-
1
-
-
84865226981
-
Next-generation sequencing data interpretation: enhancing reproducibility and accessibility
-
Nekrutenko, A. and Taylor, J. (2012) Next-generation sequencing data interpretation: enhancing reproducibility and accessibility. Nat. Rev. Genet. 13, 667-672
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 667-672
-
-
Nekrutenko, A.1
Taylor, J.2
-
2
-
-
41649109807
-
Translating insights from the cancer genome into clinical practice
-
Chin, L. and Gray, J.W. (2008) Translating insights from the cancer genome into clinical practice. Nature 452, 533-563
-
(2008)
Nature
, vol.452
, pp. 533-563
-
-
Chin, L.1
Gray, J.W.2
-
3
-
-
76649130555
-
Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship
-
Kim, H. et al. (2010) Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc. Natl. Acad. Sci. U.S.A. 107, 2183-2188
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 2183-2188
-
-
Kim, H.1
-
4
-
-
79958254401
-
Integrated bioinformatics analysis for cancer target identification
-
Yang, Y. et al. (2011) Integrated bioinformatics analysis for cancer target identification. Methods Mol. Biol. 719, 527-545
-
(2011)
Methods Mol. Biol.
, vol.719
, pp. 527-545
-
-
Yang, Y.1
-
5
-
-
44849093562
-
Oncogene addiction
-
Weinstein, I.B. and Joe, A. (2008) Oncogene addiction. Cancer Res. 68, 3077-3080
-
(2008)
Cancer Res
, vol.68
, pp. 3077-3080
-
-
Weinstein, I.B.1
Joe, A.2
-
6
-
-
80155191242
-
Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils
-
Torti, D. and Trusolino, L. (2011) Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils. EMBO Mol. Med. 3, 623-636
-
(2011)
EMBO Mol. Med.
, vol.3
, pp. 623-636
-
-
Torti, D.1
Trusolino, L.2
-
7
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2
-
Herbst, R.S. et al. (2004) Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2. J. Clin. Oncol. 22, 785-794
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
-
8
-
-
70450193142
-
Imatinib and beyond - exploring the full potential of targeted therapy for CML
-
Quintas-Cardama, A. et al. (2009) Imatinib and beyond - exploring the full potential of targeted therapy for CML. Nat. Rev. Clin. Oncol. 6, 535-543
-
(2009)
Nat. Rev. Clin. Oncol.
, vol.6
, pp. 535-543
-
-
Quintas-Cardama, A.1
-
9
-
-
80053386829
-
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis
-
Shaw, A.T. et al. (2011) Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncol. 12, 1004-1012
-
(2011)
Lancet Oncol
, vol.12
, pp. 1004-1012
-
-
Shaw, A.T.1
-
10
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty, K.T. et al. (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 9, 809-819
-
(2010)
N. Engl. J. Med.
, vol.9
, pp. 809-819
-
-
Flaherty, K.T.1
-
11
-
-
0035656688
-
Non-coding RNA genes and the modern RNA world
-
Eddy, S.R. (2001) Non-coding RNA genes and the modern RNA world. Nat. Rev. Genet. 2, 919-929
-
(2001)
Nat. Rev. Genet.
, vol.2
, pp. 919-929
-
-
Eddy, S.R.1
-
12
-
-
77957361864
-
Targeting microRNAs in cancer: rationale, strategies and challenges
-
Garzon, R. et al. (2010) Targeting microRNAs in cancer: rationale, strategies and challenges. Nat. Rev. Drug Discov. 9, 775-789
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 775-789
-
-
Garzon, R.1
-
13
-
-
84874246197
-
RNA directed therapeutics: mechanisms and status
-
Crooke, S.T. (2013) RNA directed therapeutics: mechanisms and status. Drug Discov. Today: Ther. Strat. http://dx.doi.org/10.1016/j.ddstr.2012.12.001
-
(2013)
Drug Discov. Today: Ther. Strat
-
-
Crooke, S.T.1
-
14
-
-
77949485460
-
Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolemia: a randomized, double-blind, placebo-controlled trial
-
Raal, F.J. et al. (2010) Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolemia: a randomized, double-blind, placebo-controlled trial. Lancet 375, 998-1006
-
(2010)
Lancet
, vol.375
, pp. 998-1006
-
-
Raal, F.J.1
-
15
-
-
80052468423
-
Randomized phase II trial of Custirsen (OGX-011) in combination with docetaxel or mitoxantrone as second-line therapy in patients with metastatic castrate-resistant prostate cancer progressing after first-line docetaxel: CUOG trial P-06c
-
Saad, F. et al. (2011) Randomized phase II trial of Custirsen (OGX-011) in combination with docetaxel or mitoxantrone as second-line therapy in patients with metastatic castrate-resistant prostate cancer progressing after first-line docetaxel: CUOG trial P-06c. Clin. Cancer Res. 17, 5765-5773
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5765-5773
-
-
Saad, F.1
-
16
-
-
67649271530
-
Antisense oligonucleotide pharmacokinetics and metabolism
-
Geary, R.S. (2009) Antisense oligonucleotide pharmacokinetics and metabolism. Expert Opin. Drug Metab. Toxicol. 4, 381-391
-
(2009)
Expert Opin. Drug Metab. Toxicol.
