-
1
-
-
84865443841
-
Four-Membered Heterocycles: Structure and Reactivity
-
in, ed. J. Alvarez-Builla, J. J. Vaquero and J. Barluenga, Wiley-VCH, ch. 3, 163-268
-
G. Rousseau and S. Robin, Four-Membered Heterocycles: Structure and Reactivity, in Modern Heterocyclic Chemistry, ed., J. Alvarez-Builla, J. J. Vaquero, and, J. Barluenga, Wiley-VCH, ch. 3, 2011, pp. 163-268
-
(2011)
Modern Heterocyclic Chemistry
-
-
Rousseau, G.1
Robin, S.2
-
2
-
-
84984559459
-
-
ed., Elsevier Ltd, 1-989
-
Four-membered Heterocycles together with all Fused Systems containing a Four-membered Heterocyclic Ring in Comprehensive Heterocyclic Chemistry III, ed., A. R. Katritzky, C. A. Ramsden, E. F. V. Scriven, and, R. J. K. Taylor, Elsevier Ltd, 2008, vol. 2, pp. 1-989
-
(2008)
Four-membered Heterocycles Together with All Fused Systems Containing A Four-membered Heterocyclic Ring in Comprehensive Heterocyclic Chemistry III
, vol.2
-
-
Katritzky, A.R.1
Ramsden, C.A.2
Scriven, E.F.V.3
Taylor, R.J.K.4
-
16
-
-
77955732976
-
-
WO 2008110308 A2 20080918
-
M. Muehlebach, W. Lutz, J. Wenger, J. Finney, C. J. Mathews and D. Fawke, PCT Int. Appl, WO 2008110308 A2 20080918, 2008
-
(2008)
PCT Int. Appl
-
-
Muehlebach, M.1
Lutz, W.2
Wenger, J.3
Finney, J.4
Mathews, C.J.5
Fawke, D.6
-
17
-
-
84903363599
-
-
CN 102796109 A 20121128
-
W. Zhao, X. Dong, W. Zhang, F. Wang, J. LI, Y. Zhao, F. Zhao and W. Wang, 2012, PTC CN 102796109 A 20121128
-
(2012)
PTC
-
-
Zhao, W.1
Dong, X.2
Zhang, W.3
Wang, F.4
Li, J.5
Zhao, Y.6
Zhao, F.7
Wang, W.8
-
19
-
-
77955732976
-
-
WO 2008035315 A2 20080327, For a recent work on the importance in drug-discovery of small-sized saturated heterocycles see
-
S. Rudra et al. PCT Int. Appl, WO 2008035315 A2 20080327, 2008
-
(2008)
PCT Int. Appl
-
-
Rudra, S.1
-
27
-
-
84892862408
-
-
L. Degennaro M. Zenzola P. Trinchera C. Laura A. Giovine G. Romanazzi A. Falcicchio R. Luisi Chem. Commun. 2014 50 1698
-
(2014)
Chem. Commun.
, vol.50
, pp. 1698
-
-
Degennaro, L.1
Zenzola, M.2
Trinchera, P.3
Laura, C.4
Giovine, A.5
Romanazzi, G.6
Falcicchio, A.7
Luisi, R.8
-
34
-
-
84889376344
-
-
ed., Wiley-VCH, Weinheim
-
Organosulfur Chemistry in Asymmetric Synthesis, ed., T. Toru, and, C. Bolm, Wiley-VCH, Weinheim, 2008
-
(2008)
Organosulfur Chemistry in Asymmetric Synthesis
-
-
Toru, T.1
Bolm, C.2
-
36
-
-
6444228185
-
-
We use the trans/cis descriptors with reference to the spatial relationship between the introduced electrophile and the oxygen atom of the SO group CCDC number of cis- 2a. The crystallographic analysis of the cis- 2a, revealed a puckered conformation for the four-membered ring, an equatorial benzhydryl group and an intramolecular hydrogen bond between the hydroxyl group and the axial oxygen atom of the sulfinyl group (see ESI) Stereochemical issues have been reported in the lithiation/functionalization of thiane oxide, see
-
J. F. King J. R. Du Manoir Can. J. Chem. 1973 51 4082
-
(1973)
Can. J. Chem.
, vol.51
, pp. 4082
-
-
King, J.F.1
Du Manoir, J.R.2
-
38
-
-
0000232886
-
-
To shed light on this intriguing process, spectroscopic and computational investigations are underway to prove the configurational (in)stability and the structure in solution of 1-Li and the stereochemical course of its reaction with electrophile (retentive or invertive). A planar intermediate could not be ruled out as demonstrated for the closely related thiane 1-oxide, see
-
G. Chassaing R. Lett A. Marquet Tetrahedron Lett. 1978 19 471
-
(1978)
Tetrahedron Lett.
, vol.19
, pp. 471
-
-
Chassaing, G.1
Lett, R.2
Marquet, A.3
-
39
-
-
0004446358
-
-
ref. 18b The trans/cis descriptors are used to indicate the relative configuration of the functionalized carbons C2 and C4 A double functionalization has been reported in the lithiation of thiane-1-oxide derivatives see
-
R. Lett G. Chassaig Tetrahedron 1978 34 2705
-
(1978)
Tetrahedron
, vol.34
, pp. 2705
-
-
Lett, R.1
Chassaig, G.2
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