Serum negative autoimmune thyroiditis displays a milder clinical picture compared with classic Hashimoto's thyroiditis

European Journal of Endocrinology

Volumn 171, Issue 1, 2014, Pages 31-36

  Rotondi, Mario ^a   De Martinis, Luca ^a   Coperchini, Francesca ^a   Pignatti, Patrizia ^b   Pirali, Barbara ^a   Ghilotti, Stefania ^a   Fonte, Rodolfo ^a   Magri, Flavia ^a   Chiovato, Luca ^a  

^a IRCCS   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LIOTHYRONINE; THYROGLOBULIN ANTIBODY; THYROID ANTIBODY; THYROID PEROXIDASE; THYROTROPIN; THYROXINE;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOIMMUNE THYROIDITIS; CASE CONTROL STUDY; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME BLOOD LEVEL; FEMALE; GENDER BIAS; HASHIMOTO DISEASE; HUMAN; HYPOTHYROIDISM; LIOTHYRONINE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; THYROGLOBULIN BLOOD LEVEL; THYROID NODULE; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AUTOANTIBODIES; CASE-CONTROL STUDIES; FEMALE; HASHIMOTO DISEASE; HUMANS; MALE; MIDDLE AGED; PEROXIDASE; THYROGLOBULIN; THYROIDITIS, AUTOIMMUNE; YOUNG ADULT;

EID: 84903515186     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-14-0147     Document Type: Article

References (27)