, vol.4
, pp. 381-391
-
-
Geary, R.S.1
-
17
-
-
84861451481
-
Clinical development of an antisense therapy for the treatment of transthyretin-associated polyneuropathy
-
Ackermann, E.J. et al. (2012) Clinical development of an antisense therapy for the treatment of transthyretin-associated polyneuropathy. Amyloid 19, 43-44
-
(2012)
Amyloid
, vol.19
, pp. 43-44
-
-
Ackermann, E.J.1
-
18
-
-
84863229481
-
Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys
-
Younis, H.S. et al. (2012) Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys. Blood 10, 2401-2408
-
(2012)
Blood
, vol.10
, pp. 2401-2408
-
-
Younis, H.S.1
-
19
-
-
84867619259
-
Pharmacodynamics and subchronic toxicity in mice and monkeys of ISIS 388626 a second-generation antisense oligonucleotide that targets human sodium glucose cotransporter 2
-
Zanardi, T.A. et al. (2012) Pharmacodynamics and subchronic toxicity in mice and monkeys of ISIS 388626, a second-generation antisense oligonucleotide that targets human sodium glucose cotransporter 2. J. Pharmacol. Exp. Ther. 2, 489-496
-
(2012)
J. Pharmacol. Exp. Ther.
, vol.2
, pp. 489-496
-
-
Zanardi, T.A.1
-
20
-
-
84868208876
-
Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases
-
Southwell, A.L. et al. (2012) Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases. Trends Mol. Med. 11, 634-643
-
(2012)
Trends Mol. Med.
, vol.11
, pp. 634-643
-
-
Southwell, A.L.1
-
21
-
-
38949153810
-
A phase I study of OGX-011, a 20-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer
-
Chi, K.N. et al. (2008) A phase I study of OGX-011, a 20-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer. Clin. Cancer Res. 14, 833-839
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 833-839
-
-
Chi, K.N.1
-
22
-
-
78650335854
-
Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study
-
Talbot, D.C. et al. (2010) Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study. Clin. Cancer Res. 24, 6150-6158
-
(2010)
Clin. Cancer Res.
, vol.24
, pp. 6150-6158
-
-
Talbot, D.C.1
-
23
-
-
84864439453
-
Targeting nuclear RNA for in vivo correction of myotonic dystrophy
-
Wheeler, T.M. et al. (2012) Targeting nuclear RNA for in vivo correction of myotonic dystrophy. Nature 488, 111-115
-
(2012)
Nature
, vol.488
, pp. 111-115
-
-
Wheeler, T.M.1
-
24
-
-
77949297395
-
Synthesis and biophysical evaluation of 20,40-constrained 20O-methoxyethyl and 20 40-constrained 20O-ethyl nucleic acid analogues
-
Seth, P.P. et al. (2010) Synthesis and biophysical evaluation of 20,40-constrained 20O-methoxyethyl and 20,40-constrained 20O-ethyl nucleic acid analogues. J. Org. Chem. 5, 1569-1581
-
(2010)
J. Org. Chem.
, vol.5
, pp. 1569-1581
-
-
Seth, P.P.1
-
25
-
-
77949512140
-
RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
-
Bennett, C.F. and Swayze, E.E. (2010) RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu. Rev. Pharmacol. Toxicol. 50, 259-293
-
(2010)
Annu. Rev. Pharmacol. Toxicol.
, vol.50
, pp. 259-293
-
-
Bennett, C.F.1
Swayze, E.E.2
-
26
-
-
0035119936
-
Pharmacokinetic properties of 20-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats
-
Geary, R.S. et al. (2001) Pharmacokinetic properties of 20-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats. J. Pharmacol. Exp. Ther. 3, 890-897
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.3
, pp. 890-897
-
-
Geary, R.S.1
-
27
-
-
80054114844
-
A phase 1 dose escalation, pharmacokinetic, and pharmacodynamic evaluation of eIF-4E antisense oligonucleotide LY2275796 in patients with advanced cancer
-
Hong, D.S. (2011) A phase 1 dose escalation, pharmacokinetic, and pharmacodynamic evaluation of eIF-4E antisense oligonucleotide LY2275796 in patients with advanced cancer. Clin. Cancer Res. 20, 6582-6591
-
(2011)
Clin. Cancer Res.
