^a   Hernandez Ilizaliturri, Francisco ^c   Kulvait, Vojtech ^a   Zivny, Jan ^a   Vokurka, Martin ^a   Necas, Emanuel ^a   Trneny, Marek ^a,b   Klener, Pavel ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION   (Czech Republic)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

experimental therapy; immunodeficient mice; lymphoma microenvironment; mantle cell lymphoma; mouse xenograft model

Indexed keywords

BEVACIZUMAB; BORTEZOMIB; CD3 ANTIGEN; CISPLATIN; CYCLIN D1; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOTOXIC AGENT; FIBRINOGEN RECEPTOR; FLUDARABINE; GEMCITABINE; INTERLEUKIN 2 RECEPTOR GAMMA; LENALIDOMIDE; RITUXIMAB; TEMSIROLIMUS;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INFILTRATION; CELL DENSITY; CELL PROLIFERATION; CELL SELECTION; CELL SUBPOPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IN VITRO STUDY; IN VIVO STUDY; LYMPHOMA CELL; MALE; MANTLE CELL LYMPHOMA; MIDDLE AGED; MOUSE; NONHUMAN; OVERALL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL INOCULATION; TUMOR ENGRAFTMENT;

AGED; ANIMALS; BONE MARROW; BRAIN; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; KAPLAN-MEIER ESTIMATE; LIVER; LYMPHOMA, MANTLE-CELL; MALE; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; MIDDLE AGED; SPLEEN; TRANSCRIPTOME; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 84903522708     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2014.61     Document Type: Article

References (19)

1. Bosch F, Jares P, Campo E, et al. PRAD-1/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma. Blood 1994;84:2726-2732.
2. Pinyol M, Hernandez L, Cazorla M, et al. Deletions and loss of expression of p16INK4a and p21Waf1 genes are associated with aggressive variants of mantle cell lymphomas. Blood 1997;89:272-280.
3. Hernandez L, Bea S, Pinyol M, et al. CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus. Cancer Res 2005;65: 2199-2206.
4. Camacho E, Hernandez L, Hernandez S, et al. ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances. Blood 2002;99:238-244.
5. Greiner TC, Moynihan MJ, Chan WC, et al. p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis. Blood 1996;87:4302-4310.
6. Lenz G, Dreyling M, Hiddemann W. Mantle cell lymphoma: established therapeutic options and future directions. Ann Hematol 2004;83: 71-77.
7. Weisenburger DD, Vose JM, Greiner TC, et al. Mantle cell lymphoma. A clinicopathologic study of 68 cases from the Nebraska Lymphoma Study Group. Am J Hematol 2000;64:190-196.
8. Ford RJ, Shen L, Lin-Lee YC, et al. Development of a murine model for blastoid variant mantle-cell lymphoma. Blood 2007;109:4899-4906.
9. Vincent-Fabert C, Fiancette R, Rouaud P, et al. A defect of the INK4-Cdk4 checkpoint and Myc collaborate in blastoid mantle cell lymphoma-like lymphoma formation in mice. Am J Pathol 2012;180:1688-1701.
10. Smith MR, Joshi I, Jin F, et al. Murine model for mantle cell lymphoma. Leukemia 2006;20:891-893.
11. Wang M, Zhang L, Han X, et al. A severe combined immunodeficienthu in vivo mouse model of human primary mantle cell lymphoma. Clin Cancer Res 2008;14:2154-2160.
12. Rolland D, Camara-Clayette V, Barbarat A, et al. Farnesyltransferase inhibitor R115777 inhibits cell growth and induces apoptosis in mantle cell lymphoma. Cancer Chemother Pharmacol 2008;61:855-863.
13. Gupta M, Hendrickson AE, Yun SS, et al. Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies. Blood 2012;119:476-487.
14. Jones RJ, Baladandayuthapani V, Neelapu S, et al. HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma. Blood 2011;118:4140-4149.
15. Mahadevan D, Stejskal A, Cooke LS, et al. Aurora A inhibitor (MLN8237) plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B-cell non-Hodgkin lymphoma. Clin Cancer Res 2012;18:2210-2219.
16. Gomori G. Silver impregnation of reticulum in paraffin sections. Am J Pathol 1937;13:993-1002 5.
17. Team RDC. R: a language and environment for statistical computing: R Foundation for Statistical Computing 2011) (ISBN 3-900051- 07-0).
18. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. 2005; Accessed at http://www.springerlink.com/ content/g26110k024423738/.
19. Dunning MJ, Smith ML, Ritchie ME, et al. beadarray: R classes and methods for Illumina bead-based data. Bioinformatics 2007;23: 2183-2184.