Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease

BMC Nephrology

Volumn 15, Issue 1, 2014, Pages

  Poesen, Ruben ^a   Viaene, Liesbeth ^a   Verbeke, Kristin ^b   Augustijns, Patrick ^c   Bammens, Bert ^a   Claes, Kathleen ^a   Kuypers, Dirk ^a   Evenepoel, Pieter ^a   Meijers, Björn ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

Author keywords

Cardiovascular disease; Gut; P cresyl sulfate

Indexed keywords

ALBUMIN; ANGIOTENSIN RECEPTOR ANTAGONIST; C REACTIVE PROTEIN; CALCIUM; CHOLESTEROL; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; PARA CRESOL; PHOSPHATE; 4-CRESOL; BIOLOGICAL MARKER; CRESOL;

AGED; ALBUMIN BLOOD LEVEL; ARTICLE; BRAIN ISCHEMIA; CALCIUM BLOOD LEVEL; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SURGERY; CHRONIC KIDNEY DISEASE; CREATININE URINE LEVEL; FEMALE; FOLLOW UP; HEART DEATH; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART VENTRICLE ARRHYTHMIA; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; INTESTINE; MAJOR CLINICAL STUDY; MALE; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PROSPECTIVE STUDY; RENAL REPLACEMENT THERAPY; SYSTOLIC BLOOD PRESSURE; URINARY EXCRETION; BELGIUM; CARDIOVASCULAR DISEASES; CLINICAL TRIAL; COMORBIDITY; EPIDEMIOLOGY; INCIDENCE; INTESTINE ABSORPTION; MIDDLE AGED; RENAL INSUFFICIENCY, CHRONIC; REPRODUCIBILITY; RISK FACTOR; SENSITIVITY AND SPECIFICITY; URINE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BELGIUM; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; COMORBIDITY; CRESOLS; FEMALE; HUMANS; INCIDENCE; INTESTINAL ABSORPTION; MALE; MIDDLE AGED; RENAL INSUFFICIENCY, CHRONIC; REPRODUCIBILITY OF RESULTS; RISK FACTORS; SENSITIVITY AND SPECIFICITY;

EID: 84903267036     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/1471-2369-15-87     Document Type: Article

References (23)