, vol.20
, pp. 6582-6591
-
-
Hong, D.S.1
-
28
-
-
79951602633
-
Targeted therapy for high-grade glioma with the TGF-b2 inhibitor trabedersen: results of a randomized and controlled phase IIb study
-
Bogdahn, U. et al. (2011) Targeted therapy for high-grade glioma with the TGF-b2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro-Oncology 1, 132-142
-
(2011)
Neuro-Oncology
, vol.1
, pp. 132-142
-
-
Bogdahn, U.1
-
29
-
-
0033258543
-
Pleiotropic cell-division defects and apoptosis induced by interference with surviving function
-
Li, F. et al. (1999) Pleiotropic cell-division defects and apoptosis induced by interference with surviving function. Nat. Cell Biol. 1, 461-466
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 461-466
-
-
Li, F.1
-
30
-
-
78650335854
-
Tumor surviving is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study
-
Talbot, D.C. et al. (2010) Tumor surviving is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study. Clin. Cancer Res. 16, 6150-6158
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 6150-6158
-
-
Talbot, D.C.1
-
31
-
-
0036405323
-
Antisense therapy: current status in prostate cancer and other malignancies
-
Gleave, M. et al. (2002) Antisense therapy: current status in prostate cancer and other malignancies. Cancer Metastasis Rev. 21, 79-92
-
(2002)
Cancer Metastasis Rev
, vol.21
, pp. 79-92
-
-
Gleave, M.1
-
32
-
-
0034870685
-
Chemosensitization of human renal cell cancer using antisense oligonucleotides target the antiapoptotic gene clusterin
-
Zellweger, T. et al. (2001) Chemosensitization of human renal cell cancer using antisense oligonucleotides target the antiapoptotic gene clusterin. Neoplasia 3, 360-367
-
(2001)
Neoplasia
, vol.3
, pp. 360-367
-
-
Zellweger, T.1
-
33
-
-
26944445883
-
Clusterin inhibits apoptosis by interacting with Bax
-
Zhang, H. et al. (2005) Clusterin inhibits apoptosis by interacting with Bax. Nat. Cell Biol. 7, 909-915
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 909-915
-
-
Zhang, H.1
-
34
-
-
75149124457
-
Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells
-
Zoubeidi, A. et al. (2010) Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. Mol. Cancer Res. 8, 119-130
-
(2010)
Mol. Cancer Res.
, vol.8
, pp. 119-130
-
-
Zoubeidi, A.1
-
35
-
-
0033903190
-
Over expression of clusterin in human breast carcinoma
-
Redondo, M. et al. (2000) Over expression of clusterin in human breast carcinoma. Am. J. Pathol. 157, 393-399
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 393-399
-
-
Redondo, M.1
-
36
-
-
0036144277
-
Over expression of clusterin in transitional cell carcinoma of the bladder is related to disease progression and recurrence
-
Miyake, H. et al. (2002) Over expression of clusterin in transitional cell carcinoma of the bladder is related to disease progression and recurrence. Urology 59, 150-154
-
(2002)
Urology
, vol.59
, pp. 150-154
-
-
Miyake, H.1
-
37
-
-
0036143452
-
Over expression of clusterin in an independent prognostic factor for nonpapillary renal cell carcinoma
-
Miyake, H. et al. (2002) Over expression of clusterin in an independent prognostic factor for nonpapillary renal cell carcinoma. J. Urol. 167, 703-706
-
(2002)
J. Urol.
, vol.167
, pp. 703-706
-
-
Miyake, H.1
-
38
-
-
0042423739
-
Clusterin as a biomarker in murine and human intestinal neoplasia
-
Chen, X. et al. (2003) Clusterin as a biomarker in murine and human intestinal neoplasia. Proc. Natl. Acad. Sci. U.S.A. 100, 9530-9535
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 9530-9535
-
-
Chen, X.1
-
39
-
-
0030843011
-
Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer
-
Steinberg, J. et al. (1997) Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer. Clin. Cancer Res. 3, 1707-1711
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 1707-1711
-
-
Steinberg, J.1
-
40
-
-
0037083472
-
Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy
-
July, L.V. et al. (2002) Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy. Prostate 50, 179-188
-
(2002)
Prostate
, vol.50
, pp. 179-188
-
-
July, L.V.1
-
41
-
-
24744470522
-
A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 20methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer
-
Chi, K.N. et al. (2005) A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 20methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J. Natl. Cancer 97, 1287-1296
-
(2005)
J. Natl. Cancer
, vol.97
, pp. 1287-1296
-
-
Chi, K.N.1
-
42
-
-
77957957234
-
Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer
-
Chi, K.N. et al. (2010) Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer. J. Clin. Oncol. 28, 4247-4254
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 4247-4254
-
-
Chi, K.N.1
|