Severe Septic Patients with Mitochondrial DNA Haplogroup JT Show Higher Survival Rates: A Prospective, Multicenter, Observational Study

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Lorente, Leonardo ^a   Iceta, Ruth ^b   Martín, María M ^c   López Gallardo, Esther ^b   Solé Violán, Jordi ^d   Blanquer, José ^e   Labarta, Lorenzo ^f   Díaz, César ^g   Borreguero León, Juan María ^a   Jiménez, Alejandro ^a   Montoya, Julio ^b   Ruiz Pesini, Eduardo ^b,h  

^a HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^b UNIVERSITY OF ZARAGOZA   (Spain)

^c HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^d Hospital Universitario Dr   (Spain)

^e HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^f HOSPITAL SAN JORGE   (Spain)

^g HOSPITAL UNIVERSITARIO INSULAR DE GRAN CANARIA   (Spain)

^h FUNDACIÓN ARAID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; MITOCHONDRIAL DNA; MITOCHONDRIAL DNA HAPLOGROUP JT; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEASUREMENT ACCURACY; OBSERVATIONAL STUDY; PREDICTION; PROSPECTIVE STUDY; SCORING SYSTEM; SEPSIS; SEPSIS RELATED ORGAN FAILURE ASSESSMENT SCORE; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE; SURVIVAL TIME;

AGED; DNA, MITOCHONDRIAL; FEMALE; HAPLOTYPES; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SEPSIS;

EID: 84884182531     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073320     Document Type: Article

References (23)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, et al. (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29: 1303-1310. doi:10.1097/00003246-200107000-00002.
2. Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, et al. (2006) Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 34: 344-353. doi:10.1097/01.CCM.0000194725.48928.3A.
3. Pierrakos C, Vincent JL, (2010) Sepsis biomarkers: a review. Crit Care 14: R15. doi:10.1186/cc8872.
4. Namath A, Patterson AJ, (2011) Genetic polymorphisms in sepsis. Crit Care Nurs Clin North Am 23: 181-202. doi:10.1016/j.ccell.2010.12.011.
5. Lichtenstern C, Brenner T, Bardenheuer HJ, Weigand MA, (2012) Predictors of survival in sepsis: what is the best inflammatory marker to measure? Curr Opin Infect Dis 25: 328-336. doi:10.1097/QCO.0b013e3283522038.
6. Baudouin SV, Saunders D, Tiangyou W, Elson JL, Poynter J, et al. (2005) Mitochondrial DNA and survival after sepsis: a prospective study. Lancet 366: 2118-2121.
7. Yang Y, Zhang P, Lv R, He Q, Zhu Y, et al. (2011) Mitochondrial DNA haplogroup R in the Han population and recovery from septic encephalopathy. Intensive Care Med 37: 1613-1619. doi:10.1007/s00134-011-2319-9.
8. Yang Y, Shou Z, Zhang P, He Q, Xiao H, et al. (2008) Mitochondrial DNA haplogroup R predicts survival advantage in severe sepsis in the Han population. Genet Med 10: 187-192. doi:10.1097/GIM.0b013e318163c343. PubMed: 18344708.
9. Lorente L, Iceta R, Martín MM, López-Gallardo E, Solé-Violán J, et al. (2012) Survival and mitochondrial function in septic patients according to mitochondrial DNA haplogroup. Crit Care 16: R10. doi:10.1186/cc11697.
10. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, et al. (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31: 1250-1256. doi:10.1097/01.CCM.0000050454.01978.3B.
11. Knaus WA, Draper EA, Wagner DP, Zimmerman JE, (1985) APACHE II: a severity of disease classification system. Crit Care Med 13: 818-829. doi:10.1097/00003246-198510000-00009.
12. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, et al. (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22: 707-710. doi:10.1007/BF01709751.
13. Andrews RM, Kubacka I, Chinnery PF, Lightowlers RN, Turnbull DM, et al. (1999) Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. Nat Genet 23: 147. doi:10.1038/13779. PubMed: 10508508.
14. Lorente L, Martín MM, López-Gallardo E, Iceta R, Solé-Violán J, et al. (2011) Platelet cytochrome c oxidase activity and quantity in septic patients. Crit Care Med 39: 1289-1294. doi:10.1097/CCM.0b013e31820ee20c.
15. Lorente L, Martín MM, Ruiz-Pesini E, (2012) Platelet mitochondrial function in sepsis. Author reply. Crit Care Med 40: 357-358. doi:10.1097/CCM.0b013e318236e341. PubMed: 22179385.
16. Canter JA, Norris PR, Moore JH, Jenkins JM, Morris JA, (2007) Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe trauma. Ann Surg 246: 406-411. doi:10.1097/SLA.0b013e3181469955. PubMed: 17717444.
17. Gomez R, O'Keeffe T, Chang LY, Huebinger RM, Minei JP, et al. (2009) Association of mitochondrial allele 4216C with increased risk for complicated sepsis and death after traumatic injury. J Trauma 66: 850-857. doi:10.1097/TA.0b013e3181991ac8. PubMed: 19276764.
18. van Oven M, Kayser M, (2009) Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat 30: E386-E394. doi:10.1002/humu.20921. PubMed: 18853457.
19. Hwang S, Kwak SH, Bhak J, Kang HS, Lee YR, et al. (2011) Gene expression pattern in transmitochondrial cytoplasmic hybrid cells harboring type 2 diabetes-associated mitochondrial DNA haplogroups. PLOS ONE 6: e22116. doi:10.1371/journal.pone.0022116. PubMed: 21765942.
20. Gómez-Durán A, Pacheu-Grau D, López-Gallardo E, Díez-Sánchez C, Montoya J, et al. (2010) Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups. Hum Mol Genet 19: 3343-3353. doi:10.1093/hmg/ddq246. PubMed: 20566709.
21. Bellizzi D, Cavalcante P, Taverna D, Rose G, Passarino G, et al. (2006) Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines. Genes Cells 11: 883-891. doi:10.1111/j.1365-2443.2006.00986.x. PubMed: 16866872.
22. Hack CE, De Groot ER, Felt-Bersma RJ, Nuijens JH, Strack Van Schijndel RJ, et al. (1989) Increased plasma levels of interleukin-6 in sepsis. Blood 74: 1704-1710. PubMed: 2790194.
23. Patel RT, Deen KI, Youngs D, Warwick J, Keighley MR, (1994) Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis. Br J Surg 81: 1306-1308. doi:10.1002/bjs.1800810914. PubMed: 7953393.