Intra-myocardial injection of both growth factors and heart derived Sca-1+/CD31- cells attenuates post-MI LV remodeling more than does cell transplantation Alone: Neither intervention enhances functionally significant cardiomyocyte regeneration

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Wang, Xiaohong ^a   Li, Qinglu ^a   Hu, Qingsong ^a   Suntharalingam, Piradeep ^a   From, Arthur H L ^a   Zhang, Jianyi ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CD31 ANTIGEN; MESSENGER RNA; RECOMBINANT SCATTER FACTOR; RECOMBINANT SOMATOMEDIN C; STEM CELL ANTIGEN 1; LY ANTIGEN; LY6A PROTEIN, MOUSE; MEMBRANE PROTEIN; SCATTER FACTOR; SOMATOMEDIN C;

ADULT; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; CELL SUSPENSION; CELL VIABILITY; CORONARY ARTERY LIGATION; CULTURE MEDIUM; ECHOCARDIOGRAPHY; FEMALE; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART VENTRICLE REMODELING; IN VITRO STUDY; IN VIVO STUDY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MOUSE; MUSCLE REGENERATION; NONHUMAN; PROTEIN EXPRESSION; STEM CELL TRANSPLANTATION; TREATMENT RESPONSE; ANIMAL; BAGG ALBINO MOUSE; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CELL CULTURE; CELL TRANSPLANTATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HEART INJURIES; PATHOLOGY; PROCEDURES; REGENERATION; TRANSPLANTATION;

ANIMALS; ANTIGENS, CD31; ANTIGENS, LY; CELL TRANSPLANTATION; CELLS, CULTURED; FEMALE; GENE EXPRESSION; HEART INJURIES; HEPATOCYTE GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR I; MEMBRANE PROTEINS; MICE, INBRED BALB C; MYOCARDIUM; MYOCYTES, CARDIAC; REGENERATION; RNA, MESSENGER; VENTRICULAR REMODELING;

EID: 84903390277     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095247     Document Type: Article

References (36)

1. Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, et al. (2006) Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress. Circulation 113: 1203-1212.
2. Bialik S, Geenen DL, Sasson IE, Cheng R, Horner JW, et al. (1997) Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest 100: 1363-1372. (Pubitemid 27425760)
3. Weber KT (1997) Monitoring tissue repair and fibrosis from a distance. Circulation 96: 2488-2492.
4. Guarita-Souza LC, Carvalho KA, Woitowicz V, Rebelatto C, Senegaglia A, et al. (2006) Simultaneous autologous transplantation of cocultured mesenchymal stem cells and skeletal myoblasts improves ventricular function in a murine model of Chagas disease. Circulation 114: I120-124. (Pubitemid 44297139)
5. Li Z, Wu JC, Sheikh AY, Kraft D, Cao F, et al. (2007) Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Circulation 116: I46-54. (Pubitemid 47480769)
6. Rota M, Padin-Iruegas ME, Misao Y, De Angelis A, Maestroni S, et al. (2008) Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function. Circ Res 103: 107-116.
7. van der Bogt KE, Sheikh AY, Schrepfer S, Hoyt G, Cao F, et al. (2008) Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation 118: S121-129.
8. Miyahara Y, Nagaya N, Kataoka M, Yanagawa B, Tanaka K, et al. (2006) Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med 12: 459-465.
9. Passier R, van Laake LW, Mummery CL (2008) Stem-cell-based therapy and lessons from the heart. Nature 453: 322-329. (Pubitemid 351693138)
10. Gnecchi M, He H, Noiseux N, Liang OD, Zhang L, et al. (2006) Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 20: 661-669. (Pubitemid 44933310)
11. Zeng L, Hu Q, Wang X, Mansoor A, Lee J et al. (2007) Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling. Circulation 115: 1866-1875. (Pubitemid 46598900)
12. Penn MS, Mangi AA (2008) Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res 102: 1471-1482.
13. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, et al. (2003) Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 9: 1195-1201. (Pubitemid 37173705)
14. Crow MT, Mani K, Nam YJ, Kitsis RN (2004) The mitochondrial death pathway and cardiac myocyte apoptosis. Circ Res 95: 957-970. (Pubitemid 39532326)
15. Rappolee DA, Iyer A, Patel Y (1996) Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis. Circ Res 78: 1028-1036. (Pubitemid 26166711)
16. Devin JK, Young PP (2008) The effects of growth hormone and insulin-like growth factor-1 on the aging cardiovascular system and its progenitor cells. Curr Opin Investig Drugs 9: 983-992.
17. Linke A, Muller P, Nurzynska D, Casarsa C, Torella D, et al. (2005) Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci U S A 102: 8966-8971. (Pubitemid 40881062)
18. Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, et al. (2005) Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res 97: 663-673. (Pubitemid 41416335)
19. Ueda H, Nakamura T, Matsumoto K, Sawa Y, Matsuda H, et al. (2001) A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats. Cardiovasc Res 51: 41-50. (Pubitemid 32523053)
20. Nakamura T, Mizuno S, Matsumoto K, Sawa Y, Matsuda H, et al. (2000) Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. J Clin Invest 106: 1511-1519. (Pubitemid 32038589)
21. Jayasankar V, Woo YJ, Bish LT, Pirolli TJ, Chatterjee S, et al. (2003) Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure. Circulation 108 Suppl 1: II230-236. (Pubitemid 37099960)
22. Miyagawa S, Sawa Y, Taketani S, Kawaguchi N, Nakamura T, et al. (2002) Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty. Circulation 105: 2556-2561. (Pubitemid 34568980)
23. Anversa P, Rota M, Urbanek K, Hosoda T, Sonnenblick EH, et al. (2005) Myocardial aging-a stem cell problem. Basic Res Cardiol 100: 482-493. (Pubitemid 41662428)
24. Kajstura J, Rota M, Whang B, Cascapera S, Hosoda T, et al. (2005) Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ Res 96: 127-137. (Pubitemid 40095762)
25. Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, et al. (2006) Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci U S A 103: 8155-8160. (Pubitemid 43801068)
26. - cardiac progenitor cell population in postinfarction left ventricular remodeling. Stem Cells 24: 1779-1788.
27. - cells in post-infarction left ventricular remodeling. Circulation 120: S790.
28. Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, et al. (2004) Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 95: 911-921. (Pubitemid 39435006)
29. Tang YL, Shen L, Qian K, Phillips MI (2007) A novel two-step procedure to expand cardiac Sca-1+ cells clonally. Biochem Biophys Res Commun 359: 877-883. (Pubitemid 46946901)
30. Gnecchi M, He H, Liang OD, Melo LG, Morello F, et al. (2005) Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 11: 367-368. (Pubitemid 40562318)
31. Gnecchi M, He H, Melo LG, Noiseaux N, Morello F, et al. (2009) Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction. Stem Cells 27: 971-979.
32. Gnecchi M, Zhang Z, Ni A, Dzau VJ (2008) Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 103: 1204-1219.
33. Akasaka Y, Morimoto N, Ishikawa Y, Fujita K, Ito K, et al. (2006) Myocardial apoptosis associated with the expression of proinflammatory cytokines during the course of myocardial infarction. Mod Pathol 19: 588-598.
34. Whelan RS, Kaplinskiy V, Kitsis RN (2010) Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physiol 72: 19-44.
35. Giordano FJ, Gerber HP, Williams SP, VanBruggen N, Bunting S, et al. (2001) A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A 98: 5780-5785. (Pubitemid 32435719)
36. Tang XL, Rokosh G, Sanganalmath SK, Yuan F, Sato H, et al. (2010) Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation 121: 293-305.