Importance of pericardial fat in the formation of complex fractionated atrial electrogram region in atrial fibrillation

International Journal of Cardiology

Volumn 174, Issue 3, 2014, Pages 557-564

  Kanazawa, Hisanori ^a   Yamabe, Hiroshige ^a   Enomoto, Koji ^a   Koyama, Junjiroh ^a   Morihisa, Kenji ^a   Hoshiyama, Tadashi ^a   Matsui, Kunihiko ^b   Ogawa, Hisao ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b YAMAGUCHI UNIVERSITY HOSPITAL   (Japan)

Author keywords

atrial fibrillation; complex fractionated atrial electrogram; fibrosis; inflammation; pericardial fat

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; IOHEXOL;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR PARAMETERS; COMPLEX FRACTIONATED ATRIAL ELECTROGRAM REGION; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; FAT MASS; FEMALE; HEART ATRIUM FIBRILLATION; HEART LEFT ATRIAL DIAMETER; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; HUMAN TISSUE; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PAROXYSMAL HEART ATRIUM FIBRILLATION; PATHOGENESIS; PATHOLOGICAL ANATOMY; PERICARDIAL FAT; PERSISTENT HEART ATRIUM FIBRILLATION; PREVALENCE; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING; WAIST CIRCUMFERENCE; AGED; HEART FUNCTION TEST; MIDDLE AGED; PATHOPHYSIOLOGY; PERICARDIUM; PHYSIOLOGY; PROCEDURES; RADIOGRAPHY;

ADIPOSE TISSUE; AGED; ATRIAL FIBRILLATION; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; HUMANS; MALE; MIDDLE AGED; PERICARDIUM; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84903303648     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2014.04.135     Document Type: Article

References (25)

1. M.K. Chung, D.O. Martin, and D. Sprecher et al. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation Circulation 104 2001 2886 2891
2. R.J. Aviles, D.O. Martin, and C. Apperson-Hansen et al. Inflammation as a risk factor for atrial fibrillation Circulation 108 2003 3006 3010
3. S. Nattel, B. Burstein, and D. Dobrev Atrial remodeling and atrial fibrillation: mechanisms and implications Circ Arrhythm Electrophysiol 1 2008 62 73
4. L. Yue, J. Xie, and S. Nattel Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation Cardiovasc Res 89 2011 744 753
5. M.O. Al Chekakie, C.C. Welles, and R. Metoyer et al. Pericardial fat is independently associated with human atrial fibrillation J Am Coll Cardiol 56 2010 784 788
6. C.X. Wong, H.S. Abed, and P. Molaee et al. Pericardial fat is associated with atrial fibrillation severity and ablation outcome J Am Coll Cardiol 57 2011 1745 1751
7. S.Y. Shin, H.S. Yong, and H.E. Lim et al. Total and interatrial epicardial adipose tissues are independently associated with left atrial remodeling in patients with atrial fibrillation J Cardiovasc Electrophysiol 22 2011 647 655
8. T. Mazurek, L. Zhang, and A. Zalewski et al. Human epicardial adipose tissue is a source of inflammatory mediators Circulation 108 2003 2460 2466
9. H.S. Sacks, and J.N. Fain Human epicardial adipose tissue: a review Am Heart J 153 2007 907 917
10. H. Yamabe, K. Morihisa, and Y. Tanaka et al. Mechanisms of the maintenance of atrial fibrillation: role of the complex fractionated atrial electrogram assessed by noncontact mapping Heart Rhythm 6 2009 1120 1128
11. H. Yamabe, K. Morihisa, J. Koyama, K. Enomoto, H. Kanazawa, and H. Ogawa Analysis of the mechanisms initiating random wave propagation at the onset of atrial fibrillation using noncontact mapping: role of complex fractionated electrogram region Heart Rhythm 8 2011 1228 1236
12. V. Jacquemet, and C.S. Henriquez Genesis of complex fractionated atrial electrograms in zones of slow conduction: a computer model of microfibrosis Heart Rhythm 6 2009 803 810
13. X. Liu, H.F. Shi, H.W. Tan, X.H. Wang, L. Zhou, and J.N. Gu Decreased connexin 43 and increased fibrosis in atrial regions susceptible to complex fractionated atrial electrograms Cardiology 114 2009 22 29
14. H. Calkins, K.H. Kuck, and R. Cappato et al. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design Heart Rhythm 9 2012 632 696
15. M. Konishi, S. Sugiyama, and K. Sugamura et al. Association of pericardial fat accumulation rather than abdominal obesity with coronary atherosclerotic plaque formation in patients with suspected coronary artery disease Atherosclerosis 209 2010 573 578
16. M. Konishi, S. Sugiyama, and Y. Sato et al. Pericardial fat inflammation correlates with coronary artery disease Atherosclerosis 213 2010 649 655
17. G.A. Rosito, J.M. Massaro, and U. Hoffmann et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study Circulation 117 2008 605 613
18. A.S. Jadidi, E. Duncan, and S. Miyazaki et al. Functional nature of electrogram fractionation demonstrated by left atrial high-density mapping Circ Arrhythm Electrophysiol 5 2012 32 42
19. A. Verma, P. Novak, and L. Macle et al. A prospective, multicenter evaluation of ablating complex fractionated electrograms (CFEs) during atrial fibrillation (AF) identified by an automated mapping algorithm: acute effects on AF and efficacy as an adjuvant strategy Heart Rhythm 5 2008 198 205
20. K. Nademanee, J. McKenzie, and E. Kosar et al. A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate J Am Coll Cardiol 43 2004 2044 2053
21. N. Venteclef, V. Guglielmi, and E. Balse et al. Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines Eur Heart J Mar 22 2013 10.1093/eurheartj/eht099
22. A. Verma, R. Mantovan, and L. Macle et al. Substrate and trigger ablation for reduction of atrial fibrillation (STAR AF): a randomized, multicentre, international trial Eur Heart J 31 2010 1344 1356
23. W.J. Li, Y.Y. Bai, and H.Y. Zhang et al. Additional ablation of complex fractionated atrial electrograms after pulmonary vein isolation in patients with atrial fibrillation: a meta-analysis Circ Arrhythm Electrophysiol 4 2011 143 148
24. E. Solheim, M.K. Off, P.I. Hoff, P. Schuster, O.J. Ohm, and J. Chen Characteristics and distribution of complex fractionated atrial electrograms in patients with paroxysmal and persistent atrial fibrillation J Interv Card Electrophysiol 28 2010 87 93
25. T. Ashihara, R. Haraguchi, and K. Nakazawa et al. The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: implications for electrogram-based catheter ablation Circ Res 110 2012 275 284