Differential Activation of Acid Sphingomyelinase and Ceramide Release Determines Invasiveness of Neisseria meningitidis into Brain Endothelial Cells

PLoS Pathogens

Volumn 10, Issue 6, 2014, Pages

  Simonis, Alexander ^a   Hebling, Sabrina ^a   Gulbins, Erich ^b   Schneider Schaulies, Sibylle ^a   Schubert Unkmeir, Alexandra ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; OUTER MEMBRANE PROTEIN C; PHOSPHOLIPASE C; SMALL INTERFERING RNA; SPHINGOMYELIN PHOSPHODIESTERASE; BACTERIAL PROTEIN; ENZYME INHIBITOR; OPC PROTEIN, BACTERIA; OUTER MEMBRANE PROTEIN; PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE C; SPHINGOMYELIN PHOSPHODIESTERASE 1, HUMAN;

ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATION; BRAIN CAPILLARY ENDOTHELIAL CELL; CELL ACTIVATION; CELL CULTURE; CELL INVASION; CONTROLLED STUDY; ENZYME ACTIVATION; ESCHERICHIA COLI; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MENINGOCOCCOSIS; NONHUMAN; PATHOGENICITY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BACTERIUM ADHERENCE; BRAIN; CELL MEMBRANE; DRUG EFFECTS; ENZYMOLOGY; EPIDEMIC MENINGITIS; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; MICROBIOLOGY; MICROVASCULATURE; MUTATION; NEISSERIA MENINGITIDIS; PHYSIOLOGY; SURFACE PROPERTY; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; TRANSFORMED CELL LINE; UPREGULATION; VASCULAR ENDOTHELIUM; VASCULARIZATION;

BACTERIAL ADHESION; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BRAIN; CELL LINE, TRANSFORMED; CELL MEMBRANE; CERAMIDES; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; HOST-PATHOGEN INTERACTIONS; HUMANS; MEMBRANE MICRODOMAINS; MENINGITIS, MENINGOCOCCAL; MICROVESSELS; MUTATION; NEISSERIA MENINGITIDIS; SPHINGOMYELIN PHOSPHODIESTERASE; SURFACE PROPERTIES; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; TYPE C PHOSPHOLIPASES; UP-REGULATION;

EID: 84903473067     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004160     Document Type: Article

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