Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity

Biomaterials

Volumn 35, Issue 27, 2014, Pages 7951-7962

  Luo, Zhong ^a,b   Hu, Yan ^a   Cai, Kaiyong ^a   Ding, Xingwei ^a   Zhang, Quan ^b   Li, Menghuan ^b   Ma, Xing ^c   Zhang, Beilu ^a   Zeng, Yongfei ^b   Li, Peizhou ^b   Li, Jinghua ^b   Liu, Junjie ^b   Zhao, Yanli ^b,c  

^a CHONGQING UNIVERSITY   (China)

^b Nanyang Technological University   (Singapore)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Drug delivery system; Hollow mesoporous silica nanoreservoirs; Invivo studies; Redox triggered release; Targeted tumor therapy

Indexed keywords

CELL DEATH; COVALENT BONDS; DRUG DELIVERY; GRAFTING (CHEMICAL);

DRUG DELIVERY SYSTEM; IN-VIVO; NANORESERVOIRS; REDOX-TRIGGERED RELEASE; TUMOR THERAPY;

TUMORS;

ASIALOGLYCOPROTEIN RECEPTOR; BETA CYCLODEXTRIN; DOXORUBICIN; DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE; LACTOBIONIC ACID; NANOMATERIAL; SILICON DIOXIDE; ANTINEOPLASTIC AGENT; BETA CYCLODEXTRIN DERIVATIVE; DISACCHARIDE; NANOPARTICLE; SOLUTION AND SOLUBILITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICANCER DRUG DELIVERY; APOPTOSIS; ARTICLE; CANCER TISSUE; CELL DEATH; CELL ENCAPSULATION; CELL FUNCTION; CELL INTERACTION; CELL STRUCTURE; CELL VIABILITY; COMPARATIVE STUDY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DISULFIDE BOND; DNA FRAGMENTATION; DNA STRUCTURE; DRUG ANALYSIS; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SYNTHESIS; DRUG TOXICITY; FLOW CYTOMETRY; HEPG2 CELL LINE; HOLLOW MESOPOROUS SILICA NANORESERVOIRS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; LIGAND BINDING; MASS SPECTROMETRY; MOUSE; NANOFABRICATION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RESERVOIR; SPECTROFLUOROMETRY; THERMOGRAVIMETRY; TREATMENT RESPONSE; TUMOR CELL; TUMOR DIFFERENTIATION; TUMOR GROWTH; TUMOR VOLUME; ANIMAL; CHEMISTRY; DRUG EFFECTS; ENDOCYTOSIS; INTRACELLULAR SPACE; METABOLISM; NEOPLASMS; NUDE MOUSE; OXIDATION REDUCTION REACTION; PATHOLOGY; POROSITY; SOLUTION AND SOLUBILITY; ULTRASTRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BETA-CYCLODEXTRINS; DISACCHARIDES; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; HEP G2 CELLS; HUMANS; INTRACELLULAR SPACE; MICE, NUDE; NANOPARTICLES; NEOPLASMS; OXIDATION-REDUCTION; POROSITY; SILICON DIOXIDE; SOLUTIONS;

EID: 84903438855     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.05.058     Document Type: Article

References (48)

1. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J Clin 2011, 61:69-90.
2. Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 2005, 5:161-171.
3. Farokhzad O.C., Langer R. Impact of nanotechnology on drug delivery. ACS Nano 2009, 3:16-20.
4. Ambrogio M.W., Thomas C.R., Zhao Y.-L., Zink J.I., Stoddart J.F. Mechanized silica nanoparticles: a new frontier in theranostic nanomedicine. Acc Chem Res 2011, 44:903-913.
5. Tang F., Li L., Chen D. Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery. Adv Mater 2012, 24:1504-1534.
6. Chen Y., Chen H., Shi J. Invivo bio-safety evaluations and diagnostic/therapeutic applications of chemically designed mesoporous silica nanoparticles. Adv Mater 2013, 25:3144-3176.
7. Sun X., Zhao Y., Lin V.S., Slowing I.I., Trewyn B.G. Luciferase and luciferin co-immobilized mesoporous silica nanoparticle materials for intracellular biocatalysis. JAm Chem Soc 2011, 133:18554-18557.
8. Zhu C.L., Lu C.H., Song X.Y., Yang H.H., Wang X.R. Bioresponsive controlled release using mesoporous silica nanoparticles capped with aptamer-based molecular gate. JAm Chem Soc 2011, 133:1278-1281.
9. Gan Q., Lu X., Dong W., Yuan Y., Qian J., Li Y., et al. Endosomal pH-activatable magnetic nanoparticle-capped mesoporous silica for intracellular controlled release. JMater Chem 2012, 22:15960-15968.
10. 4 nanoparticles-capped mesoporous silica. Biomaterials 2011, 32:1932-1942.
11. Lai C.-Y., Trewyn B.G., Jeftinija D.M., Jeftinija K., Xu S., Jeftinija S., et al. Amesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. JAm Chem Soc 2003, 125:4451-4459.
12. Muhammad F., Guo M., Qi W., Sun F., Wang A., Guo Y., et al. pH-triggered controlled drug release from mesoporous silica nanoparticles via intracelluar dissolution of ZnO nanolids. JAm Chem Soc 2011, 133:8778-8781.
13. Bernardos A., Aznar E., Marcos M.D., Martinez-Manez R., Sancenon F., Soto J., et al. Enzyme-responsive controlled release using mesoporous silica supports capped with lactose. Angew Chem Int Ed Engl 2009, 48:5884-5887.
14. Bernardos A., Mondragon L., Aznar E., Marcos M.D., Martinez-Manez R., Sancenon F., et al. Enzyme-responsive intracellular controlled release using nanometric silica mesoporous supports capped with "saccharides". ACS Nano 2010, 4:6353-6368.
15. Schlossbauer A., Kecht J., Bein T. Biotin-avidin as a protease-responsive cap system for controlled guest release from colloidal mesoporous silica. Angew Chem Int Ed Engl 2009, 48:3092-3095.
16. Li L.-L., Xie M., Wang J., Li X., Wang C., Yuan Q., et al. Avitamin-responsive mesoporous nanocarrier with DNA aptamer-mediated cell targeting. Chem Commun 2013, 49:5823-5825.
17. Chen C., Zhou L., Geng J., Ren J., Qu X. Photosensitizer-incorporated quadruplex DNA-gated nanovehicles for light-triggered, targeted dual drug delivery to cancer cells. Small 2013, 9:2793-2800.
18. Zhang P., Cheng F., Zhou R., Cao J., Li J., Burda C., et al. DNA-hybrid-gated multifunctional mesoporous silica nanocarriers for dual-targeted and microRNA-responsive controlled drug delivery. Angew Chem Int Ed Engl 2014, 53:2371-2375.
19. Liu J., Jiang X., Ashley C., Brinker C.J. Electrostatically mediated liposome fusion and lipid exchange with a nanoparticle-supported bilayer for control of surface charge, drug containment, and delivery. JAm Chem Soc 2009, 131:7567-7569.
20. Liu J., Stace-Naughton A., Jiang X., Brinker C.J. Porous nanoparticle supported lipid bilayers (protocells) as delivery vehicles. JAm Chem Soc 2009, 131:1354-1355.
21. Luo Z., Cai K., Hu Y., Zhao L., Liu P., Duan L., et al. Mesoporous silica nanoparticles end-capped with collagen: redox-responsive nanoreservoirs for targeted drug delivery. Angew Chem Int Ed Engl 2011, 50:640-643.
22. Du L., Liao S., Khatib H.A., Stoddart J.F., Zink J.I. Controlled-access hollow mechanized silica nanocontainers. JAm Chem Soc 2009, 131:15136-15142.
23. Thomas C.R., Ferris D.P., Lee J.H., Choi E., Cho M.H., Kim E.S., et al. Noninvasive remote-controlled release of drug molecules invitro using magnetic actuation of mechanized nanoparticles. JAm Chem Soc 2010, 132:10623-10625.
24. He Q., Gao Y., Zhang L., Zhang Z., Gao F., Ji X., et al. ApH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance. Biomaterials 2011, 32:7711-7720.