1. New insights into uremia-induced alterations in metabolic pathways. Rhee EP, Thadhani R, Curr Opin Nephrol Hypertens 2011 20 593 598 10.1097/MNH. 0b013e32834b8a1d 21885966
2. Colonic contribution to uremic solutes. Aronov PA, Luo FJ, Plummer NS, Quan Z, Holmes S, Hostetter TH, Meyer TW, J Am Soc Nephrol 2011 22 1769 1776 10.1681/ASN.2010121220 21784895
3. p-Cresol and cardiovascular risk in mild-to-moderate kidney disease. Meijers BK, Claes K, Bammens B, de Loor H, Viaene L, Verbeke K, Kuypers D, Vanrenterghem Y, Evenepoel P, Clin J Am Soc Nephrol 2010 5 1182 1189 10.2215/CJN.07971109 20430946
4. Free p-cresol is associated with cardiovascular disease in hemodialysis patients. Meijers BK, Bammens B, De Moor B, Verbeke K, Vanrenterghem Y, Evenepoel P, Kidney Int 2008 73 1174 1180 10.1038/ki.2008.31 18305466 (Pubitemid 351620433)
5. Serum Levels of Free Retained Organic Solutes and Outcomes in Hemodialysis Patients [Abstract]. Shafi T, Meyer TW, Hostetter TH, Melamed ML, Liu Y, Banerjee T, Powe NR, ASN Kidney Week 2013 2013 2013
6. Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients. Bammens B, Evenepoel P, Keuleers H, Verbeke K, Vanrenterghem Y, Kidney Int 2006 69 1081 1087 10.1038/sj.ki.5000115 16421516 (Pubitemid 43372184)
7. Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease. Liabeuf S, Barreto DV, Barreto FC, Meert N, Glorieux G, Schepers E, Temmar M, Choukroun G, Vanholder R, Massy ZA, Nephrol Dial Transplant 2010 25 1183 1191 10.1093/ndt/gfp592 19914995
8. p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease. Wu IW, Hsu KH, Lee CC, Sun CY, Hsu HJ, Tsai CJ, Tzen CY, Wang YC, Lin CY, Wu MS, Nephrol Dial Transplant 2011 26 938 947 10.1093/ndt/gfq580 20884620
9. Uremic solutes from colon microbes. Meyer TW, Hostetter TH, Kidney Int 2012 81 949 954 10.1038/ki.2011.504 22318422
10. Characterization of uremic toxin transport by organic anion transporters in the kidney. Deguchi T, Kusuhara H, Takadate A, Endou H, Otagiri M, Sugiyama Y, Kidney Int 2004 65 162 174 10.1111/j.1523-1755.2004.00354.x 14675047 (Pubitemid 38037501)
11. Estimated glomerular filtration rate is a poor predictor of concentration for a broad range of uremic toxins. Eloot S, Schepers E, Barreto DV, Barreto FC, Liabeuf S, Van Biesen W, Verbeke F, Glorieux G, Choukroun G, Massy Z, Vanholder R, Clin J Am Soc Nephrol 2011 6 1266 1273 10.2215/CJN.09981110 21617084
12. Renal Clearance and Intestinal Generation of p-Cresyl Sulfate and Indoxyl Sulfate in CKD. Poesen R, Viaene L, Verbeke K, Claes K, Bammens B, Sprangers B, Naesens M, Vanrenterghem Y, Kuypers D, Evenepoel P, Meijers B, Clin J Am Soc Nephrol 2013 8 1508 1514 10.2215/CJN.00300113 23813557
13. A new equation to estimate glomerular filtration rate. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF III, Feldman HI, Kusek JW, Eggers P, Van LF, Greene T, Coresh J, Ann Intern Med 2009 150 604 612 10.7326/0003-4819-150-9- 200905050-00006 19414839
14. Sodium octanoate to reverse indoxyl sulfate and p-cresyl sulfate albumin binding in uremic and normal serum during sample preparation followed by fluorescence liquid chromatography. de Loor H, Meijers BK, Meyer TW, Bammens B, Verbeke K, Dehaen W, Evenepoel P, J Chromatogr A 2009 1216 4684 4688 10.1016/j.chroma.2009.04.015 19394619
15. Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Intersalt Cooperative Research Group. BMJ 1988 297 319 328 3416162
16. The precision of estimating protein intake of patients with chronic renal failure. Masud T, Manatunga A, Cotsonis G, Mitch WE, Kidney Int 2002 62 1750 1756 10.1046/j.1523-1755.2002.00606.x 12371976 (Pubitemid 35286283)
17. A method for estimating nitrogen intake of patients with chronic renal failure. Maroni BJ, Steinman TI, Mitch WE, Kidney Int 1985 27 58 65 10.1038/ki.1985.10 3981873 (Pubitemid 15130686)
18. The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression. Meijers BK, Evenepoel P, Nephrol Dial Transplant 2011 26 759 761 10.1093/ndt/gfq818 21343587
19. p-Cresyl sulfate promotes insulin resistance associated with CKD. Koppe L, Pillon NJ, Vella RE, Croze ML, Pelletier CC, Chambert S, Massy Z, Glorieux G, Vanholder R, Dugenet Y, Soula HA, Fouque D, Soulage CO, J Am Soc Nephrol 2013 24 88 99 10.1681/ASN.2012050503 23274953
20. Resistant starch lowers fecal concentrations of ammonia and phenols in humans. Birkett A, Muir J, Phillips J, Jones G, O'Dea K, Am J Clin Nutr 1996 63 766 772 8615362 (Pubitemid 26126598)
21. Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism. Smith EA, Macfarlane GT, J Appl Bacteriol 1996 81 288 302 10.1111/j.1365-2672.1996.tb04331.x 8810056
22. Influence of dietary protein supplements on the formation of bacterial metabolites in the colon. Geypens B, Claus D, Evenepoel P, Hiele M, Maes B, Peeters M, Rutgeerts P, Ghoos Y, Gut 1997 41 70 76 10.1136/gut.41.1.70 9274475 (Pubitemid 27351643)
23. Chronic kidney disease alters intestinal microbial flora. Vaziri ND, Wong J, Pahl M, Piceno YM, Yuan J, Desantis TZ, Ni Z, Nguyen TH, Andersen GL, Kidney Int 2013 83 308 315 10.1038/ki.2012.345 22992469