Sulfite disrupts brain mitochondrial energy homeostasis and induces mitochondrial permeability transition pore opening via thiol group modification

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 9, 2014, Pages 1413-1422

  Grings, Mateus ^a   Moura, Alana P ^a   Amaral, Alexandre U ^a   Parmeggiani, Belisa ^a   Gasparotto, Juciano ^a   Moreira, José C F ^a   Gelain, Daniel P ^a   Wyse, Angela T S ^a   Wajner, Moacir ^a,b   Leipnitz, Guilhian ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Bioenergetic dysfunction; Brain mitochondria; Calcium; Mitochondrial permeability transition; Sulfite; Sulfite oxidase deficiency

Indexed keywords

ADENOSINE DIPHOSPHATE; CALCIUM ION; CYCLOSPORIN A; CYTOCHROME C; DITHIOTHREITOL; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; MALATE DEHYDROGENASE; MALIC ACID; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; N ETHYLMALEIMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RUTHENIUM RED; SULFITE; SULFITE OXIDASE; THIOL GROUP; THIOSULFATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN MITOCHONDRION; BRAIN SLICE; CELL VIABILITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; INFANT; MALE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; MITOCHONDRION SWELLING; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL; CELL STIMULATION; CULTURE MEDIUM; HOMEOSTASIS; PROTEIN MODIFICATION;

BIOENERGETIC DYSFUNCTION; BRAIN MITOCHONDRIA; CALCIUM; MITOCHONDRIAL PERMEABILITY TRANSITION; SULFITE; SULFITE OXIDASE DEFICIENCY;

AMINO ACID METABOLISM, INBORN ERRORS; ANIMALS; BRAIN; CELL PROLIFERATION; CYTOCHROMES C; ENERGY METABOLISM; HOMEOSTASIS; IMMUNOBLOTTING; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NADP; OXYGEN CONSUMPTION; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; SULFITE OXIDASE; SULFITES;

EID: 84903474219     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.04.022     Document Type: Article

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