Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 9, 2014, Pages 1464-1471

  Ohtaki, Hirofumi ^a   Ito, Hiroyasu ^a   Ando, Kazuki ^a   Ishikawa, Tetsuya ^b   Hoshi, Masato ^a   Ando, Tatsuya ^a   Takamatsu, Manabu ^a   Hara, Akira ^a   Moriwaki, Hisataka ^a   Saito, Kuniaki ^c   Seishima, Mitsuru ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Fulminant hepatitis; Hepatitis B virus; Indoleamine 2,3 dioxygenase; Kynurenine

Indexed keywords

ALANINE AMINOTRANSFERASE; GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 10; INTERLEUKIN 6; KYNURENINE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; RECOMBINANT GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE EXACERBATION; ENZYME ACTIVITY; HEPATITIS B; HEPATITIS B VIRUS; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

FULMINANT HEPATITIS; HEPATITIS B VIRUS; INDOLEAMINE 2,3-DIOXYGENASE; KYNURENINE;

ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEPATITIS B VIRUS; HEPATITIS, VIRAL, ANIMAL; HEPATOCYTES; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERFERON-GAMMA; KYNURENINE; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84903433466     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.04.015     Document Type: Article

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