25. Luo Z., Ding X., Hu Y., Wu S., Xiang Y., Zeng Y., et al. Engineering a hollow nanocontainer platform with multifunctional molecular machines for tumor-targeted therapy invitro and invivo. ACS Nano 2013, 7:10271-10284.
26. Kim H., Kim S., Park C., Lee H., Park H.J., Kim C. Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers. Adv Mater 2010, 22:4280-4283.
27. Luo Z., Cai K., Hu Y., Li J., Ding X., Zhang B., et al. Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles. Adv Mater 2011, 24:431-435.
28. Verma A., Simard J.M., Worrall J.W., Rotello V.M. Tunable reactivation of nanoparticle-inhibited beta-galactosidase by glutathione at intracellular concentrations. JAm Chem Soc 2004, 126:13987-13991.
29. Zhang X., Yang P., Dai Y., Pa Ma, Li X., Cheng Z., et al. Multifunctional up-converting nanocomposites with smart polymer brushes gated mesopores for cell imaging and thermo/pH dual-responsive drug controlled release. Adv Funct Mater 2013, 23:4067-4078.
30. Zhang Q., Liu F., Nguyen K.T., Ma X., Wang X., Xing B., et al. Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery. Adv Funct Mater 2012, 22:5144-5156.
31. Ma X., Zhao Y., Ng K.W., Zhao Y. Integrated hollow mesoporous silica nanoparticles for target drug/siRNA co-delivery. Chem - Eur J 2013, 19:15593-155603.
32. Luo Z., Cai K., Hu Y., Zhang B., Xu D. Cell-specific intracellular anticancer drug delivery from mesoporous silica nanoparticles with pH sensitivity. Adv Healthcare Mater 2012, 1:321-325.
33. Hu Y., Cai K., Luo Z., Jandt K.D. Layer-by-layer assembly of β-estradiol loaded mesoporous silica nanoparticles on titanium substrates and its implication for bone homeostasis. Adv Mater 2010, 22:4146-4150.
34. Yan H., Teh C., Sreejith S., Zhu L., Kwok A., Fang W., et al. Functional mesoporous silica nanoparticles for photothermal-controlled drug delivery invivo. Angew Chem Int Ed Engl 2012, 51:8373-8377.
35. Kim E.-M., Jeong H.-J., Kim S.-L., Sohn M.-H., Nah J.-W., Bom H.-S., et al. Asialoglycoprotein-receptor-targeted hepatocyte imaging using 99mTc galactosylated chitosan. Nucl Med Biol 2006, 33:529-534.
36. Hu S., Li J., Xiang J., Pan J., Luo S., Cheng J.-P. Asymmetric supramolecular primary amine catalysis in aqueous buffer: connections of selective recognition and asymmetric catalysis. JAm Chem Soc 2010, 132:7216-7228.
37. Fang X., Chen C., Liu Z., Liu P., Zheng N. Acationic surfactant assisted selective etching strategy to hollow mesoporous silica spheres. Nanoscale 2011, 3:1632-1639.
38. Schrand A.M., Schlager J.J., Dai L., Hussain S.M. Preparation of cells for assessing ultrastructural localization of nanoparticles with transmission electron microscopy. Nat Protoc 2010, 5:744-757.
39. Dhar S., Kolishetti N., Lippard S.J., Farokhzad O.C. Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy invivo. Proc Natl Acad Sci USA 2011, 108:1850-1855.
40. Yang K., Xu H., Cheng L., Sun C., Wang J., Liu Z. Invitro and invivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles. Adv Mater 2012, 24:5586-5592.
41. Idris N.M., Gnanasammandhan M.K., Zhang J., Ho P.C., Mahendran R., Zhang Y. Invivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. Nat Med 2012, 18:1580-1585.
42. Lu J., Liong M., Zink J.I., Tamanoi F. Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. Small 2007, 3:1341-1346.
43. Patel K., Angelos S., Dichtel W.R., Coskun A., Yang Y.-W., Zink J.I., et al. Enzyme-responsive snap-top covered silica nanocontainers. JAm Chem Soc 2008, 130:2382-2383.
44. Cui Y., Dong H., Cai X., Wang D., Li Y. Mesoporous silica nanoparticles capped with disulfide-linked PEG gatekeepers for glutathione-mediated controlled release. ACS Appl Mater Interfaces 2012, 4:3177-3183.
45. Wang F., Wang Y.-C., Dou S., Xiong M.-H., Sun T.-M., Wang J. Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano 2011, 5:3679-3692.
46. Tewey K., Rowe T., Yang L., Halligan B., Liu L. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 1984, 226:466-468.
47. Huang I.P., Sun S.-P., Cheng S.-H., Lee C.-H., Wu C.-Y., Yang C.-S., et al. Enhanced chemotherapy of cancer using pH-sensitive mesoporous silica nanoparticles to antagonize P-glycoprotein-mediated drug resistance. Mol Cancer Ther 2011, 10:761-769.
48. Wang Y., Arriaga E.A. Monitoring incorporation, transformation and subcellular distribution of N-l-leucyl-doxorubicin in uterine sarcoma cells using capillary electrophoretic techniques. Cancer Lett 2008, 262:123-132.