1. Pearce EN, Farwell AP & Braverman LE. Thyroiditis. New England Journal of Medicine 2003 348 2646-2655. (doi:10.1056/NEJMra021194)
2. Dayan CM & Daniels GH. Chronic autoimmune thyroiditis. New England Journal of Medicine 1996 335 99-107. (doi:10.1056/NEJM199607113350206)
3. Mariotti S, Anelli S, Ruf J, Bechi R, Czarnocka B, Lombardi A, Carayon P & Pinchera A. Comparison of serum thyroid microsomal and thyroid peroxidase autoantibodies in thyroid diseases. Journal of Clinical Endocrinology and Metabolism 1987 65 987-993. (doi:10.1210/jcem-65-5-987)
4. Mariotti S, Caturegli P, Piccolo P, Barbesino G & Pinchera A. Antithyroid peroxidase autoantibodies in thyroid diseases. Journal of Clinical Endocrinology and Metabolism 1990 71 661-669. (doi:10.1210/jcem-71-3-661)
5. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA & Braverman LE. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). Journal of Clinical Endocrinology and Metabolism 2002 87 489-499. (doi:10.1210/jcem.87.2.8182)
6. O'Leary PC, Feddema PH, Michelangeli VP, Leedman PJ, Chew GT, Knuiman M, Kaye J& Walsh JP. Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study. Clinical Endocrinology 2006 64 97-104. (doi:10.1111/j.1365-2265.2005.02424.x)
7. Weetman AP. Autoimmune thyroid disease: propagation and progression. European Journal of Endocrinology 2003 148 1-9. (doi:10.1530/eje.0.1480001)
8. Chiovato L, Bassi P, Santini F, Mammoli C, Lapi P, Carayon P & Pinchera A. Antibodies producing complement-mediated thyroid cytotoxicity in patients with atrophic or goitrous autoimmune thyroiditis. Journal of Clinical Endocrinology and Metabolism 1993 77 1700-1705. (doi:10.1210/jcem.77.6.7903315)
9. Dussault JH, Letarte J, Guyda H & Laberge C. Lack of influence of thyroid antibodies on thyroid function in the newborn infant and on a mass screening program for congenital hypothyroidism. Journal of Pediatrics 1980 96 385-389. (doi:10.1016/S0022-3476(80)80677-9)
10. Weetman AP. Cellular immune responses in autoimmune thyroid disease. Clinical Endocrinology 2004 61 405-413. (doi:10.1111/j.1365-2265.2004.02085.x)
11. Takamatsu J, Yoshida S, Yokozawa T, Hirai K, Kuma K, Ohsawa N & Hosoya T. Correlation of antithyroglobulin and antithyroid-peroxidase antibody profiles with clinical and ultrasound characteristics of chronic thyroiditis. Thyroid 1998 8 1101-1106. (doi:10.1089/thy.1998.8.1101)
12. Baker JR Jr, Saunders NB, Wartofsky L, Tseng YC & Burman KD. Seronegative Hashimoto thyroiditis with thyroid autoantibody production localized to the thyroid. Annals of Internal Medicine 1988 108 26-30. (doi:10.7326/0003-4819-108-1-26)
13. Zhang DM, Zhou ZG, Zhang C, Huang G, Jin P, Wang JP, Wei JL & Hu BY. Subclassification of seronegative type 1 diabetic subjects with HLA-DQ genotypes. Zhonghua Nei Ke Za Zhi 2004 43 174-178.
14. Spina MP, Cerri A, Piacentini V, Stringa A & Visca U. Seronegative hashitoxicosis in patient with rheumatoid arthritis. Minerva Endocrinologica 1990 15 173-176.
15. Punzi L, Schiavon F, Ramonda R, Cavasin F, Ruffatti A & Todesco S. Anti-thyroid microsomal antibody in synovial fluid as a revealing feature of seronegative autoimmune thyroiditis. Clinical Rheumatology 1991 10 181-183. (doi:10.1007/BF02207661)
16. Bülow Pedersen I, Laurberg P, Knudsen N, Jørgensen T, Perrild H, Ovesen L & Rasmussen LB. A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure. Clinical Endocrinology 2005 62 713-720. (doi:10.1111/j.1365-2265. 2005.02284.x)
17. Marcocci C, Vitti P, Cetani F, Catalano F, Concetti R & Pinchera A. Thyroid ultrasonography helps to identify patients with diffuse lymphocytic thyroiditis who are prone to develop hypothyroidism. Journal of Clinical Endocrinology and Metabolism 1991 72 209-213. (doi:10.1210/jcem-72-1-209)
18. Rago T, Chiovato L, Grasso L, Pinchera A & Vitti P. Thyroid ultrasonography as a tool for detecting thyroid autoimmune diseases and predicting thyroid dysfunction in apparently healthy subjects. Journal of Endocrinological Investigation 2001 24 763-769. (doi:10.1007/BF03343925)
19. Raber W, Gessl A, Nowotny P & Vierhapper H. Thyroid ultrasound versus antithyroid peroxidase antibody determination: a cohort study of four hundred fifty-one subjects. Thyroid 2002 12 725-731. (doi:10. 1089/105072502760258712)
20. Vejbjerg P, Knudsen N, Perrild H, Laurberg P, Pedersen IB, Rasmussen LB, Ovesen L & Jørgensen T. The association between hypoechogenicity or irregular echo pattern at thyroid ultrasonography and thyroid function in the general population. European Journal of Endocrinology 2006 155 547-552. (doi:10.1530/eje.1.02255)
21. Takami HE, Miyabe R & Kameyama K. Hashimoto's thyroiditis. World Journal of Surgery 2008 32 688-692. (doi:10.1007/s00268-008-9485-0)
22. Weetman AP. Autoimmune thyroid disease. Autoimmunity 2004 37 337-340. (doi:10.1080/08916930410001705394)
23. Weetman AP. Diseases associated with thyroid autoimmunity: explanations for the expanding spectrum. Clinical Endocrinology 2011 74 411-418. (doi:10.1111/j.1365-2265.2010.03855.x)
24. Radetti G, Kleon W, Buzi F, Crivellaro C, Pappalardo L, di Iorgi N & Maghnie M. Thyroid function and structure are affected in childhood obesity. Journal of Clinical Endocrinology and Metabolism 2008 93 4749-4754. (doi:10.1210/jc.2008-0823)
25. Rotondi M, Leporati P, La Manna A, Pirali B, Mondello T, Fonte R, Magri F & Chiovato L. Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism? European Journal of Endocrinology 2009 160 403-408. (doi:10.1530/EJE-08-0734)
26. Rotondi M, Cappelli C, Leporati P, Chytiris S, Zerbini F, Fonte R, Magri F, Castellano M & Chiovato L. A hypoechoic pattern of the thyroid at ultrasound does not indicate autoimmune thyroid diseases in patients with morbid obesity. European Journal of Endocrinology 2010 163 105-109. (doi:10.1530/EJE-10-0288)
27. Rotondi M, Magri F & Chiovato L. Thyroid and obesity: not a one-way interaction. Journal of Clinical Endocrinology and Metabolism 2011 96 344-346. (doi:10.1210/jc.2010-2515)