Biphasic modulation of α-ENaC expression by lipopolysaccharide in vitro and in vivo

Molecular Medicine Reports

Volumn 10, Issue 2, 2014, Pages 773-777

  Sheng, Shu Jing ^a,b   Nie, Yi Chu ^a   Lin, Feng ^a   Li, Pei Bo ^a   Liu, Meng Hua ^a   Xie, Cheng Shi ^b   Long, Chao Feng ^b   Su, Wei Wei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangdong Zhongsheng Pharmaceutical Co Ltd   (China)

Author keywords

Acute lung injury; Epithelial sodium channel; Lipopolysaccharide; Pulmonary edema

Indexed keywords

ALPHA EPITHELIAL SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG; MESSENGER RNA;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG EDEMA; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; DRUG EFFECTS; GENETICS; LUNG; METABOLISM; PATHOLOGY; TIME; TOXICITY; TUMOR CELL LINE;

ACUTE LUNG INJURY; ANIMALS; CELL LINE, TUMOR; EPITHELIAL SODIUM CHANNELS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; RNA, MESSENGER; TIME FACTORS;

EID: 84903276584     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2303     Document Type: Article

References (22)

1. Maybauer MO, Maybauer DM and Herndon DN: Incidence and outcomes of acute lung injury. N Engl J Med 354: 416-417, 2006. (Pubitemid 43145071)
2. Ware LB and Matthay MA: Alveolar. uid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 163: 1376-1383, 2001. (Pubitemid 32506602)
3. Berthiaume Y, Folkesson HG and Matthay MA: Lung edema clearance: 20 years of progress: invited review: alveolar edema fluid clearance in the injured lung. J Appl Physiol (1985) 93: 2207-2213, 2002.
4. + channel is made of three homologous subunits. Nature 367: 463-467, 1994.
5. Hummler E, Barker P, Gatzy J, et al: Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet 12: 325-328, 1996.
6. Egli M, Duplain H, Lepori M, et al: Defective respiratory amiloride-sensitive sodium transport predisposes to pulmonary oedema and delays its resolution in mice. J Physiol 560: 857-865, 2004. (Pubitemid 39530123)
7. Rittirsch D, Flierl MA, Day DE, et al: Acute lung injury induced by lipopolysaccharide is independent of complement activation. J Immunol 180: 7664-7672, 2008.
8. Dagenais A, Gosselin D, Guilbault C, et al: Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa. Respir Res 6: 2, 2005.
9. Dodrill MW and Fedan JS: Lipopolysaccharide hyperpolarizes guinea pig airway epithelium by increasing the activities of the epithelial Na(+) channel and the Na(+)-K(+) pump. Am J Physiol Lung Cell Mol Physiol 299: L550-L558, 2010.
10. Baines DL, Albert AP, Hazell MJ, et al: Lipopolysaccharide modifies amiloride-sensitive Na+ transport processes across human airway cells: role of mitogen-activated protein kinases ERK 1/2 and 5. Pflugers Arch 459: 451-463, 2010.
11. Song JJ, Kwon SK, Cho CG, et al: Expression of ENaC in LPS-induced inflammation of middle ear mucosa. Acta. Otolaryngol 132: 1145-1150, 2012.
12. Dodrill MW, Beezhold DH, Meighan T, et al: Lipopolysaccharide increases Na(+),K(+)-pump, but not ENaC, expression in guinea-pig airway epithelium. Eur J Pharmacol 651: 176-186, 2011.
13. Su X, Wang L, Song Y and Bai C: Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide. Intensive Care Med 30: 133-140, 2003. (Pubitemid 38147119)
14. Berthiaume Y and Matthay MA: Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol 159: 350-359, 2007. (Pubitemid 350123611)
15. Roux J, Kawakatsu H, Gartland B, et al: Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem 280: 18579-18589, 2005. (Pubitemid 41379556)
16. Galietta LJ, Pagesy P, Folli C, et al: IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro. J Immunol 168: 839-845, 2002. (Pubitemid 34049586)
17. Galietta LJ, Folli C, Marchetti C, et al: Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-gamma. Am J Physiol Lung Cell Mol Physiol 278: L1186-L1194, 2000. (Pubitemid 30439242)
18. Frank J, Roux J, Kawakatsu H, et al: Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem 278: 43939-43950, 2003. (Pubitemid 37377133)
19. Clerici C and Matthay MA. Hypoxia regulates gene expression of alveolar epithelial transport proteins. J Appl Physiol (1985) 88: 1890-1896, 2000.
20. Wodopia R, Ko HS, Billian J, et al: Hypoxia decreases proteins involved in epithelial electrolyte transport in A549 cells and rat lung. Am J Physiol Lung Cell Mol Physiol 279: L1110-L1119, 2000. (Pubitemid 32009497)
21. Rezaiguia S, Garat C, Delclaux C, et al: Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism. J Clin Invest 99: 325-335, 1997. (Pubitemid 27053472)
22. Viget NB, Guery BP, Ader F, et al: Keratinocyte growth factor protects against Pseudomonas aeruginosa-induced lung injury. Am J Physiol Lung Cell Mol Physiol 279: 1199-1209, 2000.