Two distinct populations of Bovine IL-17+ T-cells can be induced and WC1 + IL-17+ γ 3δ T-cells are effective killers of protozoan parasites

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Peckham, R K ^a   Brill, R ^a   Foster, D S ^a   Bowen, A L ^a   Leigh, J A ^a   Coffey, T J ^a   Flynn, R J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DMBT1 PROTEIN, BOS TAURUS; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 6; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; BOVINE; CD4+ T LYMPHOCYTE; CELL CULTURE; CHLOROCEBUS AETHIOPS; COCULTURE; CYTOTOXICITY; DRUG EFFECTS; FIBROBLAST; HOST PARASITE INTERACTION; IMMUNOLOGY; METABOLISM; NEOSPORA; PARASITOLOGY; PHYSIOLOGY; TH17 CELL; TIME FACTOR; VERO CELL LINE;

ANIMALS; CATTLE; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COCULTURE TECHNIQUES; CYTOTOXICITY, IMMUNOLOGIC; FIBROBLASTS; HOST-PARASITE INTERACTIONS; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-6; MEMBRANE GLYCOPROTEINS; NEOSPORA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; TH17 CELLS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; VERO CELLS;

EID: 84903442756     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05431     Document Type: Article

References (19)

1. Cua, D. J. & Tato, C. M. Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunol. 10, 479-489, doi:10.1038/nri2800 (2010).
2. Oldenhove, G. et al. Decrease of Foxp31 Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 31, 772-786, doi:10.1016/j.immuni.2009.10.001 (2009).
3. Ribot, J. C. et al. Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-gamma-or IL-17-producing gammadelta T cells upon infection. J Immunol. 185, 6421-6425, doi:10.4049/jimmunol.1002283 (2010).
4. Akilov, O. E., Ustyugova, I. V., Zhi, L., Hasan, T. & Wu, M. X. Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1. J Immunol. 183, 7994-8003, doi:10.4049/jimmunol.0900866 (2009).
5. Williams, D. J., Hartley, C. S., Bjorkman, C. & Trees, A. J. Endogenous and exogenous transplacental transmission of Neospora caninum-how the route of transmission impacts on epidemiology and control of disease. Parasitol. 136, 1895-1900, doi:10.1017/S0031182009990588 (2009).
6. Lopez-Gatius, F. et al. Protection against abortion linked to gamma interferon production in pregnant dairy cows naturally infected with Neospora caninum. Theriogenology 68, 1067-1073, doi:10.1016/j.theriogenology.2007.08.006 (2007). (Pubitemid 47410296)
7. Rosbottom, A. et al. Upregulation of cytokines is detected in the placentas of cattle infected with Neospora caninum and is more marked early in gestation when fetal death is observed. Infect. Immun. 76, 2352-2361, doi:10.1128/IAI.01780-06 (2008).
8. Andrianarivo, A. G. et al. A POLYGEN-adjuvanted killed Neospora caninum tachyzoite preparation failed to prevent foetal infection in pregnant cattle following i.v./i.m. experimental tachyzoite challenge. Int. J Parasitol. 30, 985-990 (2000). (Pubitemid 30649674)
9. Rosbottom, A. et al. Up regulation of the maternal immune response in the placenta of cattle naturally infected with Neospora caninum. PloS one 6, e15799, doi:10.1371/journal.pone.0015799 (2011).
10. Flynn, R. J. & Marshall, E. S. Parasite limiting macrophages promote IL-17 secretion in naive bovine CD4(1) T-cells during Neospora caninum infection. Vet Immunol and Immunopathol 144, 423-429, doi:10.1016/j.vetimm.2011. 09.008 (2011).
11. Daubenberger, C. A., Taracha, E. L., Gaidulis, L., Davis, W. C. & McKeever, D. J. Bovine gammadelta T-cell responses to the intracellular protozoan parasite Theileria parva. Infect. Immun 67, 2241-2249 (1999). (Pubitemid 29200478)
12. Geherin, S. A., Lee, M. H., Wilson, R. P. & Debes, G. F. Ovine skin-recirculating gamma-delta T cells express IFN-g and IL-17 and exit tissue independently of CCR7. Vet Immunol. Immunopathol. 155, 10 (2013).
13. Guiton, R. et al. Interleukin 17 Receptor Signaling is Deleterious during Toxoplasma gondii Infection in Susceptible BL6 Mice. J Infect. Dis. 202, 8 (2010).
14. Stumhofer, J. S. et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7, 8 (2006).
15. Kelly, M. N. et al. Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection. Infect. Immun. 73, 4 (2005).
16. Andrade, R. M., Wessendarp, M., Gubbels, M. J., Striepen, B. & Subauste, C. S. CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin. Invest. 116, 11 (2006).
17. Fries, K. M. et al. CD40 expression by human fibroblasts. Clin. Immunol. Immunopathol. 77, 9 (1995).
18. Estes, D. M., Brown, W. C. & Hirano, A. CD40 ligand-dependent signaling of bovine B lymphocyte development and differentiation. Vet. Immunol. Immunopathol. 63, 5 (1998).
19. Dobbs, K. B. et al. Regulation of pluripotency of inner cell mass and growth and differentiation of trophectoderm of the bovine embryo by colony stimulating factor 2. Biol. Reprod. 89, 141, doi:10.1095/biolreprod.113.113183 (2013).